XSB1624 : crystallin, beta B2 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0082
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp; crystallin; beta B2; betaB2-crystallin; Philly cataract |
| Gene Names | Crybb2; crystallin, beta B2 |
| Gene Locus | 5 60.0 cM; chromosome 5 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 205 aa
Average Mass: 23.381 kDa
Monoisotopic Mass: 23.366 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 8 --- | ||||
| Crystall 1. | 18 | 100 | 162.2 | 1.5e-45 |
| Crystall 2. | 108 | 190 | 162.0 | 1.8e-45 |
3. Sequence Information
Fasta Sequence: XSB1624.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1E7N (X-ray; 235 A; A/B=2-107)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] MASDHQTQ8-AGKPQPLNPK
Gln8 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| - | - | Met1 | Ala2 | Ser3 | Asp4 | His5 | Gln6 | Thr7 | Gln8 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala9 | Gly10 | Lys11 | Pro12 | Gln13 | Pro14 | Leu15 | Asn16 | Pro17 | Lys18 |
Sequence conservation (by blast)
* References
[PubMed ID: 18719080] Zhang J, Li J, Huang C, Xue L, Peng Y, Fu Q, Gao L, Zhang J, Li W, Targeted knockout of the mouse betaB2-crystallin gene (Crybb2) induces age-related cataract. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5476-83. Epub 2008 Aug 21.