XSB1076 : PREDICTED: epidermal growth factor receptor isoform 6 [Pan troglodytes]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Pan troglodytes (chimpanzee) |
| Protein Names | epidermal growth factor receptor isoform 6 |
| Gene Names | EGFR; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 14 mRNAs, 634 ESTs, 35 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| XP_001156546 | XM_001156546 | 463415 | N/A | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1212 aa
Average Mass: 134.564 kDa
Monoisotopic Mass: 134.476 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 57 | 168 | 151.2 | 3.2e-42 |
| Furin-like 1. | 184 | 338 | 264.9 | 1.9e-76 |
| Recep_L_domain 2. | 361 | 481 | 155.1 | 2e-43 |
| CBM_10 1. | 498 | 525 | -4.6 | 9.2 |
| NinF 1. | 549 | 614 | 0.1 | 2.4 |
| Gram_pos_anchor 1. | 637 | 674 | 2.7 | 1.6 |
| Pkinase_Tyr 1. | 714 | 970 | 401.7 | 1.2e-117 |
| --- cleavage 735 (inside Pkinase_Tyr 714..970) --- | ||||
3. Sequence Information
Fasta Sequence: XSB1076.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] GTVYKGLWIP735-EGEKVKIPVA
Pro735 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly726 | Thr727 | Val728 | Tyr729 | Lys730 | Gly731 | Leu732 | Trp733 | Ile734 | Pro735 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu736 | Gly737 | Glu738 | Lys739 | Val740 | Lys741 | Ile742 | Pro743 | Val744 | Ala745 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 120.00 | 21 | - |
| 2 | Homo sapiens | 120.00 | 15 | epidermal growth factor receptor |
| 3 | Mus musculus | 120.00 | 8 | AF275367_1 epidermal growth factor receptor |
| 4 | Rattus norvegicus | 120.00 | 7 | epidermal growth factor receptor |
| 5 | Pan troglodytes | 120.00 | 7 | PREDICTED: epidermal growth factor receptor isofor |
| 6 | synthetic construct | 120.00 | 4 | epidermal growth factor receptor |
| 7 | Monodelphis domestica | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 8 | Canis familiaris | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Macaca mulatta | 120.00 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 10 | Rous-associated virus type 1 | 119.00 | 2 | polyprotein |
| 11 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 12 | Bos taurus | 119.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 13 | Xenopus laevis | 115.00 | 3 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 115.00 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Danio rerio | 112.00 | 4 | epidermal growth factor receptor |
| 16 | Tetraodon nigroviridis | 111.00 | 3 | unnamed protein product |
| 17 | Xiphophorus xiphidium | 110.00 | 2 | epidermal growth factor receptor |
| 18 | Gallus gallus | 107.00 | 4 | erbB-2 |
| 19 | Felis catus | 106.00 | 2 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 20 | Mesocricetus auratus | 106.00 | 1 | ERBB2_MESAU Receptor tyrosine-protein kinase erbB- |
| 21 | Canis lupus familiaris | 106.00 | 1 | erbB-2 |
| 22 | Xiphophorus sp. | 102.00 | 1 | XMRK_XIPMA Melanoma receptor tyrosine-protein kina |
| 23 | Ovis aries | 94.00 | 1 | erythroblastic leukemia viral oncogene-like 2 |
| 24 | Strongylocentrotus purpuratus | 80.90 | 1 | PREDICTED: similar to v-erb-a erythroblastic leuke |
| 25 | Drosophila melanogaster | 80.10 | 147 | mutant epidermal growth factor receptor |
| 26 | Drosophila simulans | 78.20 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Homo sapiens | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Mus musculus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Rattus norvegicus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Pan troglodytes | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| synthetic construct | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Monodelphis domestica | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Canis familiaris | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Macaca mulatta | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Rous-associated virus type 1 | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 278 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 337 |
