XSB1840 : spectrin alpha 2 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0061
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | spectrin alpha 2 |
| Gene Names | Spna2; RP23-443G7.6-004 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| CAM46237 |
N/A |
N/A |
A3KGU7 |
N/A |
N/A |
N/A |
mmu: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2477 aa
Average Mass: 285.152 kDa
Monoisotopic Mass: 284.977 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Spectrin 1. | 44 | 147 | 126.7 | 7.3e-35 |
| Spectrin 2. | 149 | 253 | 137.0 | 5.9e-38 |
| Spectrin 3. | 255 | 359 | 138.5 | 2.1e-38 |
| Spectrin 4. | 361 | 465 | 111.7 | 2.4e-30 |
| Spectrin 5. | 467 | 571 | 127.2 | 5.4e-35 |
| Spectrin 6. | 573 | 676 | 125.9 | 1.3e-34 |
| Spectrin 7. | 678 | 782 | 146.3 | 9.3e-41 |
| Spectrin 8. | 784 | 888 | 155.6 | 1.5e-43 |
| SH3_1 1. | 970 | 1024 | 78.9 | 1.8e-20 |
| Spectrin 9. | 1091 | 1231 | 68.3 | 2.8e-17 |
| --- cleavage 1176 (inside Spectrin 1091..1231) --- |
| Spectrin 10. | 1233 | 1337 | 147.8 | 3.4e-41 |
| Spectrin 11. | 1339 | 1442 | 115.6 | 1.6e-31 |
| Spectrin 12. | 1445 | 1549 | 119.6 | 1e-32 |
| Spectrin 13. | 1551 | 1661 | 86.0 | 1.3e-22 |
| Spectrin 14. | 1663 | 1767 | 132.2 | 1.6e-36 |
| Spectrin 15. | 1769 | 1873 | 149.9 | 7.8e-42 |
| Spectrin 16. | 1875 | 1979 | 130.9 | 4e-36 |
| Spectrin 17. | 1981 | 2086 | 117.1 | 6e-32 |
| Spectrin 18. | 2096 | 2200 | 72.2 | 1.9e-18 |
| Spectrin 19. | 2210 | 2315 | 68.7 | 2.1e-17 |
| efhand 1. | 2332 | 2360 | 36.5 | 1e-07 |
| efhand 2. | 2375 | 2403 | 23.4 | 0.00096 |
| efhand_Ca_insen 1. | 2407 | 2476 | 44.6 | 3.8e-10 |
3. Sequence Information
Fasta Sequence: XSB1840.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VQAVQQQEVY1176-GAMPRDEADS
Tyr1176 
Gly
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val1167 | Gln1168 | Ala1169 | Val1170 | Gln1171 | Gln1172 | Gln1173 | Glu1174 | Val1175 | Tyr1176 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Gly1177 | Ala1178 | Met1179 | Pro1180 | Arg1181 | Asp1182 | Glu1183 | Ala1184 | Asp1185 | Ser1186 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWKSARLMVHTVATFN
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
94.70 |
19 |
spectrin alpha 2 |
| 2 |
Bos taurus |
93.60 |
2 |
PREDICTED: similar to SPTAN1 protein isoform 2 |
| 3 |
N/A |
92.80 |
4 |
S |
| 4 |
Rattus norvegicus |
92.80 |
3 |
alpha-spectrin 2 |
| 5 |
Homo sapiens |
91.30 |
16 |
alpha II spectrin |
| 6 |
Monodelphis domestica |
90.10 |
2 |
PREDICTED: similar to spectrin alpha 2 isoform 1 |
| 7 |
Canis familiaris |
90.10 |
1 |
PREDICTED: similar to Spectrin alpha chain, brain |
| 8 |
Gallus gallus |
87.00 |
3 |
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) |
| 9 |
Xenopus tropicalis |
67.80 |
1 |
hypothetical protein LOC100036647 |
| 10 |
Tetraodon nigroviridis |
61.60 |
2 |
unnamed protein product |
| 11 |
Danio rerio |
59.70 |
1 |
alpha II-spectrin |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#||||||||||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
|
| Bos taurus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#|||||||+||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GAMPRDESDSKTASPWKSARLMVHTVATFN 1206
|
| N/A |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||||||||||||||||||||||||||
Sbjct 93 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDEADSKTASPWKSARLMVHTVATFN 152
|
| Rattus norvegicus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||||||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDEADSKTASPWKSARLMVHTVATFN 1206
|
| Homo sapiens |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||| ||||||||||||||||||||||
Sbjct 1147 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDETDSKTASPWKSARLMVHTVATFN 1206
|
| Monodelphis domestica |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||+ ||||||||||||||||||||||
Sbjct 1127 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1186
|
| Canis familiaris |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||||||||||| |#| ||||+ ||||||||||||||||||||||
Sbjct 1243 LKDINKVAEDLESEGLMAEEVQAVQQQEVY#GMMPRDDTDSKTASPWKSARLMVHTVATFN 1302
|
| Gallus gallus |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
|||||||| |||||||| |#| ||||| |||| |||||||+|||||||||
Sbjct 1147 LKDINKVANDLESEGLMAEEVQAVEHQEVY#GMMPRDETDSKTVSPWKSARMMVHTVATFN 1206
|
| Xenopus tropicalis |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY#GAMPRDEADSKTASPWKSARLMVHTVATFN 1206
||||||||++||||||+ |#| | |||||||+|||||| | | |||||
Sbjct 1147 LKDINKVADELESEGLITEEVQPVQHQEVY#G-MQRDEADSKSASPWKSVRTAVLAVATFN 1205
|
| Tetraodon nigroviridis |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXXY---#GAMP-RDEADSKTASPWKSARLMVHTV 1202
|+|||||| +||||||| #|| | +||||||||||||+ || | |
Sbjct 1267 LRDINKVAAELESEGLMAEETPMVQAQQQQELL#GAAPGKDEADSKTASPWKNVRLAVQTT 1326
Query 1203 ATFN 1206
| ||
Sbjct 1327 ANFN 1330
|
| Danio rerio |
Query 1147 LKDINKVAEDLESEGLMXXXXXXXXXXXX--Y#GAMP-RDEADSKTASPWKSARLMVHTVA 1203
|+|||||| +||||||| #|+ | +|||||| |||||| || | | |
Sbjct 1147 LRDINKVASELESEGLMAEEAPVVQAQQVEVL#GSAPGKDEADSKGASPWKSVRLAVQTTA 1206
Query 1204 TFN 1206
||
Sbjct 1207 NFN 1209
|
