XSB1616 : skeletal muscle ryanodine receptor
[ CaMP Format ]
This entry is computationally expanded from SB0015
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle-type ryanodine receptor; Skeletal muscle calcium release channel |
| Gene Names | RYR1; RYDR |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| AAC51191 |
N/A |
N/A |
P21817 |
N/A |
N/A |
N/A |
hsa:6261 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 5038 aa
Average Mass: 565.176 kDa
Monoisotopic Mass: 564.815 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Ins145_P3_rec 1. | 8 | 210 | 360.1 | 4.1e-105 |
| MIR 1. | 211 | 390 | 265.5 | 1.2e-76 |
| RYDR_ITPR 1. | 439 | 643 | 328.4 | 1.4e-95 |
| SPRY 1. | 658 | 796 | 137.6 | 3.9e-38 |
| RyR 1. | 849 | 943 | 222.5 | 1.1e-63 |
| RyR 2. | 963 | 1057 | 211.0 | 3.1e-60 |
| SPRY 2. | 1084 | 1207 | 162.1 | 1.7e-45 |
| CsbD 1. | 1342 | 1381 | -23.7 | 7.6 |
| --- cleavage 1399 --- |
| SPRY 3. | 1429 | 1569 | 144.3 | 3.8e-40 |
| DUF2164 1. | 1929 | 1975 | -42.7 | 4.5 |
| RYDR_ITPR 2. | 2157 | 2365 | 308.3 | 1.6e-89 |
| RyR 3. | 2734 | 2828 | 217.2 | 4.2e-62 |
| --- cleavage 2843 --- |
| RyR 4. | 2854 | 2942 | 184.7 | 2.7e-52 |
| Exonuc_VII_S 1. | 3096 | 3125 | -27.5 | 6.7 |
| Transposase_12 1. | 3326 | 3386 | -56.9 | 4 |
| DUF1081 1. | 3505 | 3594 | -32.0 | 3.7 |
| Peptidase_C41 1. | 3626 | 3779 | -35.6 | 2.3 |
| HTH_DeoR 1. | 3812 | 3861 | -17.5 | 5.4 |
| RIH_assoc 1. | 3870 | 4003 | 326.0 | 7.8e-95 |
| CHCH 1. | 4098 | 4137 | -5.8 | 7.5 |
| Hpt 1. | 4231 | 4323 | -10.0 | 7.5 |
| RR_TM4-6 1. | 4382 | 4671 | 427.1 | 2.7e-125 |
| Ion_trans 1. | 4762 | 4937 | 36.2 | 1.4e-07 |
| zf-C2H2 1. | 4957 | 4984 | 2.3 | 6.9 |
3. Sequence Information
Fasta Sequence: XSB1616.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] TEKKKTRKIS2843-QSAQTYDPRE
Ser2843 
Gln
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Thr2834 | Glu2835 | Lys2836 | Lys2837 | Lys2838 | Thr2839 | Arg2840 | Lys2841 | Ile2842 | Ser2843 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gln2844 | Ser2845 | Ala2846 | Gln2847 | Thr2848 | Tyr2849 | Asp2850 | Pro2851 | Arg2852 | Glu2853 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
KAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQA
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
83.20 |
11 |
skeletal muscle ryanodine receptor isoform 1 |
| 2 |
N/A |
83.20 |
6 |
- |
| 3 |
Oryctolagus cuniculus |
80.50 |
2 |
RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t |
| 4 |
Mus musculus |
80.10 |
4 |
ryanodine receptor |
| 5 |
Rattus norvegicus |
80.10 |
2 |
PREDICTED: similar to ryanodine receptor 1, skelet |
| 6 |
Sus scrofa |
78.60 |
4 |
ryanodine receptor |
| 7 |
Bos taurus |
66.60 |
2 |
PREDICTED: similar to Ryanodine receptor 1 (Skelet |
| 8 |
Danio rerio |
62.00 |
2 |
PREDICTED: similar to ryanodine receptor RyR1 |
| 9 |
Tetraodon nigroviridis |
59.30 |
3 |
unnamed protein product |
| 10 |
Macaca mulatta |
57.80 |
1 |
PREDICTED: similar to ryanodine receptor 1 (skelet |
| 11 |
Prot=RyR1 isform from fish |
57.40 |
1 |
- |
| 12 |
Rana catesbeiana |
44.30 |
1 |
ryanodine receptor alpha isoform |
| 13 |
Hemicentrotus pulcherrimus |
38.90 |
1 |
ryanodine receptor |
| 14 |
Pan troglodytes |
36.60 |
1 |
PREDICTED: cardiac muscle ryanodine receptor |
| 15 |
Canis familiaris |
36.60 |
1 |
PREDICTED: similar to Ryanodine receptor 2 (Cardia |
| 16 |
Monodelphis domestica |
36.60 |
1 |
PREDICTED: similar to cardiac muscle ryanodine rec |
| 17 |
Gallus gallus |
35.00 |
1 |
PREDICTED: similar to cardiac muscle ryanodine rec |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||| ||#||||||||||||||||||||||||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|
| N/A |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||| ||#||||||||||||||||||||||||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|
| Oryctolagus cuniculus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||| ||#|+|||||||||||||||||| |||||||||
Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
