XSB1657 : huntingtin (Huntington disease), isoform CRA_d [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0051
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | huntingtin (Huntington disease); isoform CRA_d |
| Gene Names | HD |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3014 aa
Average Mass: 333.338 kDa
Monoisotopic Mass: 333.126 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HEAT 1. | 2 | 30 | 2.6 | 24 |
| HEAT 2. | 75 | 111 | 6.9 | 6.9 |
| HEAT 3. | 118 | 153 | 15.3 | 0.25 |
| DUF1242 1. | 182 | 211 | -7.9 | 9.1 |
| HEAT 4. | 224 | 259 | 5.3 | 11 |
| --- cleavage 406 --- | ||||
| DUF801 1. | 430 | 458 | 8.8 | 1.6 |
| HEAT 5. | 615 | 651 | 0.8 | 39 |
| Arm 1. | 669 | 707 | 9.3 | 0.81 |
| HEAT 6. | 773 | 810 | 22.5 | 0.0017 |
| L_biotic_typeA 1. | 860 | 898 | -19.8 | 8.7 |
| COG5 1. | 1113 | 1200 | -58.2 | 5.2 |
| LolA 1. | 1236 | 1362 | -68.6 | 9.9 |
| Utp13 1. | 1433 | 1536 | -64.3 | 1.5 |
| Peptidase_M3_N 1. | 1603 | 1653 | -12.0 | 10 |
| PerC 1. | 1697 | 1772 | -41.0 | 5.3 |
| Corona_5a 1. | 1853 | 1909 | -1.4 | 1.3 |
| Myticin-prepro 1. | 2157 | 2242 | -48.3 | 9.4 |
| DUF2131 1. | 2283 | 2347 | -22.7 | 2.1 |
| TnsA_C 1. | 2369 | 2440 | -12.9 | 7.9 |
| Cyclase_polyket 1. | 2627 | 2714 | -54.7 | 9.6 |
| HEAT 7. | 2881 | 2919 | 1.2 | 35 |
3. Sequence Information
Fasta Sequence: XSB1657.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] DEEDILSHSS406-SQVSAVPSDP
Ser406 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp397 | Glu398 | Glu399 | Asp400 | Ile401 | Leu402 | Ser403 | His404 | Ser405 | Ser406 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser407 | Gln408 | Val409 | Ser410 | Ala411 | Val412 | Pro413 | Ser414 | Asp415 | Pro416 |
Sequence conservation (by blast)
* References
[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.