XSB1223 : jun oncogene [Gallus gallus]
[ CaMP Format ]
This entry is computationally expanded from SB0086
* Basic Information
| Organism | Gallus gallus (chicken) |
| Protein Names | Transcription factor AP-1; Proto-oncogene c-jun; jun oncogene; v-jun sarcoma virus 17 oncogene |
| Gene Names | JUN; jun oncogene |
| Gene Locus | 8; chromosome 8 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001026460 | NM_001031289 | 424673 | P18870 | N/A | N/A | N/A | gga:424673 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 310 aa
Average Mass: 33.941 kDa
Monoisotopic Mass: 33.919 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Jun 1. | 1 | 220 | 493.0 | 4.1e-145 |
| --- cleavage 86 (inside Jun 1..220) --- | ||||
| bZIP_1 1. | 229 | 292 | 84.9 | 2.9e-22 |
3. Sequence Information
Fasta Sequence: XSB1223.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] IQSSNGLITT86-TPTPTQFLCP
Thr86 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile77 | Gln78 | Ser79 | Ser80 | Asn81 | Gly82 | Leu83 | Ile84 | Thr85 | Thr86 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr87 | Pro88 | Thr89 | Pro90 | Thr91 | Gln92 | Phe93 | Leu94 | Cys95 | Pro96 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 120.00 | 7 | J |
| 2 | Danio rerio | 120.00 | 5 | c-Jun protein |
| 3 | Gallus gallus | 120.00 | 2 | jun oncogene |
| 4 | Monodelphis domestica | 120.00 | 2 | PREDICTED: similar to fc49b10 G-protein coupled re |
| 5 | Ctenopharyngodon idella | 120.00 | 2 | c-Jun protein |
| 6 | Serinus canaria | 120.00 | 1 | JUN_SERCA Transcription factor AP-1 (Proto-oncogen |
| 7 | Crocodylus niloticus | 120.00 | 1 | c-jun |
| 8 | Coturnix coturnix | 120.00 | 1 | JUN_COTJA Transcription factor AP-1 (Proto-oncogen |
| 9 | Alligator mississippiensis | 120.00 | 1 | c-jun |
| 10 | Pseudemys nelsoni | 120.00 | 1 | c-jun |
| 11 | Xenopus laevis | 119.00 | 7 | similar to v-jun sarcoma virus 17 oncogene homolog |
| 12 | Mus musculus | 118.00 | 11 | unnamed protein product |
| 13 | Canis familiaris | 118.00 | 10 | PREDICTED: similar to Transcription factor AP-1 (A |
| 14 | Homo sapiens | 118.00 | 10 | JUN |
| 15 | Tetraodon nigroviridis | 118.00 | 6 | unnamed protein product |
| 16 | synthetic construct | 118.00 | 5 | v-jun sarcoma virus 17 oncogene-like |
| 17 | Rattus norvegicus | 118.00 | 5 | v-jun sarcoma virus 17 oncogene homolog |
| 18 | Bos taurus | 118.00 | 5 | jun oncogene |
| 19 | Macaca mulatta | 118.00 | 2 | PREDICTED: similar to Transcription factor AP-1 (A |
| 20 | Sus scrofa | 118.00 | 1 | C-JUN protein |
| 21 | Oryctolagus cuniculus | 118.00 | 1 | c-jun transcription factor |
| 22 | Carassius auratus | 118.00 | 1 | c-Jun protein |
| 23 | Macaca fuscata | 118.00 | 1 | transcription factor c-Jun |
| 24 | Oncorhynchus mykiss | 116.00 | 2 | transcription factor AP-1 |
| 25 | Takifugu rubripes | 114.00 | 6 | c-Jun protein |
| 26 | Xiphophorus maculatus | 106.00 | 2 | c-JUN |
| 27 | Ovis aries | 87.40 | 2 | c-Jun protein |
| 28 | Pan troglodytes | 83.60 | 2 | PREDICTED: jun D proto-oncogene |
| 29 | Cyprinus carpio | 79.30 | 1 | JUNB_CYPCA Transcription factor jun-B gb |
| 30 | Strongylocentrotus purpuratus | 77.00 | 1 | PREDICTED: similar to transcription factor AP-1 |
| 31 | Apis mellifera | 68.20 | 1 | PREDICTED: similar to c-Jun protein |
| 32 | Aedes aegypti | 58.50 | 1 | jun |
| 33 | Anopheles gambiae str. PEST | 53.10 | 1 | ENSANGP00000020405 |
| 34 | Xenopus tropicalis | 47.00 | 1 | jun B proto-oncogene |
| 35 | Ciona intestinalis | 43.90 | 1 | transcription factor protein |
| 36 | Tribolium castaneum | 41.20 | 1 | PREDICTED: similar to Transcription factor AP-1 (J |
| 37 | Poecilia reticulata | 37.40 | 1 | transcription factor JunB |
| 38 | Drosophila pseudoobscura | 33.90 | 1 | GA15338-PA |
| 39 | Schistosoma japonicum | 33.90 | 1 | SJCHGC03684 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Danio rerio | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Gallus gallus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Monodelphis domestica | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Ctenopharyngodon idella | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Serinus canaria | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Crocodylus niloticus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Coturnix coturnix | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Alligator mississippiensis | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Pseudemys nelsoni | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Xenopus laevis | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||+|||||||| Sbjct 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |
