XSB1061 : Chain B, Crystal Structure Of The DhPH DOMAINS OF LEUKEMIA- Associated Rhogef In Complex With Rhoa
[ CaMP Format ]
This entry is computationally expanded from SB0038
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Transforming protein RhoA; H12 |
| Gene Names | ARH12, ARHA, RHO12; ARH12; ARHA; RHO12 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 196 aa
Average Mass: 22.101 kDa
Monoisotopic Mass: 22.087 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Ras 1. | 10 | 183 | 336.4 | 5.6e-98 |
| --- cleavage 183 (inside Ras 10..183) --- | ||||
3. Sequence Information
Fasta Sequence: XSB1061.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1A2B (X-ray; 240 A; A=1-181), 1CC0 (X-ray; 500 A; A/C=1-190), 1CXZ (X-ray; 220 A; A=1-181), 1DPF (X-ray; 200 A; A=1-180), 1FTN (X-ray; 210 A; A=1-193), 1KMQ (X-ray; 155 A; A=4-181), 1LB1 (X-ray; 281 A; B/D/F/H=1-189), 1OW3 (X-ray; 180 A; B=1-193), 1S1C (X-ray; 260 A; A/B=1-181), 1TX4 (X-ray; 165 A; B=3-179), 1X86 (X-ray; 322 A; B/D/F/H=1-193), 1XCG (X-ray; 250 A; B/F=3-180), 2RGN (X-ray; 350 A; C/F=1-193)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] FEMATRAALQ183-ARRGKKKSGC
Gln183 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe174 | Glu175 | Met176 | Ala177 | Thr178 | Arg179 | Ala180 | Ala181 | Leu182 | Gln183 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala184 | Arg185 | Arg186 | Gly187 | Lys188 | Lys189 | Lys190 | Ser191 | Gly192 | Cys193 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| IGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 88.60 | 21 | B |
| 2 | Homo sapiens | 88.60 | 11 | ras homolog gene family, member A |
| 3 | synthetic construct | 88.60 | 8 | ras homolog gene family, member A |
| 4 | Canis familiaris | 88.60 | 5 | PREDICTED: similar to ras homolog gene family, mem |
| 5 | Canis lupus familiaris | 88.60 | 1 | ras homolog gene family, member A |
| 6 | Macaca mulatta | 88.60 | 1 | PREDICTED: similar to ras homolog gene family, mem |
| 7 | Mus musculus | 88.20 | 7 | unnamed protein product |
| 8 | Rattus norvegicus | 88.20 | 5 | aplysia ras-related homolog A2 |
| 9 | Gallus gallus | 87.40 | 5 | ras homolog gene family, member A |
| 10 | Pongo pygmaeus | 84.00 | 1 | hypothetical protein |
| 11 | Monodelphis domestica | 82.40 | 4 | PREDICTED: hypothetical protein |
| 12 | Tetraodon nigroviridis | 80.90 | 5 | unnamed protein product |
| 13 | Danio rerio | 79.30 | 18 | small GTPase RhoA |
| 14 | Xenopus laevis | 77.80 | 6 | hypothetical protein LOC379416 |
| 15 | Xenopus tropicalis | 77.80 | 5 | ras homolog gene family, member A |
| 16 | Ciona intestinalis | 72.80 | 2 | RhoA protein |
| 17 | Halocynthia roretzi | 71.60 | 1 | GTP binding protein Rho |
| 18 | Caenorhabditis elegans | 65.50 | 4 | RHO (small G protein) family member (rho-1) |
| 19 | Biomphalaria glabrata | 64.70 | 1 | guanine nucleotide-binding protein Rho |
| 20 | Aspergillus oryzae | 61.60 | 2 | unnamed protein product |
| 21 | Anopheles gambiae str. PEST | 61.20 | 1 | ENSANGP00000015684 |
| 22 | Aedes aegypti | 61.20 | 1 | gtpase_rho |
| 23 | Magnaporthe grisea 70-15 | 60.80 | 2 | hypothetical protein MGG_07176 |
| 24 | Strongylocentrotus purpuratus | 60.50 | 7 | PREDICTED: similar to Rho1 GTPase |
| 25 | Schistosoma mansoni | 59.70 | 2 | Rho2 GTPase |
| 26 | Ustilago maydis 521 | 59.30 | 3 | hypothetical protein UM05734.1 |
