XSB1095 : epidermal growth factor receptor [Danio rerio]
[ CaMP Format ]
This entry is computationally expanded from SB0050
* Basic Information
| Organism | Danio rerio (zebrafish) |
| Protein Names | epidermal growth factor receptor |
| Gene Names | egfr; epidermal growth factor receptor |
| Gene Locus | 2; chromosome 2 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_919405 | NM_194424 | 378478 | Q7SZF7 | N/A | N/A | N/A | dre:378478 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1191 aa
Average Mass: 132.484 kDa
Monoisotopic Mass: 132.397 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Recep_L_domain 1. | 54 | 166 | 115.0 | 2.4e-31 |
| Furin-like 1. | 182 | 336 | 286.1 | 7.9e-83 |
| Recep_L_domain 2. | 359 | 479 | 139.4 | 1.1e-38 |
| SapA 1. | 573 | 599 | -10.7 | 3.1 |
| SKG6 1. | 638 | 671 | -3.2 | 1.7 |
| Pkinase_Tyr 1. | 711 | 967 | 459.4 | 5.2e-135 |
| --- cleavage 732 (inside Pkinase_Tyr 711..967) --- | ||||
3. Sequence Information
Fasta Sequence: XSB1095.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GTVHKGLWVP732-EGENVKIPVA
Pro732 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly723 | Thr724 | Val725 | His726 | Lys727 | Gly728 | Leu729 | Trp730 | Val731 | Pro732 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu733 | Gly734 | Glu735 | Asn736 | Val737 | Lys738 | Ile739 | Pro740 | Val741 | Ala742 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LRILKETEFKKIKVLGSGAFGTVHKGLWVPEGENVKIPVAIKVLREATSPKANKEIMDEA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Danio rerio | 120.00 | 5 | epidermal growth factor receptor |
| 2 | N/A | 112.00 | 23 | - |
| 3 | Homo sapiens | 112.00 | 18 | epidermal growth factor receptor isoform a |
| 4 | Mus musculus | 112.00 | 10 | AF275367_1 epidermal growth factor receptor |
| 5 | Pan troglodytes | 112.00 | 8 | PREDICTED: epidermal growth factor receptor isofor |
| 6 | Rattus norvegicus | 112.00 | 8 | epidermal growth factor receptor |
| 7 | Macaca mulatta | 112.00 | 6 | PREDICTED: epidermal growth factor receptor, parti |
| 8 | Monodelphis domestica | 112.00 | 4 | PREDICTED: similar to Epidermal growth factor rece |
| 9 | synthetic construct | 112.00 | 4 | epidermal growth factor receptor |
| 10 | Canis familiaris | 112.00 | 4 | PREDICTED: similar to Epidermal growth factor rece |
| 11 | Tetraodon nigroviridis | 112.00 | 3 | unnamed protein product |
| 12 | Rous-associated virus type 1 | 112.00 | 2 | polyprotein |
| 13 | Sus scrofa | 112.00 | 2 | epidermal growth factor receptor |
| 14 | Bos taurus | 112.00 | 1 | PREDICTED: similar to epidermal growth factor rece |
| 15 | Xiphophorus xiphidium | 111.00 | 2 | epidermal growth factor receptor |
| 16 | Xenopus laevis | 110.00 | 3 | epidermal growth factor receptor |
| 17 | Felis catus | 108.00 | 2 | v-erb-b2 erythroblastic leukemia viral oncogene ho |
| 18 | Mesocricetus auratus | 108.00 | 1 | ERBB2_MESAU Receptor tyrosine-protein kinase erbB- |
| 19 | Canis lupus familiaris | 108.00 | 1 | erbB-2 |
| 20 | Gallus gallus | 107.00 | 5 | erbB-2 |
| 21 | Avian erythroblastosis virus | 107.00 | 2 | gag,v-erb-A,v-erb-B |
| 22 | Xiphophorus sp. | 104.00 | 1 | XMRK_XIPMA Melanoma receptor tyrosine-protein kina |
| 23 | Ovis aries | 96.30 | 1 | erythroblastic leukemia viral oncogene-like 2 |
| 24 | Pongo pygmaeus | 79.30 | 1 | ERBB3_PONPY Receptor tyrosine-protein kinase erbB- |
| 25 | Ciona intestinalis | 77.80 | 1 | epidermal growth factor receptor |
