XSB1079 : PREDICTED: epidermal growth factor receptor isoform 4 [Pan troglodytes]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Pan troglodytes (chimpanzee) |
| Protein Names | epidermal growth factor receptor isoform 4 |
| Gene Names | EGFR; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 14 mRNAs, 634 ESTs, 35 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| XP_001156439 | XM_001156439 | 463415 | N/A | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1149 aa
Average Mass: 128.012 kDa
Monoisotopic Mass: 127.929 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 57 | 168 | 151.2 | 3.2e-42 |
| CXCXC 1. | 191 | 204 | 1.7 | 10 |
| Granulin 1. | 229 | 248 | -19.8 | 5.2 |
| Recep_L_domain 2. | 300 | 420 | 155.1 | 2e-43 |
| CBM_10 1. | 437 | 464 | -4.6 | 9.2 |
| NinF 1. | 488 | 553 | 0.1 | 2.4 |
| Gram_pos_anchor 1. | 574 | 611 | 0.6 | 2.7 |
| Pkinase_Tyr 1. | 651 | 907 | 401.7 | 1.2e-117 |
| --- cleavage 672 (inside Pkinase_Tyr 651..907) --- | ||||
3. Sequence Information
Fasta Sequence: XSB1079.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] GTVYKGLWIP672-EGEKVKIPVA
Pro672 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly663 | Thr664 | Val665 | Tyr666 | Lys667 | Gly668 | Leu669 | Trp670 | Ile671 | Pro672 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu673 | Gly674 | Glu675 | Lys676 | Val677 | Lys678 | Ile679 | Pro680 | Val681 | Ala682 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 120.00 | 21 | - |
| 2 | Homo sapiens | 120.00 | 15 | EGFR protein |
| 3 | Mus musculus | 120.00 | 8 | AF275367_1 epidermal growth factor receptor |
| 4 | Rattus norvegicus | 120.00 | 7 | epidermal growth factor receptor |
| 5 | Pan troglodytes | 120.00 | 7 | PREDICTED: epidermal growth factor receptor isofor |
| 6 | synthetic construct | 120.00 | 4 | epidermal growth factor receptor |
| 7 | Monodelphis domestica | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 8 | Canis familiaris | 120.00 | 3 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Macaca mulatta | 120.00 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 10 | Rous-associated virus type 1 | 119.00 | 2 | polyprotein |
| 11 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 12 | Bos taurus | 119.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 13 | Xenopus laevis | 115.00 | 3 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 115.00 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Danio rerio | 112.00 | 4 | epidermal growth factor receptor |
| 16 | Tetraodon nigroviridis | 111.00 | 3 | unnamed protein product |
| 17 | Xiphophorus xiphidium | 110.00 | 2 | epidermal growth factor receptor |
| 18 | Gallus gallus | 107.00 | 4 | erbB-2 |
| 19 | Felis catus | 106.00 | 2 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 20 | Mesocricetus auratus | 106.00 | 1 | ERBB2_MESAU Receptor tyrosine-protein kinase erbB- |
| 21 | Canis lupus familiaris | 106.00 | 1 | erbB-2 |
| 22 | Xiphophorus sp. | 102.00 | 1 | XMRK_XIPMA Melanoma receptor tyrosine-protein kina |
| 23 | Ovis aries | 94.00 | 1 | erythroblastic leukemia viral oncogene-like 2 |
| 24 | Strongylocentrotus purpuratus | 80.90 | 1 | PREDICTED: similar to v-erb-a erythroblastic leuke |
| 25 | Drosophila melanogaster | 80.10 | 147 | mutant epidermal growth factor receptor |