| 27 | Phaeosphaeria nodorum SN15 | 59.30 | 3 | hypothetical protein SNOG_04837 |
| 28 | Drosophila melanogaster | 58.90 | 1 | Rho1 CG8416-PA, isoform A |
| 29 | Schistosoma japonicum | 58.50 | 7 | AF521619_1 rho GTPase-like protein |
| 30 | Aspergillus fumigatus Af293 | 58.50 | 2 | Rho GTPase Rho1 |
| 31 | Neosartorya fischeri NRRL 181 | 58.50 | 2 | Rho GTPase Rho1 |
| 32 | Aspergillus clavatus NRRL 1 | 58.50 | 2 | Rho GTPase Rho1 |
| 33 | Chaetomium globosum CBS 148.51 | 58.50 | 2 | neuronal RhoA GEF protein |
| 34 | Tigriopus japonicus | 58.50 | 1 | RhoA |
| 35 | Tribolium castaneum | 58.20 | 3 | PREDICTED: similar to Ras-like GTP-binding protein |
| 36 | Cryptococcus neoformans var. neoformans JEC21 | 58.20 | 2 | Rho1 GTPase |
| 37 | Paracoccidioides brasiliensis | 58.20 | 2 | Rho1 GTPase |
| 38 | Coccidioides immitis RS | 58.20 | 2 | protein rhoA |
| 39 | Apis mellifera | 58.20 | 2 | PREDICTED: similar to Ras-like GTP-binding protein |
| 40 | Monacrosporium haptotylum | 57.80 | 1 | GTPase |
| 41 | Aspergillus terreus NIH2624 | 57.40 | 2 | protein rho1 |
| 42 | Maconellicoccus hirsutus | 57.40 | 1 | putative Rho1 |
| 43 | Aspergillus niger | 56.60 | 2 | hypothetical protein An18g05980 |
| 44 | Aspergillus nidulans FGSC A4 | 56.20 | 2 | hypothetical protein AN5740.2 |
| 45 | Blumeria graminis | 56.20 | 1 | GTPase rho1 |
| 46 | Hemicentrotus pulcherrimus | 55.80 | 1 | Rho1 GTPase |
| 47 | Coprinopsis cinerea okayama7#130 | 55.80 | 1 | Rho1 protein |
| 48 | Lytechinus variegatus | 55.50 | 1 | Ras homology protein |
| 49 | Yarrowia lipolytica | 55.10 | 6 | RHO1 |
| 50 | Suberites domuncula | 54.70 | 3 | Rho1 |
| 51 | Gibberella zeae PH-1 | 54.70 | 3 | hypothetical protein FG04400.1 |
| 52 | Lodderomyces elongisporus NRRL YB-4239 | 54.70 | 2 | protein RHO1 |
| 53 | Marsupenaeus japonicus | 54.70 | 1 | Rho |
| 54 | Fusarium oxysporum | 54.70 | 1 | small GTPase-binding protein |
| 55 | Pichia stipitis CBS 6054 | 53.90 | 3 | predicted protein |
| 56 | Candida albicans SC5314 | 52.80 | 3 | Ras family GTP-binding protein Rho1p |
| 57 | Ashbya gossypii ATCC 10895 | 52.40 | 3 | ABR183Wp |
| 58 | Schizosaccharomyces pombe 972h- | 52.00 | 3 | hypothetical protein SPAC1F7.04 |
| 59 | Kluyveromyces lactis | 52.00 | 1 | unnamed protein product |
| 60 | Cordyceps militaris | 51.20 | 2 | Rho1 |
| 61 | Amylomyces rouxii | 51.20 | 1 | AF487548_1 Rho1 GTP-binding protein |
| 62 | Debaryomyces hansenii CBS767 | 50.80 | 1 | hypothetical protein DEHA0B11792g |
| 63 | Branchiostoma belcheri | 50.80 | 1 | GTP binding protein Rho |
| 64 | Candida glabrata CBS138 | 48.90 | 1 | hypothetical protein CAGL0I08459g |
| 65 | Pichia guilliermondii ATCC 6260 | 48.10 | 3 | protein RHO1 |
| 66 | Cryptococcus neoformans var. neoformans B-3501A | 48.10 | 1 | hypothetical protein CNBG2140 |
| 67 | Eremothecium sinecaudum | 47.40 | 1 | RhoH |
| 68 | Neurospora crassa OR74A | 47.40 | 1 | hypothetical protein |
| 69 | Caenorhabditis briggsae | 46.60 | 3 | Hypothetical protein CBG13699 |
| 70 | Caenorhabditis remanei | 45.40 | 1 | guanine nucleotide regulatory protein |
| 71 | Saccharomyces cerevisiae | 43.90 | 3 | AF458975_2 RHO2 |
| 72 | Dictyostelium discoideum AX4 | 42.70 | 1 | Rho GTPase |
| 73 | Arabidopsis thaliana | 42.40 | 6 | Rho1Ps homolog |
| 74 | Oryctolagus cuniculus | 42.40 | 1 | small GTP-binding protein RhoA; ras homolog gene f |
