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XSB1204 : protein kinase C, gamma [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0089

* Basic Information

OrganismHomo sapiens (human)
Protein NamesProtein kinase C gamma type; PKC-gamma; 2.7.11.13; protein kinase C; gamma
Gene NamesPRKCG; PKCG; protein kinase C, gamma
Gene Locus19q13.4; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_002730 NM_002739 5582 P05129 176980 9402 N/A hsa:5582

* Information From OMIM

Description: PRKCG is a member of the protein kinase C (PKC) gene family (see Coussens et al, 1986 and PRKCA; OMIM:176960).

* Structure Information

1. Primary Information

Length: 697 aa

Average Mass: 78.448 kDa

Monoisotopic Mass: 78.397 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
C1_1 1. 368887.16e-23
C1_1 2. 10115389.01.6e-23
C2 1. 173260140.64.7e-39
--- cleavage 338 ---
--- cleavage 321 ---
Pkinase 1. 351614274.62.2e-79
Pkinase_C 1. 63467952.41.7e-12

3. Sequence Information

Fasta Sequence: XSB1204.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2E73 (NMR; -; A=36-105), 2UZP (X-ray; 200 A; A/B/C=154-295)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] PSPTDPKRCF338-FGASPGRLHI

Phe338 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro329Ser330Pro331Thr332Asp333Pro334Lys335Arg336Cys337Phe338
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Phe339Gly340Ala341Ser342Pro343Gly344Arg345Leu346His347Ile348

Sequence conservation (by blast)

[Site 2] YERVRMGPSS321-SPIPSPSPSP

Ser321 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Tyr312Glu313Arg314Val315Arg316Met317Gly318Pro319Ser320Ser321
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser322Pro323Ile324Pro325Ser326Pro327Ser328Pro329Ser330Pro331

Sequence conservation (by blast)

* References

[PubMed ID: 19060919] Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C, The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene. 2009 Feb 12;28(6):792-802. Epub 2008 Dec 8.

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