XSB1823 : spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) variant [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0061
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Spectrin alpha chain, brain; Spectrin, non-erythroid alpha chain; Alpha-II spectrin; Fodrin alpha chain; spectrin; alpha; non-erythrocytic 1 (alpha-fodrin) variant |
| Gene Names | SPTA2 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| BAD93097 |
N/A |
N/A |
Q13813 |
N/A |
N/A |
N/A |
hsa:6709 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2506 aa
Average Mass: 288.213 kDa
Monoisotopic Mass: 288.036 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Spectrin 1. | 78 | 181 | 128.0 | 3.1e-35 |
| Spectrin 2. | 183 | 287 | 139.8 | 8.3e-39 |
| Spectrin 3. | 289 | 393 | 139.5 | 1e-38 |
| Spectrin 4. | 395 | 499 | 115.0 | 2.5e-31 |
| Spectrin 5. | 501 | 605 | 131.3 | 3e-36 |
| Spectrin 6. | 607 | 710 | 125.4 | 1.9e-34 |
| Spectrin 7. | 712 | 816 | 146.3 | 9.3e-41 |
| Spectrin 8. | 818 | 922 | 153.3 | 7.5e-43 |
| SH3_1 1. | 1004 | 1058 | 78.9 | 1.8e-20 |
| Spectrin 9. | 1125 | 1265 | 71.6 | 2.9e-18 |
| --- cleavage 1210 (inside Spectrin 1125..1265) --- |
| Spectrin 10. | 1267 | 1371 | 149.2 | 1.3e-41 |
| Spectrin 11. | 1373 | 1477 | 119.7 | 9.5e-33 |
| Spectrin 12. | 1479 | 1583 | 127.9 | 3.3e-35 |
| Spectrin 13. | 1585 | 1690 | 100.8 | 4.6e-27 |
| Spectrin 14. | 1692 | 1796 | 135.1 | 2.3e-37 |
| Spectrin 15. | 1798 | 1902 | 146.8 | 6.5e-41 |
| Spectrin 16. | 1904 | 2008 | 130.9 | 4e-36 |
| Spectrin 17. | 2010 | 2115 | 121.0 | 3.8e-33 |
| Spectrin 18. | 2125 | 2229 | 72.2 | 1.9e-18 |
| Spectrin 19. | 2239 | 2344 | 68.7 | 2.1e-17 |
| efhand 1. | 2361 | 2389 | 36.5 | 1e-07 |
| efhand 2. | 2404 | 2432 | 23.4 | 0.00096 |
| efhand_Ca_insen 1. | 2436 | 2505 | 44.6 | 3.8e-10 |
3. Sequence Information
Fasta Sequence: XSB1823.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB:
2FOT (X-ray; 245 A; C=1172-1210), 3FB2 (X-ray; 230 A; A/B=1337-1544)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VQAVQQQEVY1210-GMMPRDETDS
Tyr1210 
Gly
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val1201 | Gln1202 | Ala1203 | Val1204 | Gln1205 | Gln1206 | Gln1207 | Glu1208 | Val1209 | Tyr1210 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gly1211 | Met1212 | Met1213 | Pro1214 | Arg1215 | Asp1216 | Glu1217 | Thr1218 | Asp1219 | Ser1220 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
95.50 |
16 |
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) |
| 2 |
N/A |
95.50 |
4 |
- |
| 3 |
Monodelphis domestica |
94.40 |
2 |
PREDICTED: similar to spectrin alpha 2 isoform 1 |
| 4 |
Canis familiaris |
94.40 |
1 |
PREDICTED: similar to Spectrin alpha chain, brain |
| 5 |
Rattus norvegicus |
93.60 |
3 |
alpha-spectrin 2 |
| 6 |
Bos taurus |
91.70 |
2 |
PREDICTED: similar to SPTAN1 protein isoform 2 |
| 7 |
Mus musculus |
91.30 |
19 |
PREDICTED: similar to Spectrin alpha chain, brain |
| 8 |
Gallus gallus |
91.30 |
3 |
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) |
| 9 |
Xenopus tropicalis |
66.60 |
1 |
hypothetical protein LOC100036647 |
| 10 |
Tetraodon nigroviridis |
58.20 |
2 |
unnamed protein product |
| 11 |
Danio rerio |
57.40 |
1 |
alpha II-spectrin |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#||||||||||||||||||||||||||||||
Sbjct 1181 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
|
| N/A |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#||||||||||||||||||||||||||||||
Sbjct 472 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDETDSKTASPWKSARLMVHTVATFN 531
|
| Monodelphis domestica |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#||||||+|||||||||||||||||||||||
Sbjct 1127 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1186
|
| Canis familiaris |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#||||||+|||||||||||||||||||||||
Sbjct 1243 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1302
|
| Rattus norvegicus |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#||||||| ||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDEADSKTASPWKSARLMVHTVATFN 1206
|
| Bos taurus |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#| |||||+||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDESDSKTASPWKSARLMVHTVATFN 1206
|
| Mus musculus |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||||||||||| |#| ||||| ||||||||||||||||||||||
Sbjct 1160 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1219
|
| Gallus gallus |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
|||||||| |||||||| |#|||||||||||| |||||||+|||||||||
Sbjct 1147 LKDINKVANDLESEGLMAEEVQAVEHQEVY#GMMPRDETDSKTVSPWKSARMMVHTVATFN 1206
|
| Xenopus tropicalis |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1240
||||||||++||||||+ |#|| ||| |||+|||||| | | |||||
Sbjct 1147 LKDINKVADELESEGLITEEVQPVQHQEVY#GMQ-RDEADSKSASPWKSVRTAVLAVATFN 1205
|
| Tetraodon nigroviridis |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GMMP----RDETDSKTASPWKSARLMVHTV 1236
|+|||||| +||||||| # ++ +|| |||||||||+ || | |
Sbjct 1267 LRDINKVAAELESEGLMAEETPMVQAQQQQ#ELLGAAPGKDEADSKTASPWKNVRLAVQTT 1326
Query 1237 ATFN 1240
| ||
Sbjct 1327 ANFN 1330
|
| Danio rerio |
Query 1181 LKDINKVAEDLESEGLMXXXXXXXXXXXX--Y#GMMP-RDETDSKTASPWKSARLMVHTVA 1237
|+|||||| +||||||| #| | +|| ||| |||||| || | | |
Sbjct 1147 LRDINKVASELESEGLMAEEAPVVQAQQVEVL#GSAPGKDEADSKGASPWKSVRLAVQTTA 1206
Query 1238 TFN 1240
||
Sbjct 1207 NFN 1209
|