| Mus musculus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Canis familiaris | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Homo sapiens | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Tetraodon nigroviridis | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||+||||||+||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFICPKNVTEEQEGFAEGFVRALAE 119 |
| synthetic construct | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Rattus norvegicus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Bos taurus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Macaca mulatta | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Sus scrofa | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Oryctolagus cuniculus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 8 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 67 |
| Carassius auratus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||| ||||| Sbjct 56 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFARALAE 115 |
| Macaca fuscata | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Oncorhynchus mykiss | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |||||| |||||||||||||||||||||||#||||||||||+||||||||||||||||||| Sbjct 59 LTSPDVQLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPRNVTDEQEGFAEGFVRALAE 118 |
| Takifugu rubripes | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||||||||||#|||||||+ |||||+||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFISPKNVTEEQEGFAEGFVRALAE 119 |
| Xiphophorus maculatus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 ||||||||||||||||||||||| +|| |#|||||||+|||||+|||||||||||||||| Sbjct 62 LTSPDVGLLKLASPELERLIIQSCSGL--T#TPTPTQFICPKNVSDEQEGFAEGFVRALAE 119 |
| Ovis aries | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVT 100 |||||||||||||||||||||||||| |||#|||||||||||||| Sbjct 47 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVT 90 |
| Pan troglodytes | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 | |||+||||||||||||||||| |||+||#||| +||| || |++ ||||||+|| + Sbjct 88 LASPDLGLLKLASPELERLIIQS-NGLVTT#TPTSSQFLYPKVAASEEQEFAEGFVKALED 146 |
| Cyprinus carpio | Query 61 DVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 | | ||||||||||||||+|||++||# ||| |+| + +||||||||||||+|| Sbjct 58 DSGSLKLASPELERLIIQTSNGVLTT#-PTPGQYLYSRGITDEQEGFAEGFVKAL 110 |
| Strongylocentrotus purpuratus | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 |++||| +|||||||||++|| | | | |#|||| ||+ |||||+|| ||+||| || Sbjct 38 LSTPDVQMLKLASPELEKMII-SQQGNICT#TPTPGQFISPKNVTEEQAAFAQGFVEAL 94 |
| Apis mellifera | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |+|||+ +|||+|||||+ || + |+| # |||| | || ||+ || +| ||| || | Sbjct 61 LSSPDLNMLKLSSPELEKFIIAQQDSLVTN#LVTPTQILFPKAVTEAQELYARGFVDALNE 120 |
| Aedes aegypti | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 +||||+ +||| |||||++|| |+ #||||+ | | | ||| ||+|| || Sbjct 65 ITSPDLQVLKLVSPELEKIIINSA---ALP#TPTPSSILYPTKATTEQEQFAKGFDEAL 119 |
| Anopheles gambiae str. PEST | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 | |||+ +||| |||||++| | #||||+ + | + | ||+ ||+|| || Sbjct 14 LPSPDLQMLKLVSPELEKII---STNATLP#TPTPSAIIFPPSATSEQQQFAKGFEDAL 68 |
| Xenopus tropicalis | Query 60 PDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPK--NVTDEQEGFAEGFVRAL 114 | ||+|+|||||+|| | |+|+ # + + +|+||||| +|||+|| Sbjct 61 PAPSSLKMAAPELERMIIHSGPGVISG#PSGGQLYYSSRGNGITEEQEGFVDGFVKAL 117 |
| Ciona intestinalis | Query 57 LTSPD-VGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 |++|| | +||+ ||+ +|+++ || #| +|| +| | ||| +|+|||| | Sbjct 134 LSTPDLVNMLKVGSPDFDRMLVHSSQA---N#TQNNSQFF-QRNATQEQEIYAQGFVREL 188 |
| Tribolium castaneum | Query 59 SPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 114 +|| |||+ +| +| +|+ ++ |+ #||+|+ + |++|| ||| || ||| || Sbjct 32 TPD--LLKVDTPTIENIILANN---ISH#TPSPS-LIFPRDVTVEQEKFAGGFVEAL 81 |
| Poecilia reticulata | Query 92 QFLCPKNVTDEQEGFAEGFVRALAE 116 |+ + +||||||||||||+|| | Sbjct 1 QYFYNRGITDEQEGFAEGFVKALDE 25 |
| Drosophila pseudoobscura | Query 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPK--NVTDEQEGFAEGFVRAL 114 + |||+ + +|+||++++ + + #|| | + | || ||| | +|| || Sbjct 82 INSPDLQAKTVNTPDLEKILLSNH---MMQ#TPQPGKVFPTKVGPVTSEQEAFGKGFEEAL 138 |
| Schistosoma japonicum | Query 64 LLKLASPELERL--IIQSS-----NGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 | +| || | |++| | +# || || ||+||+||| || | + | | Sbjct 66 LSSFLTPSLEELQPILRSEVEKILQHLKAS#PQTPGSFLNPKHVTEEQERFANVFTQKLNE 125 |
* References
[PubMed ID: 15534203] Miura Y, Kainuma M, Jiang H, Velasco H, Vogt PK, Hakomori S, Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside). Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16204-9. Epub 2004 Nov 8.
[PubMed ID: 2577867] ... Nishimura T, Vogt PK, The avian cellular homolog of the oncogene jun. Oncogene. 1988 Dec;3(6):659-63.