XSB1857 : Troponin T, fast skeletal muscle
[ CaMP Format ]
This entry is computationally expanded from SB0029
* Basic Information
| Organism | Oryctolagus cuniculus (rabbit) |
| Protein Names | TnTf; Fast skeletal muscle troponin T; fTnT |
| Gene Names | TNNT3 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 279 aa
Average Mass: 33.034 kDa
Monoisotopic Mass: 33.014 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 65 --- | ||||
| Troponin 1. | 83 | 225 | 194.6 | 2.8e-55 |
3. Sequence Information
Fasta Sequence: XSB1857.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] EEEKPRPKLT65-APKIPEGEKV
Thr65 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu56 | Glu57 | Glu58 | Lys59 | Pro60 | Arg61 | Pro62 | Lys63 | Leu64 | Thr65 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala66 | Pro67 | Lys68 | Ile69 | Pro70 | Glu71 | Gly72 | Glu73 | Lys74 | Val75 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| VHVPEEVHEDALEDMREEEEEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 108.00 | 15 | T |
| 2 | Mus musculus | 89.00 | 28 | troponin T3, skeletal, fast |
| 3 | rabbits, skeletal muscle, Peptide Partial, 234 aa | 85.10 | 1 | troponin T alpha isoform, TnT alpha isoform, TnT-7 |
| 4 | Sus scrofa | 83.60 | 10 | troponin T3, skeletal, fast |
| 5 | Homo sapiens | 83.20 | 30 | troponin T3, skeletal, fast isoform 3 |
| 6 | synthetic construct | 83.20 | 2 | troponin T3, skeletal, fast |
| 7 | Bos taurus | 82.40 | 10 | troponin T fast skeletal muscle type |
| 8 | Macaca mulatta | 82.40 | 6 | PREDICTED: similar to Troponin T, fast skeletal mu |
| 9 | Canis familiaris | 82.40 | 6 | PREDICTED: similar to Troponin T, fast skeletal mu |
| 10 | rabbits, skeletal muscle, Peptide, 249 aa | 82.00 | 1 | troponin T beta isoform, TnT beta isoform, TnT-5 { |
| 11 | Rattus norvegicus | 81.60 | 48 | troponin T class IVd alpha-1 |
| 12 | Xenopus laevis | 80.10 | 11 | fast troponin T |
| 13 | Hyla chrysoscelis | 79.30 | 1 | troponin T |
| 14 | Gallus gallus | 79.00 | 4 | fast skeletal muscle troponin T isoform |
| 15 | Coturnix japonica | 78.20 | 13 | fast troponin T isoform |
| 16 | Mitu tomentosa | 76.60 | 2 | fast skeletal muscle troponin T isoform 2-e16 |
| 17 | Meleagris gallopavo | 75.10 | 4 | fast skeletal muscle troponin T |
| 18 | Xenopus tropicalis | 75.10 | 2 | troponin T type 3 (skeletal, fast) |
| 19 | Tetraodon nigroviridis | 69.70 | 5 | unnamed protein product |
| 20 | Danio rerio | 68.60 | 20 | PREDICTED: similar to fast troponin T isoform 1 |
| 21 | Sparus aurata | 68.20 | 5 | fast/white muscle troponin T embryonic isoform |
| 22 | Salmo salar | 63.90 | 1 | fast myotomal muscle troponin-T |
| 23 | Gadus morhua | 63.50 | 1 | AF500272_1 fast skeletal muscle troponin T |
| 24 | Bufo marinus | 57.80 | 2 | high molecular weight slow troponin T |
| 25 | Monodelphis domestica | 57.40 | 2 | PREDICTED: similar to cardiac troponin T |
| 26 | Oryctolagus cuniculus | 57.40 | 1 | unnamed protein product |
| 27 | Pan troglodytes | 55.50 | 11 | PREDICTED: similar to troponin T type 2, cardiac i |
| 28 | Cavia porcellus | 53.10 | 6 | cardiac troponin 2 adult #2 isoform |
| 29 | Felis catus | 53.10 | 1 | cardiac troponin T |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 36 VHVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 |||||||||||||||| |||||||#|||||||||||||||||||||||||||||| Sbjct 36 VHVPEEVHEDALEDMREEEEEEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 |
