XSB1053 : PREDICTED: hypothetical protein isoform 6 [Pan troglodytes]
[ CaMP Format ]
This entry is computationally expanded from SB0020
* Basic Information
| Organism | Pan troglodytes (chimpanzee) |
| Protein Names | hypothetical protein isoform 6 |
| Gene Names | LOC451317; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 1 mRNA, 715 ESTs, 24 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| XP_001169048 | XM_001169048 | 451317 | N/A | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 714 aa
Average Mass: 81.894 kDa
Monoisotopic Mass: 81.842 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 27 --- | ||||
| --- cleavage 15 --- | ||||
| Peptidase_C2 1. | 55 | 354 | 813.7 | 1.1e-241 |
| Calpain_III 1. | 365 | 522 | 387.5 | 2.3e-113 |
| efhand 1. | 546 | 573 | 1.1 | 16 |
| efhand 2. | 589 | 617 | 16.6 | 0.11 |
| efhand 3. | 619 | 647 | 18.5 | 0.028 |
| efhand 4. | 684 | 711 | 6.2 | 4.5 |
3. Sequence Information
Fasta Sequence: XSB1053.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] VQKQRARELG27-LGRHENAIKY
Gly27 
Leu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val18 | Gln19 | Lys20 | Gln21 | Arg22 | Ala23 | Arg24 | Glu25 | Leu26 | Gly27 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu28 | Gly29 | Arg30 | His31 | Glu32 | Asn33 | Ala34 | Ile35 | Lys36 | Tyr37 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFR |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 117.00 | 23 | CAPN1 protein |
| 2 | Pan troglodytes | 117.00 | 5 | PREDICTED: hypothetical protein isoform 6 |
| 3 | synthetic construct | 117.00 | 1 | Homo sapiens calpain 1, (mu/I) large subunit |
| 4 | Pongo pygmaeus | 117.00 | 1 | CAN1_PONPY Calpain-1 catalytic subunit (Calpain-1 |
| 5 | Macaca mulatta | 113.00 | 3 | PREDICTED: calpain 1, large subunit isoform 4 |
| 6 | N/A | 107.00 | 14 | C |
| 7 | Bos taurus | 107.00 | 7 | micromolar calcium activated neutral protease 1 |
| 8 | Sus scrofa | 107.00 | 5 | micromolar calcium-activated neutral protease 1 is |
| 9 | Canis familiaris | 107.00 | 4 | PREDICTED: similar to Calpain-1 catalytic subunit |
| 10 | Mus musculus | 103.00 | 18 | calpain 1 |
| 11 | Rattus norvegicus | 103.00 | 7 | calpain 1 |
| 12 | Xenopus laevis | 89.40 | 9 | calpain 1, (mu/I) large subunit |
| 13 | Gallus gallus | 84.00 | 5 | mu-calpain large subunit |
| 14 | Xenopus tropicalis | 83.20 | 5 | CAPN1 protein |
| 15 | Coturnix coturnix | 58.90 | 1 | quail calpain |
| 16 | catalytic | 57.40 | 1 | Calpain 2, large |
| 17 | Oncorhynchus mykiss | 56.20 | 3 | calpain 1 catalytic subunit |
| 18 | Danio rerio | 54.30 | 23 | PREDICTED: similar to calpain 1 catalytic subunit |
| 19 | Stizostedion vitreum vitreum | 53.90 | 1 | putative calpain-like protein |
| 20 | Monodelphis domestica | 52.80 | 2 | PREDICTED: similar to calpain 2 |
| 21 | Tetraodon nigroviridis | 49.30 | 6 | unnamed protein product |
| 22 | Macaca fascicularis | 42.00 | 1 | unnamed protein product |
| 23 | Bos grunniens | 41.60 | 1 | micromolar calcium-activated neutral protease 1 la |