| 26 | Drosophila simulans | 78.20 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Homo sapiens | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Mus musculus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Rattus norvegicus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Pan troglodytes | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| synthetic construct | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Monodelphis domestica | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Canis familiaris | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Macaca mulatta | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |
| Rous-associated virus type 1 | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 278 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 337 |
| Sus scrofa | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 699 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 758 |
| Bos taurus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||||||||+||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 681 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 740 |
| Xenopus laevis | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||||||||||||||||+|||||#||| +||||||||||||||||||||||||| Sbjct 289 LRILKETEFKKIKVLGSGAFGTVYQGLWIP#EGEGIKIPVAIKELREATSPKANKEILDEA 348 |
| Avian erythroblastosis virus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||||||||+|||| |||||||||||||#||||| |||||||||||||||||||||||| Sbjct 546 LRILKETEFKKVKVLGFGAFGTVYKGLWIP#EGEKVTIPVAIKELREATSPKANKEILDEA 605 |
| Danio rerio | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |
| Tetraodon nigroviridis | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||| |||||||||||||||||||||+|#||| |||||||| |||||||||||+||||| Sbjct 674 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANKDILDEA 733 |
| Xiphophorus xiphidium | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||||| |||||||||||||||||||||+|#||| |||||||| ||||||||||+|||||| Sbjct 714 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANQEILDEA 773 |
| Gallus gallus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 +||||||| ||+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 701 MRILKETELKKVKVLGSGAFGTVYKGIWIP#DGESVKIPVAIKVLRENTSPKANKEILDEA 760 |
| Felis catus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Mesocricetus auratus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Canis lupus familiaris | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| ||||||||||||| Sbjct 711 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 770 |
| Xiphophorus sp. | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 ||||||||||| +||||||||||||||| |#+|| ++|||||| |||||||| |+|+|||| Sbjct 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNP#DGENIRIPVAIKVLREATSPKVNQEVLDEA 761 |
| Ovis aries | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKAN 695 +||||||| +|+||||||||||||||+|||#+|| |||||||| ||| |||||| Sbjct 63 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKAN 115 |
| Strongylocentrotus purpuratus | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILD 700 |+|+|+|| | |||||||||||||||||#+|||++|||||| ||| || | +|+|+ Sbjct 1012 LKIIKDTELKLGPVLGSGAFGTVYKGLWIP#DGEKIRIPVAIKALRE-VSPHAAEELLE 1068 |
| Drosophila melanogaster | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||+|+|| +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 830 LRIVKDTELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 889 |
| Drosophila simulans | Query 643 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 702 |||+|+ | +| ||| |||| ||||+|+|#||| |||||||||| ++| ++++| | || Sbjct 829 LRIVKDAELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 888 |
[Site 2] LTEDSIDDTF1025-LPVPEYINQS
