XSB1142 : prodynorphin [Rattus norvegicus]
[ CaMP Format ]
This entry is computationally expanded from SB0049
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | Proenkephalin-B; Beta-neoendorphin-dynorphin; Preprodynorphin; Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin; Big Dyn; Dynorphin A(1-17); Dynorphin A; Dyn-A17; Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin; Dynorphin B; Dyn-B; Dynorphin B(1-13); Leumorphin; Dynorphin B-29; prodynorphin; RecName: Full=Proenkephalin-B; AltName: Full=Beta-neoendorphin-dynorphin; AltName: Full=Preprodynorphin; Contains:RecName: Full=Alpha-neoendorphin; Contains:RecName: Full=Beta-neoendorphin; Contains:RecName: Full=Big dynorphin; Short=Big Dyn; Contains:RecName: Full=Dynorphin A; 1-17; 1-13; 1-8 |
| Gene Names | Pdyn |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 204 aa
Average Mass: 23.386 kDa
Monoisotopic Mass: 23.372 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Opiods_neuropep 1. | 1 | 26 | -12.7 | 2 |
| DUF2059 1. | 75 | 149 | -24.0 | 3.2 |
3. Sequence Information
Fasta Sequence: XSB1142.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] FLRRIRPKLK170-WDNQKRYGGF
Lys170 
Trp
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe161 | Leu162 | Arg163 | Arg164 | Ile165 | Arg166 | Pro167 | Lys168 | Leu169 | Lys170 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Trp171 | Asp172 | Asn173 | Gln174 | Lys175 | Arg176 | Tyr177 | Gly178 | Gly179 | Phe180 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| DRGQDGDQVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQENPNTYSE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 131.00 | 4 | prodynorphin |
| 2 | Mus musculus | 128.00 | 7 | preprodynorphin |
| 3 | Contains: Beta-neoendorphin; Dynorphin A; Leu-enkephalin; Rimorphin; Dynorphin B | 115.00 | 1 | PDYN_CAVPO Beta-neoendorphin-dynorphin precursor ( |
| 4 | Homo sapiens | 114.00 | 5 | preproenkephalin |
| 5 | Macaca mulatta | 114.00 | 3 | preprodynorphin |
| 6 | Canis familiaris | 114.00 | 3 | PREDICTED: similar to Beta-neoendorphin-dynorphin |
| 7 | Gorilla gorilla | 114.00 | 1 | preprodynorphin |
| 8 | Pongo pygmaeus | 114.00 | 1 | preprodynorphin |
| 9 | Macaca nemestrina | 114.00 | 1 | preprodynorphin |
| 10 | Papio papio | 114.00 | 1 | preprodynorphin |
| 11 | Pan troglodytes | 113.00 | 4 | PREDICTED: beta-neoendorphin-dynorphin isoform 1 |
| 12 | Pan paniscus | 113.00 | 1 | preprodynorphin |
| 13 | Pan troglodytes verus | 113.00 | 1 | preprodynorphin |
| 14 | Sus scrofa | 112.00 | 1 | beta-neoendorphin-dynorphin preproprotein |
| 15 | Bos taurus | 109.00 | 4 | PREDICTED: similar to prodynorphin |
| 16 | mice, brain, Peptide Partial, 63 aa | 105.00 | 1 | AAB29180.1 |
| 17 | Monodelphis domestica | 99.80 | 2 | PREDICTED: similar to Beta-neoendorphin-dynorphin |
| 18 | Macaca fascicularis | 99.00 | 1 | prodynorphin |
| 19 | Polypterus senegalus | 86.30 | 2 | prodynorphin precursor |
| 20 | Xenopus laevis | 85.90 | 4 | dorphin A |
| 21 | Neoceratodus forsteri | 85.90 | 2 | prodynorphin |
| 22 | Anguilla rostrata | 83.60 | 2 | prodynorphin |
| 23 | Danio rerio | 82.00 | 8 | prodynorphin |
| 24 | Bufo marinus | 73.60 | 1 | AF084455_1 prodynorphin |
| 25 | Oncorhynchus masou | 72.40 | 1 | prodynorphin |
| 26 | Bombina orientalis | 71.20 | 2 | dorphin |
| 27 | Oreochromis mossambicus | 64.30 | 1 | prodynorphin precursor |
| 28 | N/A | 57.00 | 8 | 0 |
| 29 | Taricha granulosa | 53.90 | 1 | proenkephalin |
| 30 | Necturus maculosus | 53.50 | 1 | proenkephalin |
| 31 | Amphiuma means | 53.50 | 1 | proenkephalin |
| 32 | Protopterus annectens | 53.10 | 2 | AF232670_1 proenkephalin |
| 33 | Gallus gallus | 52.40 | 2 | PREDICTED: similar to proenkephalin |
| 34 | Heterodontus portusjacksoni | 42.40 | 1 | proenkephalin |
| 35 | Amia calva | 40.00 | 1 | proenkephalin |
| 36 | Lepisosteus platyrhynchus | 39.30 | 1 | proenkephalin |
| 37 | Tetraodon nigroviridis | 35.80 | 2 | unnamed protein product |
| 38 | Rattus sp. | 35.40 | 1 | ORL1 receptor agonist precursor |
| 39 | Contains: Synenkephalin; Met-enkephalin; Leu-enkephalin | 35.00 | 1 | PENK_FELCA Proenkephalin A |
