CaMPDB :: Substrate

XSB1617 : ryanodine receptor [Sus scrofa]

This entry is computationally expanded from SB0015

* Basic Information

Organism	Sus scrofa (pig)
Protein Names	ryanodine receptor; calcium release channel; halothane; porcine stress syndrome
Gene Names	RYR1; ryanodine receptor 1
Gene Locus	chromosome 6; chromosome 6
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_001001534	NM_001001534	396718	Q29105	N/A	N/A	N/A	ssc:396718

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 5035 aa

Average Mass: 565.157 kDa

Monoisotopic Mass: 564.796 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Ins145_P3_rec 1.	9	211	356.6	4.6e-104
MIR 1.	212	391	270.7	3.4e-78
RYDR_ITPR 1.	440	644	332.9	6.3e-97
SPRY 1.	659	797	135.5	1.7e-37
RyR 1.	850	944	222.5	1.1e-63
RyR 2.	964	1058	212.3	1.3e-60
SPRY 2.	1085	1208	160.5	4.9e-45
--- cleavage 1400 ---
SPRY 3.	1430	1570	153.8	5.2e-43
RNA_polI_A34 1.	1771	1926	-77.2	5.7
RIIa 1.	1938	1975	-8.8	6.8
PRA-PH 1.	2054	2127	-46.8	2.8
RYDR_ITPR 2.	2158	2366	306.7	5e-89
RyR 3.	2735	2829	217.2	4.2e-62
--- cleavage 2844 ---
RyR 4.	2855	2943	184.4	3.2e-52
Hpt 1.	3091	3165	-9.0	6
Transposase_12 1.	3327	3387	-55.4	2.9
XPA_C 1.	3524	3569	-8.6	9.7
GvpG 1.	3694	3770	-24.4	3.6
HTH_DeoR 1.	3808	3857	-17.5	5.4
RIH_assoc 1.	3866	3999	326.0	7.8e-95
CHCH 1.	4094	4133	-5.0	6.1
HR1 1.	4183	4256	-14.8	4.7
CoatB 1.	4266	4313	-9.1	7.3
RR_TM4-6 1.	4378	4668	417.9	1.6e-122
Ion_trans 1.	4759	4934	36.2	1.4e-07
zf-C2H2 1.	4954	4981	2.3	6.9

3. Sequence Information

Fasta Sequence: XSB1617.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] TEKKKTRKIS²⁸⁴⁴-QSAQTYDARE

Ser²⁸⁴⁴ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Thr²⁸³⁵	Glu²⁸³⁶	Lys²⁸³⁷	Lys²⁸³⁸	Lys²⁸³⁹	Thr²⁸⁴⁰	Arg²⁸⁴¹	Lys²⁸⁴²	Ile²⁸⁴³	Ser²⁸⁴⁴

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln²⁸⁴⁵	Ser²⁸⁴⁶	Ala²⁸⁴⁷	Gln²⁸⁴⁸	Thr²⁸⁴⁹	Tyr²⁸⁵⁰	Asp²⁸⁵¹	Ala²⁸⁵²	Arg²⁸⁵³	Glu²⁸⁵⁴

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
KAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDAREGYNPQPPDLSGVTLSRELQA

Summary

#	organism	max score	hits	top seq
1	N/A	82.80	6	R
2	Sus scrofa	82.80	4	ryanodine receptor
3	Oryctolagus cuniculus	79.70	2	RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t
4	Homo sapiens	78.60	12	skeletal muscle ryanodine receptor isoform 2
5	Mus musculus	75.90	4	ryanodine receptor 1, skeletal muscle
6	Rattus norvegicus	75.90	2	PREDICTED: similar to ryanodine receptor 1, skelet
7	Bos taurus	70.90	2	PREDICTED: similar to Ryanodine receptor 1 (Skelet
8	Danio rerio	61.20	2	PREDICTED: similar to ryanodine receptor RyR1
9	Tetraodon nigroviridis	58.50	3	unnamed protein product
10	Prot=RyR1 isform from fish	54.30	1	-
11	Macaca mulatta	53.10	1	PREDICTED: similar to ryanodine receptor 1 (skelet
12	Rana catesbeiana	43.50	1	ryanodine receptor alpha isoform
13	Hemicentrotus pulcherrimus	40.40	1	ryanodine receptor
14	Pan troglodytes	39.30	1	PREDICTED: cardiac muscle ryanodine receptor
15	Canis familiaris	39.30	1	PREDICTED: similar to Ryanodine receptor 2 (Cardia
16	Monodelphis domestica	37.70	1	PREDICTED: similar to cardiac muscle ryanodine rec
17	Gallus gallus	37.70	1	PREDICTED: similar to cardiac muscle ryanodine rec
18	Strongylocentrotus purpuratus	32.70	1	PREDICTED: similar to ryanodine receptor, partial

