CaMPDB :: Substrate

XSB1639 : PREDICTED: filamin 1 (actin-binding protein-280) isoform 4 [Macaca mulatta]

This entry is computationally expanded from SB0090

* Basic Information

Organism	Macaca mulatta (rhesus monkey)
Protein Names	filamin 1 (actin-binding protein-280) isoform 4
Gene Names	FLNA; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 12 mRNAs, 807 ESTs, 17 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_001091073	XM_001091073	699524	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2647 aa

Average Mass: 280.598 kDa

Monoisotopic Mass: 280.423 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	44	149	108.9	1.7e-29
CH 2.	167	269	102.9	1.1e-27
Filamin 1.	278	371	108.6	2.1e-29
Filamin 2.	378	471	130.6	5e-36
Filamin 3.	477	567	133.0	9.3e-37
Filamin 4.	573	660	106.2	1.1e-28
Filamin 5.	669	760	148.4	2.2e-41
Filamin 6.	766	863	123.9	5.4e-34
Filamin 7.	869	962	129.4	1.1e-35
Filamin 8.	968	1058	102.8	1.2e-27
Filamin 9.	1064	1151	158.5	2e-44
Filamin 10.	1157	1246	134.1	4.5e-37
Filamin 11.	1252	1346	120.3	6.5e-33
Filamin 12.	1352	1439	151.8	2e-42
Filamin 13.	1445	1536	152.9	9.8e-43
Filamin 14.	1542	1633	147.1	5.4e-41
Filamin 15.	1639	1737	106.4	1e-28
--- cleavage 1769 ---
Filamin 16.	1773	1857	33.9	6.6e-07
Filamin 17.	1862	1949	156.7	6.8e-44
Filamin 18.	1950	2036	25.5	6.3e-05
Filamin 19.	2044	2131	146.4	8.8e-41
Filamin 20.	2150	2227	19.3	0.00023
Filamin 21.	2235	2322	139.8	8.6e-39
Filamin 22.	2329	2417	91.4	3.2e-24
Filamin 23.	2426	2513	127.9	3.3e-35
Filamin 24.	2554	2643	110.2	6.7e-30

3. Sequence Information

Fasta Sequence: XSB1639.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QYTYAQGGQQ¹⁷⁶⁹-TWAPERPLVG

Gln¹⁷⁶⁹ Thr

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Gln¹⁷⁶⁰	Tyr¹⁷⁶¹	Thr¹⁷⁶²	Tyr¹⁷⁶³	Ala¹⁷⁶⁴	Gln¹⁷⁶⁵	Gly¹⁷⁶⁶	Gly¹⁷⁶⁷	Gln¹⁷⁶⁸	Gln¹⁷⁶⁹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Thr¹⁷⁷⁰	Trp¹⁷⁷¹	Ala¹⁷⁷²	Pro¹⁷⁷³	Glu¹⁷⁷⁴	Arg¹⁷⁷⁵	Pro¹⁷⁷⁶	Leu¹⁷⁷⁷	Val¹⁷⁷⁸	Gly¹⁷⁷⁹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDMTSLRPFDLVIPFTI

Summary

#	organism	max score	hits	top seq
1	Macaca mulatta	126.00	5	PREDICTED: filamin 1 (actin-binding protein-280) i
2	Homo sapiens	124.00	17	FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) (
3	Canis familiaris	116.00	13	PREDICTED: similar to Filamin A (Alpha-filamin) (F
4	Bos taurus	113.00	1	PREDICTED: similar to filamin
5	Mus musculus	111.00	12	filamin, alpha
6	N/A	111.00	2	F
7	Rattus norvegicus	106.00	3	PREDICTED: similar to Filamin-A (Alpha-filamin) (F
8	Gallus gallus	45.40	2	filamin
9	Pan troglodytes	42.70	3	PREDICTED: filamin B, beta (actin binding protein
10	Tetraodon nigroviridis	42.70	2	unnamed protein product
11	Danio rerio	42.40	1	PREDICTED: similar to gamma-filamin

Top-ranked sequences

organism	matching
Macaca mulatta	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799
Homo sapiens	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1799
Canis familiaris	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|+ \|\|\|\|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|+\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1740 ALAGDQPAAQPPLRPQQLAPPYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
Bos taurus	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|+ \|\| \|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|++\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2023 ALAGDQPTAQPSLRPQQLAPPYTYAQGGQQ#TWAPERPLVGVNGLDVSSLRPFDLVIPFTI 2082
Mus musculus	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|+\|\| \|\|\|\|\|\|\|\|\|\|\| \| \|\| \|\|#\|\| \|\|\|\|+\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1732 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1791
N/A	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|+\|\| \|\|\|\|\|\|\|\|\|\|\| \| \|\| \|\|#\|\| \|\|\|\|+\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1740 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
Rattus norvegicus	Query 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|\|\|\|\|\|\|+\|\| \|\|\| \|\|\| \|\|\|\| \|\| \|\|#\|\| \|\|\|\|+\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1740 ALAGDQPTVQTPLRPQQLPSQYTYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
Gallus gallus	Query 1769 Q#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \|# \| \|\|\|\|+\|\|\|\|\|\|+ \|\|\|\|\|\|\|\|\| \|\| Sbjct 1719 Q#VMATERPLLGVNGLDV-GLRPFDLVIPLTI 1748
Pan troglodytes	Query 1743 GDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \| \| + \| + + ++\|+ + \| #\|\| \| \| \|+ ++ +\|\|\|\|\|\|\|\| + Sbjct 1719 GQYPGLSPGILKDNSSEKHTFMKTKQL#TWVTEEAYVPVSNMNGLGFKPFDLVIPFAV 1775
Tetraodon nigroviridis	Query 1772 APERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \| +\|\|+ \|+\|\|\|\|+ \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1718 ATDRPM-GMNGLDVAGLRPFDLVIPFTI 1744
Danio rerio	Query 1746 PSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799 \| ++ \| \|\| \| \|\| # \|\| \| \|+ \|+ ++ \|\|\|\|+\|\|\|\|\|\|+ Sbjct 1276 PIIEEPCDKLQLQQPYAPYQGYSP#HWATEEPVTAVDIIEPV-LRPFNLVIPFTV 1328

* References

None.