| 40 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | 35.00 | 1 | PENKB_XENLA Proenkephalin A-B precursor |
| 41 | Contains: Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | 35.00 | 1 | PENKA_XENLA Proenkephalin A-A precursor |
| 42 | Spea multiplicata | 34.70 | 1 | AF195886_1 proenkephalin |
| 43 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | 33.50 | 3 | PENK_MESAU Proenkephalin A precursor |
| 44 | Cricetinae | 33.50 | 1 | AAB32115.1 |
| 45 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | 33.50 | 1 | PENK_MOUSE Proenkephalin A precursor |
| 46 | synthetic construct | 33.10 | 4 | proenkephalin |
| 47 | Acipenser transmontanus | 33.10 | 1 | AF095739_1 proorphanin |
| 48 | Xenopus tropicalis | 32.70 | 1 | MGC107924 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 141 DRGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 141 DRGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 |
| Mus musculus | Query 141 DRGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 185 DGGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 244 |
| Contains: Beta-neoendorphin; Dynorphin A; Leu-enkephalin; Rimorphin; Dynorphin B | Query 144 QDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 +||| |||||||||||||||||||||#|||||||||||||||||||||||+|| ||| Sbjct 184 RDGDNAGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYSE 240 |
| Homo sapiens | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 151 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 205 |
| Macaca mulatta | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 150 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 204 |
| Canis familiaris | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| ||||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 196 DGDAVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 250 |
| Gorilla gorilla | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 151 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 205 |
| Pongo pygmaeus | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 151 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 205 |
| Macaca nemestrina | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 150 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 204 |
| Papio papio | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| +|||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 150 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 204 |
| Pan troglodytes | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| |||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 194 DGDSTGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 248 |
| Pan paniscus | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| |||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 151 DGDSTGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 205 |
| Pan troglodytes verus | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||| |||||||||||||||||||||#|||||||||||||||||||||||+|| || Sbjct 151 DGDSTGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYS 205 |
| Sus scrofa | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | |+||||||||||||||||||||||#|||||||||||||||||||||||+|| | | Sbjct 196 DRDKVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPNAYYE 251 |
| Bos taurus | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 +| +||||||||||||||||||||||#|||||||||||||||||||||||+|+ | | Sbjct 198 EGGEVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQEDPSAYYE 253 |
| mice, brain, Peptide Partial, 63 aa | Query 141 DRGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVT 189 | ||||||||||||||||||||||||||||#||||||||||||||||||| Sbjct 15 DGGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVT 63 |
| Monodelphis domestica | Query 146 GDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 || |||+||||||+||||||||#|||||||||||||||||||||+|+|| || Sbjct 194 GDVQEQEDLHKRYGGFMRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSEEDPNAYS 247 |
