logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1175 : neurofibromin 2 (bilateral acoustic neuroma), isoform CRA_f [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismHomo sapiens (human)
Protein Namesneurofibromin 2 (bilateral acoustic neuroma); isoform CRA_f
Gene NamesNF2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW59819 N/A 4771 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 513 aa

Average Mass: 60.074 kDa

Monoisotopic Mass: 60.036 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_M 1. 27145141.82.1e-39
FERM_C 1. 149238177.63.5e-50
--- cleavage 217 (inside FERM_C 149..238) ---
--- cleavage 221 (inside FERM_C 149..238) ---
ERM 1. 270502307.13.7e-89

3. Sequence Information

Fasta Sequence: XSB1175.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] FNSSKLRVNK217-LILQLCIGNH

Lys217 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe208Asn209Ser210Ser211Lys212Leu213Arg214Val215Asn216Lys217
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu218Ile219Leu220Gln221Leu222Cys223Ile224Gly225Asn226His227

Sequence conservation (by blast)

[Site 2] KLRVNKLILQ221-LCIGNHDLFM

Gln221 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys212Leu213Arg214Val215Asn216Lys217Leu218Ile219Leu220Gln221
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu222Cys223Ile224Gly225Asn226His227Asp228Leu229Phe230Met231

Sequence conservation (by blast)

* References

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