logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1176 : neurofibromin 2 (bilateral acoustic neuroma), isoform CRA_j [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0009

* Basic Information

OrganismHomo sapiens (human)
Protein Namesneurofibromin 2 (bilateral acoustic neuroma); isoform CRA_j
Gene NamesNF2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW59826 N/A 4771 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 552 aa

Average Mass: 64.794 kDa

Monoisotopic Mass: 64.754 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 16458.13.3e-14
FERM_M 1. 66184141.82.1e-39
FERM_C 1. 188277177.63.5e-50
--- cleavage 256 (inside FERM_C 188..277) ---
--- cleavage 260 (inside FERM_C 188..277) ---
ERM 1. 309541307.13.7e-89

3. Sequence Information

Fasta Sequence: XSB1176.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] FNSSKLRVNK256-LILQLCIGNH

Lys256 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe247Asn248Ser249Ser250Lys251Leu252Arg253Val254Asn255Lys256
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu257Ile258Leu259Gln260Leu261Cys262Ile263Gly264Asn265His266

Sequence conservation (by blast)

[Site 2] KLRVNKLILQ260-LCIGNHDLFM

Gln260 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys251Leu252Arg253Val254Asn255Lys256Leu257Ile258Leu259Gln260
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu261Cys262Ile263Gly264Asn265His266Asp267Leu268Phe269Met270

Sequence conservation (by blast)

* References

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