| Macaca fascicularis | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTR 190 ||| +|||||||||||||||||||||#|||||||||||||||||||| Sbjct 189 DGDSMGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTR 234 |
| Polypterus senegalus | Query 141 DRGQDGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | +| | |+| ||||||+||+|||||#||||||||||||| ||+ || | |++||+ Sbjct 197 DYEEDNSQ---EELQKRYGGFMRRVRPKLK#WDNQKRYGGFLRRHFKISVRSDEEPSSYSD 253 |
| Xenopus laevis | Query 141 DRGQDGD-QVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 + ||+ | + | +| ||||||||||||||+#||||||||||||||||| ||+|+| +| Sbjct 182 ETGQEVDLEHGTAELEKRYGGFLRRIRPKLR#WDNQKRYGGFLRRQFKVNARSEEDPTMFS 241 |
| Neoceratodus forsteri | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTY 198 +|| |+| ||||||+||||||++#||||||||||||| ||+ || |+|+ | Sbjct 207 EGDNQVQEELQKRYGGFMRRIRPKIR#WDNQKRYGGFLRRHFKITVRSDEDPSPY 260 |
| Anguilla rostrata | Query 147 DQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTY 198 |+ |+| ||||||+||||||||#||+|||||||||| ||+ || | | +| Sbjct 197 DENSQEELQKRYGGFMRRIRPKLK#WDSQKRYGGFLRRHFKISVRSDEEPGSY 248 |
| Danio rerio | Query 147 DQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | + | ||||||+|||||||+#||||||||||||| ||+ || | |++| + Sbjct 196 DDTNPQVLQKRYGGFMRRIRPKLR#WDNQKRYGGFLRRHFKISVRSDEEPSSYED 249 |
| Bufo marinus | Query 163 RRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 ||||||||#||||||||||||||||| |||+|+|+|+| Sbjct 1 RRIRPKLK#WDNQKRYGGFLRRQFKVTTRSEEDPSTFS 37 |
| Oncorhynchus masou | Query 156 KRYGGFLRRIRPKL------K#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ||||||+||||||| |#||||||||||||| +|+ || | |++| + Sbjct 1 KRYGGFMRRIRPKLNNLNTMK#WDNQKRYGGFLRRHYKLSVRSDEEPSSYDD 51 |
| Bombina orientalis | Query 153 DLYKRYGGFLRRIRPKLK#WDN-QKRYGGFLRRQFKVVTRSQENPNTYS 199 +| ||||||+||||||||# +||||||||||||| |||+| | ++| Sbjct 191 ELQKRYGGFMRRIRPKLK#LGTIRKRYGGFLRRQFKVTTRSEEEPGSFS 238 |
| Oreochromis mossambicus | Query 152 EDLYKRYGGFLRRIRPK---LK#WDNQKRYGGFLRRQFKVVTRSQENP 195 |+| ||||||+||+||| ||#|| ||||||||| ||+ || | | Sbjct 176 EELQKRYGGFMRRVRPKLNNLK#WD--KRYGGFLRRHFKISMRSVEEP 220 |
| N/A | Query 158 YGGFLRRIRPKLK#WDNQKRYGGFL 181 |||||||||||||#||||||||||| Query 158 YGGFLRRIRPKLK#WDNQKRYGGFL 181 |
| Taricha granulosa | Query 150 GHEDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | +||+||||||+||+ ||+ # | |||||||+|| |+| +||+ Sbjct 198 GAKDLHKRYGGFMRRVGRPEWW#LDYQKRYGGFMRRFADSSAPSEEEAESYSK 249 |
| Necturus maculosus | Query 150 GHEDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | +||+||||||+||+ ||+ # | |||||||+|| | |+ +||+ Sbjct 198 GAKDLHKRYGGFMRRVGRPEWW#LDYQKRYGGFMRRFADYSAPSDEDGESYSK 249 |
| Amphiuma means | Query 150 GHEDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 | +||+||||||+||+ ||+ # | |||||||+|| | |+ +||+ Sbjct 198 GAKDLHKRYGGFMRRVGRPEWW#QDYQKRYGGFMRRFTDYSAPSDEDGESYSK 249 |
| Protopterus annectens | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRR 183 +|| ||||||+||+ ||+ |# |||||||||+|| Sbjct 203 KDLQKRYGGFMRRVGRPEWK#LDNQKRYGGFMRR 235 |
| Gallus gallus | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ++| ||||||+||+ ||+ # | ||||||||+| + |+|+ |||+ Sbjct 203 KELQKRYGGFMRRVGRPEWW#LDYQKRYGGFLKRFADSILPSEEDGETYSK 252 |
| Heterodontus portusjacksoni | Query 153 DLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 +| ||||||+|| |# |||||||++| ++ | |+ ||+ Sbjct 205 ELQKRYGGFMRRFG---K#PGYQKRYGGFMKRWNDILVPSDEDGEIYSK 249 |
| Amia calva | Query 150 GHEDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRR 183 | ++| ||||||+||+ ||+ |# | ||||||||+| Sbjct 197 GIKELQKRYGGFMRRVGRPEWK#ED-QKRYGGFLKR 230 Query 143 GQDGDQVGHED--LYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 | | + | | + ||||||+| |+ | # ++ |||||||+|| Sbjct 164 GSDMESHGDHDGEIMKRYGGFMRSIKRSLD#LEDGIKELQKRYGGFMRR 211 |
| Lepisosteus platyrhynchus | Query 142 RGQDGDQVGHEDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRR 183 | || + | ++| ||||||+||+ ||+ |# | ||||||||+| Sbjct 83 RSQDLED-GIKELQKRYGGFMRRVVRPEWK#ED-QKRYGGFLKR 123 Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 |||+ | + ||||||+| +| # ++ |||||||+|| Sbjct 63 DGDRDG--ETMKRYGGFMRSVRRSQD#LEDGIKELQKRYGGFMRR 104 |
