CaMPDB :: Substrate

XSB1871 : crystallin, beta A1 [Mus musculus]

This entry is computationally expanded from SB0096

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	Beta-A3/A1 crystallin protein; Crystallin, beta A1; crystallin; beta A1; beta-A3/A1-crystallin
Gene Names	Cryba1; RP23-273P3.7-001, mCG_10833; crystallin, beta A1
Gene Locus	11 44.71 cM; chromosome 11
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_034095	NM_009965	12957	Q9QXC6	N/A	N/A	N/A	mmu:12957

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 215 aa

Average Mass: 25.206 kDa

Monoisotopic Mass: 25.190 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
--- cleavage 11 ---
Crystall 1.	32	116	177.0	5.3e-50
Crystall 2.	125	213	185.9	1.1e-52

3. Sequence Information

Fasta Sequence: XSB1871.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] ETQTVQRELE¹¹-TLPTTKMAQT

Glu¹¹ Thr

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu²	Thr³	Gln⁴	Thr⁵	Val⁶	Gln⁷	Arg⁸	Glu⁹	Leu¹⁰	Glu¹¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Thr¹²	Leu¹³	Pro¹⁴	Thr¹⁵	Thr¹⁶	Lys¹⁷	Met¹⁸	Ala¹⁹	Gln²⁰	Thr²¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
METQTVQRELETLPTTKMAQTNPMPGSLGPWKITIYDQENF

Summary

#	organism	max score	hits	top seq
1	Mus musculus	89.00	2	crystallin, beta A1
2	Cavia porcellus	89.00	2	beta A3-crystallin
3	Rattus norvegicus	88.20	2	PREDICTED: similar to Beta crystallin A3
4	Oryctolagus cuniculus	87.40	2	beta A3-crystallin
5	Canis lupus familiaris	85.50	1	crystallin, beta A1
6	N/A	84.70	5	-
7	Bos taurus	84.70	2	beta A3 crystallin
8	Contains: Beta crystallin A3, isoform A1, Delta4 form; Beta crystallin A3, isoform A1, Delta7 form; Beta crystallin A3, isoform A1, Delta8 form	84.70	1	CRBA1_BOVIN Beta crystallin A3
9	Macaca mulatta	82.00	1	PREDICTED: similar to crystallin, beta A3
10	Pan troglodytes	80.90	1	PREDICTED: similar to Beta crystallin A3
11	Homo sapiens	80.90	1	crystallin, beta A3
12	Monodelphis domestica	78.60	1	PREDICTED: similar to beta A3-crystallin
13	Rana catesbeiana	58.20	4	CRB32_RANCA Beta crystallin A3-2 emb
14	Xenopus laevis	49.70	1	crystallin, beta A1
15	Gallus gallus	48.90	1	crystallin, beta A1
16	Tetraodon nigroviridis	48.50	1	unnamed protein product
17	Rana temporaria	47.40	2	unnamed protein product
18	rats, Sprague-Dawley, lens, Peptide Partial, 20 aa	47.40	1	beta-crystallin isoform A3 {internal fragment}
19	Danio rerio	43.90	3	hypothetical protein LOC436683
20	Xenopus tropicalis	41.60	1	Unknown (protein for MGC:122148)

Top-ranked sequences

organism	matching
Mus musculus	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41
Cavia porcellus	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41
Rattus norvegicus	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQRELE#TLPTTKMAQTNPMPGSMGPWKITIYDQENF 41
Oryctolagus cuniculus	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41
Canis lupus familiaris	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#TLPTTKMAQTNPMPGSAGPWKITIYDQENF 41
N/A	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#SLPTTKMAQTNPMPGSVGPWKITIYDQENF 41
Bos taurus	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#SLPTTKMAQTNPMPGSVGPWKITIYDQENF 41
Contains: Beta crystallin A3, isoform A1, Delta4 form; Beta crystallin A3, isoform A1, Delta7 form; Beta crystallin A3, isoform A1, Delta8 form	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#SLPTTKMAQTNPMPGSVGPWKITIYDQENF 41
Macaca mulatta	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|+\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQTVQQELE#TLPTTKMAQTNPTQGSLGPWKITIYDQENF 41
Pan troglodytes	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\| \|+\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQAEQQELE#TLPTTKMAQTNPTPGSLGPWKITIYDQENF 41
Homo sapiens	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\| \|+\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 METQAEQQELE#TLPTTKMAQTNPTPGSLGPWKITIYDQENF 41
Monodelphis domestica	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\| \|\|\|\|\|\|#\|+\| +\|\|\|\|\|\|\|\|\| \|\|\|\|\|+\|\|\|\|\|\|\|\| Sbjct 1 METQAVQRELE#TVPAARMAQTNPMPGPLGPWKVTIYDQENF 41
Rana catesbeiana	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\| +\| \| \|# + + \|\|\|\| \|\|+\| \|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1 MEIPAIQTERE#DITSEKMAQINPLPVPLGPWKITVYDQENF 41
Xenopus laevis	Query 1 METQTVQRELE#TLPTTKMAQTNPMPGSLGPWKITIYDQENF 41 \|\| \|\| \| \|# \| \|\|\|+\|\|\|+ +\| \|\|\|\|+\|\|\|\|\|\| Sbjct 1 MEISPVQTERE#NF-TKKMAETNPLSMRMGSWKITVYDQENF 40
Gallus gallus	Query 18 MAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|+\| +\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1 MAQTNPLPVPMGPWKITVYDQENF 24
Tetraodon nigroviridis	Query 16 TKMAQTNPMPGSLGPWKITIYDQENF 41 \|\|\|\|\|\|\|\|\|\| +\|\|\|\|\|\|+\|\|\|\|+\| Sbjct 1 TKMAQTNPMP--MGPWKITVYDQEHF 24
Rana temporaria	Query 18 MAQTNPMPGSLGPWKITIYDQENF 41 \|\|\| \|\|+\| \|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 1 MAQINPLPVPLGPWKITVYDQENF 24
rats, Sprague-Dawley, lens, Peptide Partial, 20 aa	Query 12 TLPTTKMAQTNPMPGSLGPW 31 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| Sbjct 1 TLPTTKMAQTNPMPGSMGPW 20
Danio rerio	Query 18 MAQTNPMPGSLGPWKITIYDQENF 41 \|\| \|\|\|\|\| \|\|\|\|\|+\|+\|\|\|\|\|\| Sbjct 1 MALTNPMP--LGPWKLTVYDQENF 22
Xenopus tropicalis	Query 18 MAQTNPMPGSLGPWKITIYDQENF 41 \|\|+\|\|\|+ +\| \|\|\|\|+\|\|\|\|\|\| Sbjct 1 MAETNPLSMRMGSWKITVYDQENF 24

* References

[PubMed ID: 17213798] Xiao W, Liu W, Li Z, Liang D, Li L, White LD, Fox DA, Overbeek PA, Chen Q, Gene expression profiling in embryonic mouse lenses. Mol Vis. 2006 Dec 26;12:1692-8.

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