logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1173 : neurofibromin 2 (bilateral acoustic neuroma), isoform CRA_b [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismHomo sapiens (human)
Protein Namesneurofibromin 2 (bilateral acoustic neuroma); isoform CRA_b
Gene NamesNF2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW59815 N/A 4771 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 562 aa

Average Mass: 65.955 kDa

Monoisotopic Mass: 65.913 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 17478.72.1e-20
FERM_M 1. 76194141.82.1e-39
FERM_C 1. 198287177.63.5e-50
--- cleavage 266 (inside FERM_C 198..287) ---
--- cleavage 270 (inside FERM_C 198..287) ---
ERM 1. 319551307.13.7e-89

3. Sequence Information

Fasta Sequence: XSB1173.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] FNSSKLRVNK266-LILQLCIGNH

Lys266 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe257Asn258Ser259Ser260Lys261Leu262Arg263Val264Asn265Lys266
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu267Ile268Leu269Gln270Leu271Cys272Ile273Gly274Asn275His276

Sequence conservation (by blast)

[Site 2] KLRVNKLILQ270-LCIGNHDLFM

Gln270 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys261Leu262Arg263Val264Asn265Lys266Leu267Ile268Leu269Gln270
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu271Cys272Ile273Gly274Asn275His276Asp277Leu278Phe279Met280

Sequence conservation (by blast)

* References

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