| 75 | Entamoeba histolytica HM-1:IMSS | 42.00 | 2 | Rho family GTPase |
| 76 | Musa acuminata | 42.00 | 1 | rop |
| 77 | Pneumocystis carinii | 42.00 | 1 | CDC42p |
| 78 | Nicotiana tabacum | 41.60 | 4 | NTGP2 |
| 79 | Trichomonas vaginalis G3 | 41.60 | 2 | multidrug resistance protein, putative |
| 80 | Oryza sativa (indica cultivar-group) | 41.60 | 1 | hypothetical protein OsI_009385 |
| 81 | Oryza sativa subsp. japonica | 41.60 | 1 | RAC5_ORYSJ Rac-like GTP-binding protein 5 precurso |
| 82 | Oryza sativa (japonica cultivar-group) | 41.60 | 1 | Os02g0834000 |
| 83 | Brassica rapa | 41.20 | 1 | rac-like small GTP binding protein |
| 84 | Bos taurus | 41.20 | 1 | PREDICTED: hypothetical protein |
| 85 | Candida albicans | 41.20 | 1 | Rho3p |
| 86 | Physcomitrella patens | 40.80 | 3 | AF115476_1 rac-like GTP binding protein |
| 87 | Aplysia californica | 40.80 | 1 | Rac |
| 88 | Solanum chacoense | 40.40 | 1 | Rac-like GTP-binding protein |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| Homo sapiens | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| synthetic construct | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| Canis familiaris | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| Canis lupus familiaris | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| Macaca mulatta | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||||||| Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |
| Mus musculus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#|||||||||||+| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLIL 193 |
| Rattus norvegicus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#|||||||||||+| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLIL 193 |
| Gallus gallus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#|||||||||||+| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLLL 193 |
| Pongo pygmaeus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||||||||| ||| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGRLVL 193 |
| Monodelphis domestica | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#||| |||| |||| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARREKKKSRCLVL 193 |
| Tetraodon nigroviridis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||# ||||| | |+|| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#VRRGKKNSRCVVL 193 |
| Danio rerio | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||||||||||||||||||||||||||#|||||| + | +| Sbjct 151 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKSNKCCLL 193 |
| Xenopus laevis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | |+||||||||||||||||||+|||||||#|||||||+ ||++ Sbjct 151 ISAYGYMECSAKTKDGVREVFELATRAALQ#ARRGKKKTTCLLI 193 |
| Xenopus tropicalis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | |+||||||||||||||||||+|||||||#|||||||+ ||++ Sbjct 151 ISAYGYMECSAKTKDGVREVFELATRAALQ#ARRGKKKTTCLLI 193 |
| Ciona intestinalis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+|||||||+||+|||||||+||+||||# ++ |||||| || Sbjct 151 IGAYGYMECSARTKEGVREVFELATKAALQ#TKKRKKKSGCEVL 193 |
| Halocynthia roretzi | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||||||+|||+|||+||||||| |||||||# |+ ||| || || Sbjct 151 IGAFGYLECSSKTKEGVREVFENATRAALQ#TRKHKKKGGCDVL 193 |