|
| Mus musculus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||+ ||#|+|||||||||||||||||| |||||||||
Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
|
| Rattus norvegicus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||+ ||#|+|||||||||||||||||| |||||||||
Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
|
| Sus scrofa |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
|||||||||| ||#||||||| |||||||||||| |||||||||
Sbjct 2815 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874
|
| Bos taurus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVT 2866
|||||||||| ||#||||||| |||||||||||| ||
Sbjct 966 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVT 1018
|
| Danio rerio |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDPREGYNPQPPDLSAVTLSRELQ 2872
|||||||||+ ||#|+|| |||| ||+||| |+| +|||||||
Sbjct 2852 KAMIAWEWTLDKARDGEDEKVEKKTARKIS#QTAQATYDPSHGYSPQPIDISGMTLSRELQ 2911
Query 2873 A 2873
+
Sbjct 2912 S 2912
|
| Tetraodon nigroviridis |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDPREGYNPQPPDLSAVTLSRELQ 2872
|||+|||||+ ||#|+|| |||| ||+||| |+| + ||||||
Sbjct 2341 KAMLAWEWTLEKARDGEGEVEKKAATRKIS#QTAQATYDPSHGYSPQPIDISGMALSRELQ 2400
Query 2873 A 2873
+
Sbjct 2401 S 2401
|
| Macaca mulatta |
Query 2845 SAQTYDPREGYNPQPPDLSAVTLSRELQ 2872
| +|||||||||||||||||||||||||
Sbjct 818 SEKTYDPREGYNPQPPDLSAVTLSRELQ 845
|
| Prot=RyR1 isform from fish |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDPREGYNPQPPDLSAVTLSRELQ 2872
|||+|||| | ||#|+|| |||| ||+||| |+| | |||+||
Sbjct 2853 KAMLAWEWNIEKAREEEESEKKKATSRKIS#QTAQATYDPSHGYSPQPIDISHVALSRDLQ 2912
Query 2873 A 2873
+
Sbjct 2913 S 2913
|
| Rana catesbeiana |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXX-IS#QSAQ-TYDPR-EGYNPQPPDLSAVTLSRE 2870
|||||||| + ||#|+|| |||| + ++| | ||+ +|||||
Sbjct 2800 KAMIAWEWLVEKAREGEEDRTEKKTKTRKIS#QTAQQTYDPMVQTFSPTPIDLTGLTLSRE 2859
Query 2871 LQA 2873
||+
Sbjct 2860 LQS 2862
|
| Hemicentrotus pulcherrimus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQ 2872
||++|| |++ # | + ||||+| |+| +||+||+|
Sbjct 2985 KALLAWGWSVERSKASEQQSQAHRPRRLSK#ASLGAMESPHGYNPRPIDVSNITLTREMQ 3043
|
| Pan troglodytes |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
| |+|| | | # | + | ||+|+ |+| |||||+| |
Sbjct 2826 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQVSVDAAHGYSPRAIDMSNVTLSRDLHA 2885
|
| Canis familiaris |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
| |+|| | | # | + | ||+|+ |+| |||||+| |
Sbjct 2774 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQVSVDAAHGYSPRAIDMSNVTLSRDLHA 2833
|
| Monodelphis domestica |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
| |+|| | | # | + | ||+|+ |+| |||||+| |
Sbjct 2850 KTMLAWGWRIERTREGDSMALYTRTRRISQ#TSQVSIDTAHGYSPRAIDMSNVTLSRDLHA 2909
|
| Gallus gallus |
Query 2814 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
| |+|| | | # | + | ||+|+ |+| |||||++ |
Sbjct 614 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQISVDAAHGYSPRAIDMSNVTLSRDVHA 673
|
[Site 2] FKAKKVAMMT1399-QPPATPTLPR
Thr1399 Gln
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Phe1390 | Lys1391 | Ala1392 | Lys1393 | Lys1394 | Val1395 | Ala1396 | Met1397 | Met1398 | Thr1399 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gln1400 | Pro1401 | Pro1402 | Ala1403 | Thr1404 | Pro1405 | Thr1406 | Leu1407 | Pro1408 | Arg1409 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
ARAENEKDATTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNT
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
125.00 |
6 |
skeletal muscle ryanodine receptor isoform 1 |
| 2 |
N/A |
125.00 |
4 |
- |
| 3 |
Oryctolagus cuniculus |
120.00 |
1 |
RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t |
| 4 |
Mus musculus |
119.00 |
2 |
ryanodine receptor 1, skeletal muscle |
| 5 |
Rattus norvegicus |
119.00 |
2 |
PREDICTED: similar to ryanodine receptor 1, skelet |
| 6 |
Sus scrofa |
117.00 |
4 |
ryanodine receptor |
| 7 |
Monodelphis domestica |
110.00 |
1 |
PREDICTED: hypothetical protein |
| 8 |
