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XSB1111 : vimentin [Bos taurus]

[ CaMP Format ]

This entry is computationally expanded from SB0037

* Basic Information

OrganismBos taurus (cattle)
Protein Namesvimentin
Gene NamesVIM; vimentin
Gene Locus13q16-q17; chromosome 13
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776394 NM_173969 280955 P48616 N/A N/A N/A bta:280955

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 466 aa

Average Mass: 53.728 kDa

Monoisotopic Mass: 53.695 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Filament_head 1. 6101121.23.3e-33
--- cleavage 91 (inside Filament_head 6..101) ---
Filament 1. 102410610.61.6e-180
--- cleavage 264 (inside Filament 102..410) ---

3. Sequence Information

Fasta Sequence: XSB1111.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] QIDMDVSKPD264-LTAALRDVRQ

Asp264 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln255Ile256Asp257Met258Asp259Val260Ser261Lys262Pro263Asp264
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu265Thr266Ala267Ala268Leu269Arg270Asp271Val272Arg273Gln274

Sequence conservation (by blast)

[Site 2] DSVDFSLADA91-INTEFKNTRT

Ala91 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asp82Ser83Val84Asp85Phe86Ser87Leu88Ala89Asp90Ala91
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile92Asn93Thr94Glu95Phe96Lys97Asn98Thr99Arg100Thr101

Sequence conservation (by blast)

* References

[PubMed ID: 16876394] Blain EJ, Gilbert SJ, Hayes AJ, Duance VC, Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biol. 2006 Sep;25(7):398-408. Epub 2006 Jun 18.

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