CaMPDB :: Substrate

XSB1145 : Glutamate [NMDA] receptor subunit epsilon-1

This entry is computationally expanded from SB0072

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A
Gene Names	Grin2a
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
Q00959	N/A	N/A	Q00959	N/A	N/A	N/A	rno:24409

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1464 aa

Average Mass: 165.469 kDa

Monoisotopic Mass: 165.363 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
HS1_rep 1.	179	215	6.7	3.1
Lig_chan-Glu_bd 1.	439	502	80.6	5.5e-21
Lig_chan 1.	554	838	376.9	3.7e-110
NMDAR2_C 1.	839	1464	1159.4	0
--- cleavage 1329 (inside NMDAR2_C 839..1464) ---
--- cleavage 1278 (inside NMDAR2_C 839..1464) ---

3. Sequence Information

Fasta Sequence: XSB1145.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2A5S (X-ray; 170 A; A=401-802), 2A5T (X-ray; 200 A; B=401-802)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] LEGNLYGSLF¹³²⁹-SVPSSKLLGN

Phe¹³²⁹ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Leu¹³²⁰	Glu¹³²¹	Gly¹³²²	Asn¹³²³	Leu¹³²⁴	Tyr¹³²⁵	Gly¹³²⁶	Ser¹³²⁷	Leu¹³²⁸	Phe¹³²⁹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser¹³³⁰	Val¹³³¹	Pro¹³³²	Ser¹³³³	Ser¹³³⁴	Lys¹³³⁵	Leu¹³³⁶	Leu¹³³⁷	Gly¹³³⁸	Asn¹³³⁹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
REIDLSRPSRSISLKDRERLLEGNLYGSLFSVPSSKLLGNKSSLFPQGLEDSKRSKSLLP

Summary

#	organism	max score	hits	top seq
1	N/A	117.00	4	1
2	Rattus norvegicus	117.00	4	N-methyl-D-aspartate receptor NMDAR2A subunit; NMD
3	NMDA	117.00	3	NMDE1_RAT Glutamate
4	Mus musculus	117.00	2	glutamate receptor, ionotropic, NMDA2A (epsilon 1)
5	Canis familiaris	112.00	1	PREDICTED: similar to glutamate receptor, ionotrop
6	Saimiri boliviensis	111.00	1	glutamate receptor ionotropic N-methyl-D-aspartate
7	Homo sapiens	110.00	2	N-methyl-D-aspartate receptor subunit 2A precursor
8	Pan troglodytes	110.00	1	N-methyl-D-aspartate receptor subunit 2A
9	Monodelphis domestica	105.00	1	PREDICTED: similar to N-methyl-D-aspartate recepto
10	Bos taurus	105.00	1	PREDICTED: similar to N-methyl-D-aspartate recepto
11	Gallus gallus	85.90	1	PREDICTED: similar to N-methyl-D-aspartate recepto
12	Danio rerio	72.00	2	PREDICTED: similar to N-methyl-D-aspartate recepto
13	Tetraodon nigroviridis	50.40	1	unnamed protein product

Top-ranked sequences

organism	matching
N/A	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
Rattus norvegicus	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
NMDA	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
Mus musculus	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
Canis familiaris	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\| Sbjct 1300 REMDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLSGNKSSLFPQGLEDRKRSKSLLP 1359
Saimiri boliviensis	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|#\|\|\|\|\|\|\| \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1224 REIDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1283
Homo sapiens	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|#\|\|\|\|\|\|\| \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
Pan troglodytes	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|#\|\|\|\|\|\|\| \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
Monodelphis domestica	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\| \|\|\| \| \|\|\|+\|\|\|\|\|\| \| Sbjct 1305 REIDLGRPSRSISLKDKERLLEGNLYGSLF#SVPSSKLLGNKGSLFSQALEDTKRSKSLFP 1364
Bos taurus	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\| \|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\| Sbjct 1072 REVDPSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLAGNKGSLFPQGLEVGKRSKSLLP 1131
Gallus gallus	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|+\|+ \|+ + \| \|+\|#\|\|\|\|\|\|\|\| \|\|+\|\| \|\|\|\|\|\|\|\|\|\| \| Sbjct 1294 REIDLGRPSRSISLKDKEKFLQSSPYASMF#SVPSSKLLSNKASLLTHALEDSKRSKSLYP 1353
Danio rerio	Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359 +\|\|\|\|+\|\|+\|\|+\|\|\|+++\| \|\| + \| ++\|#++ + \|\| \|++\| \|\| + \|\|+\|\|\|\|\|\|\| \| Sbjct 1289 KEIDLNRPARSVSLKEKDRFLEDSPYANMF#NIKADKLFGSRSMLFNRNLEESKRSKSLYP 1348
Tetraodon nigroviridis	Query 1300 REIDLSRPSRSISLKDRERLLEGNL-YGSLF#SVP--SSKLLG--NKSSLFPQGLEDSKRS 1354 +++\|+ \|\|+\|\|+\|\|\|+++\| + \| +\|\|#++ \| +\| \| +\|\| +\| \|\|+\|\|\|\| Sbjct 1216 KDVDVGRPARSVSLKEKDRFATSDSHYANLF#NMRPYSGRLFGTSSKSMMFNHNLEESKRS 1275 Query 1355 KSLLP 1359 \|\|\| \| Sbjct 1276 KSLYP 1280

