XSB1249 : protein kinase C [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0055
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Protein kinase C alpha type; PKC-alpha; PKC-A; 2.7.11.13; protein kinase C |
| Gene Names | UV25 PKC; Pkca |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 672 aa
Average Mass: 76.761 kDa
Monoisotopic Mass: 76.711 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| C1_1 1. | 37 | 89 | 83.2 | 9.4e-22 |
| C1_1 2. | 102 | 154 | 91.8 | 2.4e-24 |
| C2 1. | 173 | 260 | 127.0 | 6.1e-35 |
| --- cleavage 316 --- | ||||
| --- cleavage 309 --- | ||||
| --- cleavage 324 --- | ||||
| Pkinase 1. | 339 | 597 | 289.1 | 1e-83 |
| Pkinase_C 1. | 617 | 662 | 55.8 | 1.6e-13 |
3. Sequence Information
Fasta Sequence: XSB1249.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites]
Cleavage sites (±10aa)
[Site 1] KAKLGPAGNK316-VISPSEDRKQ
Lys316 
Val
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Lys307 | Ala308 | Lys309 | Leu310 | Gly311 | Pro312 | Ala313 | Gly314 | Asn315 | Lys316 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val317 | Ile318 | Ser319 | Pro320 | Ser321 | Glu322 | Asp323 | Arg324 | Lys325 | Gln326 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| NVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDLNFLMVLG |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Mus musculus | 123.00 | 8 | protein kinase C |
| 2 | Homo sapiens | 122.00 | 11 | protein kinase C, alpha |
| 3 | N/A | 122.00 | 10 | - |
| 4 | synthetic construct | 122.00 | 1 | protein kinase C alpha |
| 5 | Rattus norvegicus | 120.00 | 5 | PREDICTED: similar to Protein kinase C alpha type |
| 6 | Oryctolagus cuniculus | 119.00 | 5 | KPCA_RABIT Protein kinase C alpha type (PKC-alpha) |
| 7 | Canis familiaris | 119.00 | 5 | PREDICTED: similar to Protein kinase C, alpha type |
| 8 | Bos taurus | 119.00 | 4 | protein kinase C, alpha |
| 9 | Monodelphis domestica | 108.00 | 4 | PREDICTED: similar to protein kinase C |
| 10 | Gallus gallus | 105.00 | 3 | protein kinase C, alpha |
| 11 | Xenopus tropicalis | 95.10 | 1 | hypothetical protein LOC780209 |
| 12 | Latimeria chalumnae | 94.70 | 2 | protein kinase C alpha |
| 13 | Xenopus laevis | 87.80 | 1 | protein kinase C, alpha |
| 14 | Protopterus dolloi | 82.40 | 2 | protein kinase C alpha |
| 15 | Takifugu rubripes | 71.60 | 1 | protein kinase C, alpha type |
| 16 | Danio rerio | 67.00 | 7 | protein kinase C, beta 1 |
| 17 | Scyliorhinus canicula | 66.20 | 2 | protein kinase C alpha |
| 18 | Tetraodon nigroviridis | 65.10 | 3 | unnamed protein product |
| 19 | Macaca mulatta | 58.20 | 9 | PREDICTED: protein kinase C, beta isoform 1 |
| 20 | Petromyzon marinus | 54.70 | 1 | protein kinase C |
| 21 | Myxine glutinosa | 43.50 | 1 | protein kinase C |
| 22 | Macaca fascicularis | 36.60 | 1 | KPCG_MACFA Protein kinase C gamma type (PKC-gamma) |
| 23 | Branchiostoma lanceolatum | 35.80 | 1 | protein kinase C |
| 24 | Bombyx mori | 34.70 | 1 | conventional protein kinase C |
| 25 | Apis mellifera | 33.90 | 1 | PREDICTED: similar to Protein C kinase 53E CG6622- |
| 26 | Anopheles gambiae str. PEST | 32.70 | 1 | ENSANGP00000009078 |
| 27 | Aedes aegypti | 32.30 | 1 | protein kinase c |
Top-ranked sequences
| organism | matching |
|---|---|
| Mus musculus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |
| Homo sapiens | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||||||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDFNFLMVLG 346 |
| N/A | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||||||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 273 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDFNFLMVLG 332 |
| synthetic construct | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||||||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDFNFLMVLG 346 |
| Rattus norvegicus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||+|||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 287 NVPIPEGDEEGNVELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDFNFLMVLG 346 |
| Oryctolagus cuniculus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||||||||+||+|||||||||||||||||#|||||||||||||||||||||| ||||||| Sbjct 287 NVPIPEGDEDGNVELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDFNFLMVLG 346 |
| Canis familiaris | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||+|||||||||||||||||#||||||||+||||||||||||| ||||||| Sbjct 205 NVPIPEGDEEGNVELRQKFEKAKLGPAGNK#VISPSEDRRQPSNNLDRVKLTDFNFLMVLG 264 |
| Bos taurus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 ||||||||||||+|||||||||||||||||#||||||||+||||||||||||| ||||||| Sbjct 287 NVPIPEGDEEGNVELRQKFEKAKLGPAGNK#VISPSEDRRQPSNNLDRVKLTDFNFLMVLG 346 |
| Monodelphis domestica | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||||||||||||||||||||||||| |||#||| |+||| |+|||||||||| ||||||| Sbjct 287 NVPIPEGDEEGNMELRQKFEKAKLGPVGNK#VISSSDDRK-PTNNLDRVKLTDFNFLMVLG 345 |
