XSB1878 : caspase 9, apoptosis-related cysteine peptidase [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0042
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Caspase 9, apoptosis-related cysteine peptidase; caspase 9; apoptosis-related cysteine peptidase |
| Gene Names | CASP9; RP11-265F14.3-005 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| CAI12974 |
N/A |
N/A |
Q5JRU8 |
N/A |
1511 |
N/A |
hsa: |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 254 aa
Average Mass: 28.377 kDa
Monoisotopic Mass: 28.359 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| CARD 1. | 6 | 92 | 91.5 | 3e-24 |
| --- cleavage 115 --- |
| Peptidase_C14 1. | 161 | 253 | -65.4 | 0.5 |
3. Sequence Information
Fasta Sequence: XSB1878.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] LTPVVLRPEI115-RKPEVLRPET
Ile115 
Arg
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Leu106 | Thr107 | Pro108 | Val109 | Val110 | Leu111 | Arg112 | Pro113 | Glu114 | Ile115 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Arg116 | Lys117 | Pro118 | Glu119 | Val120 | Leu121 | Arg122 | Pro123 | Glu124 | Thr125 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
ASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESL
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
120.00 |
10 |
caspase 9, apoptosis-related cysteine peptidase |
| 2 |
Pan troglodytes |
120.00 |
4 |
PREDICTED: caspase 9 isoform 2 |
| 3 |
synthetic construct |
120.00 |
1 |
Homo sapiens caspase 9, apoptosis-related cysteine |
| 4 |
N/A |
119.00 |
1 |
G |
| 5 |
Macaca fascicularis |
113.00 |
2 |
caspase 9 |
| 6 |
Macaca mulatta |
113.00 |
1 |
PREDICTED: similar to caspase 9 isoform alpha prep |
| 7 |
Mus musculus |
59.30 |
8 |
caspase 9 |
| 8 |
Rattus norvegicus |
53.90 |
5 |
25 kDa caspase-9 dominant negative protein |
| 9 |
Canis familiaris |
48.90 |
2 |
PREDICTED: caspase 9, apoptosis-related cysteine p |
| 10 |
Canis lupus familiaris |
45.80 |
1 |
caspase 9 |
| 11 |
Monodelphis domestica |
40.40 |
1 |
PREDICTED: similar to ICE-LAP6 |
| 12 |
Chromobacterium violaceum ATCC 12472 |
38.90 |
1 |
hypothetical protein CV2832 |
| 13 |
Bacillus weihenstephanensis KBAB4 |
33.50 |
1 |
Extensin-like protein:NEAr transporter |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|
| Pan troglodytes |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|
| synthetic construct |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|
| N/A |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|||||||||| |||||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 86 ASFLRTNRQAGKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|
| Macaca fascicularis |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|||||||||| |||||||||||||||||||#|||||||||||||||||||| ||||| |||
Sbjct 72 ASFLRTNRQAVKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGCGDVGAPESL 131
|
| Macaca mulatta |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALESL 145
|||||||||| |||||||||||||||||||#|||||||||||||||||||| ||||| |||
Sbjct 86 ASFLRTNRQAVKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGCGDVGAPESL 145
|
| Mus musculus |
Query 99 SKPTLENLTPVVLRPEI#R-----KPEVLRPETPRPVDIGSGGFGDV 139
|+| + ||||||| || # ||||||||||||||||||| ||
Sbjct 131 SQPAVGNLTPVVLGPEE#LWPARLKPEVLRPETPRPVDIGSGGAHDV 176
|
| Rattus norvegicus |
Query 99 SKPTLENLTPVVLRPEI#R-----KPEVLRPETPRPVDIGSGGFGDV 139
|+| | ||||||| || # +|||| |||||||||||| ||
Sbjct 132 SQPALGNLTPVVLGPEE#LWPTRLRPEVLTPETPRPVDIGSGRAHDV 177
|
| Canis familiaris |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDV 139
|| | +||| || | | |||| | # +|+|+|| ||| | ||| | ||
Sbjct 86 ASCLTMSRQADP-SKLTPGKLAPVVLGPAE#LQPQVVRPSVPRPTDNGSGRFSDV 138
|
| Canis lupus familiaris |
Query 99 SKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDV 139
|| | | |||| | # +|+|+|| ||| | ||| | ||
Sbjct 129 SKLTPGKLAPVVLGPAE#LQPQVVRPSVPRPTDNGSGRFSDV 169
|
| Monodelphis domestica |
Query 86 ASFLRTNRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRPVDIGSGGFGDVGALES 144
|+ | ||+| | +| | || | | || # +| +|+ | | | || +| | |
Sbjct 84 AALLSENREAGKCLRPHL-NLGPPVSRPLC#DPEQVTKPQLPSPYHSGGGGCIFIGPLRS 141
|
| Chromobacterium violaceum ATCC 12472 |
Query 96 AKLSKPTLENLTPVVLRPEI#RKPEVL-RPETPRPVDIGSGGFGDVG 140
| |||| |+|+ + ||| #+ |+| | |+| + | || +|
Sbjct 111 AALSKPQLQNVFMAIERPET#KPGEILPGEEVPQPTPVNPGEFGSIG 156
|
| Bacillus weihenstephanensis KBAB4 |
Query 92 NRQAAKLSKPTLENLTPVVLRPEI#RKPEVLRPETPRP 128
| + ++ || +| | | +||+# |||| +|| +|
Sbjct 457 NEEKPEVEKPEVEK--PEVEKPEV#EKPEVEKPEVEKP 491
|
