XSB1812 : spectrin, beta, erythrocytic (includes spherocytosis, clinical type I), isoform CRA_b [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0078
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | spectrin; beta; erythrocytic (includes spherocytosis; clinical type I); isoform CRA_b |
| Gene Names | SPTB |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2363 aa
Average Mass: 271.771 kDa
Monoisotopic Mass: 271.603 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 55 | 158 | 121.7 | 2.4e-33 |
| CH 2. | 174 | 278 | 148.6 | 1.9e-41 |
| Spectrin 1. | 302 | 412 | 73.7 | 6.9e-19 |
| Spectrin 2. | 422 | 526 | 106.1 | 1.2e-28 |
| Spectrin 3. | 528 | 635 | 96.5 | 9.2e-26 |
| Spectrin 4. | 637 | 741 | 125.6 | 1.6e-34 |
| Spectrin 5. | 743 | 846 | 99.5 | 1.2e-26 |
| Spectrin 6. | 848 | 952 | 75.9 | 1.5e-19 |
| Spectrin 7. | 954 | 1059 | 86.0 | 1.3e-22 |
| Spectrin 8. | 1061 | 1166 | 99.7 | 9.9e-27 |
| Spectrin 9. | 1168 | 1272 | 27.3 | 6.5e-05 |
| Spectrin 10. | 1274 | 1377 | 108.0 | 3.3e-29 |
| Spectrin 11. | 1381 | 1476 | 30.2 | 8.7e-06 |
| Spectrin 12. | 1478 | 1582 | 77.7 | 4.2e-20 |
| Spectrin 13. | 1584 | 1688 | 98.3 | 2.6e-26 |
| Spectrin 14. | 1690 | 1795 | 114.3 | 4e-31 |
| Spectrin 15. | 1797 | 1901 | 86.4 | 9.9e-23 |
| Spectrin 16. | 1903 | 2007 | 102.4 | 1.6e-27 |
| Spectrin 17. | 2009 | 2095 | 17.6 | 0.0011 |
| --- cleavage 2058 (inside Spectrin 2009..2095) --- | ||||
| PH 1. | 2179 | 2323 | 52.9 | 1.2e-12 |
3. Sequence Information
Fasta Sequence: XSB1812.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] KRHEAFEKST2058-ASWAERFAAL
Thr2058 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Lys2049 | Arg2050 | His2051 | Glu2052 | Ala2053 | Phe2054 | Glu2055 | Lys2056 | Ser2057 | Thr2058 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala2059 | Ser2060 | Trp2061 | Ala2062 | Glu2063 | Arg2064 | Phe2065 | Ala2066 | Ala2067 | Leu2068 |
Sequence conservation (by blast)
* References
[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.