XSB1854 : spectrin alpha chain [Gallus gallus]
[ CaMP Format ]
This entry is computationally expanded from SB0061
* Basic Information
| Organism | Gallus gallus (chicken) |
| Protein Names | Spectrin alpha chain, brain; Spectrin, non-erythroid alpha chain; Fodrin alpha chain; spectrin alpha chain |
| Gene Names | SPTAN1; SPTA2 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| CAA32663 | N/A | N/A | P07751 | N/A | N/A | N/A | gga:374234 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2449 aa
Average Mass: 282.012 kDa
Monoisotopic Mass: 281.838 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Spectrin 1. | 16 | 119 | 131.1 | 3.4e-36 |
| Spectrin 2. | 121 | 225 | 140.5 | 5.2e-39 |
| Spectrin 3. | 227 | 331 | 119.5 | 1.1e-32 |
| Spectrin 4. | 333 | 437 | 113.3 | 7.8e-31 |
| Spectrin 5. | 439 | 543 | 129.4 | 1.1e-35 |
| Spectrin 6. | 545 | 648 | 128.0 | 3.1e-35 |
| Spectrin 7. | 650 | 754 | 141.2 | 3.1e-39 |
| Spectrin 8. | 756 | 860 | 152.8 | 1e-42 |
| SH3_1 1. | 942 | 996 | 78.9 | 1.8e-20 |
| Spectrin 9. | 1063 | 1203 | 70.0 | 9e-18 |
| --- cleavage 1148 (inside Spectrin 1063..1203) --- | ||||
| Spectrin 10. | 1205 | 1309 | 128.1 | 2.8e-35 |
| Spectrin 11. | 1311 | 1415 | 118.5 | 2.3e-32 |
| Spectrin 12. | 1417 | 1521 | 119.1 | 1.4e-32 |
| Spectrin 13. | 1523 | 1633 | 85.2 | 2.4e-22 |
| Spectrin 14. | 1635 | 1739 | 135.7 | 1.5e-37 |
| Spectrin 15. | 1741 | 1845 | 149.2 | 1.2e-41 |
| Spectrin 16. | 1847 | 1951 | 125.3 | 2e-34 |
| Spectrin 17. | 1953 | 2058 | 115.4 | 1.9e-31 |
| Spectrin 18. | 2068 | 2172 | 72.2 | 1.9e-18 |
| Spectrin 19. | 2182 | 2287 | 68.7 | 2.1e-17 |
| efhand 1. | 2304 | 2332 | 36.5 | 1e-07 |
| efhand 2. | 2347 | 2375 | 22.4 | 0.0019 |
| efhand_Ca_insen 1. | 2379 | 2448 | 46.4 | 1.1e-10 |
3. Sequence Information
Fasta Sequence: XSB1854.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1AEY (NMR; -; A=965-1025), 1AJ3 (NMR; -; A=1763-1872), 1BK2 (X-ray; 201 A; A=969-1025), 1CUN (X-ray; 200 A; A/B/C=1772-1982), 1E6G (X-ray; 230 A; A=965-1025), 1E6H (X-ray; 201 A; A=965-1025), 1E7O (X-ray; 320 A; A=965-1025), 1G2B (X-ray; 112 A; A=967-1010, A=1011-1025), 1H8K (X-ray; 270 A; A=965-1025), 1HD3 (X-ray; 198 A; A=965-1025), 1M8M (NMR; -; A=965-1025), 1NEG (X-ray; 230 A; A=965-1024), 1PWT (X-ray; 177 A; A=967-1025), 1QKW (X-ray; 200 A; A=964-1025), 1QKX (X-ray; 180 A; A=964-1025), 1SHG (X-ray; 180 A; A=965-1025), 1TUC (X-ray; 202 A; A=967-1025), 1TUD (X-ray; 177 A; A=967-1025), 1U06 (X-ray; 149 A; A=965-1025), 1U4Q (X-ray; 250 A; A/B=1662-1982), 1U5P (X-ray; 200 A; A=1662-1876), 1UUE (X-ray; 260 A; A=965-1025), 2CDT (X-ray; 254 A; A=965-1025), 2F2V (X-ray; 185 A; A=965-1025), 2F2W (X-ray; 170 A; A=965-1025), 2F2X (X-ray; 160 A; A=965-1025), 2JM8 (NMR; -; A=965-1025), 2JM9 (NMR; -; A=965-1025), 2JMA (NMR; -; A=965-1025), 2JMC (NMR; -; A=967-1025), 2NUZ (X-ray; 185 A; A=965-1025), 2OAW (X-ray; 190 A; A/B/C/D=969-1025), 2PQH (X-ray; 175 A; A/B=968-1035), 2RMO (NMR; -; A=965-1025), 2ROT (NMR; -; A=965-1025)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VQAVEHQEVY1148-GMMPRDETDS
Tyr1148 
Gly
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val1139 | Gln1140 | Ala1141 | Val1142 | Glu1143 | His1144 | Gln1145 | Glu1146 | Val1147 | Tyr1148 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly1149 | Met1150 | Met1151 | Pro1152 | Arg1153 | Asp1154 | Glu1155 | Thr1156 | Asp1157 | Ser1158 |
Sequence conservation (by blast)
* References
[PubMed ID: 2910879] Wasenius VM, Saraste M, Salven P, Eramaa M, Holm L, Lehto VP, Primary structure of the brain alpha-spectrin. J Cell Biol. 1989 Jan;108(1):79-93.