XSB1642 : PREDICTED: similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin) isoform 2 [Canis familiaris]
[ CaMP Format ]
This entry is computationally expanded from SB0090
* Basic Information
| Organism | Canis lupus familiaris (dog) |
| Protein Names | similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin) isoform 2 |
| Gene Names | LOC481084; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 397 ESTs, 102 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2646 aa
Average Mass: 280.625 kDa
Monoisotopic Mass: 280.450 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| CH 1. | 44 | 149 | 108.9 | 1.7e-29 |
| CH 2. | 167 | 269 | 102.9 | 1.1e-27 |
| Filamin 1. | 278 | 371 | 120.4 | 5.9e-33 |
| Filamin 2. | 378 | 471 | 132.0 | 1.9e-36 |
| Filamin 3. | 477 | 567 | 131.3 | 3e-36 |
| Filamin 4. | 573 | 660 | 107.3 | 5e-29 |
| Filamin 5. | 669 | 760 | 147.8 | 3.4e-41 |
| Filamin 6. | 766 | 863 | 124.0 | 4.9e-34 |
| Filamin 7. | 869 | 962 | 128.7 | 1.9e-35 |
| Filamin 8. | 968 | 1058 | 103.5 | 7e-28 |
| Filamin 9. | 1064 | 1151 | 155.6 | 1.5e-43 |
| Filamin 10. | 1157 | 1246 | 137.4 | 4.6e-38 |
| Filamin 11. | 1252 | 1346 | 117.9 | 3.4e-32 |
| Filamin 12. | 1352 | 1439 | 151.8 | 2e-42 |
| Filamin 13. | 1445 | 1536 | 152.0 | 1.9e-42 |
| Filamin 14. | 1542 | 1633 | 147.1 | 5.4e-41 |
| Filamin 15. | 1639 | 1737 | 104.8 | 2.8e-28 |
| --- cleavage 1769 --- |
| Filamin 16. | 1782 | 1857 | 27.9 | 3.9e-05 |
| Filamin 17. | 1862 | 1949 | 155.1 | 2.1e-43 |
| Filamin 18. | 1950 | 2036 | 25.5 | 6.3e-05 |
| Filamin 19. | 2044 | 2131 | 146.4 | 8.8e-41 |
| Filamin 20. | 2154 | 2227 | 18.0 | 0.00031 |
| Filamin 21. | 2235 | 2322 | 139.8 | 8.6e-39 |
| Filamin 22. | 2329 | 2417 | 91.4 | 3.2e-24 |
| Filamin 23. | 2426 | 2513 | 127.9 | 3.3e-35 |
| Filamin 24. | 2553 | 2642 | 115.3 | 2e-31 |
3. Sequence Information
Fasta Sequence: XSB1642.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] PYTYAQGGQQ1769-TWAPERPLMG
Gln1769 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Pro1760 | Tyr1761 | Thr1762 | Tyr1763 | Ala1764 | Gln1765 | Gly1766 | Gly1767 | Gln1768 | Gln1769 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr1770 | Trp1771 | Ala1772 | Pro1773 | Glu1774 | Arg1775 | Pro1776 | Leu1777 | Met1778 | Gly1779 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
ALAGDQPAAQPPLRPQQLAPPYTYAQGGQQTWAPERPLMGVNGLDVTSLRPFDLVIPFTI
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Canis familiaris |
88.60 |
12 |
PREDICTED: similar to Filamin A (Alpha-filamin) (F |
| 2 |
Homo sapiens |
87.00 |
13 |
FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) ( |
| 3 |
Macaca mulatta |
85.90 |
5 |
PREDICTED: filamin 1 (actin-binding protein-280) i |
| 4 |
Bos taurus |
85.50 |
2 |
PREDICTED: similar to filamin |
| 5 |
Rattus norvegicus |
80.10 |
3 |
PREDICTED: similar to Filamin-A (Alpha-filamin) (F |
| 6 |
Mus musculus |
78.20 |
12 |
filamin, alpha |
| 7 |
N/A |
78.20 |
1 |
F |
| 8 |
Gallus gallus |
47.00 |
2 |
filamin |
| 9 |
Tetraodon nigroviridis |
45.10 |
2 |
unnamed protein product |
| 10 |
Danio rerio |
35.40 |
1 |
PREDICTED: similar to gamma-filamin |
| 11 |
Pan troglodytes |
35.00 |
2 |
PREDICTED: filamin B, beta (actin binding protein |
Top-ranked sequences
| organism | matching |
|---|
| Canis familiaris |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| |||||||||#||||||||||||||||||||||||||||||
Sbjct 1740 ALAGDQPAAQPPLRPQQLAPPYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
|
| Homo sapiens |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| |||||||||#||||||||+|||||||||||||||||||||
Sbjct 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDVTSLRPFDLVIPFTI 1799
|
| Macaca mulatta |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| |||||||||#||||||||+||||||+||||||||||||||
Sbjct 1740 ALAGDQPSVQPPLRSQQLAPQYTYAQGGQQ#TWAPERPLVGVNGLDMTSLRPFDLVIPFTI 1799
|
| Bos taurus |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| |||||||||#||||||||+|||||||+|||||||||||||
Sbjct 2023 ALAGDQPTAQPSLRPQQLAPPYTYAQGGQQ#TWAPERPLVGVNGLDVSSLRPFDLVIPFTI 2082
|
| Rattus norvegicus |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| ||| || ||#|| ||||++|||||||||||||||||||||
Sbjct 1740 ALAGDQPTVQTPLRPQQLPSQYTYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
|
| Mus musculus |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| | | || ||#|| ||||++|||||||||||||||||||||
Sbjct 1732 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1791
|
| N/A |
Query 1740 ALAGDXXXXXXXXXXXXXXXXYTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
||||| | | || ||#|| ||||++|||||||||||||||||||||
Sbjct 1740 ALAGDQPTVQTPLRSQQLAPQYNYPQGSQQ#TWIPERPMVGVNGLDVTSLRPFDLVIPFTI 1799
|
| Gallus gallus |
Query 1769 Q#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
|# | ||||+||||||| ||||||||| ||
Sbjct 1719 Q#VMATERPLLGVNGLDV-GLRPFDLVIPLTI 1748
|
| Tetraodon nigroviridis |
Query 1772 APERPLMGVNGLDVTSLRPFDLVIPFTI 1799
| +|| ||+||||| ||||||||||||
Sbjct 1718 ATDRP-MGMNGLDVAGLRPFDLVIPFTI 1744
|
| Danio rerio |
Query 1761 YTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
| || # || | |+ |+ ++ ||||+||||||+
Sbjct 1291 YAPYQGYSP#HWATEEPVTAVDIIEPV-LRPFNLVIPFTV 1328
|
| Pan troglodytes |
Query 1761 YTYAQGGQQ#TWAPERPLMGVNGLDVTSLRPFDLVIPFTI 1799
+|+ + | #|| | + |+ ++ +|||||||| +
Sbjct 1737 HTFMKTKQL#TWVTEEAYVPVSNMNGLGFKPFDLVIPFAV 1775
|