| Sus scrofa | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 704 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Bos taurus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 681 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 740 |
| Xenopus laevis | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||||||||||||||||+|||||#||| +||||||||||||||||||||||||| Sbjct 289 LRILKETEFKKIKVLGSGAFGTVYQGLWIP#EGEGIKIPVAIKELREATSPKANKEILDEA 348 |
| Avian erythroblastosis virus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||||||||+|||| |||||||||||||#||||| |||||||||||||||||||||||| Sbjct 546 LRILKETEFKKVKVLGFGAFGTVYKGLWIP#EGEKVTIPVAIKELREATSPKANKEILDEA 605 |
| Danio rerio | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |
| Tetraodon nigroviridis | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||| |||||||||||||||||||||+|#||| |||||||| |||||||||||+||||| Sbjct 674 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANKDILDEA 733 |
| Xiphophorus xiphidium | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||||| |||||||||||||||||||||+|#||| |||||||| ||||||||||+|||||| Sbjct 714 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANQEILDEA 773 |
| Gallus gallus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 +||||||| ||+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 701 MRILKETELKKVKVLGSGAFGTVYKGIWIP#DGESVKIPVAIKVLRENTSPKANKEILDEA 760 |
| Felis catus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Mesocricetus auratus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Canis lupus familiaris | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 711 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 770 |
| Xiphophorus sp. | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 ||||||||||| +||||||||||||||| |#+|| ++|||||| |||||||| |+|+|||| Sbjct 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNP#DGENIRIPVAIKVLREATSPKVNQEVLDEA 761 |
| Ovis aries | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKAN 758 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| |||||| Sbjct 63 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKAN 115 |
| Strongylocentrotus purpuratus | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILD 763 |+|+|+|| | |||||||||||||||||#+|||++|||||| ||| || | +|+|+ Sbjct 1012 LKIIKDTELKLGPVLGSGAFGTVYKGLWIP#DGEKIRIPVAIKALRE-VSPHAAEELLE 1068 |
| Drosophila melanogaster | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||+|+|| +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 830 LRIVKDTELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 889 |
| Drosophila simulans | Query 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |||+|+ | +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 829 LRIVKDAELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 888 |
[Site 2] LTEDSIDDTF1088-LPVPEYINQS
Phe1088 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu1079 | Thr1080 | Glu1081 | Asp1082 | Ser1083 | Ile1084 | Asp1085 | Asp1086 | Thr1087 | Phe1088 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu1089 | Pro1090 | Val1091 | Pro1092 | Glu1093 | Tyr1094 | Ile1095 | Asn1096 | Gln1097 | Ser1098 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLN |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 128.00 | 13 | cell growth inhibiting protein 40 |
| 2 | Pan troglodytes | 128.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 128.00 | 2 | epidermal growth factor receptor |
| 4 | Canis familiaris | 122.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 5 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 6 | N/A | 117.00 | 10 | - |
| 7 | Mus musculus | 117.00 | 4 | epidermal growth factor receptor isoform 1 |
| 8 | Bos taurus | 117.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 9 | Rattus norvegicus | 116.00 | 1 | epidermal growth factor receptor |
| 10 | Monodelphis domestica | 100.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 11 | Rous-associated virus type 1 | 79.30 | 2 | polyprotein |
| 12 | Macaca mulatta | 74.30 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 13 | Xenopus laevis | 72.40 | 1 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 38.90 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Gallus gallus | 36.60 | 3 | v-erb-a erythroblastic leukemia viral oncogene hom |
