logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1174 : neurofibromin 2 (bilateral acoustic neuroma), isoform CRA_c [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismHomo sapiens (human)
Protein Namesneurofibromin 2 (bilateral acoustic neuroma); isoform CRA_c
Gene NamesNF2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW59816 N/A 4771 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 589 aa

Average Mass: 68.961 kDa

Monoisotopic Mass: 68.918 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 2610295.02.7e-25
FERM_M 1. 104222141.82.1e-39
FERM_C 1. 226315177.63.5e-50
--- cleavage 294 (inside FERM_C 226..315) ---
--- cleavage 298 (inside FERM_C 226..315) ---
ERM 1. 347587309.38.2e-90

3. Sequence Information

Fasta Sequence: XSB1174.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] FNSSKLRVNK294-LILQLCIGNH

Lys294 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe285Asn286Ser287Ser288Lys289Leu290Arg291Val292Asn293Lys294
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu295Ile296Leu297Gln298Leu299Cys300Ile301Gly302Asn303His304

Sequence conservation (by blast)

[Site 2] KLRVNKLILQ298-LCIGNHDLFM

Gln298 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys289Leu290Arg291Val292Asn293Lys294Leu295Ile296Leu297Gln298
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu299Cys300Ile301Gly302Asn303His304Asp305Leu306Phe307Met308

Sequence conservation (by blast)

* References

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