| Tetraodon nigroviridis | Query 156 KRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQE 193 ||||||+ + |#|+||||+ ||++ + |+ + Sbjct 70 KRYGGFVGIRKSARK#WNNQKRFSEFLKQYLGMSARTTD 107 |
| Rattus sp. | Query 145 DGDQVGHEDLYKRYGGFLRRIRPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNT 197 + |+| + | ||+||| + |# ||||+ |+|+ + +| + | Sbjct 109 EADEVEQKQLQKRFGGFTGARKSARK#LANQKRFSEFMRQYLVLSMQSSQRRRT 161 |
| Contains: Synenkephalin; Met-enkephalin; Leu-enkephalin | Query 154 LYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYS 199 | ||||||+||+ ||+ # | ||||||||+| | | | +|| Sbjct 142 LQKRYGGFMRRVGRPEWW#MDYQKRYGGFLKR-FADSLPSDEEGESYS 187 Query 142 RGQDGDQVGHEDLYKRYGGFLRRIR--PKLK#WDN---QKRYGGFLRR 183 ||+| ||+ | +|||+| ++ |+| # + |||||||+|| Sbjct 111 RGRDD-----EDVSKSHGGFMRALKGSPQLA#QEAKMLQKRYGGFMRR 152 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | Query 154 LYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 + ||||||+||+ ||+ # | |||||||+ | | |+ +||+ Sbjct 154 IQKRYGGFMRRVGRPEWW#QDYQKRYGGFMTRFTDSFLPSDEDGESYSK 201 Query 153 DLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 ++ ||||||+| | # ++ |||||||+|| Sbjct 129 EMNKRYGGFMRGYRRSTD#LEDETRGIQKRYGGFMRR 164 |
| Contains: Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | Query 154 LYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 + ||||||+||+ ||+ # | |||||||+ | | |+ +||+ Sbjct 200 IQKRYGGFMRRVGRPEWW#EDYQKRYGGFMTRFTDSFLPSDEDGESYSK 247 Query 153 DLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 ++ ||||||+| | # ++ |||||||+|| Sbjct 175 EINKRYGGFMRGYRRSTD#LEDETSGIQKRYGGFMRR 210 |
| Spea multiplicata | Query 153 DLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 +++||||||+||+ ||+ # | |||||||+|| | | |+ +||+ Sbjct 197 EMHKRYGGFMRRVGRPEWW#QDYQKRYGGFMRRFSDSVLPSDEDGESYSK 245 Query 156 KRYGGFLRRI----RPKLK#WDNQ------KRYGGFLRRQF 185 ||||||++++ ||+ +# || |+||||++++| Sbjct 103 KRYGGFMKKMDELYRPEAE#EDNNGGEILAKKYGGFMKKEF 142 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ++| ||||||+||+ ||+ # | ||||||||+| | | | +||+ Sbjct 205 KELQKRYGGFMRRVGRPEWW#MDYQKRYGGFLKR-FAESLPSDEEAESYSK 253 Query 152 EDLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 +++ ||||||+| ++ +# ++ |||||||+|| Sbjct 181 DNMSKRYGGFMRGLKRSPQ#VEDEAKELQKRYGGFMRR 217 Query 153 DLYKRYGGFLRRIRPKLK#WDNQ------------KRYGGFLR 182 | |||||||+| | # | + ||||||+| Sbjct 226 DYQKRYGGFLKRFAESLP#SDEEAESYSKEVPEIEKRYGGFMR 267 |
| Cricetinae | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ++| ||||||+||+ ||+ # | ||||||||+| | | | +||+ Sbjct 205 KELQKRYGGFMRRVGRPEWW#MDYQKRYGGFLKR-FAESLPSDEEAESYSK 253 Query 152 EDLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 +++ ||||||+| ++ +# ++ |||||||+|| Sbjct 181 DNMSKRYGGFMRGLKRSPQ#VEDEAKELQKRYGGFMRR 217 Query 153 DLYKRYGGFLRRIRPKLK#WDNQ------------KRYGGFLR 182 | |||||||+| | # | + ||||||+| Sbjct 226 DYQKRYGGFLKRFAESLP#SDEEAESYSKEVPEIEKRYGGFMR 267 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ++| ||||||+||+ ||+ # | ||||||||+| + + +| | | Sbjct 206 KELQKRYGGFMRRVGRPEWW#MDYQKRYGGFLKRFAESLPSDEEGENYSKE 255 Query 156 KRYGGFLRRIR--PKLK---#WDNQKRYGGFLRR 183 ||||||+| ++ |+|+ # + |||||||+|| Sbjct 186 KRYGGFMRSLKRSPQLEDEA#KELQKRYGGFMRR 218 Query 153 DLYKRYGGFLRRIRPKLK#WDNQ------------KRYGGFLR 182 | |||||||+| | # | + ||||||+| Sbjct 227 DYQKRYGGFLKRFAESLP#SDEEGENYSKEVPEIEKRYGGFMR 268 |
| synthetic construct | Query 152 EDLYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 ++| ||||||+||+ ||+ # | ||||||||+| | | | +||+ Sbjct 204 KELQKRYGGFMRRVGRPEWW#MDYQKRYGGFLKR-FAEALPSDEEGESYSK 252 Query 144 QDGDQVGHEDLYKRYGGFLRRIR--PKLK---#WDNQKRYGGFLRR 183 ||| |++ ||||||+| ++ |+|+ # + |||||||+|| Sbjct 173 QDGSD-NEEEVSKRYGGFMRGLKRSPQLEDEA#KELQKRYGGFMRR 216 Query 153 DLYKRYGGFLRRIRPKLK#WDNQ------------KRYGGFLR 182 | |||||||+| | # | + ||||||+| Sbjct 225 DYQKRYGGFLKRFAEALP#SDEEGESYSKEVPEMEKRYGGFMR 266 |
| Acipenser transmontanus | Query 154 LYKRYGGFLRRIRPKLK#WDNQKRYGGFLRR 183 | ||||||+ + |#|+| ||| |++ Sbjct 157 LQKRYGGFIGIRKSARK#WNNPKRYNELLKQ 186 |
