CaMPDB :: Substrate

XSB1233 : KIAA1027 protein [Homo sapiens]

This entry is computationally expanded from SB0081

* Basic Information

Organism	Homo sapiens (human)
Protein Names	Talin-1; KIAA1027 protein
Gene Names	KIAA1027; KIAA1027, TLN; TLN
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
BAA82979	N/A	N/A	Q9Y490	N/A	N/A	N/A	hsa:7094

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2550 aa

Average Mass: 270.764 kDa

Monoisotopic Mass: 270.596 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
FERM_N 1.	99	208	99.6	1.1e-26
FERM_M 1.	210	322	144.7	2.8e-40
--- cleavage 442 ---
Talin_middle 1.	500	661	370.4	3.2e-108
Stork_head 1.	737	804	-14.0	3.2
Inhibitor_I34 1.	849	914	-11.3	7.9
PMEI 1.	955	1113	-11.7	0.16
DUF1707 1.	1169	1213	-23.6	3.1
XhlA 1.	1369	1420	-17.4	7
Mucin 1.	1485	1623	-38.4	9.2
WSK 1.	1644	1673	0.9	8
HHH 1.	1814	1843	0.1	6.9
VBS 1.	1858	1982	288.7	1.3e-83
Vir_act_alpha_C 1.	2193	2271	-16.6	0.79
Wos2 1.	2286	2331	-3.6	3.1
I_LWEQ 1.	2350	2542	371.9	1.2e-108

3. Sequence Information

Fasta Sequence: XSB1233.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1SYQ (X-ray; 242 A; B=607-631)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] VSPKKSTVLQ⁴⁴²-QQYNRVGKVE

Gln⁴⁴² Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val⁴³³	Ser⁴³⁴	Pro⁴³⁵	Lys⁴³⁶	Lys⁴³⁷	Ser⁴³⁸	Thr⁴³⁹	Val⁴⁴⁰	Leu⁴⁴¹	Gln⁴⁴²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln⁴⁴³	Gln⁴⁴⁴	Tyr⁴⁴⁵	Asn⁴⁴⁶	Arg⁴⁴⁷	Val⁴⁴⁸	Gly⁴⁴⁹	Lys⁴⁵⁰	Val⁴⁵¹	Glu⁴⁵²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
KSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENF

Summary

#	organism	max score	hits	top seq
1	Mus musculus	122.00	20	unnamed protein product
2	Canis familiaris	122.00	16	PREDICTED: similar to talin 1 isoform 9
3	Homo sapiens	122.00	12	KIAA1027 protein
4	Macaca mulatta	122.00	3	PREDICTED: talin 1
5	N/A	122.00	2	1
6	Bos taurus	122.00	2	PREDICTED: similar to KIAA1027 protein
7	Rattus norvegicus	120.00	5	PREDICTED: similar to Talin-1
8	Gallus gallus	112.00	1	talin 1
9	Tetraodon nigroviridis	110.00	3	unnamed protein product
10	Monodelphis domestica	108.00	1	PREDICTED: similar to pleckstrin and Sec7 domain c
11	Danio rerio	107.00	4	talin 1
12	Pan troglodytes	107.00	2	PREDICTED: talin 2 isoform 1
13	Apis mellifera	72.80	2	PREDICTED: similar to rhea CG6831-PA, partial
14	Tribolium castaneum	72.80	1	PREDICTED: similar to CG6831-PA
15	Anopheles gambiae str. PEST	66.20	1	ENSANGP00000019107
16	Drosophila pseudoobscura	62.00	1	GA19890-PA
17	Drosophila melanogaster	60.80	1	rhea CG6831-PA
18	Aedes aegypti	60.10	1	talin
19	Strongylocentrotus purpuratus	58.20	1	PREDICTED: similar to talin
20	Caenorhabditis elegans	47.40	2	Y71G12B.11a
21	Caenorhabditis briggsae	47.40	1	Hypothetical protein CBG22153
22	Podocoryne carnea	35.00	1	AF308653_1 talin

