CaMPDB :: Substrate

XSB1814 : PREDICTED: spectrin beta isoform 4 [Pan troglodytes]

This entry is computationally expanded from SB0078

* Basic Information

Organism	Pan troglodytes (chimpanzee)
Protein Names	spectrin beta isoform 4
Gene Names	SPTB; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 10 mRNAs, 117 ESTs, 33 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_510006	XM_510006	452970	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2326 aa

Average Mass: 267.709 kDa

Monoisotopic Mass: 267.544 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	55	158	121.7	2.4e-33
CH 2.	174	278	149.2	1.3e-41
Spectrin 1.	302	412	73.7	6.9e-19
Spectrin 2.	422	526	106.6	8.3e-29
Spectrin 3.	528	635	97.8	3.6e-26
Spectrin 4.	637	741	125.8	1.4e-34
Spectrin 5.	743	846	99.5	1.2e-26
Spectrin 6.	848	952	75.9	1.5e-19
Spectrin 7.	954	1059	86.0	1.3e-22
Spectrin 8.	1061	1166	99.7	9.9e-27
Spectrin 9.	1168	1272	27.3	6.5e-05
Spectrin 10.	1274	1377	108.0	3.3e-29
Spectrin 11.	1381	1476	28.3	3.2e-05
Spectrin 12.	1478	1582	77.7	4.2e-20
Spectrin 13.	1584	1688	98.3	2.6e-26
Spectrin 14.	1690	1795	114.3	4e-31
Spectrin 15.	1797	1901	86.4	9.9e-23
Spectrin 16.	1903	2007	102.4	1.6e-27
Spectrin 17.	2009	2095	17.6	0.0011
--- cleavage 2058 (inside Spectrin 2009..2095) ---
PH 1.	2179	2288	71.0	4.3e-18

3. Sequence Information

Fasta Sequence: XSB1814.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] KRHEAFEKST²⁰⁵⁸-ASWAERFAAL

Thr²⁰⁵⁸ Ala

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Lys²⁰⁴⁹	Arg²⁰⁵⁰	His²⁰⁵¹	Glu²⁰⁵²	Ala²⁰⁵³	Phe²⁰⁵⁴	Glu²⁰⁵⁵	Lys²⁰⁵⁶	Ser²⁰⁵⁷	Thr²⁰⁵⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ala²⁰⁵⁹	Ser²⁰⁶⁰	Trp²⁰⁶¹	Ala²⁰⁶²	Glu²⁰⁶³	Arg²⁰⁶⁴	Phe²⁰⁶⁵	Ala²⁰⁶⁶	Ala²⁰⁶⁷	Leu²⁰⁶⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEE

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	122.00	61	spectrin, beta, erythrocytic (includes spherocytos
2	N/A	122.00	16	-
3	Mus musculus	114.00	47	mKIAA4219 protein
4	Danio rerio	79.30	9	spectrin, beta, erythrocytic
5	Drosophila melanogaster	76.30	8	beta Spectrin CG5870-PA
6	Gallus gallus	76.30	5	PREDICTED: similar to spectrin, beta, non-erythroc
7	Aedes aegypti	76.30	3	beta chain spectrin
8	Drosophila pseudoobscura	76.30	3	GA19192-PA
9	Anopheles gambiae str. PEST	75.50	3	ENSANGP00000012507
10	Canis familiaris	75.10	18	PREDICTED: similar to Spectrin beta chain, brain 1
11	Pan troglodytes	75.10	14	PREDICTED: similar to beta-spectrin isoform 1
12	Rattus norvegicus	75.10	13	spectrin beta 2
13	Macaca mulatta	75.10	5	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
14	Bos taurus	75.10	5	PREDICTED: similar to spectrin, beta, non-erythroc
15	Macaca fascicularis	75.10	2	unnamed protein product
16	mice, brain, Peptide Partial, 332 aa	75.10	1	beta-spectrin subunit
17	Apis mellifera	73.90	3	PREDICTED: similar to Spectrin beta chain
18	Tribolium castaneum	71.60	4	PREDICTED: similar to Spectrin beta chain isoform
19	Tetraodon nigroviridis	69.30	8	unnamed protein product
20	Caenorhabditis briggsae	64.70	3	Hypothetical protein CBG19038
21	Strongylocentrotus purpuratus	64.30	5	PREDICTED: similar to spectrin beta 2
22	Caenorhabditis elegans	63.20	5	AF166169_1 beta-G spectrin
23	Brugia malayi	63.20	1	beta-G spectrin
24	Sus scrofa	43.90	1	spectrin alpha non-erythrocytic 1
25	Monodelphis domestica	36.60	4	PREDICTED: similar to spectrin, alpha, erythrocyti
26	Xenopus tropicalis	35.80	1	hypothetical protein LOC100036647
27	Mus sp.	34.70	1	SPTB1_MOUSE Spectrin beta chain, erythrocyte (Beta