| Caenorhabditis elegans | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||| |+|||||||||+||||| ||+||||# ++ |||| |++| Sbjct 151 IGAFAYLECSAKTKDGIREVFEKATQAALQ#QKK-KKKSKCMIL 192 |
| Biomphalaria glabrata | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | |+ |+|||||||+||||||| |||||||# ++ ||| ||+|| Sbjct 151 INAYSYLECSAKTKEGVREVFETATRAALQ#VKK-KKKGGCIVL 192 |
| Aspergillus oryzae | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + ||| || +| Sbjct 155 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKKKKGCTIL 197 |
| Anopheles gambiae str. PEST | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+||||||| |||||||# ++ |||| |++| Sbjct 151 INAFAYLECSAKSKEGVREVFETATRAALQ#VKK-KKKSKCVLL 192 |
| Aedes aegypti | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+||||||| |||||||# ++ |||| |++| Sbjct 166 INAFAYLECSAKSKEGVREVFETATRAALQ#VKK-KKKSKCVLL 207 |
| Magnaporthe grisea 70-15 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+|||||| +||||||| |||||| #+| || ||+| Sbjct 151 IGAYKYLECSAKTNEGVREVFEHATRAALL#SRHKTKKKKCLIL 193 |
| Strongylocentrotus purpuratus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLV 195 | | |||||||| |||||||| |||||||#+++ ||| | + Sbjct 151 INAAKYMECSAKTNDGVREVFETATRAALQ#SKKRKKKLSCKI 192 |
| Schistosoma mansoni | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGC 193 | |+||+|||||||+|||+||| |||||| # +| |+| || Sbjct 151 INAYGYLECSAKTKEGVRKVFETATRAALN#TKR-KRKKGC 189 |
| Ustilago maydis 521 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAAL-Q#ARRGKKKSGCLVL 196 ||| |+|||||| +||||||| |||||| |# || +| || || Sbjct 151 IGAVRYLECSAKTGEGVREVFEHATRAALVQ#RSRGSRKKGCTVL 194 |
| Phaeosphaeria nodorum SN15 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||| |+|||||| +||||||| |||||| # |+ || ||+| Sbjct 144 IGAQKYLECSAKTNEGVREVFEHATRAALL#TRKEKKSKKCLIL 186 |
| Drosophila melanogaster | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+|||+||| |||||||# ++ +||+ ||+| Sbjct 151 INAFAYLECSAKSKEGVRDVFETATRAALQ#VKK-RKKTRCLLL 192 |
| Schistosoma japonicum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLV 195 | |+ |+|||||||+||||||| |||||||#+++ ||| |+ Sbjct 151 IHAYSYIECSAKTKEGVREVFETATRAALQ#SKKTKKKKCDLI 192 |
| Aspergillus fumigatus Af293 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + ||| | +| Sbjct 158 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKKKGKCTIL 200 |
| Neosartorya fischeri NRRL 181 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + ||| | +| Sbjct 151 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKKKGKCTIL 193 |
| Aspergillus clavatus NRRL 1 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + ||| | +| Sbjct 151 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKKKGKCTIL 193 |
| Chaetomium globosum CBS 148.51 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLV 195 | | |+|||||| +||||||| |||||| # + ||||| |++ Sbjct 152 IKATKYLECSAKTNEGVREVFEFATRAALL#KKAGKKKSKCVI 193 |
| Tigriopus japonicus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK 190 | || |+|||||+|+||||||| |||||||# ++ ||| Sbjct 151 INAFAYLECSAKSKEGVREVFETATRAALQ#VKKKKKK 187 |
| Tribolium castaneum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+||||||| |||||||# ++ ||| | +| Sbjct 151 INAFAYLECSAKSKEGVREVFENATRAALQ#VKK-KKKHRCALL 192 |
| Cryptococcus neoformans var. neoformans JEC21 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARR---GKKKSGCLVL 196 ||| ||+|||||| +||||||+ ||| |||#+++ |+ | ||+|| Sbjct 152 IGAQGYVECSAKTGEGVREVFQTATRHALQ#SKKSKSGRGKKGCVVL 197 |