| Gallus gallus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQ--PSNNLDRVKLTDLNFLMV 344 |||||+ ||+|| |||||||||||||||||#||+||||| |||||||||||| ||||| Sbjct 287 NVPIPDADEDGNAELRQKFEKAKLGPAGNK#VITPSEDRNSSVPSNNLDRVKLTDFNFLMV 346 Query 345 LG 346 || Query 345 LG 346 |
| Xenopus tropicalis | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQ--PSNNLDRVKLTDLNFLMV 344 |||||| +++||+|||||||||||||||||#||||+++|+ ||||+| |+||| +|||| Sbjct 291 NVPIPEEEDDGNIELRQKFEKAKLGPAGNK#VISPTDERRPYVPSNNIDSVRLTDFSFLMV 350 Query 345 LG 346 || Query 345 LG 346 |
| Latimeria chalumnae | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQ--PSNNLDRVKLTDLNFLMV 344 |||| | |+ ||+|||||||||||||||+|#|||| |+|| |||||||||||| ||||| Sbjct 209 NVPISEADD-GNVELRQKFEKAKLGPAGSK#VISPVEERKSSTPSNNLDRVKLTDFNFLMV 267 Query 345 LG 346 || Query 345 LG 346 |
| Xenopus laevis | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQ--PSNNLDRVKLTDLNFLMV 344 |||||| |+ ||+|||||||||||||||||#||+|+ +|+ ||||+| ++||| |||| Sbjct 291 NVPIPEADD-GNLELRQKFEKAKLGPAGNK#VINPTGERRPYIPSNNIDSIRLTDFCFLMV 349 Query 345 LG 346 || Query 345 LG 346 |
| Protopterus dolloi | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||||+ |+ ||+ ||||||||+||||| |#|||| | ||||| || | ||+|||| Sbjct 207 NVPIPDADD-GNVGLRQKFEKARLGPAGKK#VISPERKSSLPLNNLDRFKLEDFNFVMVLG 265 |
| Takifugu rubripes | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRK--QPSNNLDRVKLTDLNFLMV 344 |||||| |+ |+|||||||||||| | |#||+||+ |+ || |+|||+| | ||| + Sbjct 285 NVPIPEVDDV-NLELRQKFEKAKLGQ-GKK#VITPSDHRRFSLPSGNMDRVRLNDFNFLAL 342 Query 345 LG 346 || Query 345 LG 346 |
| Danio rerio | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSN-NLDRVKLTDLNFLMVL 345 |||+| |||| |||||||+||+||+ # | + | || | ||+||+| |||||| Sbjct 286 NVPVPPEGEEGNEELRQKFERAKIGPSKTD#GSSSNAISKFDSNGNRDRMKLSDFNFLMVL 345 Query 346 G 346 | Query 346 G 346 |
| Scyliorhinus canicula | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||| | ||+ |||+||||||||||| |# | + |+|+|| | | | ||||||| Sbjct 220 NVPIIEDDEDS--ELRKKFEKAKLGPAGKK#AI--EKKPSSPTNDLDHVHLEDFNFLMVLG 275 |
| Tetraodon nigroviridis | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK--#VISPSEDRKQPSNNLDRVKLTDLNFLMV 344 |||+| |||| |||||||+||+|| | # + + | + | ||+|| | ||||| Sbjct 223 NVPVPPEGEEGNEELRQKFERAKIGPGKNTDG#KSANAASRFDSNGNQDRMKLADFNFLMV 282 Query 345 LG 346 || Query 345 LG 346 |
| Macaca mulatta | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#V----ISPSEDRKQPSNNLDRVKLTDLNFL 342 |||+| ||| |||||||+||+ | |#| + + + + | ||+|||| ||| Sbjct 287 NVPVPPEGSEGNEELRQKFERAKIS-QGTK#VPEEKTTNTVSKFDNNGNRDRMKLTDFNFL 345 Query 343 MVLG 346 |||| Query 343 MVLG 346 |
| Petromyzon marinus | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISP--SEDRKQPS-------NNLDRVKLT 337 |||| |+|+ |+|+|||||+|||+ # + | |++|+ | |+|||| Sbjct 217 NVPIAPDIEDGDTEMRRKFEKARLGPS---#-VKPRASDERRANSLSAILNNANVDRVKAD 272 Query 338 DLNFLMVLG 346 | ||||||| Sbjct 273 DFNFLMVLG 281 |
| Myxine glutinosa | Query 287 NVPI-PEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPS---NNLDRVKLTDLNFL 342 |||+ |||+| +||||+ +++++ + # ||++|+ | + |||| | | || Sbjct 208 NVPVAPEGEE--GLELRQRLQRSQIARSDKN#KQSPAKDQPSDSASLSGLDRVNLEDFVFL 265 Query 343 MVLG 346 ||| Sbjct 266 TVLG 269 |
| Macaca fascicularis | Query 287 NVPIPEGDEEGNMELRQKFE----------KAKLGPAGNK#VISPSEDRKQPSN-----NL 331 |||+ + | | | |||| + ++||+ + #+ ||| | + Sbjct 287 NVPVADAD---NCSLLQKFEACNYPLELYERVRMGPSSSP#IPSPSPSPTDPKRCFFGASP 343 Query 332 DRVKLTDLNFLMVLG 346 |+ ++| +|||||| Sbjct 344 GRLHISDFSFLMVLG 358 |
| Branchiostoma lanceolatum | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||| + +|| +|++ +| || +# ||+ | || +| | ||||||| Sbjct 218 NVPIAD-EEENVAKLKEHLQKQKLDEQRKQ#KSKRSEECNIGS--LDHMKAADFNFLMVLG 274 |
| Bombyx mori | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSN--NLDRVKLTDLNFLMV 344 |||+|| || +| | + + | +# | ||+ | | | ++ || ||+|| Sbjct 290 NVPVPE---EG-ADLVQLKNQMRATTVGAR#RPPPPPDREVPHNVAAADVIRATDFNFIMV 345 Query 345 LG 346 || Query 345 LG 346 |
| Apis mellifera | Query 287 NVPIPE-GDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSN--NLDRVKLTDLNFLM 343 |||+|| | + ++++ +| + |# + ++|++ | | | ++ +| |||| Sbjct 304 NVPVPEEGVDLAELKMKPSPQKTSV----TK#KTTTTQDKEVPHNMGKSDLIRASDFNFLM 359 Query 344 VLG 346 ||| Query 344 VLG 346 |
| Anopheles gambiae str. PEST | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSN--NLDRVKLTDLNFLMV 344 |||+|| + ++|+ + | + |# | |+ | | | ++ || ||||| Sbjct 227 NVPVPEEGAD-LVQLKSQMRKTSI----TK#KIPMMGDKDVPHNMTKKDVIRATDFNFLMV 281 Query 345 LG 346 || Query 345 LG 346 |
| Aedes aegypti | Query 287 NVPIPEGDEEGNMELRQKFEKAKLGPAGNK#VISPSEDRKQPSNNLDRVKLTDLNFLMVLG 346 |||+|| || ++ | + | + # + +| | ++ || ||||||| Sbjct 235 NVPVPE---EGTDLVQLKSQMRKTSISKKA#PVLCDKDVPHNMGKKDVIRATDFNFLMVLG 291 |
[Site 2] ELRQKFEKAK309-LGPAGNKVIS
Lys309 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu300 | Leu301 | Arg302 | Gln303 | Lys304 | Phe305 | Glu306 | Lys307 | Ala308 | Lys309 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu310 | Gly311 | Pro312 | Ala313 | Gly314 | Asn315 | Lys316 | Val317 | Ile318 | Ser319 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| QEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Mus musculus | 125.00 | 9 | protein kinase C |