| 26 | Drosophila melanogaster | 77.40 | 127 | mutant epidermal growth factor receptor |
| 27 | Anopheles gambiae | 76.60 | 1 | putative epidermal growth factor receptor |
| 28 | Anopheles gambiae str. PEST | 76.60 | 1 | ENSANGP00000018805 |
| 29 | Strongylocentrotus purpuratus | 76.30 | 1 | PREDICTED: similar to v-erb-a erythroblastic leuke |
| 30 | Drosophila simulans | 75.50 | 1 | epidermal growth factor receptor |
Top-ranked sequences
| organism | matching |
|---|---|
| Danio rerio | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |
| N/A | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Homo sapiens | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Mus musculus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 706 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 765 |
| Pan troglodytes | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Rattus norvegicus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 705 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 764 |
| Macaca mulatta | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Monodelphis domestica | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 730 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 789 |
| synthetic construct | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 704 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 763 |
| Canis familiaris | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 1092 LRILKETEFKKIKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 1151 |
| Tetraodon nigroviridis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||| ||||||||||||||||+||||||#|||+||||||||||||||||||||+|+||| Sbjct 674 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANKDILDEA 733 |
| Rous-associated virus type 1 | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 278 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 337 |
| Sus scrofa | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 699 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 758 |
| Bos taurus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||||||||||+||||+|#||| |||||||| |||||||||||||+||| Sbjct 681 LRILKETEFKKVKVLGSGAFGTVYKGLWIP#EGEKVKIPVAIKELREATSPKANKEILDEA 740 |
| Xiphophorus xiphidium | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||| ||||||||||||||||+||||||#|||+|||||||||||||||||||+||+||| Sbjct 714 LRILKEPEFKKIKVLGSGAFGTVYKGLWVP#EGEDVKIPVAIKVLREATSPKANQEILDEA 773 |
| Xenopus laevis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||||||||||||||++|||+|#||| +||||||| |||||||||||||+||| Sbjct 289 LRILKETEFKKIKVLGSGAFGTVYQGLWIP#EGEGIKIPVAIKELREATSPKANKEILDEA 348 |
| Felis catus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Mesocricetus auratus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 712 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 771 |
| Canis lupus familiaris | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||||||+||| Sbjct 711 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKANKEILDEA 770 |
| Gallus gallus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 +||||||| ||+|||||||||||+||+|+|#+||+|||||||||||| |||||||||+||| Sbjct 701 MRILKETELKKVKVLGSGAFGTVYKGIWIP#DGESVKIPVAIKVLRENTSPKANKEILDEA 760 |
| Avian erythroblastosis virus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||||||||||+|||| ||||||+||||+|#||| | |||||| |||||||||||||+||| Sbjct 546 LRILKETEFKKVKVLGFGAFGTVYKGLWIP#EGEKVTIPVAIKELREATSPKANKEILDEA 605 |