Top-ranked sequences

organism	matching
Mus musculus	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
Canis familiaris	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
Homo sapiens	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
Macaca mulatta	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
N/A	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
Bos taurus	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472
Rattus norvegicus	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 404 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKAEHGSVALPAIMRSGASGPENF 463
Gallus gallus	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|+\|\|\|\|\| \| \|\|\|\|\|\|\|\|\|\|+\|\| \|\|\|\|\| Sbjct 404 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQFNRVGKAELGSVALPAIMRTGAGGPENF 463
Tetraodon nigroviridis	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|#\|\| \|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|+\| Sbjct 518 KSKDHFGLEGDEESTMLEDSVSPKKSTVMQ#QQCNKVGKVETGSVALPAIMRSGAAGPESF 577
Monodelphis domestica	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 +\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|#\|\|+\|\| \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|+\|\|\|\| \| Sbjct 407 QSKDRFGLEGDEESTMLEESVSPKKSTILQ#QQFNRTGKVEHGSVALPAVMRSGSSGPETF 466
Danio rerio	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPEN 471 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|+\|++\|\|\|\| \|\|\|\|\|\|\|\|+\|\|\|\| \|\|\|+ Sbjct 400 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQFNKMGKVETGSVALPAIIRSGAGGPES 458
Pan troglodytes	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 +\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|#\|\|+\|\| \|\| \|\|\|\|\|\|\|\|\|+\|\|\|\|+\|\|\|\| \| Sbjct 407 QSKDRFGLEGDEESTMLEESVSPKKSTILQ#QQFNRTGKAEHGSVALPAVMRSGSSGPETF 466
Apis mellifera	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGK--VEHGSVALPAIMRSGASG 468 \|+\|\|\|\|\|+\|\|\|\| \|\|\|+\|\|\|\|\|\| \|+\|++\|# + + \|\| \|\| \|\|\|+\|\|+\|\|+\| \| Sbjct 271 KAKDHFGIEGDEGSTMVEDSVSPLKATIMQ#HETSNAGKGNVEAVSVAIPAVMRTGVDG 328
Tribolium castaneum	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 ++\|\|\|+\|+\|\|\|\| \|\|\| \|+\|\|+\| \|+\|+\|\|# + ++\|\|\|+ \|+\| \|\|+\|\|+\| \| + \| Sbjct 411 QAKDHYGIEGDEGSTMFEESVAPHKATILQ#HELSKVGKLNTESLAKPAVMRAGTDGEKTF 470
Anopheles gambiae str. PEST	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ-#QQYNRVGKVEHGSVALPAIMRSGASGPEN 471 ++\|\|\|\|\|+\|\|\|\| \|\|\|+\|+\|\|+\| \|+\| \|\| #++ \|+ \|\|\|\| \|+\| \|\|\|\|\| \| \| + Sbjct 415 QAKDHFGIEGDEGSTMVEESVAPSKATFLQH#EETNKGGKVETHSIAKPAIMR-GTDGERS 473 Query 472 F 472 + Sbjct 474 Y 474
Drosophila pseudoobscura	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMR 463 ++\|\|\|\|\|+\|\|\|\| \|\|\|+\|+\|\|+\| \|+\| \|\|# + \|\|\| ++ \|+\| \| \|\|\| Sbjct 413 QTKDHFGIEGDEGSTMVEESVAPSKATFLQ#HETNRVEQLNVESLAHPGIMR 463
Drosophila melanogaster	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMR 463 ++\|\|\|\|\|+\|\|\|\| \|\|\|+\|+\|\|+\| \|+\| \|\|# + \|\|+ ++ \|+\| \| \|\|\| Sbjct 413 QTKDHFGIEGDEGSTMVEESVAPSKATFLQ#HETNRMEQLNVESLAHPGIMR 463
Aedes aegypti	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ-#QQYNRVGKVEHGSVALPAIMR 463 ++\|+\|\|\|+\|\|\|\| \|\|\|+\|+\|\|+\| \|+\| \|\| #++ \|\|\|\| \|+\| \|\|\|\|\| Sbjct 439 QAKEHFGIEGDEGSTMVEESVAPSKATFLQH#EETTPSGKVETQSIAKPAIMR 490
Strongylocentrotus purpuratus	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEHGSVALPAIMRSGASGPENF 472 \| \|\| \|\|+\|\|+\|\| + \|++\|\| ++ ++\|# \| + \| + \|\|\|\|+\| +\|\| \| +\| \| Sbjct 418 KGKDRMGLDGDDESLLFEENVSATRARIIQ#LQSSNKGHMTEGSVAMPGLMRPGGNGKSTF 477
Caenorhabditis elegans	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEH---GSVALPAIMRSGASG 468 +++\|\| \|+\|\|\|\| \|\|\|\|\|\| \|+\| \|+\|++ # + ++\| +\| \| \|\|+ ++\|+ \| Sbjct 432 RTQDHQGIEGDEGSTMLEDMVAPAKATLV-#-AHGQIGSGQHATDGLVAVRGVLRTPQGG 488
Caenorhabditis briggsae	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNRVGKVEH---GSVALPAIMRSGASG 468 +++\|\| \|+\|\|\|\| \|\|\|\|\|\| \|+\| \|+\|++ # + ++\| +\| \| \|\|+ ++\|+ \| Sbjct 426 RTQDHQGIEGDEGSTMLEDMVAPAKATLV-#-AHGQIGNGQHAQDGLVAVRGVLRTPQGG 482
Podocoryne carnea	Query 413 KSKDHFGLEGDEESTMLEDSVSPKKSTVLQ#QQYNR 447 ++ \| + + \|\|+\| +\|\|+ \| \| \|+\|\|\|\|#+\| \|\| Sbjct 421 RAHDMYENDVDEDSPILEEHVMPNKATVLQ#RQNNR 455

* References

[PubMed ID: 10470851] Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O, Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205.