| 24 | Oryctolagus cuniculus | 33.10 | 1 | calpain 3, (p94) |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |
| Pan troglodytes | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |
| synthetic construct | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |
| Pongo pygmaeus | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |
| Macaca mulatta | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+|||||||||||||||||||||+|||#||||||||||||||||||| |||||||||| Sbjct 1 MAEEIITPVYCTGVSAQVQKQRAKELG#LGRHENAIKYLGQDYEQLRARCLQSGTLFR 57 |
| N/A | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+||||||||||||||| ||+|||#||||||||||||||||||| |||||+||| Sbjct 1 MAEEVITPVYCTGVSAQVQKLRAKELG#LGRHENAIKYLGQDYEQLRAHCLQSGSLFR 57 |
| Bos taurus | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+|| ||||||||||||||||||+|||#|||||||||||||||||||| ||| | ||| Sbjct 1 MAEEFITPVYCTGVSAQVQKQRAKELG#LGRHENAIKYLGQDYEQLRVHCLQRGALFR 57 |
| Sus scrofa | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+||||||||||||||| ||+|||#||||||||||||||||||| |||||+||| Sbjct 1 MAEEVITPVYCTGVSAQVQKLRAKELG#LGRHENAIKYLGQDYEQLRAHCLQSGSLFR 57 |
| Canis familiaris | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+|||||||||||||||||||||+|||#||||||||||+|||+|||| ||||| ||| Sbjct 1 MAEEIITPVYCTGVSAQVQKQRAKELG#LGRHENAIKYMGQDFEQLRAHCLQSGALFR 57 |
| Mus musculus | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+|||||||||||||||+| +|||#|||||||||||||||| || |||||| ||+ Sbjct 1 MTEELITPVYCTGVSAQVQKKRDKELG#LGRHENAIKYLGQDYETLRARCLQSGVLFQ 57 |
| Rattus norvegicus | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+||||||||||||||||| +|||#|||||||||||||||| || ||||+| ||+ Sbjct 1 MAEELITPVYCTGVSAQVQKQRDKELG#LGRHENAIKYLGQDYENLRARCLQNGVLFQ 57 |
| Xenopus laevis | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+| ||| ||+|||+|||| ++||#+|+||||+|+|||||+++| |||+||||+ Sbjct 1 MAEEVIVPVYATGISAQLQKQRDQDLG#VGKHENAVKFLGQDYDRIRHECLQNGTLFK 57 |
| Gallus gallus | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+|| + ||+|||||||||+|||+ ||#||+|+||+++ |||| || ||+||+||| Sbjct 1 MAEEPVVPVFCTGVSAQVQRQRAKALG#LGQHQNAVRFRGQDYAALRDDCLRSGSLFR 57 |
| Xenopus tropicalis | Query 1 MSEEIITPVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |+||+| ||| +|+|||+|||| +|||#+|+||||+|+|||||+++ |||+ |||+ Sbjct 1 MAEEVIVPVYASGISAQLQKQRDQELG#VGKHENAVKFLGQDYDRILHECLQNRTLFK 57 |
| Coturnix coturnix | Query 13 GVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |++|++|+ | | |#+| | ||+||| |||| |+ |++|| ||| Sbjct 6 GIAARLQRDRLRAEG#VGEHNNAVKYLNQDYEALKQACIESGALFR 50 |
| catalytic | Query 13 GVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 |++|++ | | |#|| || ||||| |||| || ||++||||+ Sbjct 32 GIAAKLAKDREAAEG#LGSHERAIKYLNQDYEALRNECLEAGTLFQ 76 |
| Oncorhynchus mykiss | Query 9 VYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLF 56 || +|++|+++ | |+ |#||++ ||+|+ |||++ || ||||| +|| Sbjct 4 VYASGMAAKLRSQWDRDEG#LGQNHNAVKFQGQDFKSLRARCLQSRSLF 51 |
| Danio rerio | Query 8 PVYCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLF 56 |+ ||+|+++ + | |# |++ |+|+||||+| || |||||| || Sbjct 3 PICAMGVAARLRSEWDRNEG#FGQNHMALKFLGQDFESLRTRCLQSGHLF 51 |
