CaMPDB :: Substrate

XSB1605 : ryanodine receptor 1, skeletal muscle [Mus musculus]

This entry is computationally expanded from SB0015

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	ryanodine receptor 1; skeletal muscle; calcium release channel; skeletal muscle ryanodine receptor
Gene Names	Ryr1; ryanodine receptor 1, skeletal muscle
Gene Locus	7 10.0 cM; chromosome 7
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_033135	NM_009109	20190	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 5035 aa

Average Mass: 565.039 kDa

Monoisotopic Mass: 564.679 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Ins145_P3_rec 1.	10	212	360.3	3.5e-105
MIR 1.	213	392	264.7	2.2e-76
RYDR_ITPR 1.	441	645	331.7	1.4e-96
SPRY 1.	660	798	139.4	1.1e-38
RyR 1.	851	945	220.8	3.5e-63
RyR 2.	965	1059	212.3	1.3e-60
SPRY 2.	1086	1209	163.5	6.4e-46
--- cleavage 1401 ---
SPRY 3.	1431	1571	153.4	6.7e-43
Phage_XkdX 1.	1844	1878	-11.2	8.4
Cenp-B_dimeris 1.	1882	1984	-27.3	6.1
Hep_59 1.	2032	2101	-42.0	6.1
RYDR_ITPR 2.	2158	2366	306.7	5e-89
RyR 3.	2735	2829	217.2	4.3e-62
--- cleavage 2844 ---
RyR 4.	2855	2943	180.1	6.2e-51
Hpt 1.	3091	3165	-9.0	6
Transposase_12 1.	3327	3387	-55.7	3.1
DUF1081 1.	3506	3595	-30.9	3
DUF1911 1.	3665	3761	-51.5	8.1
HTH_DeoR 1.	3816	3865	-17.5	5.4
RIH_assoc 1.	3874	4007	326.0	7.8e-95
CHCH 1.	4102	4141	-5.9	7.8
HR1 1.	4191	4264	-10.9	2.1
HTH_1 1.	4302	4351	1.6	2.1
RR_TM4-6 1.	4379	4668	405.1	1.1e-118
Ion_trans 1.	4759	4934	37.6	4.9e-08
zf-C2H2 1.	4954	4981	2.3	6.9

3. Sequence Information

Fasta Sequence: XSB1605.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] TEKKKTRKIS²⁸⁴⁴-QTAQTYDPRE

Ser²⁸⁴⁴ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Thr²⁸³⁵	Glu²⁸³⁶	Lys²⁸³⁷	Lys²⁸³⁸	Lys²⁸³⁹	Thr²⁸⁴⁰	Arg²⁸⁴¹	Lys²⁸⁴²	Ile²⁸⁴³	Ser²⁸⁴⁴

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln²⁸⁴⁵	Thr²⁸⁴⁶	Ala²⁸⁴⁷	Gln²⁸⁴⁸	Thr²⁸⁴⁹	Tyr²⁸⁵⁰	Asp²⁸⁵¹	Pro²⁸⁵²	Arg²⁸⁵³	Glu²⁸⁵⁴

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
KAMIAWEWTVEKAREGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSVVTLSRELQA

Summary

#	organism	max score	hits	top seq
1	Mus musculus	83.60	4	ryanodine receptor
2	Rattus norvegicus	83.60	2	PREDICTED: similar to ryanodine receptor 1, skelet
3	N/A	80.50	6	1
4	Oryctolagus cuniculus	80.50	2	RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t
5	Homo sapiens	80.10	11	skeletal muscle ryanodine receptor isoform 2
6	Sus scrofa	75.90	4	ryanodine receptor
7	Bos taurus	63.90	2	PREDICTED: similar to Ryanodine receptor 1 (Skelet
8	Danio rerio	62.00	2	PREDICTED: similar to ryanodine receptor RyR1
9	Tetraodon nigroviridis	59.30	3	unnamed protein product
10	Prot=RyR1 isform from fish	58.20	1	-
11	Macaca mulatta	55.10	1	PREDICTED: similar to ryanodine receptor 1 (skelet
12	Rana catesbeiana	45.10	1	ryanodine receptor alpha isoform
13	Hemicentrotus pulcherrimus	37.70	1	ryanodine receptor
14	Canis familiaris	37.00	1	PREDICTED: similar to Ryanodine receptor 2 (Cardia
15	Pan troglodytes	37.00	1	PREDICTED: cardiac muscle ryanodine receptor
16	Monodelphis domestica	37.00	1	PREDICTED: similar to cardiac muscle ryanodine rec
17	Gallus gallus	35.80	1	PREDICTED: similar to cardiac muscle ryanodine rec