| 2 | N/A | 124.00 | 13 | - |
| 3 | Homo sapiens | 124.00 | 11 | aging-associated gene 6 protein |
| 4 | synthetic construct | 124.00 | 1 | protein kinase C alpha |
| 5 | Rattus norvegicus | 122.00 | 5 | PREDICTED: similar to Protein kinase C alpha type |
| 6 | Oryctolagus cuniculus | 121.00 | 5 | KPCA_RABIT Protein kinase C alpha type (PKC-alpha) |
| 7 | Canis familiaris | 121.00 | 4 | PREDICTED: similar to Protein kinase C, alpha type |
| 8 | Bos taurus | 121.00 | 4 | protein kinase C, alpha |
| 9 | Monodelphis domestica | 110.00 | 4 | PREDICTED: similar to protein kinase C |
| 10 | Gallus gallus | 107.00 | 3 | protein kinase C, alpha |
| 11 | Xenopus tropicalis | 99.00 | 1 | hypothetical protein LOC780209 |
| 12 | Latimeria chalumnae | 96.70 | 2 | protein kinase C alpha |
| 13 | Xenopus laevis | 93.20 | 1 | protein kinase C, alpha |
| 14 | Protopterus dolloi | 85.50 | 2 | protein kinase C alpha |
| 15 | Takifugu rubripes | 77.00 | 1 | protein kinase C, alpha type |
| 16 | Scyliorhinus canicula | 68.20 | 2 | protein kinase C alpha |
| 17 | Danio rerio | 67.40 | 7 | protein kinase C, beta 1 |
| 18 | Tetraodon nigroviridis | 65.50 | 3 | unnamed protein product |
| 19 | Macaca mulatta | 58.50 | 9 | PREDICTED: protein kinase C, beta 1 isoform 5 |
| 20 | Petromyzon marinus | 56.60 | 1 | protein kinase C |
| 21 | Myxine glutinosa | 51.20 | 1 | protein kinase C |
| 22 | Macaca fascicularis | 42.40 | 1 | KPCG_MACFA Protein kinase C gamma type (PKC-gamma) |
| 23 | Branchiostoma lanceolatum | 37.70 | 1 | protein kinase C |
| 24 | Apis mellifera | 35.80 | 1 | PREDICTED: similar to Protein C kinase 53E CG6622- |
| 25 | Bombyx mori | 35.80 | 1 | conventional protein kinase C |
| 26 | Drosophila melanogaster | 35.40 | 4 | Protein C kinase 53E CG6622-PA, isoform A |
| 27 | Anopheles gambiae str. PEST | 34.70 | 1 | ENSANGP00000009078 |
| 28 | Aedes aegypti | 34.30 | 1 | protein kinase c |
| 29 | Aplysia californica | 33.90 | 1 | KPC1_APLCA Calcium-dependent protein kinase C (APL |
Top-ranked sequences
| organism | matching |
|---|---|
| Mus musculus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTDL 339 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTDL 339 |
| N/A | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||| Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| Homo sapiens | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||| Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| synthetic construct | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||| Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| Rattus norvegicus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |||||||||||||||||||+||||||||||#||||||||||||||||||||||||||||| Sbjct 280 QEEGEYYNVPIPEGDEEGNVELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| Oryctolagus cuniculus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||||||+||+||||||||||#||||||||||||||||||||||||||||| Sbjct 280 QEEGEYYNVPIPEGDEDGNVELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |
| Canis familiaris | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |||||||||||||||||||+||||||||||#|||||||||||||||+||||||||||||| Sbjct 198 QEEGEYYNVPIPEGDEEGNVELRQKFEKAK#LGPAGNKVISPSEDRRQPSNNLDRVKLTD 256 |
| Bos taurus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |||||||||||||||||||+||||||||||#|||||||||||||||+||||||||||||| Sbjct 280 QEEGEYYNVPIPEGDEEGNVELRQKFEKAK#LGPAGNKVISPSEDRRQPSNNLDRVKLTD 338 |
| Monodelphis domestica | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||||||||||||||||||||#||| |||||| |+||| |+|||||||||| Sbjct 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPVGNKVISSSDDRK-PTNNLDRVKLTD 337 |
| Gallus gallus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQ--PSNNLDRVKLT 337 ||||||||||||+ ||+|| ||||||||||#|||||||||+||||| ||||||||||| Sbjct 280 QEEGEYYNVPIPDADEDGNAELRQKFEKAK#LGPAGNKVITPSEDRNSSVPSNNLDRVKLT 339 Query 338 D 338 | Query 338 D 338 |
| Xenopus tropicalis | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQ--PSNNLDRVKLT 337 ||||||||||||| +++||+||||||||||#|||||||||||+++|+ ||||+| |+|| Sbjct 284 QEEGEYYNVPIPEEEDDGNIELRQKFEKAK#LGPAGNKVISPTDERRPYVPSNNIDSVRLT 343 Query 338 D 338 | Query 338 D 338 |
| Latimeria chalumnae | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQ--PSNNLDRVKLT 337 ||||||||||| | |+ ||+||||||||||#|||||+||||| |+|| ||||||||||| Sbjct 202 QEEGEYYNVPISEADD-GNVELRQKFEKAK#LGPAGSKVISPVEERKSSTPSNNLDRVKLT 260 Query 338 D 338 | Query 338 D 338 |
| Xenopus laevis | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQ--PSNNLDRVKLT 337 ||||||||||||| |+ ||+||||||||||#|||||||||+|+ +|+ ||||+| ++|| Sbjct 284 QEEGEYYNVPIPEADD-GNLELRQKFEKAK#LGPAGNKVINPTGERRPYIPSNNIDSIRLT 342 Query 338 D 338 | Query 338 D 338 |
| Protopterus dolloi | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||||+ |+ ||+ ||||||||+#||||| ||||| | ||||| || | Sbjct 200 QEEGEYYNVPIPDADD-GNVGLRQKFEKAR#LGPAGKKVISPERKSSLPLNNLDRFKLED 257 |