| Paracoccidioides brasiliensis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| |||||||| |||||| #|++ ||| | +| Sbjct 151 IGAYKYLECSARTNDGVREVFESATRAALL#AKKEKKK--CKIL 191 |
| Coccidioides immitis RS | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| #|+ ||| | +| Sbjct 151 IGAYKYLECSARTGEGVREVFECATRAALL#AKTEKKKKLCKIL 193 |
| Apis mellifera | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+|+||||| |||||||# ++ ||| | +| Sbjct 151 INAFAYLECSAKSKEGIREVFETATRAALQ#VKK-KKKGRCWLL 192 |
| Monacrosporium haptotylum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||| |+|||||| |||||||| |||||| # + || | | +| Sbjct 151 IGAAKYLECSAKTNDGVREVFEHATRAALT#TFKKKKSSKCSIL 193 |
| Aspergillus terreus NIH2624 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| |||||||| |||||| # + || | +| Sbjct 151 IGAYKYLECSARTNDGVREVFESATRAALL#TKTHKKPHKCTIL 193 |
| Maconellicoccus hirsutus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | || |+|||||+|+||||||| +||||||# ++ ||| | +| Sbjct 151 INAFAYLECSAKSKEGVREVFETSTRAALQ#VKK-KKKGRCRLL 192 |
| Aspergillus niger | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + | | | +| Sbjct 151 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKSKKKCTIL 193 |
| Aspergillus nidulans FGSC A4 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||+| +||||||| |||||| # + | | | +| Sbjct 151 IGAYKYLECSARTNEGVREVFEAATRAALL#TKTHKSKKKCSIL 193 |
| Blumeria graminis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+|||||| +||||||| |||||| # ++ ||+ |++| Sbjct 151 IGAYKYLECSAKTNEGVREVFEHATRAALL#TKK-KKEKRCIIL 192 |
| Hemicentrotus pulcherrimus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | |+ |+|||||+ |||||||| |||||||# ++ || | | +| Sbjct 151 INAYKYLECSAKSNDGVREVFETATRAALQ#VKK-KKSSKCSLL 192 |
| Coprinopsis cinerea okayama7#130 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK-SGCLVL 196 ||| |+|||||| +||||||+ |||||| #++ ||+| | |+|| Sbjct 155 IGARHYLECSAKTGEGVREVFQYATRAALL#SKPGKRKHSHCIVL 198 |
| Lytechinus variegatus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 | |+ |+|||||+ |||||||| |||||||# ++ | || | +| Sbjct 151 ISAYKYLECSAKSNDGVREVFETATRAALQ#VKK-KNKSKCNLL 192 |
| Yarrowia lipolytica | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAAL------Q#ARRGKKKSGCLVL 196 ||| |+||||+| |||||+|| |||||| +# |||| |++| Sbjct 155 IGALKYLECSARTHDGVREIFEHATRAALIGPKGRE#PTSGKKKKKCVIL 203 |
| Suberites domuncula | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 |||+ |+||||| +||||||| |||||||# ++ || | || Sbjct 151 IGAYAYLECSAKYNEGVREVFETATRAALQ#TKK-KKGKLCTVL 192 |
| Gibberella zeae PH-1 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#AR--RGKKKSGCLVL 196 | |+ |+|||||| +||||||| |||||| #+| | | |||| Sbjct 151 ISAYKYLECSAKTNEGVREVFEHATRAALL#SRSTRSKSHKKCLVL 195 |
| Lodderomyces elongisporus NRRL YB-4239 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#A---RRGKKKSGCLVL 196 ||| |+|||||| ||||||| ||||+|+# | |||| |+++ Sbjct 156 IGAADYLECSAKTGRGVREVFEAATRASLR#TKDKREGKKKKKCVIV 201 |
| Marsupenaeus japonicus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGC 193 | || |+||||||++||||||| |||||| # ++ ||| | Sbjct 151 INAFAYLECSAKTQEGVREVFETATRAALA#VKK-KKKPKC 189 |
| Fusarium oxysporum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#AR--RGKKKSGCLVL 196 | |+ |+|||||| +||||||| |||||| #+| | | |||| Sbjct 151 IAAYKYLECSAKTNEGVREVFEHATRAALL#SRSTSGSKHKKCLVL 195 |