Top-ranked sequences

organism	matching
Mus musculus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
Rattus norvegicus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
N/A	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
Oryctolagus cuniculus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
Homo sapiens	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2814 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
Sus scrofa	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874
Bos taurus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVT 2867 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\| Sbjct 966 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVT 1018
Danio rerio	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \|\|\|\|\|\|\|\|\|+ \|\|#\|\|\|\| \|\|\|\| \|\|+\|\|\| \|+\| +\|\|\|\|\|\|\| Sbjct 2852 KAMIAWEWTLDKARDGEDEKVEKKTARKIS#QTAQATYDPSHGYSPQPIDISGMTLSRELQ 2911 Query 2874 A 2874 + Sbjct 2912 S 2912
Tetraodon nigroviridis	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \|\|\|+\|\|\|\|\|+ \|\|#\|\|\|\| \|\|\|\| \|\|+\|\|\| \|+\| + \|\|\|\|\|\| Sbjct 2341 KAMLAWEWTLEKARDGEGEVEKKAATRKIS#QTAQATYDPSHGYSPQPIDISGMALSRELQ 2400 Query 2874 A 2874 + Sbjct 2401 S 2401
Prot=RyR1 isform from fish	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \|\|\|+\|\|\|\| + \|\|#\|\|\|\| \|\|\|\| \|\|+\|\|\| \|+\| \| \|\|\|+\|\| Sbjct 2853 KAMLAWEWNIEKAREEEESEKKKATSRKIS#QTAQATYDPSHGYSPQPIDISHVALSRDLQ 2912 Query 2874 A 2874 + Sbjct 2913 S 2913
Macaca mulatta	Query 2848 QTYDPREGYNPQPPDLSVVTLSRELQ 2873 +\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\| Sbjct 820 KTYDPREGYNPQPPDLSAVTLSRELQ 845
Rana catesbeiana	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXX-IS#QTAQ-TYDPR-EGYNPQPPDLSVVTLSRE 2871 \|\|\|\|\|\|\|\| \| \|\|#\|\|\|\| \|\|\|\| + ++\| \| \|\|+ +\|\|\|\|\| Sbjct 2800 KAMIAWEWLVEKAREGEEDRTEKKTKTRKIS#QTAQQTYDPMVQTFSPTPIDLTGLTLSRE 2859 Query 2872 LQA 2874 \|\|+ Sbjct 2860 LQS 2862
Hemicentrotus pulcherrimus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQ 2873 \|\|++\|\| \|+\| # + + \|\|\|\|+\| \|+\| +\|\|+\|\|+\| Sbjct 2985 KALLAWGWSVERSKASEQQSQAHRPRRLSK#ASLGAMESPHGYNPRPIDVSNITLTREMQ 3043
Canis familiaris	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \| \|+\|\| \| + \|\|#\|\|+\| + \| \|\|+\|+ \|+\| \|\|\|\|\|+\| Sbjct 2774 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQVSVDAAHGYSPRAIDMSNVTLSRDLH 2832 Query 2874 A 2874 \| Query 2874 A 2874
Pan troglodytes	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \| \|+\|\| \| + \|\|#\|\|+\| + \| \|\|+\|+ \|+\| \|\|\|\|\|+\| Sbjct 2826 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQVSVDAAHGYSPRAIDMSNVTLSRDLH 2884 Query 2874 A 2874 \| Query 2874 A 2874
Monodelphis domestica	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \| \|+\|\| \| + \|\|#\|\|+\| + \| \|\|+\|+ \|+\| \|\|\|\|\|+\| Sbjct 2850 KTMLAWGWRIERTREGDSMALYTRTRR-IS#QTSQVSIDTAHGYSPRAIDMSNVTLSRDLH 2908 Query 2874 A 2874 \| Query 2874 A 2874
Gallus gallus	Query 2815 KAMIAWEWTVXXXXXXXXXXXXXXXXXXIS#QTAQ-TYDPREGYNPQPPDLSVVTLSRELQ 2873 \| \|+\|\| \| + \|\|#\|\|+\| + \| \|\|+\|+ \|+\| \|\|\|\|\|++ Sbjct 614 KTMLAWGWRIERTREGDSMALYNRTRR-IS#QTSQISVDAAHGYSPRAIDMSNVTLSRDVH 672 Query 2874 A 2874 \| Query 2874 A 2874

