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XSB1071 : Chain A, Crystal Structure Of Egfr Kinase Domain L858r Mutation In Complex With Aee788

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismHomo sapiens (human)
Protein NamesNot available
Gene NamesNot available
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
2ITT_A N/A N/A N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 327 aa

Average Mass: 37.300 kDa

Monoisotopic Mass: 37.276 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Pkinase_Tyr 1. 17273428.41.1e-125
--- cleavage 38 (inside Pkinase_Tyr 17..273) ---

3. Sequence Information

Fasta Sequence: XSB1071.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP38-EGEKVKIPVA

Pro38 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly29Thr30Val31Tyr32Lys33Gly34Leu35Trp36Ile37Pro38
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu39Gly40Glu41Lys42Val43Lys44Ile45Pro46Val47Ala48

Sequence conservation (by blast)

* References

[PubMed ID: 17349580] Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ, Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 2007 Mar;11(3):217-27.