[Site 2] QDWSQNNALQ¹²⁷⁸-FQKNKLRINR

Gln¹²⁷⁸ Phe

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Gln¹²⁶⁹	Asp¹²⁷⁰	Trp¹²⁷¹	Ser¹²⁷²	Gln¹²⁷³	Asn¹²⁷⁴	Asn¹²⁷⁵	Ala¹²⁷⁶	Leu¹²⁷⁷	Gln¹²⁷⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Phe¹²⁷⁹	Gln¹²⁸⁰	Lys¹²⁸¹	Asn¹²⁸²	Lys¹²⁸³	Leu¹²⁸⁴	Arg¹²⁸⁵	Ile¹²⁸⁶	Asn¹²⁸⁷	Arg¹²⁸⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
DEDQMLQETGNPATREEVYQQDWSQNNALQFQKNKLRINRQHSYDNILDKPREIDLSRPS

Summary

#	organism	max score	hits	top seq
1	NMDA	127.00	6	NMDE1_RAT Glutamate
2	Rattus norvegicus	127.00	4	N-methyl-D-aspartate receptor subunit
3	Mus musculus	124.00	2	glutamate receptor, ionotropic, NMDA2A (epsilon 1)
4	N/A	121.00	5	1
5	Saimiri boliviensis	119.00	1	glutamate receptor ionotropic N-methyl-D-aspartate
6	Homo sapiens	115.00	4	N-methyl-D-aspartate receptor subunit 2A precursor
7	Pan troglodytes	115.00	2	N-methyl-D-aspartate receptor subunit 2A
8	Canis familiaris	112.00	1	PREDICTED: similar to glutamate receptor, ionotrop
9	Bos taurus	110.00	2	PREDICTED: similar to N-methyl-D-aspartate recepto
10	Monodelphis domestica	102.00	1	PREDICTED: similar to N-methyl-D-aspartate recepto
11	Gallus gallus	86.70	1	PREDICTED: similar to N-methyl-D-aspartate recepto
12	Danio rerio	53.50	2	PREDICTED: similar to N-methyl-D-aspartate recepto
13	Tetraodon nigroviridis	49.70	1	unnamed protein product
14	Paramecium tetraurelia	35.00	2	hypothetical protein
15	Macaca mulatta	34.30	1	PREDICTED: N-methyl-D-aspartate receptor subunit 2
16	Canis lupus familiaris	33.90	1	N-methyl-D-aspartate receptor subunit 2B
17	Tetrahymena thermophila SB210	32.30	1	TBC domain containing protein

