CaMPDB :: Substrate

XSB1661 : PREDICTED: huntingtin [Macaca mulatta]

This entry is computationally expanded from SB0051

* Basic Information

Organism	Macaca mulatta (rhesus monkey)
Protein Names	huntingtin
Gene Names	HD; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 2 mRNAs, 72 ESTs, 3 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_001086119	XM_001086119	700306	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3133 aa

Average Mass: 0.000 kDa

Monoisotopic Mass: 0.000 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
HEAT 1.	111	147	16.5	0.11
HEAT 2.	192	228	5.2	11
HEAT 3.	235	270	15.3	0.25
DUF1242 1.	299	328	-7.9	9.1
HEAT 4.	341	376	5.3	11
--- cleavage 523 ---
DUF801 1.	547	575	8.8	1.6
HEAT 5.	732	768	0.8	39
HEAT 6.	790	826	7.3	6.3
HEAT 7.	890	927	22.5	0.0017
L_biotic_typeA 1.	977	1015	-19.8	8.7
COG5 1.	1230	1317	-58.2	5.2
Borrelia_lipo_2 1.	1383	1480	-26.7	8.2
Peptidase_M3_N 1.	1721	1771	-12.0	10
PerC 1.	1815	1890	-41.0	5.3
Corona_5a 1.	1971	2027	-1.4	1.3
Alpha_TIF 1.	2087	2342	-278.5	4
DUF2131 1.	2401	2465	-26.3	5.2
TnsA_C 1.	2487	2558	-12.9	7.9
DUF2454 1.	2600	2810	-101.8	6.1

3. Sequence Information

Fasta Sequence: XSB1661.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] DEEDILSHSS⁵²³-SQVSAVPSDP

Ser⁵²³ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Asp⁵¹⁴	Glu⁵¹⁵	Glu⁵¹⁶	Asp⁵¹⁷	Ile⁵¹⁸	Leu⁵¹⁹	Ser⁵²⁰	His⁵²¹	Ser⁵²²	Ser⁵²³

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser⁵²⁴	Gln⁵²⁵	Val⁵²⁶	Ser⁵²⁷	Ala⁵²⁸	Val⁵²⁹	Pro⁵³⁰	Ser⁵³¹	Asp⁵³²	Pro⁵³³

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQT

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	84.30	5	huntingtin
2	Macaca mulatta	84.30	1	PREDICTED: huntingtin
3	Pan troglodytes	84.30	1	PREDICTED: huntingtin
4	N/A	80.50	6	H
5	Rattus norvegicus	80.50	1	PREDICTED: similar to Huntingtin (Huntington disea
6	Mus musculus	80.50	1	huntingtin
7	Bos taurus	79.30	1	PREDICTED: similar to huntingtin
8	Canis familiaris	77.40	1	PREDICTED: similar to Huntingtin (Huntingtons dise
9	Sus scrofa	76.60	1	huntingtin
10	Gallus gallus	75.10	1	PREDICTED: similar to Huntingtons Disease protein
11	Monodelphis domestica	73.60	1	PREDICTED: similar to Huntingtons Disease protein
12	Xenopus tropicalis	63.20	1	huntingtin

Top-ranked sequences

organism	matching
Homo sapiens	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 507 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
Macaca mulatta	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 494 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 553
Pan troglodytes	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 507 LQADSVDLASCDLTSSATDGDEEDILSHSS#SQVSAVPSDPAMDLNDGTQASSPISDSSQT 566
N/A	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 484 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 543
Rattus norvegicus	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 485 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Mus musculus	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|\|\|\|\|\|\|+ \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 485 LQADSVDLSGCDLTSAATDGDEEDILSHSS#SQFSAVPSDPAMDLNDGTQASSPISDSSQT 544
Bos taurus	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\| \|+\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 498 LQTDAVDLAACDLTSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPISDSSQT 557
Canis familiaris	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\| \|\|\|\|\| \|\|\|\| \|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 495 LQPDSVDLTSCDLASAATDGDEEDILSHSS#SQISAVPSDPAMDLNDGTQASSPVSDSSQT 554
Sus scrofa	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\| \|\|\|\|\|+ \|\|\|+\|+\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 504 LQPDSVDLSGCDLSSAATDGDEEDILSHSS#SQMSAVPSDPAMDLNDGTQASSPVSDSSQT 563
Gallus gallus	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|+\|\|\|\|\|+\|\|\|\|\|\|+\|\|+\|+++\|+\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 459 LQSDSVDLSSCDLTSTATEGEDDDVLSRSS#SQISAVQSDPTMDLNDGTQASSPISDSSQT 518
Monodelphis domestica	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDGTQASSPISDSSQT 553 \|\|+\| \|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\|+\| # +\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 498 LQSDPVDLTGCDLTSAATDGDEEDMLSRSS#SQISAVPSDPAVDMNDGTQASSPISDSSQT 557
Xenopus tropicalis	Query 494 LQADSVDLASCDLTSSATDGDEEDILXXXX#XXXXXXXXXXXMDLNDG-TQASSPISDSSQ 552 \|\|+\|\|\|\|++\| \|\| \|+ \|+\|\|\|\|\|\|\| # \|+\|\|+\| \|\|\|\|\|\|+\|\|\|\|\| Sbjct 436 LQSDSVDISSSDLASTVTEGDEEDILSHSS#SQISTVQSDTNMELNEGTTQASSPVSDSSQ 495 Query 553 T 553 \| Query 553 T 553

* References

None.