| 16 | Canis lupus familiaris | 35.00 | 1 | erbB-2 |
| 17 | Felis catus | 32.70 | 1 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 18 | Leishmania braziliensis | 32.30 | 1 | mitochondrial exoribonuclease DSS-1, putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 |
| Pan troglodytes | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 |
| synthetic construct | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 |
| Canis familiaris | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 +||+||||||||||||||| ||||+|||||#|| ||||||||||||||||||||||||||| Sbjct 1443 TCPLKEDSFLQRYSSDPTGTLTEDNIDDTF#LPAPEYINQSVPKRPAGSVQNPVYHNQPLN 1502 |
| Sus scrofa | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 | |+|||||||||||||||||||||+||||#|| |||+||||||||||||||||||||||+ Sbjct 1056 SYPLKEDSFLQRYSSDPTGALTEDSLDDTF#LPAPEYVNQSVPKRPAGSVQNPVYHNQPLS 1115 |
| N/A | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Mus musculus | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Bos taurus | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPL 1117 | |+||||||||||||||||| |||+||||#||||||+|||||||||||||||||||||| Sbjct 1032 SYPLKEDSFLQRYSSDPTGALIEDSMDDTF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPL 1090 |
| Rattus norvegicus | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 || +|||+|||||||||| ||||+|||||#|||||||||||||||||||||||||||||+ Sbjct 1056 SCRVKEDAFLQRYSSDPTSVLTEDNIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLH 1115 |
| Monodelphis domestica | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGS-VQNPVYHNQPL 1117 +|| ||++|+|||||||| ||||++||+|# ||||||||| || | || +|||||||||| Sbjct 1082 TCPGKEENFIQRYSSDPTTVLTEDNVDDSF#QPVPEYINQSAPKNPTGSAIQNPVYHNQPL 1141 Query 1118 N 1118 | Query 1118 N 1118 |
| Rous-associated virus type 1 | Query 1061 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPA-GSVQNPVYHN 1114 |++||||+||||||||| |+|||| |#|| |||+|| +||+|+ ||| +|+| Sbjct 632 PVREDSFVQRYSSDPTGNFLEESIDDGF#LPAPEYVNQLMPKKPSTAMVQNQIYNN 686 |
| Macaca mulatta | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVP-EYI-------NQSVPKRPAGSVQNP 1110 ||||||||||||||||||||||||||||||#|||| |++ + |+ | |+ +| Sbjct 1057 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPGEWLVWKHSCSSASLTHSAAASLHHP 1116 Query 1111 V 1111 | Query 1111 V 1111 |
| Xenopus laevis | Query 1061 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHN 1114 | +||||+||||+||| + |||||| |#|| |||+|| ||| + |||| | Sbjct 641 PAREDSFVQRYSTDPT-VILEDSIDDEF#LPAPEYVNQMVPKPVVETQTNPVYQN 693 |
| Avian erythroblastosis virus | Query 1085 DDTF#LPVPEYINQSVPKRPA-GSVQNPVYH 1113 +| |#|| |||+|| +||+|+ ||| +|+ Sbjct 902 EDGF#LPAPEYVNQLMPKKPSTAMVQNQIYN 931 |
| Gallus gallus | Query 1063 KEDSFLQRYSSDPT---------GALTEDSI---------DDTF#LPVPEYINQSVPKRPA 1104 |||| ||||+||| | | || | # || | | | +| Sbjct 1091 KEDSSTQRYSADPTVFIPERVIRGELDEDGYMTPMRDKPKTDYL#NPVEE--NPFVSRRKN 1148 Query 1105 GSVQ---NPVYHNQP 1116 | +| || ||| | Sbjct 1149 GDLQAVDNPEYHNAP 1163 |
| Canis lupus familiaris | Query 1059 SCPIKEDSFLQRYSSDPTGALTEDSIDD----TF#LPVPEYINQ-SVPKRPAGSVQNPVYH 1113 | | ++ | ||||| ||| | ++ | # | |||+|| | +| +++ |+ Sbjct 1099 SLPSQDPSPLQRYSEDPTVPLPPETDGKVAPLTC#SPQPEYVNQPEVWPQPPLALEGPLPP 1158 Query 1114 NQP 1116 ++| Sbjct 1159 SRP 1161 |
| Felis catus | Query 1063 KEDSFLQRYSSDPTGALTEDS----IDDTF#LPVPEYINQ-SVPKRPAGSVQNPVYHNQP 1116 ++ | ||||| ||| | ++ | # | |||+|| | +| ++ |+ ++| Sbjct 1104 QDPSPLQRYSEDPTVPLPPETDGYVAPLTC#SPQPEYVNQPEVWPKPPSPLEGPLPPSRP 1162 |
| Leishmania braziliensis | Query 1062 IKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1118 + | + || ++| | | |+| + #+ + | + || | +| +||+ ||+ Sbjct 521 LSSDHLVARYYTEPEGVQTLTSLDASH#IFLAEAMQSSV--RRLSTVTRAIYHHVPLH 575 |
[Site 3] VQPTCVNSTF1153-DSPAHWAQKG
Phe1153 Asp
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val1144 | Gln1145 | Pro1146 | Thr1147 | Cys1148 | Val1149 | Asn1150 | Ser1151 | Thr1152 | Phe1153 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asp1154 | Ser1155 | Pro1156 | Ala1157 | His1158 | Trp1159 | Ala1160 | Gln1161 | Lys1162 | Gly1163 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 136.00 | 9 | epidermal growth factor receptor isoform a |