Top-ranked sequences

organism	matching
NMDA	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
Rattus norvegicus	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
Mus musculus	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQHSYDNILDKPREIDLSRPS 1308
N/A	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|+\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
Saimiri boliviensis	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|+\|\|\|\|\|\|# \|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1173 DEDQMLQETGNPATREQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPREIDLSRPS 1232
Homo sapiens	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|\|\|\|\|\|+\|\|\|\|\|\|# \|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
Pan troglodytes	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|\|\|\|\|\|+\|\|\|\|\|\|# \|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
Canis familiaris	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|+\|\| +\|\|\|\|\|\|\|\|+\|\|+ \|\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1249 DEDQMLQETGSPAAQEEVYQQDWAQNSTLQ#FQKNKLRISRQHSYDNIVDKPREMDLSRPS 1308
Bos taurus	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308 \|\|\|\|\|\|\|\|\|\|\|\|\| +\|\|\|\|\|\|\|\|+ \|+\|\|\|# \|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| \|\|\|\| Sbjct 1021 DEDQMLQETGNPAAQEEVYQQDWAPNSALQ#LQKNKLRISRQHSYDNILDKPREVDPSRPS 1080
Monodelphis domestica	Query 1249 DEDQMLQET-GNPATREEVYQQDWSQNNALQ#FQK-NKLRINRQHSYDNILDKPREIDLSR 1306 \|\|\|\|\|\|\|\|\| \|\|\| \|\| \|+\|\|\|+\|\|\|\|\|\|#\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \| Sbjct 1252 DEDQMLQETTANPAHPEETYEQDWAQNNALQ#FQKKNKLRISRQHSYDNILDKPREIDLGR 1311 Query 1307 PS 1308 \|\| Query 1307 PS 1308
Gallus gallus	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#F-QKNKLRINRQHSYDNILDKPREIDLSRP 1307 +\|\|\|\|\|\|+\| \| + \|\|+\| \|\|\|\|\|\|\|\|#+ +\|\|\|\|\|\|+\|\|\|\|+\|\|\| \|\| \|\|\|\|\| \|\| Sbjct 1242 EEDQMLQDTTNLSLPEEIYGHSWSQNNALQ#YHKKNKLRISRQHSFDNIADKSREIDLGRP 1301 Query 1308 S 1308 \| Query 1308 S 1308
Danio rerio	Query 1250 EDQMLQETG-NPATR-EEVYQQDWSQNNALQ#FQK-NKLRINRQHSYDNI-LDKPREIDLS 1305 \|\|\|\|\|\|\| +\|+ ++++ \| \| + # \|+ \|+\|+++\|\|\|\|+\|\|\| \|+\|\|+\|\|\|\|+ Sbjct 1235 EDQMLQEAMISPSMHHDDMFSHYWPQTDGPH#VQRRNRLKLSRQHSFDNIMLEKPKEIDLN 1294 Query 1306 RPS 1308 \|\|+ Sbjct 1295 RPA 1297
Tetraodon nigroviridis	Query 1249 DEDQMLQET-GNPATREEVYQQD-------WSQNNALQ#FQK-NKLRINRQHSYDNI-LDK 1298 +\|\|\|+\| + \|+\| + \|\| \| \| + # \|\| \|+\|\|++\|\|\|\|+\|\|\| \|+\| Sbjct 1155 NEDQLLTDPLGSPTLHHQQQQQADEMFGLYWPQTDGPH#VQKRNRLRLSRQHSFDNIMLEK 1214 Query 1299 PREIDLSRPS 1308 \|+++\|+ \|\|+ Sbjct 1215 PKDVDVGRPA 1224
Paramecium tetraurelia	Query 1253 MLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSY--DNILDKPREIDLS 1305 +\|\|+ \| ++ ++ \|\| \|\|#\|\|+\|+ +\|+\| + ++\|++\| ++\|\|\|\| Sbjct 165 ILQKQVNDLHKDNIFLGSEKQNLLLQ#FQQNQQFVNQQQNILEEDIINKTQQIDLS 219
Macaca mulatta	Query 1250 EDQMLQETGNPATREEV--------YQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPRE 1301 \|\| \|\|\| \|\| \| \| \| + + \| +# +\|\|\|\| \|\|\|\|\|\| +\| +\| Sbjct 1256 EDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQK#KNRNKLR--RQHSYDTFVDLQKE 1313
Canis lupus familiaris	Query 1250 EDQMLQETGNPATREEV--------YQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPRE 1301 \|\| \|\|\| \|\| \| \| \| + + \| +# +\|\|\|\| \|\|\|\|\|\| +\| +\| Sbjct 1256 EDNSLQELDQPAAPVAVPSNAPSTKYPQSPTNSKAQK#KTRNKLR--RQHSYDTFVDLQKE 1313
Tetrahymena thermophila SB210	Query 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRIN 1287 +\|+\|++\|+ \|\|\|+\|\| \| \|+ \|# \|\| ++\| Sbjct 648 NENQLIQQQKPPATQEEDYSVPQELQNSFQ#MNKNMSKLN 686

* References

[PubMed ID: 1350383] Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH, Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992 May 22;256(5060):1217-21.

» More (9) « Hide Below

[PubMed ID: 8428958] ... Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, et al., Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem. 1993 Feb 5;268(4):2836-43.

[PubMed ID: 7569905] ... Kornau HC, Schenker LT, Kennedy MB, Seeburg PH, Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.

[PubMed ID: 9694864] ... Hirao K, Hata Y, Ide N, Takeuchi M, Irie M, Yao I, Deguchi M, Toyoda A, Sudhof TC, Takai Y, A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem. 1998 Aug 14;273(33):21105-10.

[PubMed ID: 9647694] ... Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ, CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci. 1998 Jun;11(3):161-72.

[PubMed ID: 11160393] ... Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF, Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci. 2001 Feb 15;21(4):1228-37.

[PubMed ID: 11588171] ... Chan SF, Sucher NJ, An NMDA receptor signaling complex with protein phosphatase 2A. J Neurosci. 2001 Oct 15;21(20):7985-92.

[PubMed ID: 12391275] ... Al-Hallaq RA, Jarabek BR, Fu Z, Vicini S, Wolfe BB, Yasuda RP, Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits. Mol Pharmacol. 2002 Nov;62(5):1119-27.

[PubMed ID: 11929923] ... Sasaki YF, Rothe T, Premkumar LS, Das S, Cui J, Talantova MV, Wong HK, Gong X, Chan SF, Zhang D, Nakanishi N, Sucher NJ, Lipton SA, Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol. 2002 Apr;87(4):2052-63.

[PubMed ID: 16281028] ... Furukawa H, Singh SK, Mancusso R, Gouaux E, Subunit arrangement and function in NMDA receptors. Nature. 2005 Nov 10;438(7065):185-92.