logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1057 : cortactin, isoform CRA_d [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0022

* Basic Information

OrganismHomo sapiens (human)
Protein Namescortactin; isoform CRA_d
Gene NamesCTTN
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW74770 N/A 2017 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 556 aa

Average Mass: 62.201 kDa

Monoisotopic Mass: 62.163 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
HS1_rep 1. 8311968.23.1e-17
HS1_rep 2. 12015672.71.3e-18
HS1_rep 3. 15719374.44.1e-19
HS1_rep 4. 19423069.99.2e-18
HS1_rep 5. 23126768.52.5e-17
HS1_rep 6. 26830452.02.3e-12
HS1_rep 7. 31134729.71.2e-05
--- cleavage 342 (inside HS1_rep 311..347) ---
--- cleavage 357 ---
--- cleavage 352 ---
--- cleavage 364 ---
PSD5 1. 428478-25.55
SH3_1 1. 50155590.18e-24

3. Sequence Information

Fasta Sequence: XSB1057.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] AVTSKTSNIR357-ANFENLAKEK

Arg357 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala348Val349Thr350Ser351Lys352Thr353Ser354Asn355Ile356Arg357
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala358Asn359Phe360Glu361Asn362Leu363Ala364Lys365Glu366Lys367

Sequence conservation (by blast)

[Site 2] TVPVEAVTSK352-TSNIRANFEN

Lys352 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Thr343Val344Pro345Val346Glu347Ala348Val349Thr350Ser351Lys352
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr353Ser354Asn355Ile356Arg357Ala358Asn359Phe360Glu361Asn362

Sequence conservation (by blast)

[Site 3] NIRANFENLA364-KEKEQEDRRK

Ala364 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn355Ile356Arg357Ala358Asn359Phe360Glu361Asn362Leu363Ala364
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys365Glu366Lys367Glu368Gln369Glu370Asp371Arg372Arg373Lys374

Sequence conservation (by blast)

[Site 4] VTQVSSAYQK342-TVPVEAVTSK

Lys342 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val333Thr334Gln335Val336Ser337Ser338Ala339Tyr340Gln341Lys342
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr343Val344Pro345Val346Glu347Ala348Val349Thr350Ser351Lys352

Sequence conservation (by blast)

* References

[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.