| Takifugu rubripes | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRK--QPSNNLDRVKLT 337 ||||||||||||| |+ |+||||||||||#|| | |||+||+ |+ || |+|||+| Sbjct 278 QEEGEYYNVPIPEVDDV-NLELRQKFEKAK#LG-QGKKVITPSDHRRFSLPSGNMDRVRLN 335 Query 338 D 338 | Query 338 D 338 |
| Scyliorhinus canicula | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||| | ||+ |||+||||||#||||| | | + |+|+|| | | | Sbjct 213 QEEGEYYNVPIIEDDEDS--ELRKKFEKAK#LGPAGKKAI--EKKPSSPTNDLDHVHLED 267 |
| Danio rerio | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSN-NLDRVKLTD 338 ||||||+|||+| |||| |||||||+||#+||+ | + | || | ||+||+| Sbjct 279 QEEGEYFNVPVPPEGEEGNEELRQKFERAK#IGPSKTDGSSSNAISKFDSNGNRDRMKLSD 338 |
| Tetraodon nigroviridis | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNK--VISPSEDRKQPSNNLDRVKLT 337 ||||||+|||+| |||| |||||||+||#+|| | + + | + | ||+|| Sbjct 216 QEEGEYFNVPVPPEGEEGNEELRQKFERAK#IGPGKNTDGKSANAASRFDSNGNQDRMKLA 275 Query 338 D 338 | Query 338 D 338 |
| Macaca mulatta | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKV----ISPSEDRKQPSNNLDRVK 335 ||||||+|||+| ||| |||||||+||#+ | || + + + + | ||+| Sbjct 280 QEEGEYFNVPVPPEGSEGNEELRQKFERAK#IS-QGTKVPEEKTTNTVSKFDNNGNRDRMK 338 Query 336 LTD 338 ||| Query 336 LTD 338 |
| Petromyzon marinus | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISP--SEDRKQPS-------NN 330 ||||||||||| |+|+ |+|+|||||+#|||+ + | |++|+ | | Sbjct 210 QEEGEYYNVPIAPDIEDGDTEMRRKFEKAR#LGPS----VKPRASDERRANSLSAILNNAN 265 Query 331 LDRVKLTD 338 +|||| | Sbjct 266 VDRVKADD 273 |
| Myxine glutinosa | Query 280 QEEGEYYNVPI-PEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPS---NNLDRVK 335 ||||||||||+ |||+| +||||+ ++++#+ + ||++|+ | + |||| Sbjct 201 QEEGEYYNVPVAPEGEE--GLELRQRLQRSQ#IARSDKNKQSPAKDQPSDSASLSGLDRVN 258 Query 336 LTD 338 | | Sbjct 259 LED 261 |
| Macaca fascicularis | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKF----------EKAK#LGPAGNKVISPSEDRKQP 327 ||||||||||+ + | | | ||| |+ +#+||+ + + ||| | Sbjct 280 QEEGEYYNVPVADAD---NCSLLQKFEACNYPLELYERVR#MGPSSSPIPSPSPSPTDP 334 |
| Branchiostoma lanceolatum | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||| + +|| +|++ +| |#| + ||+ +|| +| | Sbjct 211 QEEGEYYNVPIAD-EEENVAKLKEHLQKQK#LDEQRKQKSKRSEECN--IGSLDHMKAAD 266 |
| Apis mellifera | Query 280 QEEGEYYNVPIP-EGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSN 329 ||||||||||+| || + ++++ +| #+ | + ++|++ | | Sbjct 297 QEEGEYYNVPVPEEGVDLAELKMKPSPQKTS#V----TKKTTTTQDKEVPHN 343 |
| Bombyx mori | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSN--NLDRVKLT 337 |||||+||||+| ||| +| | + +# | + | ||+ | | | ++ | Sbjct 283 QEEGEFYNVPVP---EEG-ADLVQLKNQMR#ATTVGARRPPPPPDREVPHNVAAADVIRAT 338 Query 338 D 338 | Query 338 D 338 |
| Drosophila melanogaster | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |+|||||||| + ||+ ++|+|| + |# ++ |+ |+ | ++ || Sbjct 289 QDEGEYYNVPCAD-DEQDLLKLKQKPSQKK#------PMVMRSDTNTHTSSKKDMIRATD 340 |
| Anopheles gambiae str. PEST | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSN--NLDRVKLT 337 ||||||||||+|| + ++|+ + | #+ | | |+ | | | ++ | Sbjct 220 QEEGEYYNVPVPE-EGADLVQLKSQMRKTS#I----TKKIPMMGDKDVPHNMTKKDVIRAT 274 Query 338 D 338 | Query 338 D 338 |
| Aedes aegypti | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 ||||||||||+| ||| ++ | + |# + + +| | ++ || Sbjct 228 QEEGEYYNVPVP---EEGTDLVQLKSQMRK#TSISKKAPVLCDKDVPHNMGKKDVIRATD 283 |
| Aplysia californica | Query 280 QEEGEYYNVPIPEGDEEGNMELRQKFEKAK#LGPAGNKVISPSEDRKQPSNNLDRVKLTD 338 |||||+| ||+ + | |++ | ++ #+ ++ | |+ | + | |+ +| Sbjct 264 QEEGEFYGVPVTDDITESIQEIKSKMHRSS#I---SSEKRYPEPDKVQNMSKQDIVRASD 319 |
[Site 3] NKVISPSEDR324-KQPSNNLDRV
Arg324 Lys
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asn315 | Lys316 | Val317 | Ile318 | Ser319 | Pro320 | Ser321 | Glu322 | Asp323 | Arg324 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys325 | Gln326 | Pro327 | Ser328 | Asn329 | Asn330 | Leu331 | Asp332 | Arg333 | Val334 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDLNFLMVLGKGSFGKVM |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Mus musculus | 122.00 | 11 | protein kinase C |
| 2 | Homo sapiens | 120.00 | 24 | protein kinase C, alpha |
| 3 | N/A | 120.00 | 17 | - |
| 4 | synthetic construct | 120.00 | 4 | protein kinase C alpha |
| 5 | Rattus norvegicus | 119.00 | 8 | PREDICTED: similar to Protein kinase C alpha type |
| 6 | Canis familiaris | 117.00 | 13 | PREDICTED: similar to Protein kinase C, alpha type |
| 7 | Bos taurus | 117.00 | 7 | protein kinase C, alpha |
| 8 | Oryctolagus cuniculus | 117.00 | 6 | KPCA_RABIT Protein kinase C alpha type (PKC-alpha) |
| 9 | Gallus gallus | 107.00 | 8 | protein kinase C, alpha |
| 10 | Monodelphis domestica | 107.00 | 6 | PREDICTED: similar to protein kinase C |
| 11 | Latimeria chalumnae | 103.00 | 2 | protein kinase C alpha |
| 12 | Xenopus tropicalis | 98.20 | 3 | hypothetical protein LOC780209 |
| 13 | Xenopus laevis | 94.00 | 2 | protein kinase C, alpha |
| 14 | Protopterus dolloi | 89.70 | 2 | protein kinase C alpha |