| Pichia stipitis CBS 6054 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGK-KKSGCLVL 196 |||+ |+||||+| ||||||| ||||+| # + | || |+|| Sbjct 155 IGAYSYLECSARTGQGVREVFETATRASLS#RKEKKTKKKKCVVL 198 |
| Candida albicans SC5314 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGK-KKSGCLVL 196 ||| |+|||||| ||||||| ||||+|+# + | || |+|| Sbjct 155 IGAADYLECSAKTGRGVREVFEAATRASLR#VKEKKEKKKKCVVL 198 |
| Ashbya gossypii ATCC 10895 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRG--------KKKSGCLVL 196 ||| |+|||||| ||||||| ||||+| # ++| ||| |+|| Sbjct 157 IGAVEYIECSAKTGFGVREVFEAATRASLM#GKQGKSKAKSDKKKKKKCVVL 207 |
| Schizosaccharomyces pombe 972h- | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARR--------GKKKSGCLVL 196 |||+ |+|||||| +||||||| |||||+ # + ||| |++| Sbjct 152 IGAYKYLECSAKTNEGVREVFESATRAAML#KHKPKVKPSSGTKKKKRCILL 202 |
| Kluyveromyces lactis | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGK--------KKSGCLVL 196 ||| |+|||||| ||||||| ||||+| # ++|| || |+|| Sbjct 158 IGAVDYIECSAKTGYGVREVFEAATRASLV#GKQGKSKPKTKSSKKKKCVVL 208 |
| Cordyceps militaris | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK 190 |||+ |+|||||| +|| |||| |||||| #+| + | Sbjct 151 IGAYKYLECSAKTNEGVHEVFEHATRAALL#SRSSRTK 187 |
| Amylomyces rouxii | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKK-KSG 192 | |+ |+|||||| +||||||| |||||| # + || ||| Sbjct 151 ISAYKYLECSAKTGEGVREVFEHATRAALM#VSKKKKSKSG 190 |
| Debaryomyces hansenii CBS767 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGK-KKSGCLVL 196 || |+||||+| +||||||| ||||+|+# + | || |+|| Sbjct 155 IGTSYYLECSARTGEGVREVFEAATRASLK#TKEKKEKKKKCVVL 198 |
| Branchiostoma belcheri | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARR 186 | || |+|||||||+||||||| ||+||| # ++ Sbjct 151 INAFAYLECSAKTKEGVREVFETATKAALA#NKK 183 |
| Candida glabrata CBS138 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ------#ARRGKKKSG 192 ||| || |||||| ||||||| ||||+| # ++ || || Sbjct 156 IGATGYYECSAKTGYGVREVFEAATRASLMGKQKNT#GKKNKKNSG 200 |
| Pichia guilliermondii ATCC 6260 | Query 159 YMECSAKTKDGVREVFEMATRAALQ#ARR-GKKKSGCLVL 196 |+||||+| +||||||| ||||+|+# + +|| |+|| Sbjct 159 YLECSARTNEGVREVFEAATRASLK#INQVSEKKKKCVVL 197 |
| Cryptococcus neoformans var. neoformans B-3501A | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ# 183 ||| ||+|||||| +||||||+ ||| |||# Sbjct 152 IGAQGYVECSAKTGEGVREVFQTATRHALQ# 181 |
| Eremothecium sinecaudum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSG 192 ||| |+|||||| +||+|||++|||||| # + +| Sbjct 96 IGAASYVECSAKTGEGVKEVFDIATRAALT#RKSRSSTAG 134 |
| Neurospora crassa OR74A | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||| |+|||+ | +|| +||| |||||| # |+ ||| |+ Sbjct 157 IGARKYLECSSLTGEGVDDVFEAATRAALL#TFEKKEGSGCCVI 199 |
| Caenorhabditis briggsae | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||| | ||||| ++||+|+|+ | | |+#+ + |+ | +| Sbjct 156 IGAIAYFECSAKLREGVKEIFDKAVRETLR#SEKKPKRKFCKIL 198 |
| Caenorhabditis remanei | Query 154 IGAFGYMECSAKTKDGVREVFE 175 |||| |+|||||||||+||||| Sbjct 151 IGAFAYLECSAKTKDGIREVFE 172 |
| Saccharomyces cerevisiae | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 ||| |||||| | +|| +|||+||| +| # ++ + |++| Sbjct 150 IGAKKYMECSALTGEGVDDVFEVATRTSLL#MKKEPGANCCIIL 192 |
