XSB1148 : N-methyl-D-aspartate receptor subunit 2A [Pan troglodytes]
[ CaMP Format ]
This entry is computationally expanded from SB0072
* Basic Information
| Organism | Pan troglodytes (chimpanzee) |
| Protein Names | Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon 1; glutamate receptor; ionotropic; N-methyl-D-aspartate subunit 2A |
| Gene Names | GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| Gene Locus | 16; chromosome 16 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001029361 | NM_001034189 | 454396 | Q5IS45 | N/A | N/A | N/A | ptr:454396 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1464 aa
Average Mass: 165.280 kDa
Monoisotopic Mass: 165.174 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HS1_rep 1. | 179 | 215 | 7.0 | 2.9 |
| Lig_chan-Glu_bd 1. | 439 | 502 | 80.6 | 5.5e-21 |
| Lig_chan 1. | 554 | 838 | 376.4 | 4.9e-110 |
| NMDAR2_C 1. | 839 | 1464 | 1205.8 | 0 |
| --- cleavage 1329 (inside NMDAR2_C 839..1464) --- | ||||
3. Sequence Information
Fasta Sequence: XSB1148.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] LEGNFYGSLF1329-SVPSSKLSGK
Phe1329 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu1320 | Glu1321 | Gly1322 | Asn1323 | Phe1324 | Tyr1325 | Gly1326 | Ser1327 | Leu1328 | Phe1329 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser1330 | Val1331 | Pro1332 | Ser1333 | Ser1334 | Lys1335 | Leu1336 | Ser1337 | Gly1338 | Lys1339 |
Sequence conservation (by blast)
* References
[PubMed ID: 15620360] Dorus S, Vallender EJ, Evans PD, Anderson JR, Gilbert SL, Mahowald M, Wyckoff GJ, Malcom CM, Lahn BT, Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell. 2004 Dec 29;119(7):1027-40.