Phe1025 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu1016 | Thr1017 | Glu1018 | Asp1019 | Ser1020 | Ile1021 | Asp1022 | Asp1023 | Thr1024 | Phe1025 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu1026 | Pro1027 | Val1028 | Pro1029 | Glu1030 | Tyr1031 | Ile1032 | Asn1033 | Gln1034 | Ser1035 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLN |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 128.00 | 13 | cell growth inhibiting protein 40 |
| 2 | Pan troglodytes | 128.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 128.00 | 2 | epidermal growth factor receptor |
| 4 | Canis familiaris | 122.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 5 | Sus scrofa | 119.00 | 2 | epidermal growth factor receptor |
| 6 | N/A | 117.00 | 10 | - |
| 7 | Mus musculus | 117.00 | 4 | epidermal growth factor receptor isoform 1 |
| 8 | Bos taurus | 117.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 9 | Rattus norvegicus | 116.00 | 1 | epidermal growth factor receptor |
| 10 | Monodelphis domestica | 100.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 11 | Rous-associated virus type 1 | 79.30 | 2 | polyprotein |
| 12 | Macaca mulatta | 74.30 | 3 | PREDICTED: epidermal growth factor receptor, parti |
| 13 | Xenopus laevis | 72.40 | 1 | epidermal growth factor receptor |
| 14 | Avian erythroblastosis virus | 38.90 | 2 | gag,v-erb-A,v-erb-B |
| 15 | Gallus gallus | 36.60 | 3 | AF121963_1 receptor tyrosine kinase precursor |
| 16 | Canis lupus familiaris | 35.00 | 1 | erbB-2 |
| 17 | Felis catus | 32.70 | 1 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 18 | Leishmania braziliensis | 32.30 | 1 | mitochondrial exoribonuclease DSS-1, putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 |
| Pan troglodytes | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 |
| synthetic construct | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 |
| Canis familiaris | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 +||+||||||||||||||| ||||+|||||#|| ||||||||||||||||||||||||||| Sbjct 1443 TCPLKEDSFLQRYSSDPTGTLTEDNIDDTF#LPAPEYINQSVPKRPAGSVQNPVYHNQPLN 1502 |
| Sus scrofa | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 | |+|||||||||||||||||||||+||||#|| |||+||||||||||||||||||||||+ Sbjct 1051 SYPLKEDSFLQRYSSDPTGALTEDSLDDTF#LPAPEYVNQSVPKRPAGSVQNPVYHNQPLS 1110 |
| N/A | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Mus musculus | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 || +|||+||||||||||||+|||+||| |#||||||+||||||||||||||||||||||+ Sbjct 1057 SCRVKEDAFLQRYSSDPTGAVTEDNIDDAF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPLH 1116 |
| Bos taurus | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPL 1054 | |+||||||||||||||||| |||+||||#||||||+|||||||||||||||||||||| Sbjct 1032 SYPLKEDSFLQRYSSDPTGALIEDSMDDTF#LPVPEYVNQSVPKRPAGSVQNPVYHNQPL 1090 |
| Rattus norvegicus | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 || +|||+|||||||||| ||||+|||||#|||||||||||||||||||||||||||||+ Sbjct 1056 SCRVKEDAFLQRYSSDPTSVLTEDNIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLH 1115 |
| Monodelphis domestica | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGS-VQNPVYHNQPL 1054 +|| ||++|+|||||||| ||||++||+|# ||||||||| || | || +|||||||||| Sbjct 1082 TCPGKEENFIQRYSSDPTTVLTEDNVDDSF#QPVPEYINQSAPKNPTGSAIQNPVYHNQPL 1141 Query 1055 N 1055 | Query 1055 N 1055 |
| Rous-associated virus type 1 | Query 998 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPA-GSVQNPVYHN 1051 |++||||+||||||||| |+|||| |#|| |||+|| +||+|+ ||| +|+| Sbjct 632 PVREDSFVQRYSSDPTGNFLEESIDDGF#LPAPEYVNQLMPKKPSTAMVQNQIYNN 686 |
