XSB1632 : filamin A, alpha (actin binding protein 280), isoform CRA_a [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0090
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | filamin A; alpha (actin binding protein 280); isoform CRA_a |
| Gene Names | FLNA |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2337 aa
Average Mass: 248.505 kDa
Monoisotopic Mass: 248.350 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 44 | 149 | 108.9 | 1.7e-29 |
| CH 2. | 167 | 269 | 99.6 | 1.1e-26 |
| Filamin 1. | 278 | 371 | 120.4 | 5.9e-33 |
| Filamin 2. | 378 | 471 | 128.7 | 1.9e-35 |
| Filamin 3. | 477 | 567 | 133.3 | 7.9e-37 |
| Filamin 4. | 573 | 660 | 107.3 | 5e-29 |
| Filamin 5. | 669 | 760 | 148.4 | 2.2e-41 |
| Filamin 6. | 766 | 863 | 123.9 | 5.4e-34 |
| Filamin 7. | 869 | 962 | 129.4 | 1.1e-35 |
| Filamin 8. | 968 | 1058 | 102.9 | 1.1e-27 |
| Filamin 9. | 1064 | 1151 | 158.5 | 2e-44 |
| Filamin 10. | 1157 | 1246 | 134.1 | 4.5e-37 |
| Filamin 11. | 1252 | 1346 | 118.3 | 2.6e-32 |
| Filamin 12. | 1352 | 1439 | 151.8 | 2e-42 |
| Filamin 13. | 1445 | 1536 | 152.9 | 9.8e-43 |
| Filamin 14. | 1542 | 1633 | 147.1 | 5.4e-41 |
| Filamin 15. | 1639 | 1737 | 104.8 | 2.8e-28 |
| --- cleavage 1769 --- | ||||
| Filamin 16. | 1773 | 1857 | 38.8 | 2.2e-08 |
| Filamin 17. | 1862 | 1949 | 155.8 | 1.3e-43 |
| Filamin 18. | 1950 | 2036 | 25.5 | 6.3e-05 |
| Filamin 19. | 2044 | 2131 | 146.4 | 8.8e-41 |
| Filamin 20. | 2150 | 2227 | 19.0 | 0.00025 |
| Filamin 21. | 2235 | 2321 | 72.1 | 2e-18 |
3. Sequence Information
Fasta Sequence: XSB1632.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] QYTYAQGGQQ1769-TWAPERPLVG
Gln1769 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gln1760 | Tyr1761 | Thr1762 | Tyr1763 | Ala1764 | Gln1765 | Gly1766 | Gly1767 | Gln1768 | Gln1769 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr1770 | Trp1771 | Ala1772 | Pro1773 | Glu1774 | Arg1775 | Pro1776 | Leu1777 | Val1778 | Gly1779 |
Sequence conservation (by blast)
* References
[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.