XSB1663 : huntingtin [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0051
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Huntingtin; Huntington disease protein homolog; HD protein homolog; Huntington disease gene homolog |
| Gene Names | Htt; Hd, Hdh; Hd; Hdh; huntingtin |
| Gene Locus | 5 20.0 cM; chromosome 5 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3120 aa
Average Mass: 344.788 kDa
Monoisotopic Mass: 344.569 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HEAT 1. | 102 | 138 | 16.0 | 0.16 |
| HEAT 2. | 183 | 219 | 6.9 | 6.9 |
| HEAT 3. | 226 | 261 | 17.6 | 0.053 |
| HEAT 4. | 332 | 367 | 5.3 | 11 |
| Mlf1IP 1. | 372 | 501 | -106.8 | 9.2 |
| --- cleavage 514 --- | ||||
| DUF801 1. | 538 | 566 | 9.4 | 1.2 |
| HEAT 5. | 724 | 760 | 11.1 | 2.2 |
| HEAT_PBS 1. | 764 | 798 | 9.7 | 4 |
| HEAT 6. | 882 | 919 | 20.1 | 0.009 |
| SFT2 1. | 995 | 1086 | -68.1 | 2.7 |
| RUN 1. | 1114 | 1317 | -43.2 | 7.2 |
| Borrelia_lipo_2 1. | 1375 | 1472 | -26.6 | 8.1 |
| Utp13 1. | 1542 | 1645 | -61.7 | 0.93 |
| Neurokinin_B 1. | 1994 | 2047 | 0.1 | 5 |
| CNTF 1. | 2136 | 2312 | -101.8 | 6.8 |
| Propeptide_C1 1. | 2423 | 2457 | -10.1 | 9.7 |
| DUF1072 1. | 2476 | 2513 | -9.3 | 7.3 |
| LIF_OSM 1. | 2774 | 2958 | -102.7 | 5.6 |
| DUF1250 1. | 2961 | 2999 | -6.9 | 9.2 |
3. Sequence Information
Fasta Sequence: XSB1663.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] DEEDILSHSS514-SQFSAVPSDP
Ser514 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp505 | Glu506 | Glu507 | Asp508 | Ile509 | Leu510 | Ser511 | His512 | Ser513 | Ser514 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser515 | Gln516 | Phe517 | Ser518 | Ala519 | Val520 | Pro521 | Ser522 | Asp523 | Pro524 |
Sequence conservation (by blast)
* References
[PubMed ID: 19264961] Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G, Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4906-11. Epub 2009 Mar 5.