| Xenopus tropicalis | Query 154 LYKRYGGFLRRI-RPKLK#WDNQKRYGGFLRRQFKVVTRSQENPNTYSE 200 + ||||||+||+ ||+ # | |||||||+|| |+|+ +||+ Sbjct 200 IQKRYGGFMRRVGRPEWW#QDYQKRYGGFMRRFTDSFLPSEEDGESYSK 247 Query 153 DLYKRYGGFLRRIRPKLK#WDN-----QKRYGGFLRR 183 ++ ||||||+| | # ++ |||||||+|| Sbjct 175 EMNKRYGGFMRGYRRSTD#LEDETRGIQKRYGGFMRR 210 Query 152 EDLYKRYGGFLRRIR-------------PKLK#WDNQKRYGGFLR 182 +| ||||||+|| | # | +||||||+| Sbjct 218 QDYQKRYGGFMRRFTDSFLPSEEDGESYSKEN#PDMEKRYGGFMR 261 |
[Site 2] LYKRYGGFLR163-RIRPKLKWDN
Arg163 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu154 | Tyr155 | Lys156 | Arg157 | Tyr158 | Gly159 | Gly160 | Phe161 | Leu162 | Arg163 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg164 | Ile165 | Arg166 | Pro167 | Lys168 | Leu169 | Lys170 | Trp171 | Asp172 | Asn173 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SEMAGDEDRGQDGDQVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 129.00 | 4 | prodynorphin |
| 2 | Mus musculus | 123.00 | 7 | beta-neoendorphin-dynorphin preproprotein |
| 3 | mice, brain, Peptide Partial, 63 aa | 116.00 | 1 | AAB29180.1 |
| 4 | Canis familiaris | 107.00 | 3 | PREDICTED: similar to Beta-neoendorphin-dynorphin |
| 5 | Contains: Beta-neoendorphin; Dynorphin A; Leu-enkephalin; Rimorphin; Dynorphin B | 107.00 | 1 | PDYN_CAVPO Beta-neoendorphin-dynorphin precursor ( |
| 6 | Sus scrofa | 107.00 | 1 | beta-neoendorphin-dynorphin preproprotein |
| 7 | Homo sapiens | 106.00 | 5 | preproenkephalin |
| 8 | Bos taurus | 106.00 | 4 | PREDICTED: similar to prodynorphin |
| 9 | Macaca mulatta | 106.00 | 2 | preprodynorphin |
| 10 | Papio papio | 106.00 | 1 | preprodynorphin |
| 11 | Pongo pygmaeus | 106.00 | 1 | preprodynorphin |
| 12 | Macaca nemestrina | 106.00 | 1 | preprodynorphin |
| 13 | Gorilla gorilla | 106.00 | 1 | preprodynorphin |
| 14 | Pan troglodytes | 105.00 | 3 | PREDICTED: beta-neoendorphin-dynorphin isoform 1 |
| 15 | Pan paniscus | 105.00 | 1 | preprodynorphin |
| 16 | Pan troglodytes verus | 105.00 | 1 | preprodynorphin |
| 17 | Macaca fascicularis | 100.00 | 1 | prodynorphin |
| 18 | Monodelphis domestica | 90.10 | 2 | PREDICTED: similar to Beta-neoendorphin-dynorphin |
| 19 | Xenopus laevis | 80.50 | 4 | dorphin A |
| 20 | Neoceratodus forsteri | 80.10 | 2 | prodynorphin |
| 21 | Anguilla rostrata | 78.20 | 2 | prodynorphin precursor |
| 22 | Polypterus senegalus | 77.80 | 2 | prodynorphin precursor |
| 23 | Danio rerio | 75.10 | 8 | prodynorphin |
| 24 | Bombina orientalis | 65.50 | 2 | dorphin |
| 25 | Oncorhynchus masou | 65.50 | 1 | prodynorphin |
| 26 | Bufo marinus | 65.50 | 1 | AF084455_1 prodynorphin |
| 27 | Oreochromis mossambicus | 61.60 | 1 | prodynorphin precursor |
| 28 | N/A | 57.00 | 8 | 0 |
| 29 | Protopterus annectens | 53.10 | 2 | AF232670_1 proenkephalin |
| 30 | Amia calva | 43.50 | 1 | proenkephalin |
| 31 | Gallus gallus | 42.40 | 2 | PREDICTED: similar to prepronociceptin |
| 32 | Lepisosteus platyrhynchus | 39.30 | 1 | proenkephalin |
| 33 | Heterodontus portusjacksoni | 38.50 | 1 | proenkephalin |
| 34 | Amphiuma means | 37.70 | 1 | proenkephalin |
| 35 | Necturus maculosus | 36.20 | 1 | proenkephalin |
| 36 | Tetraodon nigroviridis | 35.80 | 2 | unnamed protein product |
| 37 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | 35.00 | 1 | PENKB_XENLA Proenkephalin A-B precursor |
| 38 | Contains: Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | 35.00 | 1 | PENKA_XENLA Proenkephalin A-A precursor |
| 39 | Rattus sp. | 35.00 | 1 | ORL1 receptor agonist precursor |
| 40 | Contains: Synenkephalin; Met-enkephalin; Leu-enkephalin | 35.00 | 1 | PENK_FELCA Proenkephalin A |
| 41 | Taricha granulosa | 34.30 | 1 | proenkephalin |
| 42 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | 33.50 | 3 | PENK_MESAU Proenkephalin A precursor |
| 43 | Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | 33.50 | 1 | PENK_MOUSE Proenkephalin A precursor |
| 44 | Spea multiplicata | 33.50 | 1 | AF195886_1 proenkephalin |
| 45 | Cricetinae | 33.50 | 1 | AAB32115.1 |
| 46 | synthetic construct | 33.10 | 2 | proenkephalin |
| 47 | Acipenser transmontanus | 33.10 | 1 | AF095739_1 proorphanin |
| 48 | Xenopus tropicalis | 32.70 | 1 | MGC107924 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 |
