logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1086 : epidermal growth factor receptor

[ CaMP Format ]

This entry is computationally expanded from SB0050

* Basic Information

OrganismHomo sapiens (human)
Protein NamesNot available
Gene NamesNot available
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1007208A N/A N/A N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 797 aa

Average Mass: 87.963 kDa

Monoisotopic Mass: 87.906 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Furin-like 1. 42196238.81.4e-68
Recep_L_domain 1. 219338146.48.7e-41
NinF 1. 4044690.12.4
Gram_pos_anchor 1. 490527-2.14.9
Pkinase_Tyr 1. 567796316.94.2e-92
--- cleavage 588 (inside Pkinase_Tyr 567..796) ---

3. Sequence Information

Fasta Sequence: XSB1086.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GTVYKGLWIP588-EGEKVKIPVA

Pro588 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly579Thr580Val581Tyr582Lys583Gly584Leu585Trp586Ile587Pro588
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu589Gly590Glu591Lys592Val593Lys594Ile595Pro596Val597Ala598

Sequence conservation (by blast)

* References

[PubMed ID: 6330563] Xu YH, Ishii S, Clark AJ, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT, Pastan I, Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature. 1984 Jun 28-Jul 4;309(5971):806-10.