| 15 | Takifugu rubripes | 78.60 | 1 | protein kinase C, alpha type |
| 16 | Scyliorhinus canicula | 74.30 | 2 | protein kinase C alpha |
| 17 | Danio rerio | 73.90 | 14 | protein kinase C, beta 1 |
| 18 | Tetraodon nigroviridis | 72.00 | 5 | unnamed protein product |
| 19 | Macaca mulatta | 65.10 | 15 | PREDICTED: protein kinase C, beta 1 isoform 5 |
| 20 | Petromyzon marinus | 64.70 | 1 | protein kinase C |
| 21 | Myxine glutinosa | 53.10 | 1 | protein kinase C |
| 22 | Macaca fascicularis | 47.80 | 4 | KPCG_MACFA Protein kinase C gamma type (PKC-gamma) |
| 23 | Branchiostoma lanceolatum | 47.00 | 1 | protein kinase C |
| 24 | Bombyx mori | 45.40 | 1 | conventional protein kinase C |
| 25 | Aplysia californica | 44.70 | 2 | KPC2_APLCA Calcium-independent protein kinase C (A |
| 26 | Apis mellifera | 43.90 | 2 | PREDICTED: similar to Protein C kinase 53E CG6622- |
| 27 | Anopheles gambiae str. PEST | 43.10 | 3 | ENSANGP00000009078 |
| 28 | Aedes aegypti | 43.10 | 2 | protein kinase c |
| 29 | Drosophila melanogaster | 42.00 | 8 | Protein C kinase 53E CG6622-PA, isoform A |
| 30 | Tribolium castaneum | 39.70 | 3 | PREDICTED: similar to CG6622-PA, isoform A |
| 31 | Drosophila pseudoobscura | 38.90 | 3 | GA19732-PA |
| 32 | Coprinopsis cinerea okayama7#130 | 38.90 | 1 | hypothetical protein CC1G_07190 |
| 33 | Caenorhabditis briggsae | 38.90 | 1 | Hypothetical protein CBG16150 |
| 34 | Magnaporthe grisea 70-15 | 38.90 | 1 | hypothetical protein MGG_08689 |
| 35 | Magnaporthe grisea | 38.50 | 1 | AF136600_1 protein kinase C |
| 36 | Caenorhabditis elegans | 38.10 | 5 | protein kinase C2 A isoform |
| 37 | Strongylocentrotus purpuratus | 38.10 | 4 | PREDICTED: similar to protein kinase C |
| 38 | Pan troglodytes | 37.40 | 4 | PREDICTED: serum/glucocorticoid regulated kinase 3 |
| 39 | Paramecium tetraurelia | 37.40 | 1 | hypothetical protein |
| 40 | Botryotinia fuckeliana | 37.40 | 1 | protein kinase C |
| 41 | Schizosaccharomyces pombe | 37.00 | 3 | SPAC17G8.14c |
| 42 | Schizosaccharomyces pombe 972h- | 37.00 | 2 | hypothetical protein SPAC17G8.14c |
| 43 | Hydractinia echinata | 37.00 | 1 | putative calcium dependent protein kinase C |
| 44 | Leptosphaeria maculans | 36.60 | 1 | AF487263_9 protein kinase C |
| 45 | Yarrowia lipolytica | 36.60 | 1 | hypothetical protein |
| 46 | Suberites domuncula | 36.20 | 2 | Serine/Threonine protein kinase |
| 47 | Tuber excavatum | 36.20 | 2 | protein kinase C-like protein |
| 48 | Medicago truncatula | 36.20 | 1 | Protein kinase |
| 49 | Asparagus officinalis | 36.20 | 1 | S6 ribosomal protein kinase |
| 50 | Calliphora vicina | 36.20 | 1 | eye-specific protein kinase C |
| 51 | Tuber aestivum | 35.80 | 2 | protein kinase C-like protein |
| 52 | Sycon raphanus | 35.80 | 1 | Serine/Threonine protein kinase |
| 53 | Cryptococcus neoformans var. neoformans | 35.40 | 1 | protein kinase C 1 |
| 54 | Squalus acanthias | 35.40 | 1 | s-sgk1 |
| 55 | Cryptococcus neoformans var. neoformans JEC21 | 35.40 | 1 | protein kinase C |
| 56 | Cryptococcus neoformans var. neoformans B-3501A | 35.40 | 1 | hypothetical protein CNBC3910 |
| 57 | Cryptococcus neoformans var. grubii | 35.40 | 1 | protein kinase C 1 |
| 58 | Tuber indicum | 34.70 | 6 | protein kinase C-like protein |
| 59 | Phaeosphaeria nodorum SN15 | 34.70 | 2 | hypothetical protein SNOG_13609 |
| 60 | Tuber pseudoexcavatum | 34.70 | 2 | protein kinase C-like protein |
| 61 | Leishmania braziliensis | 34.70 | 1 | zinc finger protein kinase-like |
| 62 | Cochliobolus heterostrophus | 34.30 | 1 | KPC1_COCHE Protein kinase C-like emb |
| 63 | Aspergillus clavatus NRRL 1 | 34.30 | 1 | protein kinase c |
| 64 | Aspergillus oryzae | 34.30 | 1 | unnamed protein product |
| 65 | Debaryomyces hansenii CBS767 | 34.30 | 1 | hypothetical protein DEHA0G14773g |
| 66 | Sporothrix schenckii | 34.30 | 1 | AF124792_1 protein kinase C; serine/threonine prot |
| 67 | Candida albicans | 34.30 | 1 | KPC1_CANAL Protein kinase C-like 1 (PKC 1) emb |
| 68 | Plasmodium berghei strain ANKA | 34.30 | 1 | rac-beta serine/threonine protein kinase |
| 69 | Ashbya gossypii ATCC 10895 | 34.30 | 1 | ACR191Cp |
| 70 | Hydra vulgaris | 33.90 | 2 | protein kinase C |
| 71 | Coccidioides immitis RS | 33.90 | 1 | hypothetical protein CIMG_09206 |
| 72 | Neosartorya fischeri NRRL 181 | 33.90 | 1 | protein kinase c |
| 73 | Plasmodium yoelii yoelii str. 17XNL | 33.90 | 1 | hypothetical protein PY00403 |
| 74 | Aspergillus terreus NIH2624 | 33.90 | 1 | hypothetical protein ATEG_02078 |
| 75 | Fundulus heteroclitus | 33.50 | 1 | serum and glucocorticoid-regulated kinase |
Top-ranked sequences
| organism | matching |
|---|---|
| Mus musculus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |
| Homo sapiens | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||||||||||||||||||||||||||||#|||||||||||||| ||||||||||||||| Sbjct 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354 |
| N/A | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||||||||||||||||||||||||||||#|||||||||||||| ||||||||||||||| Sbjct 281 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 340 |