| Mus musculus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 |||| ||| |||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 178 SEMARDEDGGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 237 |
| mice, brain, Peptide Partial, 63 aa | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVT 189 |||| ||| |||||||||||||||||||||#|||||||||||||||||||||||||| Sbjct 8 SEMARDEDGGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVT 63 |
| Canis familiaris | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ + ||| |||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 187 SEVAGEGNG--DGDAVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 244 |
| Contains: Beta-neoendorphin; Dynorphin A; Leu-enkephalin; Rimorphin; Dynorphin B | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+| + || ||| ||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 176 SEVAREGDR--DGDNAGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 233 |
| Sus scrofa | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | | |+|||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 187 SEVAGEGDG--DRDKVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 244 |
| Homo sapiens | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 144 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 199 |
| Bos taurus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+ | | +| +|||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 187 SEVTGKEAGEGEGGEVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 246 |
| Macaca mulatta | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 143 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 198 |
| Papio papio | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 143 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 198 |
| Pongo pygmaeus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 144 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 199 |
| Macaca nemestrina | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 143 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 198 |
| Gorilla gorilla | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || +||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 144 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 199 |
| Pan troglodytes | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || ||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 187 SEVAGEGD----GDSTGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 242 |
| Pan paniscus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || ||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 144 SEVAGEGD----GDSTGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 199 |
| Pan troglodytes verus | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||+||+ | || ||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 144 SEVAGEGD----GDSTGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 199 |
| Macaca fascicularis | Query 134 SEMAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTR 190 ||+||+ | || +||||||||||||||#||||||||||||||||||||||||||| Sbjct 182 SEVAGEGD----GDSMGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTR 234 |
| Monodelphis domestica | Query 146 GDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 || |||+||||||+|#||||||||||||||||||||||||||||+| Sbjct 194 GDVQEQEDLHKRYGGFMR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSEE 241 |
| Xenopus laevis | Query 141 DRGQDGD-QVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 + ||+ | + | +| ||||||||#||||||+||||||||||||||||| ||+| Sbjct 182 ETGQEVDLEHGTAELEKRYGGFLR#RIRPKLRWDNQKRYGGFLRRQFKVNARSEE 235 |
| Neoceratodus forsteri | Query 145 DGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 +|| |+| ||||||+|#|||||++||||||||||||| ||+ || | Sbjct 207 EGDNQVQEELQKRYGGFMR#RIRPKIRWDNQKRYGGFLRRHFKITVRSDE 255 |
| Anguilla rostrata | Query 138 GDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 | + |+ |+| ||||||+|#|||||||||+|||||||||| ||+ || | Sbjct 188 GPKKSYNSADENSQEELQKRYGGFMR#RIRPKLKWDSQKRYGGFLRRHFKISVRSDE 243 |
| Polypterus senegalus | Query 141 DRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 | +| | |+| ||||||+|#|+|||||||||||||||||| ||+ || | Sbjct 197 DYEEDNSQ---EELQKRYGGFMR#RVRPKLKWDNQKRYGGFLRRHFKISVRSDE 246 |