| Macaca mulatta | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVP-EYI-------NQSVPKRPAGSVQNP 1047 ||||||||||||||||||||||||||||||#|||| |++ + |+ | |+ +| Sbjct 1057 SCPIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPGEWLVWKHSCSSASLTHSAAASLHHP 1116 Query 1048 V 1048 | Query 1048 V 1048 |
| Xenopus laevis | Query 998 PIKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHN 1051 | +||||+||||+||| + |||||| |#|| |||+|| ||| + |||| | Sbjct 641 PAREDSFVQRYSTDPT-VILEDSIDDEF#LPAPEYVNQMVPKPVVETQTNPVYQN 693 |
| Avian erythroblastosis virus | Query 1022 DDTF#LPVPEYINQSVPKRPA-GSVQNPVYH 1050 +| |#|| |||+|| +||+|+ ||| +|+ Sbjct 902 EDGF#LPAPEYVNQLMPKKPSTAMVQNQIYN 931 |
| Gallus gallus | Query 1000 KEDSFLQRYSSDPT---------GALTEDSI---------DDTF#LPVPEYINQSVPKRPA 1041 |||| ||||+||| | | || | # || | | | +| Sbjct 952 KEDSSTQRYSADPTVFIPERVIRGELDEDGYMTPMRDKPKTDYL#NPVEE--NPFVSRRKN 1009 Query 1042 GSVQ---NPVYHNQP 1053 | +| || ||| | Sbjct 1010 GDLQAVDNPEYHNAP 1024 |
| Canis lupus familiaris | Query 996 SCPIKEDSFLQRYSSDPTGALTEDSIDD----TF#LPVPEYINQ-SVPKRPAGSVQNPVYH 1050 | | ++ | ||||| ||| | ++ | # | |||+|| | +| +++ |+ Sbjct 1099 SLPSQDPSPLQRYSEDPTVPLPPETDGKVAPLTC#SPQPEYVNQPEVWPQPPLALEGPLPP 1158 Query 1051 NQP 1053 ++| Sbjct 1159 SRP 1161 |
| Felis catus | Query 1000 KEDSFLQRYSSDPTGALTEDS----IDDTF#LPVPEYINQ-SVPKRPAGSVQNPVYHNQP 1053 ++ | ||||| ||| | ++ | # | |||+|| | +| ++ |+ ++| Sbjct 1104 QDPSPLQRYSEDPTVPLPPETDGYVAPLTC#SPQPEYVNQPEVWPKPPSPLEGPLPPSRP 1162 |
| Leishmania braziliensis | Query 999 IKEDSFLQRYSSDPTGALTEDSIDDTF#LPVPEYINQSVPKRPAGSVQNPVYHNQPLN 1055 + | + || ++| | | |+| + #+ + | + || | +| +||+ ||+ Sbjct 521 LSSDHLVARYYTEPEGVQTLTSLDASH#IFLAEAMQSSV--RRLSTVTRAIYHHVPLH 575 |
[Site 3] VQPTCVNSTF1090-DSPAHWAQKG
Phe1090 Asp
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val1081 | Gln1082 | Pro1083 | Thr1084 | Cys1085 | Val1086 | Asn1087 | Ser1088 | Thr1089 | Phe1090 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Asp1091 | Ser1092 | Pro1093 | Ala1094 | His1095 | Trp1096 | Ala1097 | Gln1098 | Lys1099 | Gly1100 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 136.00 | 9 | epidermal growth factor receptor isoform a |
| 2 | Pan troglodytes | 136.00 | 6 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 136.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 110.00 | 7 | - |
| 5 | Mus musculus | 110.00 | 6 | epidermal growth factor receptor isoform 1 |
| 6 | Rattus norvegicus | 108.00 | 4 | epidermal growth factor receptor |
| 7 | Equus caballus | 108.00 | 1 | epidermal growth factor receptor |
| 8 | Sus scrofa | 105.00 | 2 | epidermal growth factor receptor |
| 9 | Canis familiaris | 103.00 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 10 | Bos taurus | 97.40 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 11 | Monodelphis domestica | 74.70 | 2 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 70.50 | 1 | epidermal growth factor receptor |
| 13 | Tetraodon nigroviridis | 38.90 | 1 | unnamed protein product |
| 14 | Gallus gallus | 38.10 | 3 | v-erb-a erythroblastic leukemia viral oncogene hom |
| 15 | Xiphophorus xiphidium | 37.40 | 1 | epidermal growth factor receptor |
| 16 | Rous-associated virus type 1 | 35.00 | 2 | polyprotein |
| 17 | Danio rerio | 32.30 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |
| Pan troglodytes | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |
| synthetic construct | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |
| N/A | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1119 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Mus musculus | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1119 | |||+||| |||||||||| ||||++| |#+||| | ||||||+||||||||||||||| Sbjct 1122 DLHYQNPHSNAVGNPEYLNTAQPTCLSSGF#NSPALWIQKGSHQMSLDNPDYQQDFFPKE 1180 |
| Rattus norvegicus | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 | |||+||| || ||||||| ||||++| |#|| | | ||||||+|||||||||||||||| Sbjct 1121 DLHYQNPHSNAVSNPEYLNTAQPTCLSSGF#DSSALWIQKGSHQMSLDNPDYQQDFFPKEA 1180 |
| Equus caballus | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |||||+||| |+ ||||||| | |||| #| | |||||+||||||||||||||||||| Sbjct 17 DPHYQNPHSNAMDNPEYLNTTHPDCVNSVL#DGTALWAQKGNHQISLDNPDYQQDFFPKEA 76 |
| Sus scrofa | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |||||+ || |||||||||| +| |+| #| || ||| |||||+|||||||| |||||| Sbjct 1116 DPHYQNSHSNAVGNPEYLNTPRPACINGGL#DGPAFWAQTGSHQINLDNPDYQQAFFPKEA 1175 |
| Canis familiaris | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 |||||+||| || ||||||| |||||| #| |+ | |+ +||||||||||||||||||| Sbjct 1508 DPHYQNPHSNAVDNPEYLNT-HPTCVNSVL#DRPSLWTQEANHQISLDNPDYQQDFFPKEA 1566 |
| Bos taurus | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKEA 1120 || ||+ | || ||||||| | |+| #| || |||||||| ||||||||| |||||| Sbjct 1097 DPQYQNSLSNAVDNPEYLNTTHPACINGVL#DGPALWAQKGSHQFSLDNPDYQQAFFPKEA 1156 |
| Monodelphis domestica | Query 1061 DPHYQDPHS-TAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1119 | ||+ |+ +|| ||||||| || |#|| + | | |+||||||||||||+| Sbjct 1148 DSLYQNSHNNSAVDNPEYLNTTQPNLAKKAF#DSNSCWNPTAKHPINLDNPDYQQDFFPQE 1207 Query 1120 A 1120 | Query 1120 A 1120 |
| Xenopus laevis | Query 1064 YQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPKE 1119 ||+ || + |||||| | + |#| + | || + ||+|||||||||||||| Sbjct 708 YQNSHSNGLNNPEYLNAGQTFVPKTDF#DYSSIWDQKANIQINLDNPDYQQDFFPKE 763 |
| Tetraodon nigroviridis | Query 1075 PEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1117 ||||| | |+ | |# || + | |+||||||||| | Sbjct 1035 PEYLNEV-PSSSNFPF#TPNT---QKYAPQNSIDNPDYQQDFTP 1073 |
| Gallus gallus | Query 1061 DPHYQDPHSTAVGNPEYLNTVQPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFPK 1118 +| | + ++ + | ||| | |#|+| +| + +| +||| |++ | Sbjct 1176 EPLYLNTFASTLENAEYLKNNLPEKAKKAF#DNPDYWNHSLPPRSTLQHPDYLQEYSTK 1233 |
| Xiphophorus xiphidium | Query 1061 DPHYQDPHSTAVGNPEYLNTV-QPTCVNSTF#DSPAHWAQKGSHQISLDNPDYQQDFFP 1117 + | + ||||| + | + #++ | | | |+||||||||| | Sbjct 1130 ESEYPNYFKNRANGPEYLNELPSSTALPLNS#NNTAIGGQNYRPQNSMDNPDYQQDFTP 1187 |
| Rous-associated virus type 1 | Query 1061 DPHYQDPHSTAVGNPEYLN---TVQPTCVNS 1088 | ||+ ||||| |||||| | || | Sbjct 698 DSRYQNSHSTAVDNPEYLNMAVRTLPECVVS 728 |
| Danio rerio | Query 1061 DPHYQDPHS---TAVGNPEYLNTVQPTCVNSTF#DSPA-----HWAQKGSHQI-------S 1105 +| || || | + + |+ + +| |# ||| + |+ | Sbjct 1096 NPVYQQPHGPPRTLLHSSPALDETEEEYLNC-F#KSPAPASVVEYLNTSHTQLLSTKPFFS 1154 Query 1106 LDNPDYQQDFFPKE 1119 +||||||||| | | Sbjct 1155 MDNPDYQQDFCPLE 1168 |
[Site 4] FFPKEAKPNG1124-IFKGSTAENA
Gly1124 Ile
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe1115 | Phe1116 | Pro1117 | Lys1118 | Glu1119 | Ala1120 | Lys1121 | Pro1122 | Asn1123 | Gly1124 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile1125 | Phe1126 | Lys1127 | Gly1128 | Ser1129 | Thr1130 | Ala1131 | Glu1132 | Asn1133 | Ala1134 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| HWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 118.00 | 5 | epidermal growth factor receptor isoform a |