Top-ranked sequences

organism	matching
Homo sapiens	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088
N/A	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088
Mus musculus	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|\| Sbjct 618 EPYLASRDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQTPERPTEE 677
Danio rerio	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|+\|\| \| \| \|\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|#\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2048 EPYVASKDVGQTVDEVEKLLKRHEAFEKST#ATWEERFSALERLTTLELLE 2097
Drosophila melanogaster	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLLSSELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQELAEE 2097
Gallus gallus	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|\|\|\|\|+ \|\|\|\|\| \| Sbjct 2036 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFAALERLTTLELLE 2085
Aedes aegypti	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLMSTELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQEAAEE 2097
Drosophila pseudoobscura	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLLSSELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQELAEE 2097
Anopheles gambiae str. PEST	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLMSTELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQDAAEE 2097
Canis familiaris	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2037 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2086
Pan troglodytes	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2037 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2086
Rattus norvegicus	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2032 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2081
Macaca mulatta	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2024 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2073
Bos taurus	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2036 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2085
Macaca fascicularis	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 367 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 416
mice, brain, Peptide Partial, 332 aa	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 163 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 212
Apis mellifera	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\| + \|\| \|\|\|\| + \|+ \|\| Sbjct 2036 EPYLMSQELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALHRLTTFELKEMKRREQEREE 2095
Tribolium castaneum	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 2080 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|+\| \| Sbjct 2037 EPYLMSTELGHTIDDVENLIKKHEAFEKSA#AAQEERFSALERLTTFELREIQ 2088
Tetraodon nigroviridis	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 2080 \|\|\|\|+\| + \| +\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|+ \|+ Sbjct 1937 EPYLSSREVGRSVDQVEKLLKRHEAFEKSA#ATWEERFSALERLTTVSAGPRR 1988
Caenorhabditis briggsae	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| \| ++ Sbjct 2024 EPYLISREYGRNLEETIKLIKKHEAFEKSA#LAQEERFLALEKLTTFELKENQHREEETQK 2083
Strongylocentrotus purpuratus	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 2078 \| \|\| \| \|+\| ++\| \|\|\|\|\|\|\|\|\|\|\|\|\|+ # \|\|\| \|\|\|\| \|\| \|\|+\| Sbjct 2026 EQYLRSDDYGDSLDEVEKLIKRHEAFEKAL#YCQEERFTALEKLTTFELRE 2075
Caenorhabditis elegans	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAE 2083 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| \| Sbjct 2027 EPYLISKEYGRNLEETIKLIKKHEAFEKSA#FAQEERFLALEKLTTFELKETQHRE 2081
Brugia malayi	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 2080 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| Sbjct 2033 EPYLVSKEYGRNLEETIKLIKKHEAFEKSA#NAQEERFLALEKLTTFELKEMQ 2084
Sus scrofa	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIA 2082 \| +\| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| #++ \|+ \|\|++ \| ++ \| Sbjct 24 EAFLLNEDLGDSLDSVEALLKKHEDFEKSL#SAQEEKITALDEFVTKLIQNNHYA 77
Monodelphis domestica	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTT 2073 \| +\| + \| \|+++ +\|\| \|+++\|\| \|\|++ # + \|+ \|+\| \| Sbjct 487 EAFLENEDLGNSLGTVEALLQKHEDFEEAF#GAQEEKITTLDKTAT 531
Xenopus tropicalis	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAE 2083 \| +\| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| #++ \|+ \|\|++ \| ++ \|+ Sbjct 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSL#SAQEEKITALDEFATKLIQNNHYAK 541 Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALE 2069 \| +\| \| \| \| ++\|\|\|\| \|\|\|+\|\| \|+\|+ # \|+ \|\|\|+ Sbjct 1464 EAFLNSEDKGDSLDSVEALIKKHEDFDKAI#NVQEEKIAALQ 1504 Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAAL 2068 \| +\|\| \|\|\| + \|\|+ \|+++\|\| \|+ #\|+ \|+ \|\| Sbjct 275 EQLMASDDFGRDLASVQALLRKHEGLERDL#AALEEKVKAL 314
Mus sp.	Query 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 2088 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|\| Sbjct 2020 EPYLASRDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQTPERPTEE 2079 Query 2036 DFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALE 2069 +\|\|+ + +\|\| \|+\|\|\| \| \|#\|++ \|\| \|\|\| Sbjct 441 NFGYDLAAVEAAKKKHEAIETDT#AAYEERVKALE 474

* References

None.