[Site 2] FKAKKVAMMT¹⁴⁰¹-QPPSTPALPR

Thr¹⁴⁰¹ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Phe¹³⁹²	Lys¹³⁹³	Ala¹³⁹⁴	Lys¹³⁹⁵	Lys¹³⁹⁶	Val¹³⁹⁷	Ala¹³⁹⁸	Met¹³⁹⁹	Met¹⁴⁰⁰	Thr¹⁴⁰¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln¹⁴⁰²	Pro¹⁴⁰³	Pro¹⁴⁰⁴	Ser¹⁴⁰⁵	Thr¹⁴⁰⁶	Pro¹⁴⁰⁷	Ala¹⁴⁰⁸	Leu¹⁴⁰⁹	Pro¹⁴¹⁰	Arg¹⁴¹¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
ARAENEKDATTEKNKKRGFLFKAKKVAMMTQPPSTPALPRLPRDVVPADNRDDPEIILNT

Summary

#	organism	max score	hits	top seq
1	Mus musculus	123.00	2	ryanodine receptor 1, skeletal muscle
2	Rattus norvegicus	123.00	2	PREDICTED: similar to ryanodine receptor 1, skelet
3	Homo sapiens	119.00	6	skeletal muscle ryanodine receptor isoform 2
4	N/A	119.00	4	-
5	Oryctolagus cuniculus	117.00	1	RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t
6	Monodelphis domestica	112.00	1	PREDICTED: hypothetical protein
7	Sus scrofa	111.00	4	ryanodine receptor
8	Tetraodon nigroviridis	80.90	2	unnamed protein product
9	Danio rerio	78.20	2	PREDICTED: hypothetical protein, partial
10	Rana catesbeiana	77.40	1	ryanodine receptor alpha isoform
11	Prot=RyR1 isform from fish	65.90	1	-
12	Chloroflexus aurantiacus J-10-fl	35.80	1	Extensin-like protein
13	Tetrahymena thermophila SB210	34.70	1	hypothetical protein TTHERM_00473160
14	Trypanosoma brucei	34.30	1	hypothetical protein, conserved
15	Verminephrobacter eiseniae EF01-2	33.50	1	outer membrane protein