| 2 | Pan troglodytes | 118.00 | 4 | PREDICTED: epidermal growth factor receptor isofor |
| 3 | synthetic construct | 118.00 | 1 | epidermal growth factor receptor |
| 4 | N/A | 106.00 | 5 | - |
| 5 | Mus musculus | 106.00 | 3 | epidermal growth factor receptor isoform 1 |
| 6 | Rattus norvegicus | 105.00 | 1 | epidermal growth factor receptor |
| 7 | Equus caballus | 103.00 | 1 | epidermal growth factor receptor |
| 8 | Canis familiaris | 98.60 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | Bos taurus | 95.50 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 10 | Sus scrofa | 89.70 | 2 | epidermal growth factor receptor |
| 11 | Monodelphis domestica | 82.40 | 1 | PREDICTED: similar to Epidermal growth factor rece |
| 12 | Xenopus laevis | 68.20 | 1 | epidermal growth factor receptor |
| 13 | Danio rerio | 36.60 | 2 | epidermal growth factor receptor |
| 14 | Tetraodon nigroviridis | 36.60 | 1 | unnamed protein product |
| 15 | Xiphophorus xiphidium | 35.00 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 |
| Pan troglodytes | Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 |
| synthetic construct | Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 1095 HWAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 |
| N/A | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Mus musculus | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 | ||||||+||||||||||||||| ||||#|||| |||||||||||| ||||||| Sbjct 1157 WIQKGSHQMSLDNPDYQQDFFPKETKPNG#IFKGPTAENAEYLRVAPPSSEFIGA 1210 |
| Rattus norvegicus | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 | ||||||+||||||||||||||||||||#|||| |||||||||||| |||| || Sbjct 1156 WIQKGSHQMSLDNPDYQQDFFPKEAKPNG#IFKGPTAENAEYLRVAPPSSEFSGA 1209 |
| Equus caballus | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIG 1148 |||||+|||||||||||||||||||| ||#|||| ||||||||||| |||||| Sbjct 52 WAQKGNHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENAEYLRVAPPSSEFIG 104 |
| Canis familiaris | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 | |+ +|||||||||||||||||||| ||#|||| ||||+|||||| ||||||| Sbjct 1542 WTQEANHQISLDNPDYQQDFFPKEAKSNG#IFKGPAAENADYLRVAPPSSEFIGA 1595 |
| Bos taurus | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 |||||||| ||||||||| ||||||| ||#|||| |||||||| || |+| || Sbjct 1132 WAQKGSHQFSLDNPDYQQAFFPKEAKSNG#IFKGPAAENAEYLRAAPAGSDFTGA 1185 |
| Sus scrofa | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 ||| |||||+|||||||| ||||||| ||#| || |||||||| || ||+ || Sbjct 1151 WAQTGSHQINLDNPDYQQAFFPKEAKSNG#ICKGPAAENAEYLRAAPASSDLTGA 1204 |
| Monodelphis domestica | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQSSEFIGA 1149 | | |+||||||||||||+||||||#+|| ||| |||||| | |||| | Sbjct 1184 WNPTAKHPINLDNPDYQQDFFPQEAKPNG#VFKVPAAENPEYLRVAAQQSEFIQA 1237 |
| Xenopus laevis | Query 1096 WAQKGSHQISLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYLRVAPQS 1143 | || + ||+|||||||||||||| | ||# || |+| ||| +|| | Sbjct 740 WDQKANIQINLDNPDYQQDFFPKEPKTNG#HFKIPAAQNPEYLGLAPVS 787 |
| Danio rerio | Query 1105 SLDNPDYQQDFFPKEAKPNG#IFKGSTAENAEYL 1137 |+||||||||| | | | + # |+| ||+ Sbjct 1154 SMDNPDYQQDFCPLELKTHT#NGHLPAAQNQEYM 1186 |
| Tetraodon nigroviridis | Query 1098 QKGSHQISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYLRV 1139 || + | |+||||||||| | + ||# ||| || | Sbjct 1054 QKYAPQNSIDNPDYQQDFTPTFKTHTNG#HI--PAAENTEYTSV 1094 |
| Xiphophorus xiphidium | Query 1103 QISLDNPDYQQDFFPK-EAKPNG#IFKGSTAENAEYL 1137 | |+||||||||| | + ||# ||| ||| Sbjct 1173 QNSMDNPDYQQDFTPTFKTHTNG#HI--PAAENVEYL 1206 |
* References
None.