logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1589 : integrin beta-7 subunit [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0062

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesIntegrin beta; integrin beta-7 subunit
Gene NamesItgb7
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAB61241 N/A N/A O09182 N/A N/A N/A rno:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 640 aa

Average Mass: 69.016 kDa

Monoisotopic Mass: 68.971 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 1310576.23.6e-170
EGF_2 1. 31234517.60.027
EGF_2 2. 36139316.30.039
EGF_2 3. 40043017.50.028
EGF_2 4. 43946930.56.9e-06
Integrin_B_tail 1. 47955688.72e-23
Integrin_b_cyt 1. 58062587.16.1e-23
--- cleavage 599 (inside Integrin_b_cyt 580..625) ---
--- cleavage 598 (inside Integrin_b_cyt 580..625) ---

3. Sequence Information

Fasta Sequence: XSB1589.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] EYSRFEKERQ599-QLNWKQDSNP

Gln599 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu590Tyr591Ser592Arg593Phe594Glu595Lys596Glu597Arg598Gln599
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln600Leu601Asn602Trp603Lys604Gln605Asp606Ser607Asn608Pro609

Sequence conservation (by blast)

[Site 2] LEYSRFEKER598-QQLNWKQDSN

Arg598 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu589Glu590Tyr591Ser592Arg593Phe594Glu595Lys596Glu597Arg598
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln599Gln600Leu601Asn602Trp603Lys604Gln605Asp606Ser607Asn608

Sequence conservation (by blast)

* References

[PubMed ID: 9233649] Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ, Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. J Immunol. 1997 Aug 1;159(3):1497-505.