XSB1866 : nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Bos taurus]
[ CaMP Format ]
This entry is computationally expanded from SB0011
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | NF kappa B inhibitor alpha; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; alpha; IkappaB alpha |
| Gene Names | NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| Gene Locus | 21; chromosome 21 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001039333 | NM_001045868 | 282291 | Q8WNW7 | N/A | N/A | N/A | bta:282291 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 314 aa
Average Mass: 35.186 kDa
Monoisotopic Mass: 35.164 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Toxin_36 1. | 39 | 51 | 7.2 | 8.6 |
| --- cleavage 50 (inside Toxin_36 39..51) --- | ||||
| Ank 1. | 73 | 109 | 6.7 | 4 |
| Ank 2. | 110 | 142 | 35.7 | 1.9e-07 |
| Ank 3. | 143 | 180 | 17.7 | 0.049 |
| Ank 4. | 182 | 214 | 43.0 | 1.2e-09 |
| Ank 5. | 216 | 248 | 42.7 | 1.4e-09 |
| SNN_linker 1. | 273 | 298 | 4.9 | 6.1 |
3. Sequence Information
Fasta Sequence: XSB1866.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] EYEQMVKELR50-EIRLEPQEAP
Arg50 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu41 | Tyr42 | Glu43 | Gln44 | Met45 | Val46 | Lys47 | Glu48 | Leu49 | Arg50 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu51 | Ile52 | Arg53 | Leu54 | Glu55 | Pro56 | Gln57 | Glu58 | Ala59 | Pro60 |
Sequence conservation (by blast)
* References
[PubMed ID: 19008357] Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G, The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17818-23. Epub 2008 Nov 13.