Top-ranked sequences

organism	matching
N/A	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874
Sus scrofa	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874
Oryctolagus cuniculus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2814 KAMIAWEWTIEKAREGEEERTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSGVTLSRELQA 2873
Homo sapiens	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2814 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDPREGYNPQPPDLSAVTLSRELQA 2873
Mus musculus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
Rattus norvegicus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKIS#QTAQTYDPREGYNPQPPDLSVVTLSRELQA 2874
Bos taurus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVT 2867 \|\|\|\|\|\|\|\|\|\| \|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 966 KAMIAWEWTIEKAREGEEEKTEKKKTRKIS#QSAQTYDAREGYNPQPPDLSGVT 1018
Danio rerio	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDAREGYNPQPPDLSGVTLSRELQ 2873 \|\|\|\|\|\|\|\|\|+ \|\|#\|+\|\| \|\|\| \|\|+\|\|\| \|+\|\|+\|\|\|\|\|\|\| Sbjct 2852 KAMIAWEWTLDKARDGEDEKVEKKTARKIS#QTAQATYDPSHGYSPQPIDISGMTLSRELQ 2911 Query 2874 A 2874 + Sbjct 2912 S 2912
Tetraodon nigroviridis	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDAREGYNPQPPDLSGVTLSRELQ 2873 \|\|\|+\|\|\|\|\|+ \|\|#\|+\|\| \|\|\| \|\|+\|\|\| \|+\|\|+ \|\|\|\|\|\| Sbjct 2341 KAMLAWEWTLEKARDGEGEVEKKAATRKIS#QTAQATYDPSHGYSPQPIDISGMALSRELQ 2400 Query 2874 A 2874 + Sbjct 2401 S 2401
Prot=RyR1 isform from fish	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQ-TYDAREGYNPQPPDLSGVTLSRELQ 2873 \|\|\|+\|\|\|\| \| \|\|#\|+\|\| \|\|\| \|\|+\|\|\| \|+\| \| \|\|\|+\|\| Sbjct 2853 KAMLAWEWNIEKAREEEESEKKKATSRKIS#QTAQATYDPSHGYSPQPIDISHVALSRDLQ 2912 Query 2874 A 2874 + Sbjct 2913 S 2913
Macaca mulatta	Query 2846 SAQTYDAREGYNPQPPDLSGVTLSRELQ 2873 \| +\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\| Sbjct 818 SEKTYDPREGYNPQPPDLSAVTLSRELQ 845
Rana catesbeiana	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXX-IS#QSAQ-TYDAR-EGYNPQPPDLSGVTLSRE 2871 \|\|\|\|\|\|\|\| + \|\|#\|+\|\| \|\|\| + ++\| \| \|\|+\|+\|\|\|\|\| Sbjct 2800 KAMIAWEWLVEKAREGEEDRTEKKTKTRKIS#QTAQQTYDPMVQTFSPTPIDLTGLTLSRE 2859 Query 2872 LQA 2874 \|\|+ Sbjct 2860 LQS 2862
Hemicentrotus pulcherrimus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQ 2873 \|\|++\|\| \|++ # \| ++ \|\|\|\|+\| \|+\| +\|\|+\|\|+\| Sbjct 2985 KALLAWGWSVERSKASEQQSQAHRPRRLSK#ASLGAMESPHGYNPRPIDVSNITLTREMQ 3043
Pan troglodytes	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \| \|+\|\| \| \| # \| + \|\| \|\|+\|+ \|+\| \|\|\|\|\|+\| \| Sbjct 2826 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQVSVDAAHGYSPRAIDMSNVTLSRDLHA 2885
Canis familiaris	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \| \|+\|\| \| \| # \| + \|\| \|\|+\|+ \|+\| \|\|\|\|\|+\| \| Sbjct 2774 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQVSVDAAHGYSPRAIDMSNVTLSRDLHA 2833
Monodelphis domestica	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \| \|+\|\| \| \| # \| + \| \|\|+\|+ \|+\| \|\|\|\|\|+\| \| Sbjct 2850 KTMLAWGWRIERTREGDSMALYTRTRRISQ#TSQVSIDTAHGYSPRAIDMSNVTLSRDLHA 2909
Gallus gallus	Query 2815 KAMIAWEWTIXXXXXXXXXXXXXXXXXXIS#QSAQTYDAREGYNPQPPDLSGVTLSRELQA 2874 \| \|+\|\| \| \| # \| + \|\| \|\|+\|+ \|+\| \|\|\|\|\|++ \| Sbjct 614 KTMLAWGWRIERTREGDSMALYNRTRRISQ#TSQISVDAAHGYSPRAIDMSNVTLSRDVHA 673
Strongylocentrotus purpuratus	Query 2851 DAREGYNPQPPDLSGVTLSRELQ 2873 ++ \|\|\|\|+\| \|+\| +\|\|+\|\|+\| Sbjct 4 ESPHGYNPRPIDVSNITLTREMQ 26