| Mus musculus | Query 39 PEEVHEDAL-EDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 |||| |||+ |+ | |||||||#|||||||||||||||||||||||||||||| Sbjct 31 PEEVQEDAVAEEEREEDEEEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 88 |
| rabbits, skeletal muscle, Peptide Partial, 234 aa | Query 46 ALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||||+| |||||||#|||||||||||||||||||||||||||||| Sbjct 1 ALEDVREEEEEEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 50 |
| Sus scrofa | Query 36 VHVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |||| |+ |||||||#|||||||||||||||||||||||||||||| Sbjct 40 VHEPEEVQEEE------------KPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 87 |
| Homo sapiens | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |+| | |||||||#|||||||||||||||||||||||||||||| Sbjct 17 EEAQEEAAEVHEEVHEPEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 72 |
| synthetic construct | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |+| | |||||||#|||||||||||||||||||||||||||||| Sbjct 17 EEAQEEAAEVHEEVHEPEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 72 |
| Bos taurus | Query 36 VHVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |||| |+ ||||+||#|||||||||||||||||||||||||||||| Sbjct 40 VHEPEEVQEEE------------KPRPRLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 87 |
| Macaca mulatta | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||| || |+ |||||||#|||||||||||||||||||||||||||||| Sbjct 23 EEVQEDTAEE----DAEEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 74 |
| Canis familiaris | Query 36 VHVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |||| |+ ||||+||#|||||||||||||||||||||||||||||| Sbjct 30 VHEPEEVQEEE------------KPRPRLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 77 |
| rabbits, skeletal muscle, Peptide, 249 aa | Query 37 HVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |+ |+ |||||||#|||||||||||||||||||||||||||||| Sbjct 7 HVEEQYEEEEEAQEEEEVHEEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 65 |
| Rattus norvegicus | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || +|+ | |||||||#|||||||||||||||||||||||||||||| Sbjct 10 EEQYEEEEEAQEEAPEPEEKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 65 |
| Xenopus laevis | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || +|+| |+ ||+||||#|||||+||||||||||||||||||+|||+| Sbjct 38 EEAYEEAEEEEHGEEYDEEKPKPKLT#APKIPDGEKVDFDDIQKKRQNKDLIELQSL 93 |
| Hyla chrysoscelis | Query 38 VPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 | || |+ |++ ||+||+|#|||||+||||||||||||||||||+|||+| Sbjct 10 VEEEYEEEEAEEVEEHHEAEEKPKPKIT#APKIPDGEKVDFDDIQKKRQNKDLIELQSL 67 |
| Gallus gallus | Query 37 HVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 | |||||+ + + ||| |||#||||||||||||||||||||||||+||||| Sbjct 13 HEAEEVHEEEVHE--PAPPPEEKPRIKLT#APKIPEGEKVDFDDIQKKRQNKDLIELQAL 69 |
| Coturnix japonica | Query 40 EEVHEDA---LEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||||| | + ++ ||| |||#||||||||||||||||||||||||+||||| Sbjct 50 EEVHEPAPPPVHELEEAPEEEEKPRIKLT#APKIPEGEKVDFDDIQKKRQNKDLIELQAL 108 |
| Mitu tomentosa | Query 37 HVPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 | || | | ||| |||#||||||||||||||||||||||||+||||| Sbjct 35 HAHEEAHAHHEEVHEPAPPPEEKPRIKLT#APKIPEGEKVDFDDIQKKRQNKDLIELQAL 93 |
| Meleagris gallopavo | Query 40 EEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || | | ||| |||#||||||||||||||||||||||||+||||| Sbjct 60 EEAHTHVEEVHHAAPPPEEKPRIKLT#APKIPEGEKVDFDDIQKKRQNKDLIELQAL 115 |