Top-ranked sequences

organism	matching
Mus musculus	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
Rattus norvegicus	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
Homo sapiens	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|+\|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
N/A	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|+\|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1369 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1428
Oryctolagus cuniculus	Query 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\|\|\|+\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPALPRLPHDVVPADNRDDPEIILNT 1430
Monodelphis domestica	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|+ \|\|\|+\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1298 ARAENEKDSATEKSKKRGFLFKAKKAAMMT#QAPATPALPRLPRDVVPADNRDDPEIILNT 1357
Sus scrofa	Query 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\|\|\|+\|\| \|\|\|\|\| +\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430
Tetraodon nigroviridis	Query 1375 ENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\|\|+\|\|\|+\|\|+\|\|\|\|\|\|\|\| \|++ # \|\| \| +\|\|\| \|\|\|\| \|+\|\|\| +\|\|\|\|\| Sbjct 1329 ENEKDASTEKSKKKGFLFKAKKAALIN#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1384
Danio rerio	Query 1375 ENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|+\|\| +\|\| \|\|+\|\|\|\|\|\|\|\| \|\|+\|# \|\| \| +\|\|\| \|\|\|\| \|+\|\|\| +\|\|\|\|\| Sbjct 355 ENDKDTASEKGKKKGFLFKAKKAAMIT#PPPPPPLMPRLIEDVVP-DDRDDVDIILNT 410
Rana catesbeiana	Query 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 + \|\|\|\|\| \|\|\|\| \|\|\|\|\|\|\|\| \|\| \| ++# \| \| +\|\|\| ++\|\|\| \|+\|\|\|\|\|\|\| \|\| Sbjct 1362 KPENEKDTTTEKTKKRGFLFKPKKPAFIS#TTPVVPTMPRLMKEVVP-DDRDDPEIIRNT 1419
Prot=RyR1 isform from fish	Query 1375 ENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431 \|\|\|\|\| \| ++\| \|\|\|\|\|\|\| \|++\|# \|\| \| +\|\|\| \|\|\|\| \|+\|\|\| +\|\|\|\|\| Sbjct 1368 ENEKDPQQRKQEER-FLFKAKKPALIT#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1422
Chloroflexus aurantiacus J-10-fl	Query 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIIL 1429 \|+\| \|\| + + \| ++\| #+\|\| \|\|+\| \| \| \|\| + \| \| \|\| Sbjct 861 RSERSADAQRGRYNRPGGRHSGRRVPDQP#EPPEAPAVPEPPTDDSPAASVPDAEAIL 917
Tetrahymena thermophila SB210	Query 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPR-DVVPADNRDDPEIILN 1430 +++\|+ \| + ++++ \| \|+\|\|++\|+ # \|\| \|+ \| + \| + + ++ \| ++\| Sbjct 297 SKSEDSNDQSPQESRNRSFIFKSEKILNQL#GLPSAPSSPTAEKQDEILDSSENNEEKLIN 356 Query 1431 T 1431 \| Query 1431 T 1431
Trypanosoma brucei	Query 1392 FKAKKVAMMT#QPPSTPA-LPRLPRDVVPAD 1420 +\| +++ +\|\|# +\|\|\| \|\|\|\|\|\|\|++ +\| Sbjct 42 YKLRRIVLMT#HMAATPATLPRLPRDIIVSD 71
Verminephrobacter eiseniae EF01-2	Query 1392 FKAKKVAMMT#QPPSTPALPRLPRDVVPADNRD 1423 \| \|+ \| +\|#\|\|\| \|\| \| \| \| \|+\|\| Sbjct 637 FAARAVTNLT#QPPVAPATPEAPGAGAPDDDRD 668

* References

[PubMed ID: 19246389] Andronache Z, Hamilton SL, Dirksen RT, Melzer W, A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4531-6. Epub 2009 Feb 25.

» More (9) « Hide Below

[PubMed ID: 19131108] ... Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF, Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. Cell Calcium. 2009 Mar;45(3):264-74. Epub 2009 Jan 7.

[PubMed ID: 18663468] ... Li XQ, Zheng YM, Rathore R, Ma J, Takeshima H, Wang YX, Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009 Feb;457(4):771-83. Epub 2008 Jul 29.

[PubMed ID: 18927079] ... Vukcevic M, Spagnoli GC, Iezzi G, Zorzato F, Treves S, Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression. J Biol Chem. 2008 Dec 12;283(50):34913-22. Epub 2008 Oct 16.

[PubMed ID: 18650434] ... Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ, S100A1 and calmodulin compete for the same binding site on ryanodine receptor. J Biol Chem. 2008 Sep 26;283(39):26676-83. Epub 2008 Jul 23.

[PubMed ID: 1315127] ... Chowdhary BP, Harbitz I, Davies W, Gustavsson I, Localization of the calcium release channel gene in cattle and horse by in situ hybridization: evidence of a conserved synteny with glucose phosphate isomerase. Anim Genet. 1992;23(1):43-50.

[PubMed ID: 1774073] ... Otsu K, Khanna VK, Archibald AL, MacLennan DH, Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families. Genomics. 1991 Nov;11(3):744-50.

[PubMed ID: 1970795] ... Cavanna JS, Greenfield AJ, Johnson KJ, Marks AR, Nadal-Ginard B, Brown SD, Establishment of the mouse chromosome 7 region with homology to the myotonic dystrophy region of human chromosome 19q. Genomics. 1990 May;7(1):12-8.

[PubMed ID: 2300206] ... McCarthy TV, Healy JM, Heffron JJ, Lehane M, Deufel T, Lehmann-Horn F, Farrall M, Johnson K, Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2. Nature. 1990 Feb 8;343(6258):562-4.

[PubMed ID: 1967823] ... MacLennan DH, Duff C, Zorzato F, Fujii J, Phillips M, Korneluk RG, Frodis W, Britt BA, Worton RG, Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. Nature. 1990 Feb 8;343(6258):559-61.