| synthetic construct | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||||||||||||||||||||||||||||#|||||||||||||| ||||||||||||||| Sbjct 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354 |
| Rattus norvegicus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||+|||||||||||||||||||||||||#|||||||||||||| ||||||||||||||| Sbjct 295 EEGNVELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354 |
| Canis familiaris | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||+|||||||||||||||||||||||||#+||||||||||||| ||||||||||||||| Sbjct 213 EEGNVELRQKFEKAKLGPAGNKVISPSEDR#RQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 272 |
| Bos taurus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||||+|||||||||||||||||||||||||#+||||||||||||| ||||||||||||||| Sbjct 295 EEGNVELRQKFEKAKLGPAGNKVISPSEDR#RQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354 |
| Oryctolagus cuniculus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+||+|||||||||||||||||||||||||#|||||||||||||| ||||||||||||||| Sbjct 295 EDGNVELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354 |
| Gallus gallus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQ--PSNNLDRVKLTDLNFLMVLGKGSFGK 352 |+|| |||||||||||||||||||+|||||# |||||||||||| ||||||||||||| Sbjct 295 EDGNAELRQKFEKAKLGPAGNKVITPSEDR#NSSVPSNNLDRVKLTDFNFLMVLGKGSFGK 354 Query 353 VM 354 || Query 353 VM 354 |
| Monodelphis domestica | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |||||||||||||||||| |||||| |+||#| |+|||||||||| ||||||||||||||| Sbjct 295 EEGNMELRQKFEKAKLGPVGNKVISSSDDR#K-PTNNLDRVKLTDFNFLMVLGKGSFGKVM 353 |
| Latimeria chalumnae | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQ--PSNNLDRVKLTDLNFLMVLGKGSFGK 352 ++||+|||||||||||||||+||||| |+|#| |||||||||||| ||||||||||||| Sbjct 216 DDGNVELRQKFEKAKLGPAGSKVISPVEER#KSSTPSNNLDRVKLTDFNFLMVLGKGSFGK 275 Query 353 VM 354 || Query 353 VM 354 |
| Xenopus tropicalis | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQ--PSNNLDRVKLTDLNFLMVLGKGSFGK 352 ++||+|||||||||||||||||||||+++|#+ ||||+| |+||| +|||||||||||| Sbjct 299 DDGNIELRQKFEKAKLGPAGNKVISPTDER#RPYVPSNNIDSVRLTDFSFLMVLGKGSFGK 358 Query 353 VM 354 || Query 353 VM 354 |
| Xenopus laevis | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQ--PSNNLDRVKLTDLNFLMVLGKGSFGK 352 ++||+|||||||||||||||||||+|+ +|#+ ||||+| ++||| |||||||||||| Sbjct 298 DDGNLELRQKFEKAKLGPAGNKVINPTGER#RPYIPSNNIDSIRLTDFCFLMVLGKGSFGK 357 Query 353 VM 354 || Query 353 VM 354 |
| Protopterus dolloi | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ++||+ ||||||||+||||| ||||| # | ||||| || | ||+|||||||||||| Sbjct 214 DDGNVGLRQKFEKARLGPAGKKVISPERKS#SLPLNNLDRFKLEDFNFVMVLGKGSFGKVM 273 |
| Takifugu rubripes | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#K--QPSNNLDRVKLTDLNFLMVLGKGSFGK 352 ++ |+|||||||||||| | |||+||+ |#+ || |+|||+| | ||| +|||||||| Sbjct 292 DDVNLELRQKFEKAKLGQ-GKKVITPSDHR#RFSLPSGNMDRVRLNDFNFLALLGKGSFGK 350 Query 353 VM 354 || Query 353 VM 354 |
| Scyliorhinus canicula | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ++ + |||+||||||||||| | | # |+|+|| | | | ||||||||||||||| Sbjct 226 DDEDSELRKKFEKAKLGPAGKKAIEKKPS-#-SPTNDLDHVHLEDFNFLMVLGKGSFGKVM 283 |
| Danio rerio | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSN-NLDRVKLTDLNFLMVLGKGSFGKV 353 |||| |||||||+||+||+ | + #| || | ||+||+| |||||||||||||| Sbjct 294 EEGNEELRQKFERAKIGPSKTDGSSSNAIS#KFDSNGNRDRMKLSDFNFLMVLGKGSFGKV 353 Query 354 M 354 | Query 354 M 354 |
| Tetraodon nigroviridis | Query 295 EEGNMELRQKFEKAKLGPAGNK--VISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGK 352 |||| |||||||+||+|| | + + |# + | ||+|| | ||||||||||||| Sbjct 231 EEGNEELRQKFERAKIGPGKNTDGKSANAASR#FDSNGNQDRMKLADFNFLMVLGKGSFGK 290 Query 353 VM 354 || Query 353 VM 354 |
| Macaca mulatta | Query 296 EGNMELRQKFEKAKLGPAGNKVISPSE------DR#KQPSNNLDRVKLTDLNFLMVLGKGS 349 ||| |||||||+||+ | || | | +# + | ||+|||| |||||||||| Sbjct 296 EGNEELRQKFERAKISQ-GTKV--PEEKTTNTVSK#FDNNGNRDRMKLTDFNFLMVLGKGS 352 Query 350 FGKVM 354 ||||| Query 350 FGKVM 354 |
| Petromyzon marinus | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSN---------NLDRVKLTDLNFLMVL 345 |+|+ |+|+|||||+|||+ + | #++ +| |+|||| | |||||| Sbjct 225 EDGDTEMRRKFEKARLGPS----VKPRASD#ERRANSLSAILNNANVDRVKADDFNFLMVL 280 Query 346 GKGSFGKVM 354 ||||||||| Query 346 GKGSFGKVM 354 |
| Myxine glutinosa | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPS---NNLDRVKLTDLNFLMVLGKGSFG 351 ||| +||||+ +++++ + ||++|+# | + |||| | | || |||||||| Sbjct 216 EEG-LELRQRLQRSQIARSDKNKQSPAKDQ#PSDSASLSGLDRVNLEDFVFLTVLGKGSFG 274 Query 352 KVM 354 ||| Query 352 KVM 354 |
| Macaca fascicularis | Query 305 FEKAKLGPAGNKVISPSEDR#KQPSN-----NLDRVKLTDLNFLMVLGKGSFGKVM 354 +|+ ++||+ + + ||| # | + |+ ++| +|||||||||||||| Sbjct 312 YERVRMGPSSSPIPSPSPSP#TDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVM 366 |
| Branchiostoma lanceolatum | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 || +|++ +| || + ||+ # | || +| | ||||||||||||||| Sbjct 225 EENVAKLKEHLQKQKLDEQRKQKSKRSEEC#NIGS--LDHMKAADFNFLMVLGKGSFGKVM 282 |