| Danio rerio | Query 147 DQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 | + | ||||||+|#||||||+||||||||||||| ||+ || | Sbjct 196 DDTNPQVLQKRYGGFMR#RIRPKLRWDNQKRYGGFLRRHFKISVRSDE 242 |
| Bombina orientalis | Query 153 DLYKRYGGFLR#RIRPKLKWDN-QKRYGGFLRRQFKVVTRSQE 193 +| ||||||+|#||||||| +||||||||||||| |||+| Sbjct 191 ELQKRYGGFMR#RIRPKLKLGTIRKRYGGFLRRQFKVTTRSEE 232 |
| Oncorhynchus masou | Query 156 KRYGGFLR#RIRPKL------KWDNQKRYGGFLRRQFKVVTRSQE 193 ||||||+|#|||||| |||||||||||||| +|+ || | Sbjct 1 KRYGGFMR#RIRPKLNNLNTMKWDNQKRYGGFLRRHYKLSVRSDE 44 |
| Bufo marinus | Query 163 R#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 |#|||||||||||||||||||||||| |||+| Sbjct 1 R#RIRPKLKWDNQKRYGGFLRRQFKVTTRSEE 31 |
| Oreochromis mossambicus | Query 152 EDLYKRYGGFLR#RIRPK---LKWDNQKRYGGFLRRQFKVVTRSQE 193 |+| ||||||+|#|+||| |||| ||||||||| ||+ || | Sbjct 176 EELQKRYGGFMR#RVRPKLNNLKWD--KRYGGFLRRHFKISMRSVE 218 |
| N/A | Query 158 YGGFLR#RIRPKLKWDNQKRYGGFL 181 ||||||#|||||||||||||||||| Query 158 YGGFLR#RIRPKLKWDNQKRYGGFL 181 |
| Protopterus annectens | Query 152 EDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 +|| ||||||+|#|+ ||+ | |||||||||+|| Sbjct 203 KDLQKRYGGFMR#RVGRPEWKLDNQKRYGGFMRR 235 |
| Amia calva | Query 150 GHEDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | ++| ||||||+|#|+ ||+ | | ||||||||+| Sbjct 197 GIKELQKRYGGFMR#RVGRPEWKED-QKRYGGFLKR 230 Query 137 AGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 || | || | ++ ||||||+|# |+ | ++ |||||||+|| Sbjct 162 AGGSDMESHGDHDG--EIMKRYGGFMR#SIKRSLDLEDGIKELQKRYGGFMRR 211 |
| Gallus gallus | Query 136 MAGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 + | || | + ||||||+ # + ||+||||+ ||++ + || | Sbjct 124 LGGGFPRGTRGSWPAARGVQKRYGGFIG#VRKSARKWNNQKRFSEFLKQYLGMSPRSSE 181 |
| Lepisosteus platyrhynchus | Query 142 RGQDGDQVGHEDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | || + | ++| ||||||+|#|+ ||+ | | ||||||||+| Sbjct 83 RSQDLED-GIKELQKRYGGFMR#RVVRPEWKED-QKRYGGFLKR 123 Query 145 DGDQVGHEDLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 |||+ | + ||||||+|# +| ++ |||||||+|| Sbjct 63 DGDRDG--ETMKRYGGFMR#SVRRSQDLEDGIKELQKRYGGFMRR 104 |
| Heterodontus portusjacksoni | Query 153 DLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 +| ||||||+|#| | |||||||++| ++ | | Sbjct 205 ELQKRYGGFMR#RFG---KPGYQKRYGGFMKRWNDILVPSDE 242 |
| Amphiuma means | Query 150 GHEDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | +||+||||||+|#|+ ||+ | |||||||+|| Sbjct 198 GAKDLHKRYGGFMR#RVGRPEWWQDYQKRYGGFMRR 232 Query 144 QDGDQVGHEDLYKRYGGFLR#RIR--PKLK---WDNQKRYGGFLRR 183 +| + |+ ||||||+|# |+ |+++ | ||||||+|| Sbjct 168 RDSNSESQGDVSKRYGGFMR#GIKRSPEMEEGAKDLHKRYGGFMRR 212 |
| Necturus maculosus | Query 150 GHEDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | +||+||||||+|#|+ ||+ | |||||||+|| Sbjct 198 GAKDLHKRYGGFMR#RVGRPEWWLDYQKRYGGFMRR 232 Query 142 RGQDGDQVGHEDLYKRYGGFLR#RIR--PKLK---WDNQKRYGGFLRR 183 | +| ++ ||||||+|# ++ |+++ | ||||||+|| Sbjct 166 RYRDSANESQGEVSKRYGGFMR#EVKRSPEMEEGAKDLHKRYGGFMRR 212 |
| Tetraodon nigroviridis | Query 156 KRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ||||||+ # + ||+||||+ ||++ + |+ + Sbjct 70 KRYGGFVG#IRKSARKWNNQKRFSEFLKQYLGMSARTTD 107 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | Query 154 LYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 + ||||||+|#|+ ||+ | |||||||+ | Sbjct 154 IQKRYGGFMR#RVGRPEWWQDYQKRYGGFMTR 184 Query 153 DLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 ++ ||||||+|# | ++ |||||||+|| Sbjct 129 EMNKRYGGFMR#GYRRSTDLEDETRGIQKRYGGFMRR 164 |
| Contains: Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Tyr; Met-enkephalin-Arg-Phe | Query 154 LYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 + ||||||+|#|+ ||+ | |||||||+ | Sbjct 200 IQKRYGGFMR#RVGRPEWWEDYQKRYGGFMTR 230 Query 153 DLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 ++ ||||||+|# | ++ |||||||+|| Sbjct 175 EINKRYGGFMR#GYRRSTDLEDETSGIQKRYGGFMRR 210 |