| 2 | Pan troglodytes | 136.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 136.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 110.00 | 7 | - |
| 5 | Mus musculus | 110.00 | 6 | AF275367_1 epidermal growth factor receptor |
| 6 | Rattus norvegicus | 108.00 | 4 | epidermal growth factor receptor |
| 7 | Equus caballus | 108.00 | 1 | epidermal growth factor receptor |
| 8 | Sus scrofa | 105.00 | 2 | epidermal growth factor receptor |
| 9 | Canis familiaris | 103.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 10 | Bos taurus | 97.40 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 11 | Monodelphis domestica | 74.70 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 70.50 | 1 | epidermal growth factor receptor |
| 13 | Tetraodon nigroviridis | 38.90 | 1 | unnamed protein product |
| 14 | Gallus gallus | 38.10 | 3 | v-erb-a erythroblastic leukemia viral oncogene hom |
| 15 | Xiphophorus xiphidium | 37.40 | 1 | epidermal growth factor receptor |
| 16 | Rous-associated virus type 1 | 35.00 | 2 | polyprotein |
| 17 | Danio rerio | 32.30 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |
| Pan troglodytes | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |
| synthetic construct | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |
| N/A | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1182 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Mus musculus | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1182 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Rattus norvegicus | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 | |||+||| || ||||||| ||||++| |#|| | | ||||||+|||||||||||||||| Sbjct 1121 DLHYQNPHSNAVSNPEYLNTAQPTCLSSGF#DSSALWIQKGSHQMSLDNPDYQQDFFPKEA 1180 |
| Equus caballus | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |||||+||| |+ ||||||| | |||| #| | |||||+||||||||||||||||||| Sbjct 17 DPHYQNPHSNAMDNPEYLNTTHPDCVNSVL#DGTALWAQKGNHQISLDNPDYQQDFFPKEA 76 |
| Sus scrofa | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |||||+ || |||||||||| +| |+| #| || ||| |||||+|||||||| |||||| Sbjct 1121 DPHYQNSHSNAVGNPEYLNTPRPACINGGL#DGPAFWAQTGSHQINLDNPDYQQAFFPKEA 1180 |
| Canis familiaris | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 |||||+||| || ||||||| |||||| #| |+ | |+ +||||||||||||||||||| Sbjct 1508 DPHYQNPHSNAVDNPEYLNT-HPTCVNSVL#DRPSLWTQEANHQISLDNPDYQQDFFPKEA 1566 |
| Bos taurus | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1183 || ||+ | || ||||||| | |+| #| || |||||||| ||||||||| |||||| Sbjct 1097 DPQYQNSLSNAVDNPEYLNTTHPACINGVL#DGPALWAQKGSHQFSLDNPDYQQAFFPKEA 1156 |
| Monodelphis domestica | Query 1124 DPHYQDPHS-TAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1182 | ||+ |+ +|| ||||||| || |#|| + | | |+||||||||||||+| Sbjct 1148 DSLYQNSHNNSAVDNPEYLNTTQPNLAKKAF#DSNSCWNPTAKHPINLDNPDYQQDFFPQE 1207 Query 1183 A 1183 | Query 1183 A 1183 |
| Xenopus laevis | Query 1127 YQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1182 ||+ || + |||||| | + |#| + | || + ||+|||||||||||||| Sbjct 708 YQNSHSNGLNNPEYLNAGQTFVPKTDF#DYSSIWDQKANIQINLDNPDYQQDFFPKE 763 |
| Tetraodon nigroviridis | Query 1138 PEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1180 ||||| | |+ | |# || + | |+||||||||| | Sbjct 1035 PEYLNEV-PSSSNFPF#TPNT---QKYAPQNSIDNPDYQQDFTP 1073 |
| Gallus gallus | Query 1124 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPK 1181 +| | + ++ + | ||| | |#|+| +| + +| +||| |++ | Sbjct 1176 EPLYLNTFASTLENAEYLKNNLPEKAKKAF#DNPDYWNHSLPPRSTLQHPDYLQEYSTK 1233 |
| Xiphophorus xiphidium | Query 1124 DPHYQDPHSTAVGNPEYLNTV-QPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1180 + | + ||||| + | + #++ | | | |+||||||||| | Sbjct 1130 ESEYPNYFKNRANGPEYLNELPSSTALPLNS#NNTAIGGQNYRPQNSMDNPDYQQDFTP 1187 |
| Rous-associated virus type 1 | Query 1124 DPHYQDPHSTAVGNPEYLN---TVQPTCVNS 1151 | ||+ ||||| |||||| | || | Sbjct 698 DSRYQNSHSTAVDNPEYLNMAVRTLPECVVS 728 |