| Bombyx mori | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSN--NLDRVKLTDLNFLMVLGKGSFGK 352 ||| +| | + + | + | ||#+ | | | ++ || ||+|||||||||| Sbjct 295 EEG-ADLVQLKNQMRATTVGARRPPPPPDR#EVPHNVAAADVIRATDFNFIMVLGKGSFGK 353 Query 353 VM 354 || Query 353 VM 354 |
| Aplysia californica | Query 314 GNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |++ ||| ||# + ++ |+ | | ||+ ||||||||||| Sbjct 380 GSRTRSPSSDR#SRSHHS--RISLHDFNFIKVLGKGSFGKVM 418 |
| Apis mellifera | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSN--NLDRVKLTDLNFLMVLGKGSFGK 352 ||| | + + + | + ++|+#+ | | | ++ +| ||||||||||||| Sbjct 309 EEGVDLAELKMKPSPQKTSVTKKTTTTQDK#EVPHNMGKSDLIRASDFNFLMVLGKGSFGK 368 Query 353 VM 354 || Query 353 VM 354 |
| Anopheles gambiae str. PEST | Query 295 EEGN--MELRQKFEKAKLGPAGNKVISPSEDR#KQPSN--NLDRVKLTDLNFLMVLGKGSF 350 ||| ++|+ + | + | | |+# | | | ++ || ||||||||||| Sbjct 232 EEGADLVQLKSQMRKTSI----TKKIPMMGDK#DVPHNMTKKDVIRATDFNFLMVLGKGSF 287 Query 351 GKVM 354 |||| Query 351 GKVM 354 |
| Aedes aegypti | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||| ++ | + | + + +| # | ++ || ||||||||||||||| Sbjct 240 EEGTDLVQLKSQMRKTSISKKAPVLCDKDV#PHNMGKKDVIRATDFNFLMVLGKGSFGKVM 299 |
| Drosophila melanogaster | Query 303 QKFEKAKLGPAGNK-VISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | | | |+ | ++ |+ # |+ | ++ || ||+ ||||||||||+ Sbjct 304 QDLLKLKQKPSQKKPMVMRSDTN#THTSSKKDMIRATDFNFIKVLGKGSFGKVL 356 |
| Tribolium castaneum | Query 324 R#KQPSNN--LDRVKLTDLNFLMVLGKGSFGKVM 354 +#++|| + | ++ +| ||||||||||||||| Sbjct 320 Q#RRPSQHGQKDIIRASDFNFLMVLGKGSFGKVM 352 |
| Drosophila pseudoobscura | Query 303 QKFEKAKLGPAGNKVISPSEDR#KQPSN--NLDRVKLTDLNFLMVLGKGSFGKVM 354 | | | |+ | + | # |+ | ++ || ||+ ||||||||||+ Sbjct 190 QDLLKLKQKPSQKKPLVMRSDT#NTHSSISKKDMIRATDFNFIKVLGKGSFGKVL 243 |
| Coprinopsis cinerea okayama7#130 | Query 306 EKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ++ + | + + ++ +#+||| +| | | ||| |||||+||||| Sbjct 685 QQGMVPPQHQQQMIQAQPQ#RQPSKKR-KVGLDDFNFLAVLGKGNFGKVM 732 |
| Caenorhabditis briggsae | Query 328 SNNLDRVKLTDLNFLMVLGKGSFGKVM 354 + | | +| +| ||| ||||||||||+ Sbjct 404 NTNRDVIKASDFNFLTVLGKGSFGKVL 430 |
| Magnaporthe grisea 70-15 | Query 302 RQKFEKAKLGPAGNKVISPSEDR#KQPS----NNLDRVKLTDLNFLMVLGKGSFGKVM 354 +| |+ + | || | |# || |+ | ||| |||||+||||| Sbjct 816 QQHQEQQIISPTAGTVIPTSAKR#PLPSATDPGTGQRIGLDHFNFLAVLGKGNFGKVM 872 |
| Magnaporthe grisea | Query 302 RQKFEKAKLGPAGNKVISPSEDR#KQPS----NNLDRVKLTDLNFLMVLGKGSFGKVM 354 +| |+ + | || | |# || |+ | ||| |||||+||||| Sbjct 816 QQHQEQQIISPTAGTVIPTSARR#PLPSATDPGTGQRIGLDHFNFLAVLGKGNFGKVM 872 |
| Caenorhabditis elegans | Query 328 SNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+| + +| +| ||| ||||||||||+ Sbjct 337 SSNHNVIKASDFNFLTVLGKGSFGKVL 363 |
| Strongylocentrotus purpuratus | Query 321 SEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | # ++++ |+ +| ||| ||||||||||| Sbjct 307 SSQN#SNSNSSMGLVRASDFNFLSVLGKGSFGKVM 340 |
| Pan troglodytes | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | + +| + |||+|| | # || +|| |+||||||||+ Sbjct 134 ERSSQKLHSTSQNINLGPSGNPHAKP----#------------TDFDFLKVIGKGSFGKVL 177 |
| Paramecium tetraurelia | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 +|| ++ +| || ++ | # | ||||| | |||+||||||| Sbjct 32 KEGEQQMNDEFMKAPTATF-EQIEETGEQV#FVDDNREAIVKLTDFQFEKVLGRGSFGKVM 90 |
| Botryotinia fuckeliana | Query 312 PAGNKVISPSEDR#KQPSNNLD-----RVKLTDLNFLMVLGKGSFGKVM 354 | +|+ + |#|| | |+ | ||| |||||+||||| Sbjct 813 PGSQQVVPQGQQR#KQVPAANDAGTGRRIGLDHFNFLAVLGKGNFGKVM 860 |
| Schizosaccharomyces pombe | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | |#++ | || | | || |||||+||||| Sbjct 556 PESPR#REKKN---RVTLDDFTFLAVLGKGNFGKVM 587 |
| Schizosaccharomyces pombe 972h- | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | |#++ | || | | || |||||+||||| Sbjct 648 PESPR#REKKN---RVTLDDFTFLAVLGKGNFGKVM 679 |
| Hydractinia echinata | Query 332 DRVKLTDLNFLMVLGKGSFGKVM 354 +|+|| | || |+||||||||| Sbjct 191 ERLKLEDFTFLKVIGKGSFGKVM 213 |
| Leptosphaeria maculans | Query 299 MELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLD----RVKLTDLNFLMVLGKGSFGKVM 354 | +| |++ |+ + |++# || | |+ | ||| |||||+||||| Sbjct 816 MSQKQPEAIAQIPPSKQLPPANPENK#VTPSANTQGSGKRIGLDHFNFLAVLGKGNFGKVM 875 |
| Yarrowia lipolytica | Query 308 AKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | || |+ | +#|+| |+ | | ||| |||||+||||| Sbjct 900 ASPAPASNRH-SVVGKK#KRP-----RIGLDDFNFLAVLGKGNFGKVM 940 |
| Suberites domuncula | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSN------NLDRVKLTDLNFLMVLGKG 348 +| +| ++| || + +++ #++ | ++ ++|| | | |+||||| Sbjct 293 DEEATKLIEEFRKATILDKAKNLVTDVPIM#RRGSELVPGAKDMPKMKLEDFNLLVVLGKG 352 Query 349 SFGKV 353 ||||| Query 349 SFGKV 353 |
| Tuber excavatum | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+ + #+|| ++ | ||| |||||+||||| Sbjct 312 PAPEP#QQPVIRPAKIGLDHFNFLAVLGKGNFGKVM 346 |