| Stizostedion vitreum vitreum | Query 12 TGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 +|++| +|++| +| |#+| |+||| |||| || |||+| +||+ Sbjct 2 SGIAATLQRRREKEQG#IGSCSQAVKYLNQDYEALRRRCLESESLFK 47 |
| Monodelphis domestica | Query 12 TGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLFR 57 +|++|+| + | |#|| || |+||| |||| | ||+ | ||+ Sbjct 2 SGIAAKVVRDREAAAG#LGTHEQAVKYLNQDYETLLSECLEEGKLFQ 47 |
| Tetraodon nigroviridis | Query 10 YCTGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLF 56 + ||++ +++ | |+ |#||++ |+|+|||||| |+ + |||| || Sbjct 7 HATGMAYKLRSQWDRDEG#LGQNHKAVKFLGQDYELLKSQSLQSGRLF 53 |
| Macaca fascicularis | Query 8 PVYC-TGVSAQVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLF 56 | | ||+ | + | + |#+|+| || + | +|+|| ||+ | || Sbjct 30 PTYTDTGMVAHINYSRLKASG#VGQHHNAHNFGNQSFEELRAVCLRKGELF 79 |
| Bos grunniens | Query 37 YLGQDYEQLRVRCLQSGTLFR 57 ||||||||||| ||| | ||| Sbjct 1 YLGQDYEQLRVHCLQRGALFR 21 |
| Oryctolagus cuniculus | Query 17 QVQKQRARELG#LGRHENAIKYLGQDYEQLRVRCLQSGTLF 56 +| ++| | |# | ||| |||+ || ||| || Sbjct 12 RVIRERDRRNG#EGTVTQPIKYEGQDFVVLRQRCLAQKCLF 51 |
[Site 2] ITPVYCTGVS15-AQVQKQRARE
Ser15 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile6 | Thr7 | Pro8 | Val9 | Tyr10 | Cys11 | Thr12 | Gly13 | Val14 | Ser15 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala16 | Gln17 | Val18 | Gln19 | Lys20 | Gln21 | Arg22 | Ala23 | Arg24 | Glu25 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 93.60 | 17 | calpain 1, large subunit |
| 2 | Pan troglodytes | 93.60 | 5 | PREDICTED: hypothetical protein isoform 6 |
| 3 | synthetic construct | 93.60 | 1 | Homo sapiens calpain 1, (mu/I) large subunit |
| 4 | Pongo pygmaeus | 93.60 | 1 | CAN1_PONPY Calpain-1 catalytic subunit (Calpain-1 |
| 5 | Macaca mulatta | 91.30 | 3 | PREDICTED: calpain 1, large subunit isoform 4 |
| 6 | Bos taurus | 89.70 | 6 | micromolar calcium activated neutral protease 1 |
| 7 | Canis familiaris | 89.00 | 4 | PREDICTED: similar to Calpain-1 catalytic subunit |
| 8 | N/A | 88.20 | 11 | C |
| 9 | Sus scrofa | 88.20 | 4 | micromolar calcium-activated neutral protease 1 is |
| 10 | Rattus norvegicus | 86.30 | 5 | calpain 1 |
| 11 | Mus musculus | 84.30 | 15 | unnamed protein product |
| 12 | Xenopus laevis | 73.20 | 7 | MGC81785 protein |
| 13 | Xenopus tropicalis | 72.00 | 3 | CAPN1 protein |
| 14 | Gallus gallus | 68.60 | 5 | mu-calpain large subunit |
| 15 | Danio rerio | 46.60 | 16 | calpain 1 |
| 16 | Coturnix coturnix | 44.70 | 1 | quail calpain |
| 17 | Monodelphis domestica | 42.40 | 1 | PREDICTED: similar to calpain 2 |
| 18 | catalytic | 42.00 | 1 | Calpain 2, large |
| 19 | Oncorhynchus mykiss | 40.40 | 3 | calpain 1 catalytic subunit |
| 20 | Stizostedion vitreum vitreum | 39.70 | 1 | putative calpain-like protein |
| 21 | Tetraodon nigroviridis | 38.50 | 3 | unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |
| Pan troglodytes | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |
| synthetic construct | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |
