XSB1662 : huntingtin [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0051
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Huntingtin; Huntington disease protein; HD protein |
| Gene Names | HD, IT15; HD; IT15 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3144 aa
Average Mass: 347.843 kDa
Monoisotopic Mass: 347.623 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HEAT 1. | 124 | 160 | 16.0 | 0.16 |
| HEAT 2. | 205 | 241 | 6.9 | 6.9 |
| HEAT 3. | 248 | 283 | 15.3 | 0.25 |
| DUF1242 1. | 312 | 341 | -7.9 | 9.1 |
| HEAT 4. | 354 | 389 | 5.3 | 11 |
| --- cleavage 536 --- | ||||
| DUF801 1. | 560 | 588 | 8.8 | 1.6 |
| HEAT 5. | 745 | 781 | 0.8 | 39 |
| Arm 1. | 799 | 837 | 7.3 | 1.5 |
| HEAT 6. | 903 | 940 | 22.5 | 0.0017 |
| L_biotic_typeA 1. | 990 | 1028 | -19.8 | 8.7 |
| COG5 1. | 1243 | 1330 | -58.2 | 5.2 |
| LolA 1. | 1366 | 1492 | -68.6 | 9.9 |
| Utp13 1. | 1563 | 1666 | -64.3 | 1.5 |
| Peptidase_M3_N 1. | 1733 | 1783 | -12.0 | 10 |
| PerC 1. | 1827 | 1902 | -41.0 | 5.3 |
| Corona_5a 1. | 1983 | 2039 | -1.4 | 1.3 |
| Myticin-prepro 1. | 2287 | 2372 | -48.3 | 9.4 |
| DUF2131 1. | 2413 | 2477 | -22.7 | 2.1 |
| TnsA_C 1. | 2499 | 2570 | -12.9 | 7.9 |
| Cyclase_polyket 1. | 2757 | 2844 | -54.7 | 9.6 |
| HEAT 7. | 3011 | 3049 | 1.2 | 35 |
3. Sequence Information
Fasta Sequence: XSB1662.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 2D3X (Model; -; A=201-327)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] DEEDILSHSS536-SQVSAVPSDP
Ser536 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp527 | Glu528 | Glu529 | Asp530 | Ile531 | Leu532 | Ser533 | His534 | Ser535 | Ser536 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser537 | Gln538 | Val539 | Ser540 | Ala541 | Val542 | Pro543 | Ser544 | Asp545 | Pro546 |
Sequence conservation (by blast)
* References
[PubMed ID: 11013077] Matsuyama N, Hadano S, Onoe K, Osuga H, Showguchi-Miyata J, Gondo Y, Ikeda JE, Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat. Genomics. 2000 Oct 1;69(1):72-85.