| Medicago truncatula | Query 302 RQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKV 353 +|| +|| + |+ +| | + +# | + + | +|| || ++|+| |||| Sbjct 540 KQKRQKAVVTPSNSKKRSSMKSK#HQKFSYTEIVNITD-NFKTIIGEGGFGKV 590 |
| Asparagus officinalis | Query 321 SEDR#KQPSN-NLDRVKLTDLNFLMVLGKGSFGKV 353 +|+ #+ ||+ |++|| | | +|| |+|+|+|||| Sbjct 106 AEEH#EVPSSENVERVGLEDFDFLKVVGQGAFGKV 139 |
| Calliphora vicina | Query 320 PSEDR#KQPSNNL---DRVKLTDLNFLMVLGKGSFGKVM 354 | | #| +|+ | ++ | ||+ ||||||+||++ Sbjct 333 PRIDN#KDMPHNMSKRDMIRAADFNFIKVLGKGSYGKIL 370 |
| Tuber aestivum | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+ + #+ | + ++ | ||| |||||+||||| Sbjct 314 PAPEP#QPPVSRPTKIGLDHFNFLAVLGKGNFGKVM 348 |
| Sycon raphanus | Query 335 KLTDLNFLMVLGKGSFGKVM 354 ||+| +|| ||||||||||| Sbjct 362 KLSDFSFLKVLGKGSFGKVM 381 |
| Cryptococcus neoformans var. neoformans | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 +| | | ||| |||||+||||| Sbjct 751 KVGLDDFNFLAVLGKGNFGKVM 772 |
| Squalus acanthias | Query 327 PSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ||+| + | +| ||| |+||||||||+ Sbjct 89 PSSN-PQAKPSDFNFLKVIGKGSFGKVL 115 |
| Cryptococcus neoformans var. neoformans JEC21 | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 +| | | ||| |||||+||||| Sbjct 751 KVGLDDFNFLAVLGKGNFGKVM 772 |
| Cryptococcus neoformans var. neoformans B-3501A | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 +| | | ||| |||||+||||| Sbjct 754 KVGLDDFNFLAVLGKGNFGKVM 775 |
| Cryptococcus neoformans var. grubii | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 +| | | ||| |||||+||||| Sbjct 751 KVGLDDFNFLAVLGKGNFGKVM 772 |
| Tuber indicum | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+ + #+| + ++ | ||| |||||+||||| Sbjct 313 PAPEP#QQVVSKPTKIGLDHFNFLAVLGKGNFGKVM 347 |
| Phaeosphaeria nodorum SN15 | Query 329 NNLDRVKLTDLNFLMVLGKGSFGKVM 354 | ||+ + | | |+||||||||| Sbjct 273 NRQDRLSIDDFELLKVVGKGSFGKVM 298 |
| Tuber pseudoexcavatum | Query 320 PSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+ + #+| + ++ | ||| |||||+||||| Sbjct 312 PAPEP#QQVVSKPTKIGLDHFNFLAVLGKGNFGKVM 346 |
| Leishmania braziliensis | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | | + +|+ + + ++|| # |+|| | | | | |+|+|+||||+ Sbjct 591 ESGQVMQQQRVINSTSPIPYSSLLSPRGSL#VSRSDNLSPVGLQDFQLLTVIGRGTFGKVL 650 |
| Cochliobolus heterostrophus | Query 310 LGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 +| | ++|+ + #+ |+ | ||| |||||+||||| Sbjct 823 VGEVPGKKVTPAANT#QGTGK---RIGLDHFNFLAVLGKGNFGKVM 864 |
| Aspergillus clavatus NRRL 1 | Query 312 PAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | +| | #+|| |+ | ||| |||||+||||| Sbjct 763 PMQQQVAVKEEVP#QQPKA---RIGLDHFNFLSVLGKGNFGKVM 802 |
| Aspergillus oryzae | Query 312 PAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | + ++ || # | |+ | ||| |||||+||||| Sbjct 741 PVMQQQVAMKEDA#P-PQQPKVRIGLDHFNFLAVLGKGNFGKVM 782 |
| Debaryomyces hansenii CBS767 | Query 326 QPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 +| ++ | | || |||||+||||| Sbjct 750 KPKRRRRKIGLDDFQFLAVLGKGNFGKVM 778 |
| Sporothrix schenckii | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 |+ | + ||| |||||+||||| Sbjct 863 RIGLDNFNFLAVLGKGNFGKVM 884 |
| Candida albicans | Query 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ++ | +++| ++ +|| | #|+ +| | | || |||||+||||| Sbjct 729 KQQNQQVQQVQQQEELGHQRTHSSGKSGKS#KRRKR---KVGLDDFQFLAVLGKGNFGKVM 785 |
| Plasmodium berghei strain ANKA | Query 298 NMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |+ + +||+| | | | +#|+ |+| + ||| |+||||+|||+ Sbjct 259 NLYIHDMYEKSKKKRL-RKFIPLSNKK#KR------RIKPDNFNFLKVIGKGSYGKVL 308 |
| Ashbya gossypii ATCC 10895 | Query 299 MELRQKFEKAKLGPAGNKVISPSEDR-#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 || + | | | + + |+ | #|+ + +| | | | |||||+||||+ Sbjct 781 MESIPQHPPAPLSPPKAQPVQPASGRH#KRKTPKRRKVSLDDFILLKVLGKGNFGKVL 837 |
| Hydra vulgaris | Query 335 KLTDLNFLMVLGKGSFGKVM 354 || | || |+||||||||| Sbjct 344 KLEDFTFLKVIGKGSFGKVM 363 |
| Coccidioides immitis RS | Query 333 RVKLTDLNFLMVLGKGSFGKVM 354 || | ||| |||||+||||| Sbjct 740 RVGLDHFNFLAVLGKGNFGKVM 761 |
| Neosartorya fischeri NRRL 181 | Query 297 GNMELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | + +|+ ++ + | +| | # | |+ | ||| |||||+||||| Sbjct 743 GMPQQQQQQQQQAVAPMQQQVAVKEEI-#-PPQQPKVRIGLDHFNFLAVLGKGNFGKVM 798 |
| Plasmodium yoelii yoelii str. 17XNL | Query 300 ELRQKFEKAKLGPAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 ++ +| +| +| | | | +#|+ ||| + ||| |+||||+|||+ Sbjct 370 DMHEKSKKKRL----RKFIPLSNKK#KR------RVKPDNFNFLKVIGKGSYGKVL 414 |
| Aspergillus terreus NIH2624 | Query 312 PAGNKVISPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 | + ++ |+ # | + |+ | ||| |||||+||||| Sbjct 747 PVMQQQVAVKEEV#PPPQPKV-RIGLDHFNFLAVLGKGNFGKVM 788 |
| Fundulus heteroclitus | Query 319 SPSEDR#KQPSNNLDRVKLTDLNFLMVLGKGSFGKVM 354 |||+ # ++ | +| +|| |+||||||||+ Sbjct 78 SPSQQI#NLGPSSNPSAKPSDFHFLKVIGKGSFGKVL 113 |
* References
[PubMed ID: 2601739] Megidish T, Mazurek N, A mutant protein kinase C that can transform fibroblasts. Nature. 1989 Dec 14;342(6251):807-11.