| Pongo pygmaeus | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |
| Macaca mulatta | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+|||||||||||||#||||||||+||||||||||||||||||||| Sbjct 1 MAEEIITPVYCTGVS#AQVQKQRAKELGLGRHENAIKYLGQDYEQL 45 |
| Bos taurus | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+|| ||||||||||#||||||||+||||||||||||||||||||| Sbjct 1 MAEEFITPVYCTGVS#AQVQKQRAKELGLGRHENAIKYLGQDYEQL 45 |
| Canis familiaris | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+|||||||||||||#||||||||+|||||||||||||+|||+||| Sbjct 1 MAEEIITPVYCTGVS#AQVQKQRAKELGLGRHENAIKYMGQDFEQL 45 |
| N/A | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+||||||||||#||||| ||+||||||||||||||||||||| Sbjct 1 MAEEVITPVYCTGVS#AQVQKLRAKELGLGRHENAIKYLGQDYEQL 45 |
| Sus scrofa | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+||||||||||#||||| ||+||||||||||||||||||||| Sbjct 1 MAEEVITPVYCTGVS#AQVQKLRAKELGLGRHENAIKYLGQDYEQL 45 |
| Rattus norvegicus | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+||||||||||#||||||| +||||||||||||||||||| | Sbjct 1 MAEELITPVYCTGVS#AQVQKQRDKELGLGRHENAIKYLGQDYENL 45 |
| Mus musculus | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+||||||||||#|||||+| +||||||||||||||||||| | Sbjct 1 MTEELITPVYCTGVS#AQVQKKRDKELGLGRHENAIKYLGQDYETL 45 |
| Xenopus laevis | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+| ||| ||+|#||+|||| |||+|+||||+|+|||||+++ Sbjct 1 MAEEVIVPVYATGIS#AQLQKQRDHELGVGKHENAVKFLGQDYDRI 45 |
| Xenopus tropicalis | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+||+| ||| +|+|#||+|||| +|||+|+||||+|+|||||+++ Sbjct 1 MAEEVIVPVYASGIS#AQLQKQRDQELGVGKHENAVKFLGQDYDRI 45 |
| Gallus gallus | Query 1 MSEEIITPVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+|| + ||+|||||#||||+|||+ ||||+|+||+++ |||| | Sbjct 1 MAEEPVVPVFCTGVS#AQVQRQRAKALGLGQHQNAVRFRGQDYAAL 45 |
| Danio rerio | Query 8 PVYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |+ ||++#|+++ | |+ |||++ ||+|+|||||| | Sbjct 3 PICATGMA#ARLRSQWDRDAGLGQNHNAVKFLGQDYETL 40 |
| Coturnix coturnix | Query 13 GVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |++#|++|+ | | |+| | ||+||| |||| | Sbjct 6 GIA#ARLQRDRLRAEGVGEHNNAVKYLNQDYEAL 38 |
| Monodelphis domestica | Query 12 TGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 +|++#|+| + | ||| || |+||| |||| | Sbjct 2 SGIA#AKVVRDREAAAGLGTHEQAVKYLNQDYETL 35 |
| catalytic | Query 13 GVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 |++#|++ | | ||| || ||||| |||| | Sbjct 32 GIA#AKLAKDREAAEGLGSHERAIKYLNQDYEAL 64 |
| Oncorhynchus mykiss | Query 9 VYCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 || +|++#|+++ | |+ |||++ ||+|+ |||++ | Sbjct 4 VYASGMA#AKLRSQWDRDEGLGQNHNAVKFQGQDFKSL 40 |
| Stizostedion vitreum vitreum | Query 12 TGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 +|++#| +|++| +| |+| |+||| |||| | Sbjct 2 SGIA#ATLQRRREKEQGIGSCSQAVKYLNQDYEAL 35 |
| Tetraodon nigroviridis | Query 10 YCTGVS#AQVQKQRARELGLGRHENAIKYLGQDYEQL 45 + ||++# +++ | |+ |||++ |+|+|||||| | Sbjct 7 HATGMA#YKLRSQWDRDEGLGQNHKAVKFLGQDYELL 42 |
* References
None.