CaMPDB :: Substrate

XSB1660 : PREDICTED: huntingtin [Pan troglodytes]

This entry is computationally expanded from SB0051

* Basic Information

Organism	Pan troglodytes (chimpanzee)
Protein Names	huntingtin
Gene Names	HD; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 1 mRNA, 196 ESTs, 4 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_517080	XM_517080	461084	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3149 aa

Average Mass: 348.095 kDa

Monoisotopic Mass: 347.874 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
HEAT 1.	124	160	16.0	0.16
HEAT 2.	205	241	6.9	6.9
HEAT 3.	248	283	15.3	0.25
DUF1242 1.	312	341	-7.9	9.1
HEAT 4.	354	389	5.3	11
--- cleavage 536 ---
DUF801 1.	560	588	8.8	1.6
HEAT 5.	745	781	0.8	39
HEAT 6.	803	839	7.3	6.3
HEAT 7.	903	940	22.5	0.0017
L_biotic_typeA 1.	990	1028	-19.8	8.7
COG5 1.	1243	1330	-58.2	5.2
Borrelia_lipo_2 1.	1396	1493	-26.7	8.2
Utp13 1.	1563	1666	-64.3	1.5
Peptidase_M3_N 1.	1733	1783	-12.0	10
PerC 1.	1827	1902	-41.0	5.3
Corona_5a 1.	1983	2039	-1.4	1.3
Bromo_TP 1.	2346	2409	-14.6	6.8
TnsA_C 1.	2496	2567	-12.9	7.9
Cyclase_polyket 1.	2754	2841	-54.7	9.6
HEAT 8.	3016	3054	1.2	35

3. Sequence Information

Fasta Sequence: XSB1660.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] DEEDILSHSS⁵³⁶-SQVSAVPSDP

Ser⁵³⁶ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Asp⁵²⁷	Glu⁵²⁸	Glu⁵²⁹	Asp⁵³⁰	Ile⁵³¹	Leu⁵³²	Ser⁵³³	His⁵³⁴	Ser⁵³⁵	Ser⁵³⁶

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser⁵³⁷	Gln⁵³⁸	Val⁵³⁹	Ser⁵⁴⁰	Ala⁵⁴¹	Val⁵⁴²	Pro⁵⁴³	Ser⁵⁴⁴	Asp⁵⁴⁵	Pro⁵⁴⁶

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQT

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	84.30	5	huntingtin
2	Macaca mulatta	84.30	1	PREDICTED: huntingtin
3	Pan troglodytes	84.30	1	PREDICTED: huntingtin
4	N/A	80.50	6	H
5	Rattus norvegicus	80.50	1	PREDICTED: similar to Huntingtin (Huntington disea
6	Mus musculus	80.50	1	huntingtin
7	Bos taurus	79.30	1	PREDICTED: similar to huntingtin
8	Canis familiaris	77.40	1	PREDICTED: similar to Huntingtin (Huntingtons dise
9	Sus scrofa	76.60	1	huntingtin
10	Gallus gallus	75.10	1	PREDICTED: similar to Huntingtons Disease protein
11	Monodelphis domestica	73.60	1	PREDICTED: similar to Huntingtons Disease protein
12	Xenopus tropicalis	63.20	1	huntingtin

Top-ranked sequences

organism	matching
Homo sapiens	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 507 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
Macaca mulatta	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 494 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 553
Pan troglodytes	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 507 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
N/A	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 484 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 543
Rattus norvegicus	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 485 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Mus musculus	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 485 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Bos taurus	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\| \|+\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 498 LQTDAVDLAACDLTSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 557
Canis familiaris	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\| \|\|\|\|\| \|\|\|\| \|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 495 LQPDSVDLTSCDLASAATDGDEEDILSHSS#SQISAVPSDPAMDLNDGTQASSPVSDSSQT 554
Sus scrofa	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\| \|\|\|\|\|+ \|\|\|+\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 504 LQPDSVDLSGCDLSSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPVSDSSQT 563
Gallus gallus	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|+\|\|\|\|\|+\|\|\|\|\|\|+\|\|+\|+++\|+\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 459 LQSDSVDLSSCDLTSTATEGEDDDVLSRSS#SQISAVQSDPTMDLNDGTQASSPISDSSQT 518
Monodelphis domestica	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 566 \|\|+\| \|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|+\| # +\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 498 LQSDPVDLTGCDLTSAATDGDEEDMLSRSS#SQISAVPSDPAVDMNDGTQASSPISDSSQT 557
Xenopus tropicalis	Query 507 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDG-TQASSPISDSSQ 565 \|\|+\|\|\|\|++\| \|\| \|+ \|+\|\|\|\|\|\|\| # \|+\|\|+\| \|\|\|\|\|\|+\|\|\|\|\| Sbjct 436 LQSDSVDISSSDLASTVTEGDEEDILSHSS#SQISTVQSDTNMELNEGTTQASSPVSDSSQ 495 Query 566 T 566 \| Query 566 T 566

* References

None.