XSB1250 : von Willebrand factor
[ CaMP Format ]
This entry is computationally expanded from SB0030
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | vWF; von Willebrand antigen II; von Willebrand antigen 2 |
| Gene Names | Vwf |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2813 aa
Average Mass: 309.269 kDa
Monoisotopic Mass: 309.063 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| VWD 1. | 35 | 179 | 137.0 | 5.8e-38 |
| C8 1. | 218 | 292 | 85.5 | 1.9e-22 |
| TIL 1. | 295 | 348 | 48.0 | 3.6e-11 |
| VWD 2. | 388 | 541 | 182.8 | 9.7e-52 |
| C8 2. | 577 | 649 | 119.3 | 1.2e-32 |
| TIL 2. | 652 | 707 | 40.3 | 7.5e-09 |
| --- cleavage 763 --- | ||||
| TIL 3. | 776 | 827 | 23.1 | 0.00025 |
| VWD 3. | 868 | 1013 | 127.1 | 5.7e-35 |
| C8 3. | 1053 | 1127 | 119.2 | 1.3e-32 |
| TIL 4. | 1142 | 1196 | 35.2 | 2.6e-07 |
| DUF1272 1. | 1197 | 1249 | -20.9 | 3.2 |
| VWA 1. | 1277 | 1453 | 108.8 | 1.8e-29 |
| VWA 2. | 1498 | 1664 | 173.7 | 5.5e-49 |
| VWA 3. | 1691 | 1864 | 138.0 | 3e-38 |
| fn1 1. | 1879 | 1919 | -8.7 | 8.4 |
| --- cleavage 1913 (inside fn1 1879..1919) --- | ||||
| VWD 4. | 1950 | 2102 | 119.2 | 1.4e-32 |
| C8 4. | 2132 | 2200 | 93.6 | 7e-25 |
| TIL 5. | 2203 | 2254 | 6.8 | 0.0084 |
| VWC 1. | 2257 | 2325 | 72.2 | 1.9e-18 |
| Toxin_35 1. | 2375 | 2396 | -0.9 | 8.8 |
| VWC 2. | 2431 | 2494 | 85.0 | 2.6e-22 |
| Antistasin 1. | 2549 | 2570 | 8.4 | 0.23 |
| VWC 3. | 2582 | 2644 | 68.4 | 2.6e-17 |
| FeS 1. | 2710 | 2742 | -8.7 | 7.2 |
3. Sequence Information
Fasta Sequence: XSB1250.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1U0O (X-ray; 270 A; C=1261-1468)
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] SSPLSHRSKR763-SLSCRPPMVK
Arg763 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser754 | Ser755 | Pro756 | Leu757 | Ser758 | His759 | Arg760 | Ser761 | Lys762 | Arg763 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser764 | Leu765 | Ser766 | Cys767 | Arg768 | Pro769 | Pro770 | Met771 | Val772 | Lys773 |
Sequence conservation (by blast)
[Site 2] CLANGQTLLQ1913-SHRVNCDHGP
Gln1913 Ser
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Cys1904 | Leu1905 | Ala1906 | Asn1907 | Gly1908 | Gln1909 | Thr1910 | Leu1911 | Leu1912 | Gln1913 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser1914 | His1915 | Arg1916 | Val1917 | Asn1918 | Cys1919 | Asp1920 | His1921 | Gly1922 | Pro1923 |
Sequence conservation (by blast)
* References
[PubMed ID: 16141072] Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63.