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XSB1853 : spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) [Gallus gallus]

[ CaMP Format ]

This entry is computationally expanded from SB0061

* Basic Information

OrganismGallus gallus (chicken)
Protein NamesSpectrin alpha chain, brain; Spectrin, non-erythroid alpha chain; Fodrin alpha chain; spectrin; alpha; non-erythrocytic 1 (alpha-fodrin); alpha-spectrin; spectrin alpha chain; nonerythroid alpha-spectrin
Gene NamesSPTAN1; SPTA2; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
Gene Locus17; chromosome 17
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001036003 NM_001042538 374234 P07751 N/A N/A N/A gga:374234

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2477 aa

Average Mass: 285.363 kDa

Monoisotopic Mass: 285.188 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Spectrin 1. 44147131.13.4e-36
Spectrin 2. 149253140.55.2e-39
Spectrin 3. 255359119.51.1e-32
Spectrin 4. 361465113.37.8e-31
Spectrin 5. 467571129.41.1e-35
Spectrin 6. 573676128.03.1e-35
Spectrin 7. 678782141.23.1e-39
Spectrin 8. 784888152.81e-42
SH3_1 1. 970102478.91.8e-20
Spectrin 9. 1091123170.09e-18
--- cleavage 1176 (inside Spectrin 1091..1231) ---
Spectrin 10. 12331337128.12.8e-35
Spectrin 11. 13391443118.52.3e-32
Spectrin 12. 14451549119.11.4e-32
Spectrin 13. 1551166185.22.4e-22
Spectrin 14. 16631767135.71.5e-37
Spectrin 15. 17691873149.21.2e-41
Spectrin 16. 18751979125.32e-34
Spectrin 17. 19812086115.41.9e-31
Spectrin 18. 2096220072.21.9e-18
Spectrin 19. 2210231568.72.1e-17
efhand 1. 2332236036.51e-07
efhand 2. 2375240322.40.0019
efhand_Ca_insen 1. 2407247646.41.1e-10

3. Sequence Information

Fasta Sequence: XSB1853.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AEY (NMR; -; A=965-1025), 1AJ3 (NMR; -; A=1763-1872), 1BK2 (X-ray; 201 A; A=969-1025), 1CUN (X-ray; 200 A; A/B/C=1772-1982), 1E6G (X-ray; 230 A; A=965-1025), 1E6H (X-ray; 201 A; A=965-1025), 1E7O (X-ray; 320 A; A=965-1025), 1G2B (X-ray; 112 A; A=967-1010, A=1011-1025), 1H8K (X-ray; 270 A; A=965-1025), 1HD3 (X-ray; 198 A; A=965-1025), 1M8M (NMR; -; A=965-1025), 1NEG (X-ray; 230 A; A=965-1024), 1PWT (X-ray; 177 A; A=967-1025), 1QKW (X-ray; 200 A; A=964-1025), 1QKX (X-ray; 180 A; A=964-1025), 1SHG (X-ray; 180 A; A=965-1025), 1TUC (X-ray; 202 A; A=967-1025), 1TUD (X-ray; 177 A; A=967-1025), 1U06 (X-ray; 149 A; A=965-1025), 1U4Q (X-ray; 250 A; A/B=1662-1982), 1U5P (X-ray; 200 A; A=1662-1876), 1UUE (X-ray; 260 A; A=965-1025), 2CDT (X-ray; 254 A; A=965-1025), 2F2V (X-ray; 185 A; A=965-1025), 2F2W (X-ray; 170 A; A=965-1025), 2F2X (X-ray; 160 A; A=965-1025), 2JM8 (NMR; -; A=965-1025), 2JM9 (NMR; -; A=965-1025), 2JMA (NMR; -; A=965-1025), 2JMC (NMR; -; A=967-1025), 2NUZ (X-ray; 185 A; A=965-1025), 2OAW (X-ray; 190 A; A/B/C/D=969-1025), 2PQH (X-ray; 175 A; A/B=968-1035), 2RMO (NMR; -; A=965-1025), 2ROT (NMR; -; A=965-1025)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] VQAVEHQEVY1176-GMMPRDETDS

Tyr1176 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val1167Gln1168Ala1169Val1170Glu1171His1172Gln1173Glu1174Val1175Tyr1176
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly1177Met1178Met1179Pro1180Arg1181Asp1182Glu1183Thr1184Asp1185Ser1186

Sequence conservation (by blast)

* References

[PubMed ID: 17890397] Randles LG, Batey S, Steward A, Clarke J, Distinguishing specific and nonspecific interdomain interactions in multidomain proteins. Biophys J. 2008 Jan 15;94(2):622-8. Epub 2007 Sep 21.

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