[Site 2] FKAKKAAMMT¹⁴⁰⁰-QPPATPTLPR

Thr¹⁴⁰⁰ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Phe¹³⁹¹	Lys¹³⁹²	Ala¹³⁹³	Lys¹³⁹⁴	Lys¹³⁹⁵	Ala¹³⁹⁶	Ala¹³⁹⁷	Met¹³⁹⁸	Met¹³⁹⁹	Thr¹⁴⁰⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln¹⁴⁰¹	Pro¹⁴⁰²	Pro¹⁴⁰³	Ala¹⁴⁰⁴	Thr¹⁴⁰⁵	Pro¹⁴⁰⁶	Thr¹⁴⁰⁷	Leu¹⁴⁰⁸	Pro¹⁴⁰⁹	Arg¹⁴¹⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
PRAENEKDATTEKNKKRGFLFKAKKAAMMTQPPATPTLPRLPHEVVPADDRDDPDIILNT

Summary

#	organism	max score	hits	top seq
1	N/A	126.00	4	R
2	Sus scrofa	126.00	4	ryanodine receptor
3	Homo sapiens	117.00	6	skeletal muscle ryanodine receptor isoform 2
4	Oryctolagus cuniculus	117.00	1	RYR1_RABIT Ryanodine receptor 1 (Skeletal muscle-t
5	Rattus norvegicus	111.00	2	PREDICTED: similar to ryanodine receptor 1, skelet
6	Mus musculus	111.00	2	ryanodine receptor 1, skeletal muscle
7	Monodelphis domestica	105.00	1	PREDICTED: hypothetical protein
8	Tetraodon nigroviridis	87.00	2	unnamed protein product
9	Rana catesbeiana	84.00	1	ryanodine receptor alpha isoform
10	Danio rerio	81.60	2	PREDICTED: hypothetical protein, partial
11	Prot=RyR1 isform from fish	70.90	1	-
12	Verminephrobacter eiseniae EF01-2	33.50	1	outer membrane protein
13	Ashbya gossypii ATCC 10895	32.30	1	AFR489Wp

