logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1811 : spectrin, beta, erythrocytic (includes spherocytosis, clinical type I), isoform CRA_d [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0052

* Basic Information

OrganismHomo sapiens (human)
Protein Namesspectrin; beta; erythrocytic (includes spherocytosis; clinical type I); isoform CRA_d
Gene NamesSPTB
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW80878 N/A 6710 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2137 aa

Average Mass: 246.469 kDa

Monoisotopic Mass: 246.317 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CH 1. 55158121.72.4e-33
CH 2. 174278148.61.9e-41
Spectrin 1. 30241273.76.9e-19
Spectrin 2. 422526106.11.2e-28
Spectrin 3. 52863596.59.2e-26
Spectrin 4. 637741125.61.6e-34
Spectrin 5. 74384699.51.2e-26
Spectrin 6. 84895275.91.5e-19
Spectrin 7. 954105986.01.3e-22
Spectrin 8. 1061116699.79.9e-27
Spectrin 9. 1168127227.36.5e-05
Spectrin 10. 12741377108.03.3e-29
Spectrin 11. 1381147628.33.2e-05
Spectrin 12. 1478158277.74.2e-20
Spectrin 13. 1584168898.32.6e-26
Spectrin 14. 16901795114.34e-31
Spectrin 15. 1797190186.49.9e-23
Spectrin 16. 19032007102.41.6e-27
Spectrin 17. 2009209517.60.0011
--- cleavage 2061 (inside Spectrin 2009..2095) ---

3. Sequence Information

Fasta Sequence: XSB1811.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EAFEKSTASW2061-AERFAALEKP

Trp2061 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu2052Ala2053Phe2054Glu2055Lys2056Ser2057Thr2058Ala2059Ser2060Trp2061
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala2062Glu2063Arg2064Phe2065Ala2066Ala2067Leu2068Glu2069Lys2070Pro2071

Sequence conservation (by blast)

* References

[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.