Tetraodon nigroviridis |
83.60 |
2 |
unnamed protein product |
| 9 |
Rana catesbeiana |
79.00 |
1 |
ryanodine receptor alpha isoform |
| 10 |
Danio rerio |
78.60 |
2 |
PREDICTED: similar to ryanodine receptor RyR1 |
| 11 |
Prot=RyR1 isform from fish |
68.60 |
1 |
- |
| 12 |
Trypanosoma brucei |
33.90 |
1 |
hypothetical protein, conserved |
| 13 |
Chloroflexus aurantiacus J-10-fl |
33.50 |
1 |
Extensin-like protein |
| 14 |
Caenorhabditis briggsae |
33.50 |
1 |
Hypothetical protein CBG05716 |
| 15 |
Verminephrobacter eiseniae EF01-2 |
32.70 |
1 |
outer membrane protein |
| 16 |
Tetrahymena thermophila SB210 |
32.70 |
1 |
hypothetical protein TTHERM_00473160 |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
|
| N/A |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
|
| Oryctolagus cuniculus |
Query 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
|||||||||||||||||||||||| ||||#|||||| |||||||||||||||||||||||
Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPALPRLPHDVVPADNRDDPEIILNT 1430
|
| Mus musculus |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||||||||||||||||||||||||||#|||+|| ||||| |||||||||||||||||
Sbjct 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
|
| Rattus norvegicus |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||||||||||||||||||||||||||#|||+|| ||||| |||||||||||||||||
Sbjct 1372 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
|
| Sus scrofa |
Query 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
|||||||||||||||||||||||| ||||#|||||||||||||+|||||+||||+|||||
Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430
|
| Monodelphis domestica |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||||+ |||+||||||||||| ||||#| |||| ||||| |||||||||||||||||
Sbjct 1298 ARAENEKDSATEKSKKRGFLFKAKKAAMMT#QAPATPALPRLPRDVVPADNRDDPEIILNT 1357
|
| Tetraodon nigroviridis |
Query 1373 ENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||||+|||+||+|||||||| |++ # || ||+||| |||| |+||| +|||||
Sbjct 1329 ENEKDASTEKSKKKGFLFKAKKAALIN#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1384
|
| Rana catesbeiana |
Query 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
+ ||||| |||| |||||||| || | ++# | ||+||| +||| |+||||||| ||
Sbjct 1362 KPENEKDTTTEKTKKRGFLFKPKKPAFIS#TTPVVPTMPRLMKEVVP-DDRDDPEIIRNT 1419
|
| Danio rerio |
Query 1372 AENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
+||||| ||||+||||| |||| | + # || ||+||| |||| |+||| ||| ||
Sbjct 1369 SENEKDTTTEKSKKRGFFSKAKKAAFIA#PPPVVPTMPRLMEDVVP-DDRDDVEIISNT 1425
|
| Prot=RyR1 isform from fish |
Query 1373 ENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
||||| | ++| ||||||| |++|# || ||+||| |||| |+||| +|||||
Sbjct 1368 ENEKDPQQRKQEER-FLFKAKKPALIT#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1422
|
| Trypanosoma brucei |
Query 1390 FKAKKVAMMT#QPPATP-TLPRLPHDVVPAD 1418
+| +++ +||# ||| |||||| |++ +|
Sbjct 42 YKLRRIVLMT#HMAATPATLPRLPRDIIVSD 71
|
| Chloroflexus aurantiacus J-10-fl |
Query 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIIL 1427
|+| || + + | ++| #+|| | +| | | || + | | ||
Sbjct 861 RSERSADAQRGRYNRPGGRHSGRRVPDQP#EPPEAPAVPEPPTDDSPAASVPDAEAIL 917
|
| Caenorhabditis briggsae |
Query 1374 NEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRL 1410
| | | ||++|| +|+ ||| #+| ||| + |
Sbjct 476 NSKRETVTKNEERGVIFELKKVLSDQ#KPSATPEVKGL 512
|
| Verminephrobacter eiseniae EF01-2 |
Query 1390 FKAKKVAMMT#QPPATPTLPRLPHDVVPADNRD 1421
| |+ | +|#||| | | | | |+||
Sbjct 637 FAARAVTNLT#QPPVAPATPEAPGAGAPDDDRD 668
|
| Tetrahymena thermophila SB210 |
Query 1370 ARAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRL-PHDVVPADNRDDPEIILN 1428
+++|+ | + ++++ | |+||++|+ # |+ |+ | | + + ++ | ++|
Sbjct 297 SKSEDSNDQSPQESRNRSFIFKSEKILNQL#GLPSAPSSPTAEKQDEILDSSENNEEKLIN 356
Query 1429 T 1429
|
Query 1429 T 1429
|
* References
[PubMed ID: 8661021] Phillips MS, Fujii J, Khanna VK, DeLeon S, Yokobata K, de Jong PJ, MacLennan DH, The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene. Genomics. 1996 May 15;34(1):24-41.