| Xiphophorus sp. | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 ||||||||||| +||||||||||+|||| |#+|||++||||||||||||||| |+|++||| Sbjct 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNP#DGENIRIPVAIKVLREATSPKVNQEVLDEA 761 |
| Ovis aries | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKAN 755 +||||||| +|+|||||||||||+||+|+|#+||||||||||||||| |||||| Sbjct 63 MRILKETELRKVKVLGSGAFGTVYKGIWIP#DGENVKIPVAIKVLRENTSPKAN 115 |
| Pongo pygmaeus | Query 704 RILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMD 760 || |||| ||+|||||| |||||||+|+|#|||++|||| |||+ + + ++ + + | Sbjct 702 RIFKETELKKLKVLGSGVFGTVHKGVWIP#EGESIKIPVCIKVIEDKSGRQSFQAVTD 758 |
| Ciona intestinalis | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#E---GENVKIPVAIKVLREATSPKANKEIM 759 |||+|| | + |+|||||||||||| |+|#+ | ||+||||||||+ +| |+ ||+ Sbjct 115 LRIVKEAELRIGKILGSGAFGTVHKGYWIP#DLAPRERVKVPVAIKVLRDESSQVASNEIL 174 Query 760 DEA 762 ||| Query 760 DEA 762 |
| Drosophila melanogaster | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|+|| +| ||| |||| |+||+|||#|||||||||||| | ++| ++++| + || Sbjct 830 LRIVKDTELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 889 |
| Anopheles gambiae | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|| | ++ ||| |||| | ||+|+|#|||+|||||||||| | + +++|| ++|| Sbjct 826 LRIIKEAEIRRGGVLGMGAFGRVFKGVWMP#EGESVKIPVAIKVLMEMSGSESSKEFLEEA 885 |
| Anopheles gambiae str. PEST | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|| | ++ ||| |||| | ||+|+|#|||+|||||||||| | + +++|| ++|| Sbjct 827 LRIIKEAEIRRGGVLGMGAFGRVFKGVWMP#EGESVKIPVAIKVLMEMSGSESSKEFLEEA 886 |
| Strongylocentrotus purpuratus | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMD 760 |+|+|+|| | ||||||||||+||||+|#+|| ++|||||| ||| || | +|+++ Sbjct 1012 LKIIKDTELKLGPVLGSGAFGTVYKGLWIP#DGEKIRIPVAIKALRE-VSPHAAEELLE 1068 |
| Drosophila simulans | Query 703 LRILKETEFKKIKVLGSGAFGTVHKGLWVP#EGENVKIPVAIKVLREATSPKANKEIMDEA 762 |||+|+ | +| ||| |||| |+||+|||#|||||||||||| | ++| ++++| + || Sbjct 829 LRIVKDAELRKGGVLGMGAFGRVYKGVWVP#EGENVKIPVAIKELLKSTGAESSEEFLREA 888 |
* References
[PubMed ID: 19063890] Lin SW, Ge W, Differential regulation of gonadotropins (FSH and LH) and growth hormone (GH) by neuroendocrine, endocrine, and paracrine factors in the zebrafish--an in vitro approach. Gen Comp Endocrinol. 2009 Jan 15;160(2):183-93. Epub 2008 Dec 3.
[PubMed ID: 18508863] ... Budi EH, Patterson LB, Parichy DM, Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development. 2008 Aug;135(15):2603-14. Epub 2008 May 28.
[PubMed ID: 17884332] ... Heiden TC, Struble CA, Rise ML, Hessner MJ, Hutz RJ, Carvan MJ 3rd, Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: insights into TCDD-induced endocrine disruption and reproductive toxicity. Reprod Toxicol. 2008 Jan;25(1):47-57. Epub 2007 Aug 11.
[PubMed ID: 17177598] ... Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q, Greulich H, Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA, Getz G, Onofrio R, Ziaugra L, Levine RL, Gabriel S, Kawaguchi T, O'Neill K, Khan H, Liau LM, Nelson SF, Rao PN, Mischel P, Pieper RO, Cloughesy T, Leahy DJ, Sellers WR, Sawyers CL, Meyerson M, Mellinghoff IK, Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med. 2006 Dec;3(12):e485.
[PubMed ID: 15115721] ... Wang Y, Ge W, Cloning of epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biol Reprod. 2004 Sep;71(3):749-60. Epub 2004 Apr 28.
[PubMed ID: 12915231] ... Goishi K, Lee P, Davidson AJ, Nishi E, Zon LI, Klagsbrun M, Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech Dev. 2003 Jul;120(7):811-22.