| Danio rerio | Query 1124 DPHYQDPHS---TAVGNPEYLNTVQPTCVNSTF#DSPA-----HWAQKGSHQI-------S 1168 +| || || | + + |+ + +| |# ||| + |+ | Sbjct 1096 NPVYQQPHGPPRTLLHSSPALDETEEEYLNC-F#KSPAPASVVEYLNTSHTQLLSTKPFFS 1154 Query 1169 LDNPDYQQDFFPKE 1182 +||||||||| | | Sbjct 1155 MDNPDYQQDFCPLE 1168 |
[Site 4] FFPKEAKPNG1187-IFKGSTAENA
Gly1187 Ile
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe1178 | Phe1179 | Pro1180 | Lys1181 | Glu1182 | Ala1183 | Lys1184 | Pro1185 | Asn1186 | Gly1187 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile1188 | Phe1189 | Lys1190 | Gly1191 | Ser1192 | Thr1193 | Ala1194 | Glu1195 | Asn1196 | Ala1197 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| HWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 118.00 | 5 | epidermal growth factor receptor isoform a |
| 2 | Pan troglodytes | 118.00 | 4 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 118.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 106.00 | 5 | - |
| 5 | Mus musculus | 106.00 | 3 | epidermal growth factor receptor isoform 1 |
| 6 | Rattus norvegicus | 105.00 | 1 | epidermal growth factor receptor |
| 7 | Equus caballus | 103.00 | 1 | epidermal growth factor receptor |
| 8 | Canis familiaris | 98.60 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Bos taurus | 95.50 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 10 | Sus scrofa | 89.70 | 2 | epidermal growth factor receptor |
| 11 | Monodelphis domestica | 82.40 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 68.20 | 1 | epidermal growth factor receptor |
| 13 | Danio rerio | 36.60 | 2 | epidermal growth factor receptor |
| 14 | Tetraodon nigroviridis | 36.60 | 1 | unnamed protein product |
| 15 | Xiphophorus xiphidium | 35.00 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 |
| Pan troglodytes | Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 |
| synthetic construct | Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1158 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 |
| N/A | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Mus musculus | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Rattus norvegicus | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 | ||||||+||||||||||||||||||||#|||| |||||||||||| |||| || Sbjct 1156 WIQKGSHQMSLDNPDYQQDFFPKEAKPNG#IFKGPTAENAEYLRVAPPSSEFSGA 1209 |
| Equus caballus | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIG 1211 |||||+|||||||||||||||||||| ||#|||| ||||||||||| |||||| Sbjct 52 WAQKGNHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENAEYLRVAPPSSEFIG 104 |
| Canis familiaris | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 | |+ +|||||||||||||||||||| ||#|||| ||||+|||||| ||||||| Sbjct 1542 WTQEANHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENADYLRVAPPSSEFIGA 1595 |
| Bos taurus | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 |||||||| ||||||||| ||||||| ||#|||| |||||||| || |+| || Sbjct 1132 WAQKGSHQFSLDNPDYQQAFFPKEAKSNG#IFKGPAAENAEYLRAAPAGSDFTGA 1185 |
| Sus scrofa | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 ||| |||||+|||||||| ||||||| ||#| || |||||||| || ||+ || Sbjct 1156 WAQTGSHQINLDNPDYQQAFFPKEAKSNG#ICKGPAAENAEYLRAAPASSDLTGA 1209 |
| Monodelphis domestica | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1212 | | |+||||||||||||+||||||#+|| ||| |||||| | |||| | Sbjct 1184 WNPTAKHPINLDNPDYQQDFFPQEAKPNG#VFKVPAAENPEYLRVAAQQSEFIQA 1237 |
| Xenopus laevis | Query 1159 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQS 1206 | || + ||+|||||||||||||| | ||# || |+| ||| +|| | Sbjct 740 WDQKANIQINLDNPDYQQDFFPKEPKTNG#HFKIPAAQNPEYLGLAPVS 787 |
| Danio rerio | Query 1168 SLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYL 1200 |+||||||||| | | | + # |+| ||+ Sbjct 1154 SMDNPDYQQDFCPLELKTHT#NGHLPAAQNQEYM 1186 |
| Tetraodon nigroviridis | Query 1161 QKGSHQISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYLRV 1202 || + | |+||||||||| | + ||# ||| || | Sbjct 1054 QKYAPQNSIDNPDYQQDFTPTFKTHTNG#HI--PAAENTEYTSV 1094 |
| Xiphophorus xiphidium | Query 1166 QISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYL 1200 | |+||||||||| | + ||# ||| ||| Sbjct 1173 QNSMDNPDYQQDFTPTFKTHTNG#HI--PAAENVEYL 1206 |
* References
None.