| Dictyostelium discoideum AX4 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ--#ARRGKKKSGCLVL 196 | || |+|||| |+ |++ ||+ | |+ + # ++ | |||| +| Sbjct 149 INAFKYLECSALTQKGLKTVFDEAIRSVINPP#VKKSKSKSGCNIL 193 |
| Arabidopsis thaliana | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK------SGCLVL 196 ||| |+||||||+ |+ ||+ | + ||# + ||| || +| Sbjct 150 IGAPAYIECSAKTQQNVKAVFDAAIKVVLQ#PPKNKKKKKRKSQKGCSIL 198 |
| Oryctolagus cuniculus | Query 154 IGAFGYMECSAKTKDGVREVF 174 | ||||+|||||||+|||||| Sbjct 142 ISAFGYLECSAKTKEGVREVF 162 |
| Entamoeba histolytica HM-1:IMSS | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ----#ARRGKKKSGCLV 195 ||| |+|||| |+ +| ||+ | || + #|++ ||| ||++ Sbjct 149 IGAVKYIECSALTQKNLRLVFDEAVRAVISPAGG#AKKDKKKGGCML 194 |
| Musa acuminata | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK----SGCLVL 196 ||| |+|||+||+ |+ ||+ | + ||# + ||| || +| Sbjct 150 IGAASYIECSSKTQQNVKAVFDAAIKVVLQ#PPKQKKKKKQQKGCSIL 196 |
| Pneumocystis carinii | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 +|| |+|||| |+ |++ ||+ | ||+# |||+ ||+| Sbjct 149 LGAVKYVECSALTQKGLKNVFDEAIVCALE#PPVTKKKTKCLIL 191 |
| Nicotiana tabacum | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSG 192 ||| |+|||+||+ |+ ||+ | + ||# + ||| | Sbjct 150 IGAPAYIECSSKTQQNVKAVFDAAIKVVLQ#PPKTKKKKG 188 |
| Trichomonas vaginalis G3 | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#AR-----RGKKKSGCLVL 196 ||| ||||||+||||+ |+| | | + # + || + ||+| Sbjct 146 IGASKYMECSARTKDGLNEIFAEAGRLIIH#PQVEPKDAKKKDTNCLLL 193 |
| Oryza sativa (indica cultivar-group) | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK-----SGCLVL 196 ||| |+|||+||+ ++ ||+ | + ||# + ||| || +| Sbjct 165 IGAAAYIECSSKTQQNIKAVFDAAIKVVLQ#PPKQKKKKKKAQKGCAIL 212 |
| Oryza sativa subsp. japonica | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK-----SGCLVL 196 ||| |+|||+||+ ++ ||+ | + ||# + ||| || +| Sbjct 150 IGAAAYIECSSKTQQNIKAVFDAAIKVVLQ#PPKQKKKKKKAQKGCAIL 197 |
| Oryza sativa (japonica cultivar-group) | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK-----SGCLVL 196 ||| |+|||+||+ ++ ||+ | + ||# + ||| || +| Sbjct 148 IGAAAYIECSSKTQQNIKAVFDAAIKVVLQ#PPKQKKKKKKAQKGCAIL 195 |
| Brassica rapa | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK------SGCLVL 196 ||| |+||||||+ |+ ||+ | + ||# + ||+ || +| Sbjct 150 IGAPAYIECSAKTQQNVKAVFDAAIKVVLQ#PPKNKKRKKRKSQKGCSIL 198 |
| Bos taurus | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKKSGCLVL 196 +|| |+|||| ||||||| | || | # | |++| Sbjct 218 VGAVKYLECSALMHDGVREVFLEAIRAVLY#PATKKNTKKCVLL 260 |
| Candida albicans | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#AR------RGKKKSGCLVL 196 +|| |+||||| || | | | | || #|+ +| ||+|+ Sbjct 162 VGALRYLECSAKKNKGVNEAFSEAARCALN#AKPKGANDNEPQKKGCVVM 210 |
| Physcomitrella patens | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAAL----Q#ARRGKKKSGCLVL 196 ||| |+|||+||+ |+ ||+ | + | |# ++ ||+ |++| Sbjct 150 IGAASYIECSSKTQQNVKAVFDAAIKVVLQPPKQ#KKKKKKQKNCVIL 196 |
| Aplysia californica | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#AR-RGKKKSGCLVL 196 | | |+|||| |+ |++ ||+ | || | # + + ||| || +| Sbjct 149 ISAVKYLECSALTQKGLKNVFDEAIRAVLC#PKPKPKKKKGCEIL 192 |
| Solanum chacoense | Query 154 IGAFGYMECSAKTKDGVREVFEMATRAALQ#ARRGKKK 190 ||| |+||||||+ ++ ||+ | + ||# + ||| Sbjct 150 IGAAAYIECSAKTQQNIKAVFDAAIKVVLQ#PPQQKKK 186 |
* References
[PubMed ID: 15331592] Kristelly R, Gao G, Tesmer JJ, Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.