XSB1600 : phosphorylase kinase gamma subunit 1 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0018
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform; 2.7.11.19; Phosphorylase kinase subunit gamma 1; phosphorylase kinase gamma subunit 1; phosphorylase b kinase gamma catalytic chain; skeletal muscle isoform |
| Gene Names | PHKG1; PHKG; phosphorylase kinase, gamma 1 (muscle) |
| Gene Locus | 7p11.2; chromosome 7 |
| GO Function | Not available |
* Information From OMIM
Description: Phosphorylase kinase (EC 2.7.1.38) is a crucial glycogenolytic regulatory enzyme. The holoenzymes are composed of 16 subunit proteins containing equimolar ratios of 4 subunit types known as alpha, beta, gamma, and delta. Skeletal muscle contains the highest amount of phosphorylase kinase enzymatic activity, although activity is also observed in liver, cardiac muscle, brain, and several other tissues. Kinetic differences exist between the cardiac and adult skeletal muscle enzymes, and the liver and skeletal muscle enzymes are known to be separate isozymes.
* Structure Information
1. Primary Information
Length: 387 aa
Average Mass: 45.024 kDa
Monoisotopic Mass: 44.995 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Pkinase 1. | 20 | 288 | 340.5 | 3.2e-99 |
3. Sequence Information
Fasta Sequence: XSB1600.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] EEVRHFSPRG303-KFKVIALTVL
Gly303 
Lys
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu294 | Glu295 | Val296 | Arg297 | His298 | Phe299 | Ser300 | Pro301 | Arg302 | Gly303 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys304 | Phe305 | Lys306 | Val307 | Ile308 | Ala309 | Leu310 | Thr311 | Val312 | Leu313 |
Sequence conservation (by blast)
* References
[PubMed ID: 12825073] Burwinkel B, Hu B, Schroers A, Clemens PR, Moses SW, Shin YS, Pongratz D, Vorgerd M, Kilimann MW, Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases. Eur J Hum Genet. 2003 Jul;11(7):516-26.