XSB1638 : unnamed protein product [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0090
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Filamin-A; Alpha-filamin; Filamin-1; Endothelial actin-binding protein; Actin-binding protein 280; ABP-280; Non-muscle filamin |
| Gene Names | FLN, FLN1; FLN; FLN1 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2647 aa
Average Mass: 280.761 kDa
Monoisotopic Mass: 280.586 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 44 | 149 | 108.9 | 1.7e-29 |
| CH 2. | 167 | 269 | 99.6 | 1.1e-26 |
| Filamin 1. | 278 | 371 | 120.4 | 5.9e-33 |
| Filamin 2. | 378 | 471 | 128.7 | 1.9e-35 |
| Filamin 3. | 477 | 567 | 133.3 | 7.9e-37 |
| Filamin 4. | 573 | 660 | 107.3 | 5e-29 |
| Filamin 5. | 669 | 760 | 148.4 | 2.2e-41 |
| Filamin 6. | 766 | 863 | 123.9 | 5.4e-34 |
| Filamin 7. | 869 | 962 | 129.4 | 1.1e-35 |
| Filamin 8. | 968 | 1058 | 102.9 | 1.1e-27 |
| Filamin 9. | 1064 | 1151 | 158.5 | 2e-44 |
| Filamin 10. | 1157 | 1246 | 134.1 | 4.5e-37 |
| Filamin 11. | 1252 | 1346 | 118.3 | 2.6e-32 |
| Filamin 12. | 1352 | 1439 | 151.8 | 2e-42 |
| Filamin 13. | 1445 | 1536 | 152.9 | 9.8e-43 |
| Filamin 14. | 1542 | 1633 | 147.1 | 5.4e-41 |
| Filamin 15. | 1639 | 1737 | 104.8 | 2.8e-28 |
| --- cleavage 1769 --- | ||||
| Filamin 16. | 1773 | 1857 | 38.8 | 2.2e-08 |
| Filamin 17. | 1862 | 1949 | 155.8 | 1.3e-43 |
| Filamin 18. | 1950 | 2036 | 25.5 | 6.3e-05 |
| Filamin 19. | 2044 | 2131 | 146.4 | 8.8e-41 |
| Filamin 20. | 2150 | 2227 | 19.0 | 0.00025 |
| Filamin 21. | 2235 | 2322 | 139.8 | 8.6e-39 |
| Filamin 22. | 2329 | 2417 | 91.4 | 3.2e-24 |
| Filamin 23. | 2426 | 2513 | 127.2 | 5.4e-35 |
| Filamin 24. | 2554 | 2643 | 107.7 | 3.9e-29 |
3. Sequence Information
Fasta Sequence: XSB1638.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 2AAV (NMR; -; A=1863-1955), 2BP3 (X-ray; 232 A; A/B=1863-1956), 2BRQ (X-ray; 210 A; A/B=2236-2329), 2J3S (X-ray; 250 A; A/B=2045-2329), 2JF1 (X-ray; 220 A; A=2236-2329), 2K3T (NMR; -; A=2427-2522), 2W0P (X-ray; 190 A; A/B=2236-2329), 3CNK (X-ray; 165 A; A/B=2559-2647)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] QYTYAQGGQQ1769-TWAPERPLVG
Gln1769 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gln1760 | Tyr1761 | Thr1762 | Tyr1763 | Ala1764 | Gln1765 | Gly1766 | Gly1767 | Gln1768 | Gln1769 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr1770 | Trp1771 | Ala1772 | Pro1773 | Glu1774 | Arg1775 | Pro1776 | Leu1777 | Val1778 | Gly1779 |
Sequence conservation (by blast)
* References
[PubMed ID: 2391361] Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH, Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990 Sep;111(3):1089-105.