XSB1667 : Huntingtin
[ CaMP Format ]
This entry is computationally expanded from SB0051
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | Huntington disease protein homolog; HD protein homolog |
| Gene Names | Hd, Hdh; Hd; Hdh |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3110 aa
Average Mass: 343.762 kDa
Monoisotopic Mass: 343.544 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HEAT 1. | 93 | 128 | 2.8 | 23 |
| HEAT 2. | 173 | 209 | 6.9 | 6.9 |
| HEAT 3. | 216 | 251 | 17.6 | 0.053 |
| HEAT 4. | 322 | 357 | 5.3 | 11 |
| DUF822 1. | 382 | 493 | -73.4 | 9.3 |
| --- cleavage 505 --- | ||||
| DUF801 1. | 529 | 557 | 9.4 | 1.2 |
| HEAT 5. | 714 | 750 | 11.1 | 2.2 |
| HEAT 6. | 772 | 808 | 8.0 | 5.1 |
| HEAT 7. | 872 | 909 | 20.5 | 0.007 |
| SFT2 1. | 985 | 1076 | -60.6 | 0.83 |
| RUN 1. | 1104 | 1307 | -43.3 | 7.3 |
| Borrelia_lipo_2 1. | 1365 | 1462 | -26.6 | 8.1 |
| Utp13 1. | 1532 | 1635 | -61.7 | 0.93 |
| Peptidase_M3_N 1. | 1702 | 1752 | -9.2 | 5.4 |
| Neurokinin_B 1. | 1984 | 2037 | 0.1 | 5.1 |
| DUF2131 1. | 2379 | 2443 | -28.8 | 9.6 |
| LIF_OSM 1. | 2764 | 2948 | -104.8 | 7.9 |
| DUF1250 1. | 2951 | 2989 | -6.9 | 9.2 |
3. Sequence Information
Fasta Sequence: XSB1667.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] DEEDILSHSS505-SQFSAVPSDP
Ser505 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp496 | Glu497 | Glu498 | Asp499 | Ile500 | Leu501 | Ser502 | His503 | Ser504 | Ser505 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser506 | Gln507 | Phe508 | Ser509 | Ala510 | Val511 | Pro512 | Ser513 | Asp514 | Pro515 |
Sequence conservation (by blast)
* References
[PubMed ID: 8528205] Schmitt I, Bachner D, Megow D, Henklein P, Hameister H, Epplen JT, Riess O, Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development. Hum Mol Genet. 1995 Jul;4(7):1173-82.