| Xenopus tropicalis | Query 38 VPEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 | || |+ ++ ||+||||#||||||||||||||||||||||||+|||+| Sbjct 10 VEEEYEEEESQEQEE------KPKPKLT#APKIPEGEKVDFDDIQKKRQNKDLIELQSL 61 |
| Tetraodon nigroviridis | Query 44 EDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 |+| |+ ||+ | |#||||||||||||||||||||||||+|||+| Sbjct 101 EEAYEEEDEGDQDEEKPKFKPT#APKIPEGEKVDFDDIQKKRQNKDLIELQSL 152 |
| Danio rerio | Query 40 EEVHEDAL--EDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 +||||+ |++ ||+ | +#|||||+|+||||||||||||||||+||||| Sbjct 65 QEVHEEEAYEEEVDEGEQDEEKPKFKPS#APKIPDGDKVDFDDIQKKRQNKDLVELQAL 122 |
| Sparus aurata | Query 39 PEEVHEDALEDMRXXXXXXXKPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 || |+|+|+ ||+ | +#|||||+||||||||||||||||||+||||| Sbjct 58 PEPEPEEAVEEEEE------KPKFKPS#APKIPDGEKVDFDDIQKKRQNKDLVELQAL 108 |
| Salmo salar | Query 61 RPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||+ #|||||+||||||||||||||||||+||| | Sbjct 11 RPQFK#APKIPDGEKVDFDDIQKKRQNKDLVELQGL 45 |
| Gadus morhua | Query 59 KPRPKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||+ | +#|||||+|||||||||||||||||| ||| | Sbjct 14 KPKFKPS#APKIPDGEKVDFDDIQKKRQNKDLSELQGL 50 |
| Bufo marinus | Query 40 EEVHEDALEDMRXXXXXXXKPRPK-----LT#APKIPEGEKVDFDDIQKKRQNKDLMELQA 94 || |+ | +|||+ | # |||||||+|||||| +|| |||+||| Sbjct 15 EEEQEEEKEPTEEAGGEEERPRPRPMMPRLA#PPKIPEGERVDFDDIHRKRMEKDLLELQT 74 Query 95 L 95 | Query 95 L 95 |
| Monodelphis domestica | Query 38 VPEEVHEDALEDMRXXXXXXXKPRPK-----LT#APKIPEGEKVDFDDIQKKRQNKDLMEL 92 | |+ |+ ++++ ||+|| | # ||||+||+|||||| +|| ||| || Sbjct 74 VEEQEEEEEVKEVEDGPVEESKPKPKPFMPNLI#PPKIPDGERVDFDDIHRKRMEKDLNEL 133 Query 93 QAL 95 | | Sbjct 134 QTL 136 |
| Oryctolagus cuniculus | Query 69 IPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||||||||||||||||||||||||||| Query 69 IPEGEKVDFDDIQKKRQNKDLMELQAL 95 |
| Pan troglodytes | Query 40 EEVHEDALEDMRXXXXXXXKPRPK-----LT#APKIPEGEKVDFDDIQKKRQNKDLMELQA 94 |+ |+ ++ ||+|+ | # ||||+||+|||||| +|| ||| |||| Sbjct 40 EDEEEEEAKEAEDGPMEESKPKPRSFMPNLV#PPKIPDGERVDFDDIHRKRMEKDLNELQA 99 Query 95 L 95 | Query 95 L 95 |
| Cavia porcellus | Query 59 KPR---PKLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 ||| | | # ||||+||+|||||| +|| ||| ||| | Sbjct 63 KPRLFMPNLV#PPKIPDGERVDFDDIHRKRMEKDLNELQTL 102 |
| Felis catus | Query 59 KPRP---KLT#APKIPEGEKVDFDDIQKKRQNKDLMELQAL 95 |||| | # ||||+||+|||||| +|| ||| ||| | Sbjct 75 KPRPFMPNLV#PPKIPDGERVDFDDIHRKRMEKDLNELQTL 114 |
* References
[PubMed ID: 320204] Pearlstone JR, Johnson P, Carpenter MR, Smillie LB, Primary structure of rabbit skeletal muscle troponin-T. Sequence determination of the NH2-terminal fragment CB3 and the complete sequence of troponin-T. J Biol Chem. 1977 Feb 10;252(3):983-9.
[PubMed ID: 8344466] ... Briggs MM, Schachat F, Origin of fetal troponin T: developmentally regulated splicing of a new exon in the fast troponin T gene. Dev Biol. 1993 Aug;158(2):503-9.
[PubMed ID: 2373251] ... Briggs MM, McGinnis HD, Schachat F, Transitions from fetal to fast troponin T isoforms are coordinated with changes in tropomyosin and alpha-actinin isoforms in developing rabbit skeletal muscle. Dev Biol. 1990 Aug;140(2):253-60.
[PubMed ID: 2704041] ... Briggs MM, Schachat F, N-terminal amino acid sequences of three functionally different troponin T isoforms from rabbit fast skeletal muscle. J Mol Biol. 1989 Mar 5;206(1):245-9.