| Rattus sp. | Query 137 AGDEDRGQDGDQVGHEDLYKRYGGFLR#RIRPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 | | + |+| + | ||+||| # + | ||||+ |+|+ + +| + Sbjct 101 ADAEPVADEADEVEQKQLQKRFGGFTG#ARKSARKLANQKRFSEFMRQYLVLSMQSSQ 157 |
| Contains: Synenkephalin; Met-enkephalin; Leu-enkephalin | Query 154 LYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | ||||||+|#|+ ||+ | ||||||||+| Sbjct 142 LQKRYGGFMR#RVGRPEWWMDYQKRYGGFLKR 172 Query 142 RGQDGDQVGHEDLYKRYGGFLR#RIR--PKLKWDN---QKRYGGFLRR 183 ||+| ||+ | +|||+|# ++ |+| + |||||||+|| Sbjct 111 RGRDD-----EDVSKSHGGFMR#ALKGSPQLAQEAKMLQKRYGGFMRR 152 |
| Taricha granulosa | Query 150 GHEDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 | +||+||||||+|#|+ ||+ | |||||||+|| Sbjct 198 GAKDLHKRYGGFMR#RVGRPEWWLDYQKRYGGFMRR 232 Query 153 DLYKRYGGFLR#RIR--PKLK---WDNQKRYGGFLRR 183 ++ ||||||+|# ++ |+++ | ||||||+|| Sbjct 177 EVSKRYGGFMR#GVKRSPEMEEGAKDLHKRYGGFMRR 212 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | Query 152 EDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 ++| ||||||+|#|+ ||+ | ||||||||+| Sbjct 205 KELQKRYGGFMR#RVGRPEWWMDYQKRYGGFLKR 237 Query 152 EDLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 +++ ||||||+|# ++ + ++ |||||||+|| Sbjct 181 DNMSKRYGGFMR#GLKRSPQVEDEAKELQKRYGGFMRR 217 Query 153 DLYKRYGGFLR#RIRPKLKWDN------------QKRYGGFLR 182 | |||||||+#| | | +||||||+| Sbjct 226 DYQKRYGGFLK#RFAESLPSDEEAESYSKEVPEIEKRYGGFMR 267 |
| Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe | Query 152 EDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 ++| ||||||+|#|+ ||+ | ||||||||+| Sbjct 206 KELQKRYGGFMR#RVGRPEWWMDYQKRYGGFLKR 238 Query 140 EDRGQDGDQVGHEDLY-KRYGGFLR#RIR--PKLK---WDNQKRYGGFLRR 183 +| | ||+ ||||||+|# ++ |+|+ + |||||||+|| Sbjct 169 KDSHQQESTNNDEDMSSKRYGGFMR#SLKRSPQLEDEAKELQKRYGGFMRR 218 Query 153 DLYKRYGGFLR#RIRPKLKWDN------------QKRYGGFLR 182 | |||||||+#| | | +||||||+| Sbjct 227 DYQKRYGGFLK#RFAESLPSDEEGENYSKEVPEIEKRYGGFMR 268 |
| Spea multiplicata | Query 153 DLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 +++||||||+|#|+ ||+ | |||||||+|| | | | Sbjct 197 EMHKRYGGFMR#RVGRPEWWQDYQKRYGGFMRRFSDSVLPSDE 238 Query 156 KRYGGFLR#RI----RPKLKWDNQ------KRYGGFLRRQF 185 ||||||++#++ ||+ + || |+||||++++| Sbjct 103 KRYGGFMK#KMDELYRPEAEEDNNGGEILAKKYGGFMKKEF 142 Query 153 DLYKRYGGFLR#RIRPKLKWDNQ-----KRYGGFLRR 183 ++ ||||||+|# | +++ ||||||+|| Sbjct 173 EINKRYGGFMR#NYRRSPDVEDEAREMHKRYGGFMRR 208 |
| Cricetinae | Query 152 EDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 ++| ||||||+|#|+ ||+ | ||||||||+| Sbjct 205 KELQKRYGGFMR#RVGRPEWWMDYQKRYGGFLKR 237 Query 152 EDLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 +++ ||||||+|# ++ + ++ |||||||+|| Sbjct 181 DNMSKRYGGFMR#GLKRSPQVEDEAKELQKRYGGFMRR 217 Query 153 DLYKRYGGFLR#RIRPKLKWDN------------QKRYGGFLR 182 | |||||||+#| | | +||||||+| Sbjct 226 DYQKRYGGFLK#RFAESLPSDEEAESYSKEVPEIEKRYGGFMR 267 |
| synthetic construct | Query 152 EDLYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRRQFKVVTRSQE 193 ++| ||||||+|#|+ ||+ | ||||||||+| + + +| Sbjct 204 KELQKRYGGFMR#RVGRPEWWMDYQKRYGGFLKRFAEALPSDEE 246 Query 144 QDGDQVGHEDLYKRYGGFLR#RIR--PKLK---WDNQKRYGGFLRR 183 ||| |++ ||||||+|# ++ |+|+ + |||||||+|| Sbjct 173 QDGSD-NEEEVSKRYGGFMR#GLKRSPQLEDEAKELQKRYGGFMRR 216 Query 153 DLYKRYGGFLR#RIRPKLKWDNQ------------KRYGGFLR 182 | |||||||+#| | | + ||||||+| Sbjct 225 DYQKRYGGFLK#RFAEALPSDEEGESYSKEVPEMEKRYGGFMR 266 |
| Acipenser transmontanus | Query 154 LYKRYGGFLR#RIRPKLKWDNQKRYGGFLRR 183 | ||||||+ # + ||+| ||| |++ Sbjct 157 LQKRYGGFIG#IRKSARKWNNPKRYNELLKQ 186 |
| Xenopus tropicalis | Query 154 LYKRYGGFLR#RI-RPKLKWDNQKRYGGFLRR 183 + ||||||+|#|+ ||+ | |||||||+|| Sbjct 200 IQKRYGGFMR#RVGRPEWWQDYQKRYGGFMRR 230 Query 153 DLYKRYGGFLR#RIRPKLKWDN-----QKRYGGFLRR 183 ++ ||||||+|# | ++ |||||||+|| Sbjct 175 EMNKRYGGFMR#GYRRSTDLEDETRGIQKRYGGFMRR 210 Query 152 EDLYKRYGGFLR#RIR-------------PKLKWDNQKRYGGFLR 182 +| ||||||+|#| | | +||||||+| Sbjct 218 QDYQKRYGGFMR#RFTDSFLPSEEDGESYSKENPDMEKRYGGFMR 261 |
* References
[PubMed ID: 3858883] Civelli O, Douglass J, Goldstein A, Herbert E, Sequence and expression of the rat prodynorphin gene. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4291-5.