XSB1668 : Huntingtin
[ CaMP Format ]
This entry is computationally expanded from SB0051
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Huntington disease protein homolog; HD protein homolog |
| Gene Names | Hd, Hdh; Hd; Hdh |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3119 aa
Average Mass: 344.690 kDa
Monoisotopic Mass: 344.471 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HEAT 1. | 101 | 137 | 17.4 | 0.059 |
| HEAT 2. | 182 | 218 | 6.9 | 6.9 |
| HEAT 3. | 225 | 260 | 17.6 | 0.053 |
| HEAT 4. | 331 | 366 | 5.3 | 11 |
| Mlf1IP 1. | 371 | 500 | -106.8 | 9.2 |
| --- cleavage 513 --- | ||||
| DUF801 1. | 537 | 565 | 9.4 | 1.2 |
| HEAT 5. | 723 | 759 | 11.1 | 2.2 |
| HEAT_PBS 1. | 763 | 797 | 9.7 | 4 |
| HEAT 6. | 881 | 918 | 20.1 | 0.009 |
| SFT2 1. | 994 | 1085 | -68.1 | 2.7 |
| RUN 1. | 1113 | 1316 | -43.2 | 7.2 |
| Borrelia_lipo_2 1. | 1374 | 1471 | -26.6 | 8.1 |
| Utp13 1. | 1541 | 1644 | -61.7 | 0.93 |
| Neurokinin_B 1. | 1993 | 2046 | 0.1 | 5 |
| CNTF 1. | 2135 | 2311 | -101.8 | 6.8 |
| Propeptide_C1 1. | 2422 | 2456 | -10.1 | 9.7 |
| DUF1072 1. | 2475 | 2512 | -9.3 | 7.3 |
| LIF_OSM 1. | 2773 | 2957 | -102.7 | 5.6 |
| DUF1250 1. | 2960 | 2998 | -6.9 | 9.2 |
3. Sequence Information
Fasta Sequence: XSB1668.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] DEEDILSHSS513-SQFSAVPSDP
Ser513 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp504 | Glu505 | Glu506 | Asp507 | Ile508 | Leu509 | Ser510 | His511 | Ser512 | Ser513 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser514 | Gln515 | Phe516 | Ser517 | Ala518 | Val519 | Pro520 | Ser521 | Asp522 | Pro523 |
Sequence conservation (by blast)
* References
[PubMed ID: 8162057] Lin B, Nasir J, MacDonald H, Hutchinson G, Graham RK, Rommens JM, Hayden MR, Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat [corrected] Hum Mol Genet. 1994 Jan;3(1):85-92.