XSB1635 : filamin A [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0090
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | filamin A |
| Gene Names | FLNA |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| BAD52436 |
N/A |
N/A |
Q60FE5 |
N/A |
N/A |
N/A |
hsa: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2620 aa
Average Mass: 278.226 kDa
Monoisotopic Mass: 278.053 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| CH 1. | 17 | 122 | 108.9 | 1.7e-29 |
| CH 2. | 140 | 242 | 99.6 | 1.1e-26 |
| Filamin 1. | 251 | 344 | 120.4 | 5.9e-33 |
| Filamin 2. | 351 | 444 | 128.7 | 1.9e-35 |
| Filamin 3. | 450 | 540 | 133.3 | 7.9e-37 |
| Filamin 4. | 546 | 633 | 107.3 | 5e-29 |
| Filamin 5. | 642 | 733 | 148.4 | 2.2e-41 |
| Filamin 6. | 739 | 836 | 123.9 | 5.4e-34 |
| Filamin 7. | 842 | 935 | 129.4 | 1.1e-35 |
| Filamin 8. | 941 | 1031 | 102.9 | 1.1e-27 |
| Filamin 9. | 1037 | 1124 | 158.5 | 2e-44 |
| Filamin 10. | 1130 | 1219 | 134.1 | 4.5e-37 |
| Filamin 11. | 1225 | 1319 | 118.3 | 2.6e-32 |
| Filamin 12. | 1325 | 1412 | 151.8 | 2e-42 |
| Filamin 13. | 1418 | 1509 | 152.9 | 9.8e-43 |
| Filamin 14. | 1515 | 1606 | 147.1 | 5.4e-41 |
| Filamin 15. | 1612 | 1710 | 104.8 | 2.8e-28 |
| --- cleavage 1742 --- |
| Filamin 16. | 1746 | 1830 | 38.8 | 2.2e-08 |
| Filamin 17. | 1835 | 1922 | 155.8 | 1.3e-43 |
| Filamin 18. | 1923 | 2009 | 25.5 | 6.3e-05 |
| Filamin 19. | 2017 | 2104 | 146.4 | 8.8e-41 |
| Filamin 20. | 2123 | 2200 | 19.0 | 0.00025 |
| Filamin 21. | 2208 | 2295 | 139.8 | 8.6e-39 |
| Filamin 22. | 2302 | 2390 | 91.4 | 3.2e-24 |
| Filamin 23. | 2399 | 2486 | 127.2 | 5.4e-35 |
| Filamin 24. | 2527 | 2616 | 115.3 | 2e-31 |
3. Sequence Information
Fasta Sequence: XSB1635.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] QYTYAQGGQQ1742-TWAPERPLVG
Gln1742 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Gln1733 | Tyr1734 | Thr1735 | Tyr1736 | Ala1737 | Gln1738 | Gly1739 | Gly1740 | Gln1741 | Gln1742 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr1743 | Trp1744 | Ala1745 | Pro1746 | Glu1747 | Arg1748 | Pro1749 | Leu1750 | Val1751 | Gly1752 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTI
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
125.00 |
17 |
filamin A |
| 2 |
Macaca mulatta |
124.00 |
5 |
PREDICTED: filamin 1 (actin-binding protein-280) i |
| 3 |
Canis familiaris |
117.00 |
13 |
PREDICTED: similar to Filamin A (Alpha-filamin) (F |
| 4 |
Bos taurus |
114.00 |
1 |
PREDICTED: similar to filamin |
| 5 |
Mus musculus |
112.00 |
12 |
filamin, alpha |
| 6 |
N/A |
112.00 |
2 |
F |
| 7 |
Rattus norvegicus |
107.00 |
3 |
PREDICTED: similar to Filamin-A (Alpha-filamin) (F |
| 8 |
Gallus gallus |
46.60 |
2 |
filamin |
| 9 |
Tetraodon nigroviridis |
43.90 |
2 |
unnamed protein product |
| 10 |
Pan troglodytes |
42.70 |
3 |
PREDICTED: filamin B, beta (actin binding protein |
| 11 |
Danio rerio |
42.40 |
1 |
PREDICTED: similar to gamma-filamin |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|
| Macaca mulatta |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
||||||||||||||||||||||||||||||#|||||||||||||||+||||||||||||||
Sbjct 1705 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1764
|
| Canis familiaris |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|||||||+ ||||| ||||| |||||||||#||||||||+|||||||||||||||||||||
Sbjct 1717 ALAGDQPAAQPPLRPQQLAPPYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1776
|
| Bos taurus |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|||||||+ || || ||||| |||||||||#||||||||||||||||+|||||||||||||
Sbjct 2023 ALAGDQPTAQPSLRPQQLAPPYTYAQGGQQ#TWAPERPLVGVNGLDVSSLRPFDLVIPFTI 2082
|
| Mus musculus |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|||||||+|| ||||||||||| | || ||#|| ||||+||||||||||||||||||||||
Sbjct 1713 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1772
|
| N/A |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|||||||+|| ||||||||||| | || ||#|| ||||+||||||||||||||||||||||
Sbjct 1740 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
|
| Rattus norvegicus |
Query 1713 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|||||||+|| ||| ||| |||| || ||#|| ||||+||||||||||||||||||||||
Sbjct 1740 ALAGDQPTVQTPLRPQQLPSQYTYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
|
| Gallus gallus |
Query 1742 Q#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
|# | ||||+||||||| ||||||||| ||
Sbjct 1719 Q#VMATERPLLGVNGLDV-GLRPFDLVIPLTI 1748
|
| Tetraodon nigroviridis |
Query 1745 APERPLVGVNGLDVTSLRPFDLVIPFTI 1772
| +||+ |+||||| ||||||||||||
Sbjct 1718 ATDRPM-GMNGLDVAGLRPFDLVIPFTI 1744
|
| Pan troglodytes |
Query 1716 GDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
| | + | + + ++|+ + | #|| | | |+ ++ +|||||||| +
Sbjct 1719 GQYPGLSPGILKDNSSEKHTFMKTKQL#TWVTEEAYVPVSNMNGLGFKPFDLVIPFAV 1775
|
| Danio rerio |
Query 1719 PSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1772
| ++ | || | || # || | |+ |+ ++ ||||+||||||+
Sbjct 1276 PIIEEPCDKLQLQQPYAPYQGYSP#HWATEEPVTAVDIIEPV-LRPFNLVIPFTV 1328
|
* References
[PubMed ID: 16106752] Kato S, Ohtoko K, Ohtake H, Kimura T, Vector-capping: a simple method for preparing a high-quality full-length cDNA library. DNA Res. 2005 Feb 28;12(1):53-62.