Top-ranked sequences

organism	matching
N/A	Query 1371 PRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1371 PRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430
Sus scrofa	Query 1371 PRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1371 PRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430
Homo sapiens	Query 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1371 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPATPTLPRLPHDVVPADNRDDPEIILNT 1429
Oryctolagus cuniculus	Query 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\| \|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPALPRLPHDVVPADNRDDPEIILNT 1430
Rattus norvegicus	Query 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\|\|\|+\|\| \|\|\|\|\| +\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
Mus musculus	Query 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\|\|\|+\|\| \|\|\|\|\| +\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1373 RAENEKDATTEKNKKRGFLFKAKKVAMMT#QPPSTPALPRLPRDVVPADNRDDPEIILNT 1431
Monodelphis domestica	Query 1372 RAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|\|+ \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\| \|\|\|\| \|\|\|\|\| +\|\|\|\|\|+\|\|\|\|+\|\|\|\|\| Sbjct 1299 RAENEKDSATEKSKKRGFLFKAKKAAMMT#QAPATPALPRLPRDVVPADNRDDPEIILNT 1357
Tetraodon nigroviridis	Query 1374 ENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\|\|+\|\|\|+\|\|+\|\|\|\|\|\|\|\|\|\|++ # \|\| \|\|+\|\|\| +\|\|\| \|\|\|\|\| \|\|\|\|\|\| Sbjct 1329 ENEKDASTEKSKKKGFLFKAKKAALIN#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1384
Rana catesbeiana	Query 1371 PRAENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|+ \|\|\|\|\| \|\|\|\| \|\|\|\|\|\|\|\| \|\| \| ++# \| \|\|+\|\|\| \|\|\|\| \|\|\|\|\|\|+\|\| \|\| Sbjct 1361 PKPENEKDTTTEKTKKRGFLFKPKKPAFIS#TTPVVPTMPRLMKEVVP-DDRDDPEIIRNT 1419
Danio rerio	Query 1374 ENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|+\|\| +\|\| \|\|+\|\|\|\|\|\|\|\|\|\|\|+\|# \|\| \| +\|\|\| +\|\|\| \|\|\|\|\| \|\|\|\|\|\| Sbjct 355 ENDKDTASEKGKKKGFLFKAKKAAMIT#PPPPPPLMPRLIEDVVP-DDRDDVDIILNT 410
Prot=RyR1 isform from fish	Query 1374 ENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|\|\|\|\| \| ++\| \|\|\|\|\|\|\| \|++\|# \|\| \|\|+\|\|\| +\|\|\| \|\|\|\|\| \|\|\|\|\|\| Sbjct 1368 ENEKDPQQRKQEER-FLFKAKKPALIT#PPPVVPTMPRLVEDVVP-DDRDDVDIILNT 1422
Verminephrobacter eiseniae EF01-2	Query 1391 FKAKKAAMMT#QPPATPTLPRLPHEVVPADDRD 1422 \| \|+ +\|#\|\|\| \| \| \| \| \|\|\|\| Sbjct 637 FAARAVTNLT#QPPVAPATPEAPGAGAPDDDRD 668
Ashbya gossypii ATCC 10895	Query 1374 ENEKDATTEKNKKRGFLFKAKKAAMMT#QPPATPTLPRLPHEVVPADDRDDPDIILNT 1430 \|+\|+\| \|++ \|+\| \| \| \|+\|\| \| # \| \| \|+ \|\|\| \| ++\|+ Sbjct 619 EDEEDRKTQELKRRRLLRKKKEAAAMV#PSPIQAT---DSDEITVADDESDAVSMVNS 672

* References

[PubMed ID: 19332786] Cornea RL, Nitu F, Gruber S, Kohler K, Satzer M, Thomas DD, Fruen BR, FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6128-33. Epub 2009 Mar 30.

» More (9) « Hide Below

[PubMed ID: 18505726] ... Jiang D, Chen W, Xiao J, Wang R, Kong H, Jones PP, Zhang L, Fruen B, Chen SR, Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. J Biol Chem. 2008 Jul 25;283(30):20813-20. Epub 2008 May 27.

[PubMed ID: 17023049] ... Ta TA, Pessah IN, Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). Neurotoxicology. 2007 Jul;28(4):770-9. Epub 2006 Aug 30.

[PubMed ID: 17202397] ... Shen QW, Underwood KR, Means WJ, McCormick RJ, Du M, The halothane gene, energy metabolism, adenosine monophosphate-activated protein kinase, and glycolysis in postmortem pig longissimus dorsi muscle. J Anim Sci. 2007 Apr;85(4):1054-61. Epub 2007 Jan 3.

[PubMed ID: 17107340] ... Murayama T, Oba T, Hara H, Wakebe K, Ikemoto N, Ogawa Y, Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia. Biochem J. 2007 Mar 1;402(2):349-57.

[PubMed ID: 7989322] ... Ledbetter MW, Preiner JK, Louis CF, Mickelson JR, Tissue distribution of ryanodine receptor isoforms and alleles determined by reverse transcription polymerase chain reaction. J Biol Chem. 1994 Dec 16;269(50):31544-51.

[PubMed ID: 1312025] ... Brenig B, Brem G, Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1). FEBS Lett. 1992 Feb 24;298(2-3):277-9.

[PubMed ID: 1329581] ... Harbitz I, Kristensen T, Bosnes M, Kran S, Davies W, DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg615----Cys615 mutation, associated with porcine malignant hyperthermia, in Norwegian landrace pigs. Anim Genet. 1992;23(5):395-402.

[PubMed ID: 1862346] ... Fujii J, Otsu K, Zorzato F, de Leon S, Khanna VK, Weiler JE, O'Brien PJ, MacLennan DH, Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science. 1991 Jul 26;253(5018):448-51.

[PubMed ID: 2174405] ... Harbitz I, Chowdhary B, Thomsen PD, Davies W, Kaufmann U, Kran S, Gustavsson I, Christensen K, Hauge JG, Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11----q21 segment of chromosome 6. Genomics. 1990 Oct;8(2):243-8.